AR070430A1 - Inhibidores del receptor de quimioquinas cxcr3 - Google Patents

Inhibidores del receptor de quimioquinas cxcr3

Info

Publication number
AR070430A1
AR070430A1 ARP090100561A ARP090100561A AR070430A1 AR 070430 A1 AR070430 A1 AR 070430A1 AR P090100561 A ARP090100561 A AR P090100561A AR P090100561 A ARP090100561 A AR P090100561A AR 070430 A1 AR070430 A1 AR 070430A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
independently
optionally substituted
membered
substituted
Prior art date
Application number
ARP090100561A
Other languages
English (en)
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR070430A1 publication Critical patent/AR070430A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems

Abstract

El compuesto 3-(amido o sulfamido)-(4-azinil sustituido) benzamida o benzosulfonamida es util como un inhibidor del receptor de quimioquinas CxCR3, y para prevenir o tratar una enfermedad mediada por el receptor de quimioquinas CxCR3 o afeccion relacionada con la misma en un paciente que lo necesite composicion farmacéutica y usos. Reivindicacion 1: Un compuesto 3-(amido o sulfamido)-4-(4-azinil sustituido)benzamida o benzosulfonamida de formula 1 en la que :Q y Q1 son independientemente CO o SO2; Y es CO o SO2 X es halogeno; m es 1, 2 o 3; R1 es alquilo inferior C1-3 (opcionalmente sustituido (aromático o ciclilo inferior)); R2, R4 y R6 son independientemente H o alquilo inferior opcionalmente sustituido; R3 es grupo aromático opcionalmente sustituido; A es CH o N, o A y R5 considerados juntos forman un espiroazaheterociclilo de 4-7 miembros de la siguiente formula (2); n y p son independientemente 0, 1, 2, 3, 4 o 5, siempre que n y p mayor o igual a 2 pero menor o igual a 5; R5 es JGZ, R8R7NQ1-alquilo inferior o azaheterociclilo de 3-7 miembros opcionalmente sustituido; Z es enlace, CO o SO2; G es alquilo inferior, cicloalquilo C3-7 o heterociclilo de 3-7 miembros; y J es grupo aromático, alcoxicarbonilo inferior, alquiltio inferior, alquilsulfinilo inferior, alquilsulfonilo inferior, alcoxi inferior, R8R7N o heterociclilo de 3-7 miembros opcionalmente sustituido (alquilo inferior o halogeno); R7 y R8 son independientemente H o alquilo inferior; R9 y R10 son independientemente H o alquilo inferior; o una de sus sales, solvatos, N-oxidos, derivados cuaternarios o profármacos farmacéuticamente aceptables, o cualquiera de sus combinaciones.
ARP090100561A 2008-02-19 2009-02-18 Inhibidores del receptor de quimioquinas cxcr3 AR070430A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2973808P 2008-02-19 2008-02-19

Publications (1)

Publication Number Publication Date
AR070430A1 true AR070430A1 (es) 2010-04-07

Family

ID=40527535

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100561A AR070430A1 (es) 2008-02-19 2009-02-18 Inhibidores del receptor de quimioquinas cxcr3

Country Status (25)

