AR070733A1 - Derivados de platino-carbeno n-heterociclico, su preparacion, su composicion farmaceutica y su uso para el tratamiento del cancer - Google Patents
Derivados de platino-carbeno n-heterociclico, su preparacion, su composicion farmaceutica y su uso para el tratamiento del cancerInfo
- Publication number
- AR070733A1 AR070733A1 ARP090100729A ARP090100729A AR070733A1 AR 070733 A1 AR070733 A1 AR 070733A1 AR P090100729 A ARP090100729 A AR P090100729A AR P090100729 A ARP090100729 A AR P090100729A AR 070733 A1 AR070733 A1 AR 070733A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- group
- derivatives
- heterociclico
- carbene
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000006580 bicyclic heterocycloalkyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004474 heteroalkylene group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate group Chemical group [N+](=O)([O-])[O-] NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente se refiere a los derivados de platino N-heterociclo, de formula general (1) en la que R1 y/o R2 representan independientemente uno del otro un grupo arilo o aralquilo, cada uno opcionalmente sustituido, un grupo alquilo C1-6 lineal o ramificado, cicloalquilo monociclico C3-7, alquenilo C2-6 lineal o ramificado, o bien R' representa un átomo de hidrogeno y R representa un grupo elegido entre los grupos cicloalquilo, heterocicloalquilo, mono o bicíclico de C3-8 o bencilo opcionalmente sustituido o bien R y R' forman junto con NH un heterocicloalquilo mono o bicíclico C3-8; V representa un átomo de nitrogeno o un radical C-R4; R3 y/o R4 representan hidrogeno, un grupo fenilo o R3 y R4 pueden formar también juntos un radical alquileno C3-6, heteroalquileno C3-6 con uno o varios heteroátomos nitrogenados, pudiendo estar modificados en forma de radical carbonilo los átomos de carbono del radical heteroalquileno; X representa iodo, bromo, cloro o un grupo nitrato (-ONO2).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0801155A FR2928151B1 (fr) | 2008-03-03 | 2008-03-03 | Derives platine-carbene n-heterocyclique, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070733A1 true AR070733A1 (es) | 2010-04-28 |
Family
ID=39739698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100729A AR070733A1 (es) | 2008-03-03 | 2009-03-02 | Derivados de platino-carbeno n-heterociclico, su preparacion, su composicion farmaceutica y su uso para el tratamiento del cancer |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8481522B2 (es) |
| EP (1) | EP2268652B1 (es) |
| JP (1) | JP5385923B2 (es) |
| AR (1) | AR070733A1 (es) |
| CL (1) | CL2009000502A1 (es) |
| FR (1) | FR2928151B1 (es) |
| TW (1) | TW200944199A (es) |
| UY (1) | UY31689A1 (es) |
| WO (1) | WO2009118475A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8168794B2 (en) | 2008-03-03 | 2012-05-01 | Novartis Ag | Pim kinase inhibitors and methods of their use |
| FR2928151B1 (fr) * | 2008-03-03 | 2010-12-31 | Sanofi Aventis | Derives platine-carbene n-heterocyclique, leur preparation et leur application en therapeutique |
| WO2011050574A1 (en) * | 2009-10-28 | 2011-05-05 | The University Of Hong Kong | Pharmaceutical composition containing cyclometalated n-heterocyclic carbene complexes for cancer treatment |
