AR072238A1 - PROCESS TO PREPARE NEUTRAL ANATYNOPLASIC DERIVATIVES OF PLATINUM (II) PHARMACEUTICAL DEGREE WITH LOW SILVER CONTENT - Google Patents

PROCESS TO PREPARE NEUTRAL ANATYNOPLASIC DERIVATIVES OF PLATINUM (II) PHARMACEUTICAL DEGREE WITH LOW SILVER CONTENT

Info

Publication number
AR072238A1
AR072238A1 ARP090100095A ARP090100095A AR072238A1 AR 072238 A1 AR072238 A1 AR 072238A1 AR P090100095 A ARP090100095 A AR P090100095A AR P090100095 A ARP090100095 A AR P090100095A AR 072238 A1 AR072238 A1 AR 072238A1
Authority
AR
Argentina
Prior art keywords
silver
cis
complex
diiode
derivatives
Prior art date
Application number
ARP090100095A
Other languages
Spanish (es)
Inventor
Lucio Nunez
Jose Iturraspe
Nora Moyano
Original Assignee
Eriochem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eriochem Sa filed Critical Eriochem Sa
Priority to ARP090100095A priority Critical patent/AR072238A1/en
Priority to PCT/ES2010/070010 priority patent/WO2010081924A1/en
Publication of AR072238A1 publication Critical patent/AR072238A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Reivindicacion 1: Un proceso para preparar derivados antineoplásicos neutros de platino (II) grado farmacéutico con un contenido de plata menor o igual a 3 ppm caracterizado porque comprende: a) proveer una cantidad pesada de complejo cis-diiodo Pt (II), b) realizar la titulacion de una muestra de dicho complejo cis-diiodo Pt (II) con una solucion de plata para determinar la cantidad estequiométrica de plata necesaria para hacer reaccionar dicho complejo cis-diiodo Pt (II), c) agregar a dicho complejo cis-diiodo Pt (II) del paso ôaö una cantidad estequiométrica de solucion de plata, dejar reaccionar con agitacion, y decantar, d) determinar la presencia de plata remanente en el sobrenadante del paso ôcö, e) opcionalmente agregar complejo cis-diiodo de Pt (II) para neutralizar los iones plata que pudieran quedar remanentes detectados en el paso ôdö, f) filtrar eliminando ioduro de plata solido y agregar al filtrado una solucion acuosa de ligando.Claim 1: A process for preparing neutral antineoplastic derivatives of pharmaceutical grade platinum (II) with a silver content less than or equal to 3 ppm characterized in that it comprises: a) providing a heavy amount of cis-diiode complex Pt (II), b) perform the titration of a sample of said cis-diiode Pt (II) complex with a silver solution to determine the stoichiometric amount of silver necessary to react said cis-diiode Pt (II) complex, c) add to said cis-complex Pt (II) diode of step ôaö a stoichiometric amount of silver solution, allow to react with stirring, and decant, d) determine the presence of remaining silver in the supernatant of step ôcö, e) optionally add cis-diode complex of Pt ( II) to neutralize the silver ions that could remain remnants detected in the ôdö step, f) filter removing solid silver iodide and add an aqueous ligand solution to the filtrate.

ARP090100095A 2009-01-13 2009-01-13 PROCESS TO PREPARE NEUTRAL ANATYNOPLASIC DERIVATIVES OF PLATINUM (II) PHARMACEUTICAL DEGREE WITH LOW SILVER CONTENT AR072238A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ARP090100095A AR072238A1 (en) 2009-01-13 2009-01-13 PROCESS TO PREPARE NEUTRAL ANATYNOPLASIC DERIVATIVES OF PLATINUM (II) PHARMACEUTICAL DEGREE WITH LOW SILVER CONTENT
PCT/ES2010/070010 WO2010081924A1 (en) 2009-01-13 2010-01-11 Process for preparing pharmaceutical-grade neutral platinum (ii) antineoplastic derivatives having low silver content

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP090100095A AR072238A1 (en) 2009-01-13 2009-01-13 PROCESS TO PREPARE NEUTRAL ANATYNOPLASIC DERIVATIVES OF PLATINUM (II) PHARMACEUTICAL DEGREE WITH LOW SILVER CONTENT

Publications (1)

Publication Number Publication Date
AR072238A1 true AR072238A1 (en) 2010-08-18

Family

ID=42339477

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100095A AR072238A1 (en) 2009-01-13 2009-01-13 PROCESS TO PREPARE NEUTRAL ANATYNOPLASIC DERIVATIVES OF PLATINUM (II) PHARMACEUTICAL DEGREE WITH LOW SILVER CONTENT

Country Status (2)

Country Link
AR (1) AR072238A1 (en)
WO (1) WO2010081924A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101891771B (en) * 2010-07-30 2012-12-12 重庆泰濠制药有限公司 Method for preparing oxaliplatin
CN103232494A (en) * 2012-05-22 2013-08-07 湖北一半天制药有限公司 Oxaliplatin preparation method
EP2913336A1 (en) * 2014-02-28 2015-09-02 Umicore AG & Co. KG Process for the preparation of carboplatin
CN111808141B (en) * 2020-06-30 2023-12-12 昆明贵研药业有限公司 Method for efficiently preparing lobaplatin anhydrous substance

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2183714B1 (en) * 2001-05-25 2004-01-16 Desynth S A A PROCEDURE FOR THE MANUFACTURE OF OXALATE (1R, 2R-CYCLHEXANODIAMINE) -PLATINO (II).
DE102004005906B3 (en) * 2004-02-05 2005-09-29 W.C. Heraeus Gmbh Process for the preparation of 1,2-diaminocylohexane-platinum (II) complexes
WO2006108428A1 (en) * 2005-04-09 2006-10-19 Vuab Pharma A.S. A process for the preparation of an oxaliplatin preparation
DE602006018205D1 (en) * 2006-06-08 2010-12-23 Vuab Pharma A S METHOD FOR PRODUCING AN OXALIPLATIN

Also Published As

Publication number Publication date
WO2010081924A1 (en) 2010-07-22

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