Country Link
US (1) US8268828B2 (es)
EP (1) EP2262784B1 (es)
JP (1) JP2011512412A (es)
KR (1) KR20100123835A (es)
CN (1) CN102007108A (es)
AR (1) AR070430A1 (es)
AU (1) AU2009215643A1 (es)
BR (1) BRPI0908815A2 (es)
CA (1) CA2715557A1 (es)
CL (1) CL2009000368A1 (es)
CO (1) CO6241113A2 (es)
CR (1) CR11604A (es)
DO (1) DOP2010000254A (es)
EC (1) ECSP10010409A (es)
IL (1) IL207597A0 (es)
MA (1) MA32191B1 (es)
MX (1) MX2010008397A (es)
NI (1) NI201000132A (es)
NZ (1) NZ587380A (es)
PE (1) PE20091576A1 (es)
RU (1) RU2010138577A (es)
SV (1) SV2010003648A (es)
TW (1) TW200948791A (es)
WO (1) WO2009105435A1 (es)
ZA (1) ZA201005314B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20091576A1 (es) 2008-02-19 2009-11-05 Sanofi Aventis DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3
EP2424840B1 (en) 2009-04-27 2014-08-06 Boehringer Ingelheim International GmbH Cxcr3 receptor antagonists
US8952004B2 (en) 2010-01-07 2015-02-10 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
KR101251788B1 (ko) 2010-12-06 2013-04-08 기아자동차주식회사 차량 연비 정보 단말표시 시스템 및 그 방법
AU2012284184B2 (en) * 2011-07-18 2017-03-09 Merck Patent Gmbh Benzamides
EP2601950A1 (en) 2011-12-06 2013-06-12 Sanofi Cycloalkane carboxylic acid derivatives as CXCR3 receptor antagonists
ES2663972T3 (es) 2012-01-10 2018-04-17 Merck Patent Gmbh Derivados de benzamida como moduladores de la hormona folículo estimulante
AU2013216354B2 (en) 2012-02-02 2017-08-31 Idorsia Pharmaceuticals Ltd 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives
EP2666769A1 (en) 2012-05-23 2013-11-27 Sanofi Substituted B-amino acid derivatives as CXCR3 receptor antagonist
WO2015011099A1 (en) 2013-07-22 2015-01-29 Actelion Pharmaceuticals Ltd 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
SG11201701598PA (en) * 2014-09-10 2017-03-30 Epizyme Inc Smyd inhibitors
TN2017000278A1 (en) 2015-01-15 2019-01-16 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
US11426397B2 (en) 2017-03-26 2022-08-30 Takeda Pharmaceutical Company Limited Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of GPR6
CN116410159B (zh) * 2023-06-09 2023-08-22 济南国鼎医药科技有限公司 一种恩曲替尼中间体的制备方法及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2052541A5 (es) 1969-06-13 1971-04-09 Takeda Chemical Industries Ltd
US3840556A (en) 1971-05-28 1974-10-08 Lilly Co Eli Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby
US6124319A (en) 1997-01-21 2000-09-26 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6469002B1 (en) 2001-04-19 2002-10-22 Millennium Pharmaceuticals, Inc. Imidazolidine compounds
US6794379B2 (en) 2001-06-06 2004-09-21 Tularik Inc. CXCR3 antagonists
GB0203994D0 (en) 2002-02-20 2002-04-03 Celltech R&D Ltd Chemical compounds
US20050272936A1 (en) 2002-06-03 2005-12-08 Axten Jeffrey M Imidazolium cxcr3 inhibitors
US6734659B1 (en) 2002-06-13 2004-05-11 Mykrolis Corporation Electronic interface for use with dual electrode capacitance diaphragm gauges
CN101142209A (zh) 2005-02-16 2008-03-12 先灵公司 具有cxcr3拮抗剂活性的吡嗪基取代的哌嗪-哌啶
US7776862B2 (en) 2005-02-16 2010-08-17 Schering Corporation Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity
CN101146793A (zh) * 2005-02-16 2008-03-19 先灵公司 具有cxcr3拮抗剂活性的新的杂环取代了的吡啶或苯基化合物
WO2007002742A1 (en) * 2005-06-28 2007-01-04 Pharmacopeia, Inc. Substituted [1,4]-diazepanes as cxcr3 antagonists and their use in the treatment of inflammatory disorders
EP1937666B1 (en) 2005-10-11 2012-02-22 Schering Corporation Substituted heterocyclic compounds with cxcr3 antagonist activity
WO2007064553A2 (en) 2005-11-29 2007-06-07 Merck & Co., Inc. Thiazole derivatives as cxcr3 receptor modulators
PE20071144A1 (es) 2006-03-21 2008-01-10 Schering Corp COMPUESTOS HETEROCICLICOS DE PIRIDINA SUSTITUIDA COMO ANTAGONISTAS DEL RECEPTOR 3 DE a-QUIMIOCINA (CXCR3)
AR061975A1 (es) 2006-07-14 2008-08-10 Schering Corp Compuestos de piperazina 1,4-sustituida con actividad antagonista de cxcr3, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor de quimioquina cxcr3
PE20091576A1 (es) 2008-02-19 2009-11-05 Sanofi Aventis DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3