| FR2969616B1 (fr) * | 2010-12-23 | 2013-01-11 | Centre Nat Rech Scient | Procede de preparation de complexes carbeniques de platine |
| FR2969615B1 (fr) * | 2010-12-23 | 2013-10-25 | Centre Nat Rech Scient | Nouveau complexes carbeniques de platine et leur utilisation comme medicaments |
| CN102206226B (zh) * | 2011-04-14 | 2013-10-23 | 天津师范大学 | 三甲基苯连接的氮杂环卡宾金属配合物及其制备方法 |
| CN104334546B (zh) | 2012-05-21 | 2017-05-03 | 诺华股份有限公司 | 作为激酶抑制剂的新的环‑取代的n‑吡啶基酰胺 |
| KR102456088B1 (ko) | 2014-04-04 | 2022-10-19 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
| WO2016004324A1 (en) * | 2014-07-02 | 2016-01-07 | University Of Florida Research Foundation, Inc. | Aptamer conjugates with n-heterocyclic carbene metal complexes for targeted drug delivery |
| CN106008609B (zh) * | 2016-05-31 | 2018-11-06 | 安徽大学 | 一种环金属铂配合物及其制备方法 |
| CN108689939A (zh) * | 2017-04-07 | 2018-10-23 | 厦门华绰生物医药科技有限公司 | 取代咪唑盐类化合物、其制备方法、药用组合物及其应用 |
| WO2021052207A1 (en) * | 2019-09-19 | 2021-03-25 | The University Of Hong Kong | Colour tunable luminescent bidentate platinum (ii) complexes for probing mismatch dna |
| EP4232453A1 (en) | 2020-10-20 | 2023-08-30 | Institut Curie | Metallic trans-(n-heterocyclic carbene)-amine-platinum complexes and uses thereof for treating cancer |
| CN116143842A (zh) * | 2023-01-10 | 2023-05-23 | 广西师范大学 | 氧化异阿朴菲生物碱与n-杂环卡宾的环金属铱配合物及其合成方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4447066A1 (de) * | 1994-12-29 | 1996-07-04 | Hoechst Ag | Heterocyclische Carbene enthaltende Metallkomplexverbindungen |
| FR2825707B1 (fr) | 2001-06-07 | 2004-11-26 | Rhodia Chimie Sa | Procede de preparation de catalyseurs metalliques a base de carbenes, pour l'hydrosilylation de composes insatures et catalyseurs de ce type |
| FR2928151B1 (fr) * | 2008-03-03 | 2010-12-31 | Sanofi Aventis | Derives platine-carbene n-heterocyclique, leur preparation et leur application en therapeutique |
-
2008
- 2008-03-03 FR FR0801155A patent/FR2928151B1/fr not_active Expired - Fee Related
-
2009
- 2009-03-02 JP JP2010549173A patent/JP5385923B2/ja not_active Expired - Fee Related
- 2009-03-02 WO PCT/FR2009/000220 patent/WO2009118475A2/fr active Application Filing
- 2009-03-02 AR ARP090100729A patent/AR070733A1/es not_active Application Discontinuation
- 2009-03-02 EP EP09724326A patent/EP2268652B1/fr active Active
- 2009-03-03 UY UY031689A patent/UY31689A1/es not_active Application Discontinuation
- 2009-03-03 CL CL2009000502A patent/CL2009000502A1/es unknown
- 2009-03-03 TW TW098106864A patent/TW200944199A/zh unknown
-
2010
- 2010-09-02 US US12/874,815 patent/US8481522B2/en not_active Expired - Fee Related
-
2013
- 2013-06-21 US US13/923,540 patent/US8980875B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8980875B2 (en) | 2015-03-17 |
| FR2928151B1 (fr) | 2010-12-31 |
| TW200944199A (en) | 2009-11-01 |
| JP2011513373A (ja) | 2011-04-28 |
| US8481522B2 (en) | 2013-07-09 |
| US20130338128A1 (en) | 2013-12-19 |
| WO2009118475A2 (fr) | 2009-10-01 |
| EP2268652A2 (fr) | 2011-01-05 |
| WO2009118475A3 (fr) | 2009-11-19 |
| FR2928151A1 (fr) | 2009-09-04 |
| US20110172199A1 (en) | 2011-07-14 |
| UY31689A1 (es) | 2009-09-30 |
| JP5385923B2 (ja) | 2014-01-08 |
| EP2268652B1 (fr) | 2012-12-19 |
| CL2009000502A1 (es) | 2010-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |