AR071146A1 - Inhibicion relacionada con arni de la via de senales tnf alfa para el tratamiento de angiogenesis ocular, uso de una molecula de arn de interferencia y molecula de arn de interferencia - Google Patents

Inhibicion relacionada con arni de la via de senales tnf alfa para el tratamiento de angiogenesis ocular, uso de una molecula de arn de interferencia y molecula de arn de interferencia

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Publication number
AR071146A1
AR071146A1 ARP080103367A AR071146A1 AR 071146 A1 AR071146 A1 AR 071146A1 AR P080103367 A ARP080103367 A AR P080103367A AR 071146 A1 AR071146 A1 AR 071146A1
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AR
Argentina
Prior art keywords
molecula
interference rna
arni
treatment
tnfalfa
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English (en)
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Alcon Res Ltd
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Publication of AR071146A1 publication Critical patent/AR071146A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/00—Drugs for disorders of the senses
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/531—Stem-loop; Hairpin

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

ARN de interferencia para la inhibicion de factor de necrosis tumoral alfa (TNFalfa) al silenciar la expresion de mARN del receptor 1 de receptor de superficie celular TNFalfa (TNFR1), o al silenciar la expresion de mARN de la enzima convertidora de TNFalfa (TACE/ADAM17). El silenciamiento de dichos objetivos de TNFalfa, en particular, es util para tratar pacientes que tienen una condicion relacionada con TNFalfa o están en situacion de riesgo de desarrollar una condicion relacionada con TNFalfa, tales como angiogénesis ocular, edema de retina, isquemia de retina y retinopatía diabética.
ARP080103367 2007-08-03 2008-08-01 Inhibicion relacionada con arni de la via de senales tnf alfa para el tratamiento de angiogenesis ocular, uso de una molecula de arn de interferencia y molecula de arn de interferencia AR071146A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95382507P 2007-08-03 2007-08-03

Publications (1)

Publication Number Publication Date
AR071146A1 true AR071146A1 (es) 2010-06-02

Family

ID=40263006

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080103367 AR071146A1 (es) 2007-08-03 2008-08-01 Inhibicion relacionada con arni de la via de senales tnf alfa para el tratamiento de angiogenesis ocular, uso de una molecula de arn de interferencia y molecula de arn de interferencia

Country Status (6)

Country Link
US (8) US20090036396A1 (es)
AR (1) AR071146A1 (es)
CL (1) CL2008002277A1 (es)
TW (1) TW200916117A (es)
UY (1) UY31267A1 (es)
WO (2) WO2009020847A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200808360A (en) 2006-04-13 2008-02-16 Alcon Mfg Ltd RNAi-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions
AR071146A1 (es) 2007-08-03 2010-06-02 Alcon Res Ltd Inhibicion relacionada con arni de la via de senales tnf alfa para el tratamiento de angiogenesis ocular, uso de una molecula de arn de interferencia y molecula de arn de interferencia
CN106943647B (zh) 2010-08-05 2020-09-04 B·布朗·梅尔松根有限公司 针安全装置和组件
WO2014174834A1 (ja) * 2013-04-25 2014-10-30 国立大学法人山口大学 神経疾患治療剤
CN107904239B (zh) * 2014-12-25 2020-11-27 广州市锐博生物科技有限公司 抑制ADAMTS-5基因的siRNA及其应用
CN104498498A (zh) * 2014-12-25 2015-04-08 广州市锐博生物科技有限公司 抑制ADAM17基因的siRNA及其应用

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EP1267903A4 (en) * 2000-02-08 2003-08-06 Pharmacia Corp METHODS OF TREATING GLAUCOMA
US6531128B1 (en) * 2000-02-08 2003-03-11 Pharmacia Corporation Methods for treating glaucoma
US20050227935A1 (en) * 2001-05-18 2005-10-13 Sirna Therapeutics, Inc. RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA)
EP1478730A4 (en) * 2002-02-20 2006-01-25 Sirna Therapeutics Inc INTERFERENCE RNA-INDUCED INHIBITION OF THE GENE EXPRESSION OF SUPERFAMILY TFN AND TFN RECEPTOR SUPERFAMILY USING SHORT INTERFERENCE NUCLEIC ACID (SINA)
JP3882725B2 (ja) * 2002-03-12 2007-02-21 株式会社デンソー 車両用回転電機
EP1560931B1 (en) * 2002-11-14 2011-07-27 Dharmacon, Inc. Functional and hyperfunctional sirna
US20090247604A1 (en) * 2004-02-05 2009-10-01 Intradigm Corporation RNAi Therapeutics for Treatment of Eye Neovascularization Diseases
US8084599B2 (en) * 2004-03-15 2011-12-27 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
KR20070085113A (ko) * 2004-05-11 2007-08-27 가부시키가이샤 알파젠 Rna간섭을 생기게 하는 폴리뉴클레오티드, 및 이를 이용한유전자발현억제 방법
WO2007016597A2 (en) * 2005-07-29 2007-02-08 The Regents Of The University Of California Targeting tnf-alpha converting enzyme (tace)-dependent growth factor shedding in cancer therapy
KR20120093306A (ko) * 2006-05-19 2012-08-22 알콘 리서치, 리미티드 종양 괴사 인자 α-관련 증상의 ＲＮＡｉ-매개 억제
AR071146A1 (es) 2007-08-03 2010-06-02 Alcon Res Ltd Inhibicion relacionada con arni de la via de senales tnf alfa para el tratamiento de angiogenesis ocular, uso de una molecula de arn de interferencia y molecula de arn de interferencia

Also Published As

Publication number Publication date
WO2009020847A3 (en) 2009-07-23
US20160326533A1 (en) 2016-11-10
US20090036396A1 (en) 2009-02-05
US20100267811A1 (en) 2010-10-21
TW200916117A (en) 2009-04-16
CL2008002277A1 (es) 2009-07-17
US8754202B2 (en) 2014-06-17
WO2009020847A2 (en) 2009-02-12
US20090036397A1 (en) 2009-02-05
US9139834B2 (en) 2015-09-22
WO2009020894A3 (en) 2009-08-27
US20110257248A1 (en) 2011-10-20
US20110190376A1 (en) 2011-08-04
US20150344886A1 (en) 2015-12-03
US20140357696A1 (en) 2014-12-04
US9422556B2 (en) 2016-08-23
WO2009020894A2 (en) 2009-02-12
UY31267A1 (es) 2009-01-05

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