Also Published As

Publication number Publication date
SV2010003648A (es) 2011-01-31
AU2009215643A1 (en) 2009-08-27
MX2010008397A (es) 2010-08-23
CO6241113A2 (es) 2011-01-20
BRPI0908815A2 (pt) 2019-09-24
JP2011512412A (ja) 2011-04-21
WO2009105435A1 (en) 2009-08-27
NI201000132A (es) 2011-03-16
KR20100123835A (ko) 2010-11-25
US8268828B2 (en) 2012-09-18
RU2010138577A (ru) 2012-03-27
US20100305088A1 (en) 2010-12-02
PE20091576A1 (es) 2009-11-05
DOP2010000254A (es) 2010-08-31
IL207597A0 (en) 2010-12-30
ECSP10010409A (es) 2010-09-30
CL2009000368A1 (es) 2009-06-26
TW200948791A (en) 2009-12-01
MA32191B1 (fr) 2011-04-01
NZ587380A (en) 2011-09-30
EP2262784A1 (en) 2010-12-22
CR11604A (es) 2010-10-05
CN102007108A (zh) 2011-04-06
CA2715557A1 (en) 2009-08-27
ZA201005314B (en) 2011-03-30
EP2262784B1 (en) 2014-04-16

Similar Documents

Publication Publication Date Title
AR070430A1 (es) Inhibidores del receptor de quimioquinas cxcr3
PE20160751A1 (es) Moduladores de tetrahidropiridopirazinas de gpr6
AR049696A1 (es) Derivados de indol
NZ704512A (en) Carboxamide or sulfonamide substituted nitrogen-containing 5-membered heterocycles as modulators for the orphan nuclear receptor ror gamma
AR064355A1 (es) Herbicidas derivados de isoxazol
UY33606A (es) DERIVADOS DE PIRAZINA COMO BLOQUEADORES DE ENaC
EA201400553A1 (ru) Производные 2-(1,2,3-триазол-2-ил)бензамида и 3-(1,2,3-триазол-2-ил)пиколинамида
PE20140934A1 (es) Derivados de pirazol
MX2013005535A (es) Compuesto de 3- (amino-aril) -piridina.
CY1115376T1 (el) Βελτιωμενη μεθοδος
AR067674A1 (es) Derivados de pirazol utiles para el tratamiento con un antagonista de receptor ccr2
RU2010116821A (ru) N-гетероциклические биарильные карбоксамиды в качестве антагонистов рецептора ccr
PE20090773A1 (es) Derivados de morfolina pirimidina
AR060593A1 (es) 5-amido-2-carboxiamida-indoles
CR20130145A (es) Moduladores del receptor gpr119 y el tratamieto de trastornos relacionados con este
CL2008003159A1 (es) Compuestos derivados de diaminas sustituidas, sus sales farmaceuticamente aceptables o sus solvatos; compuestos intermediarios; utiles como agentes antiobesidad, mediados por la inhibicion del receptor npy y5.
PE20081665A1 (es) Antagonistas del receptor de dopamina 2 de rapida disociacion
PE20141167A1 (es) Piridopirazinas sustituidas como inhibidores novedosos de ptk
MX353209B (es) Antagonistas d2, metodos de sintesis y metodos de uso.
ATE475645T1 (de) Pyrrolidinderivate als doppelte nk1/nk3- rezeptorenantagonisten
PE20161378A1 (es) Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y transtornos relacionados
RU2016149804A (ru) Производные бензолсульфонамида и их применение в качестве модуляторов орфанного рецептора y, связанного с ретиноевой кислотой
PE20090115A1 (es) Derivados de indol-2-il-piperazin-1-il-metanona
MX2011007990A (es) Intermediarios clave para la sintesis de rosuvastatina o de sales farmaceuticamente aceptables de la misma.
ECSP13012990A (es) Derivados de pirazolidin-3-ona

Legal Events

Date Code Title Description
FA Abandonment or withdrawal