AR065305A1 - Metodo de preparacion y separacion estereoselectivas de tri-o-acetil-5-desoxi-beta-d-ribofuranosa - Google Patents

Metodo de preparacion y separacion estereoselectivas de tri-o-acetil-5-desoxi-beta-d-ribofuranosa

Info

Publication number
AR065305A1
AR065305A1 ARP080100589A ARP080100589A AR065305A1 AR 065305 A1 AR065305 A1 AR 065305A1 AR P080100589 A ARP080100589 A AR P080100589A AR P080100589 A ARP080100589 A AR P080100589A AR 065305 A1 AR065305 A1 AR 065305A1
Authority
AR
Argentina
Prior art keywords
beta
formula
tri
compound
ribofuranosa
Prior art date
Application number
ARP080100589A
Other languages
English (en)
Inventor
Jaeheon Lee
Gha Seung Park
Yang Weon Ki
Jin Hee Kim
Chul Hyun Park
Chang-Ju Choi
Cathy Chang
Yong-Hoon An
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of AR065305A1 publication Critical patent/AR065305A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Saccharide Compounds (AREA)

Abstract

Un método para preparar tri-O-acetil-5-desoxi-beta-D-ribofuranosa altamente pura que comprende una etapa de acetilacion altamente estereoselectiva de 1-metilacetonida, y el anomero beta puro así obtenido puede ser ventajosamente utilizado para preparar capecitabina. Reivindicacion 1: Un método para prepara tri-O-acetil-5-desoxi-beta-D-ribofuranosa de la formula (1), que comprende las etapas de: (i) llevar a cabo la reaccion del compuesto de la formula (3) con anhídrido acético en un solvente orgánico en presencia de una alquilamina o una amina cíclica para obtener el compuesto de la formula (2); y (ii) aislar el compuesto de la formula (1) del compuesto de la formula (2) mediante recristalizacion utilizando un solvente y un anti-solvente.
ARP080100589A 2007-02-28 2008-02-12 Metodo de preparacion y separacion estereoselectivas de tri-o-acetil-5-desoxi-beta-d-ribofuranosa AR065305A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020070020336A KR100908363B1 (ko) 2007-02-28 2007-02-28 트라이-Ｏ-아세틸-5-데옥시-β-Ｄ-라이보퓨라노즈의입체선택적 제조방법 및 이의 분리방법

Publications (1)

Publication Number Publication Date
AR065305A1 true AR065305A1 (es) 2009-05-27

Family

ID=39721406

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100589A AR065305A1 (es) 2007-02-28 2008-02-12 Metodo de preparacion y separacion estereoselectivas de tri-o-acetil-5-desoxi-beta-d-ribofuranosa

Country Status (4)

Country Link
KR (1) KR100908363B1 (es)
AR (1) AR065305A1 (es)
TW (1) TW200900417A (es)
WO (1) WO2008105593A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101013312B1 (ko) * 2007-11-19 2011-02-09 한미홀딩스 주식회사 카페시타빈의 제조방법 및 이에 사용되는 β-아노머가강화된 트리알킬카보네이트 화합물의 제조방법
EP2210895A1 (en) * 2009-01-27 2010-07-28 F. Hoffmann-La Roche AG Process for the recovery of beta-Acetylfuranoside
CN102344469A (zh) * 2011-07-26 2012-02-08 江西科技师范学院 固体酸SO42-/γ-AL2O3催化合成1, 2, 3-O-三乙酰基-5-脱氧-D-呋喃核糖的方法
CN117229341B (zh) * 2023-11-07 2024-02-09 成都苑东生物制药股份有限公司 卡培他滨晶型i及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1135258A (en) 1979-06-15 1982-11-09 Richard D'souza Process for the preparation of 5'deoxy-5-fluorouridine
US5252756A (en) 1992-06-22 1993-10-12 Eli Lilly And Company Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates
US6831069B2 (en) 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs

Also Published As

Publication number Publication date
WO2008105593A1 (en) 2008-09-04
KR20080079833A (ko) 2008-09-02
TW200900417A (en) 2009-01-01
KR100908363B1 (ko) 2009-07-20

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