AR064682A1 - Metodo para medir la concentracion del factor (vii a) en una muestra - Google Patents
Metodo para medir la concentracion del factor (vii a) en una muestraInfo
- Publication number
- AR064682A1 AR064682A1 ARP070105951A ARP070105951A AR064682A1 AR 064682 A1 AR064682 A1 AR 064682A1 AR P070105951 A ARP070105951 A AR P070105951A AR P070105951 A ARP070105951 A AR P070105951A AR 064682 A1 AR064682 A1 AR 064682A1
- Authority
- AR
- Argentina
- Prior art keywords
- sample
- thrombogram
- concentration
- vii
- range
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96447—Factor VII (3.4.21.21)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Método para la medicion in vitro o ex-vivo de la concentracion de FVIIa de una muestra, que comprende los pasos que consisten en: a) mezclar dicha muestra, con un plasma humano deficiente en FVII y en por lo menos otro factor seleccionado entre FVIII, FXI; b) agregar componentes iniciadores de la reaccion de generacion de trombina, que comprenden una fuerte de iones de calcio, un agente fosfolípido y un factor tisular; c) realizar una prueba de generacion de trombina (TGT) en el medio de reaccion así obtenido para obtener parámetros que dan un trombograma; d) comparar por lo menos uno de los parámetros del trombograma con un parámetro homologo de trombogramas estándar, obteniéndose cada trombograma estándar con una concentracion fija, calibrada, de FIIIa en dicho medio de reaccion, que se encuentra en un rango de 1 pM a 5 nM, y e) deducir del paso d) la medicion de la concentracion de FVIIa de la muestra, que se encuentra dentro de dicho rango.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0611535A FR2910969B1 (fr) | 2006-12-29 | 2006-12-29 | Procede de mesure de la concentration de facteur viia (fviia) dans un echantillon |
Publications (1)
Publication Number | Publication Date |
---|---|
AR064682A1 true AR064682A1 (es) | 2009-04-22 |
Family
ID=38134121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070105951A AR064682A1 (es) | 2006-12-29 | 2007-12-28 | Metodo para medir la concentracion del factor (vii a) en una muestra |
Country Status (10)
Country | Link |
---|---|
US (1) | US20100009396A1 (es) |
EP (1) | EP2100148A2 (es) |
JP (1) | JP2010515045A (es) |
KR (1) | KR20090119753A (es) |
CN (1) | CN101573622A (es) |
AR (1) | AR064682A1 (es) |
AU (1) | AU2007346300A1 (es) |
CA (1) | CA2673623A1 (es) |
FR (1) | FR2910969B1 (es) |
WO (1) | WO2008096082A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2933496B1 (fr) * | 2008-07-02 | 2012-10-05 | Lfb Biotechnologies | Procede de mesure du taux de facteur vii active dans un echantillon |
FR2967781B1 (fr) | 2010-11-18 | 2019-06-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Determination du pouvoir thrombogene d'immunoglobulines humaines |
WO2014098056A1 (ja) * | 2012-12-18 | 2014-06-26 | 第一三共株式会社 | トロンビン産生の測定方法 |
WO2015091115A1 (en) * | 2013-12-19 | 2015-06-25 | Koninklijke Philips N.V. | Method for determining the hemostatic risk of a subject |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3947378A (en) * | 1974-12-23 | 1976-03-30 | Warner-Lambert Company | Adsorbed plasma |
DE122007000007I2 (de) * | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
US5472850A (en) * | 1991-04-10 | 1995-12-05 | Oklahoma Medical Research Foundation | Quantitative clotting assay for activated factor VII |
DE19634312A1 (de) * | 1996-08-24 | 1998-02-26 | Behringwerke Ag | Verfahren zur Herstellung von Faktor V-Mangelplasma und ein so erhaltenes Mangelplasma |
US7160540B2 (en) * | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
ES2407355T3 (es) * | 2001-07-03 | 2013-06-12 | Oklahoma Medical Research Foundation | Ensayo para medir los complejos de factor VIIa-antitrombina |
RU2373282C2 (ru) * | 2003-06-19 | 2009-11-20 | Байер Хелткэр Ллк | ВАРИАНТЫ ДОМЕНА GLA ФАКТОРА VII ИЛИ VIIa |
JP4377207B2 (ja) * | 2003-11-28 | 2009-12-02 | シスメックス株式会社 | 血液凝固時間測定方法および血液凝固時間測定用試薬 |
-
2006
- 2006-12-29 FR FR0611535A patent/FR2910969B1/fr not_active Expired - Fee Related
-
2007
- 2007-12-28 JP JP2009543505A patent/JP2010515045A/ja active Pending
- 2007-12-28 AU AU2007346300A patent/AU2007346300A1/en not_active Abandoned
- 2007-12-28 CN CNA2007800486323A patent/CN101573622A/zh active Pending
- 2007-12-28 AR ARP070105951A patent/AR064682A1/es not_active Application Discontinuation
- 2007-12-28 WO PCT/FR2007/002188 patent/WO2008096082A2/fr active Application Filing
- 2007-12-28 KR KR1020097013197A patent/KR20090119753A/ko not_active Application Discontinuation
- 2007-12-28 CA CA002673623A patent/CA2673623A1/fr not_active Abandoned
- 2007-12-28 EP EP07872461A patent/EP2100148A2/fr not_active Withdrawn
- 2007-12-28 US US12/520,019 patent/US20100009396A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2010515045A (ja) | 2010-05-06 |
WO2008096082A3 (fr) | 2008-11-13 |
AU2007346300A1 (en) | 2008-08-14 |
FR2910969B1 (fr) | 2009-02-27 |
KR20090119753A (ko) | 2009-11-19 |
EP2100148A2 (fr) | 2009-09-16 |
US20100009396A1 (en) | 2010-01-14 |
WO2008096082A2 (fr) | 2008-08-14 |
CA2673623A1 (fr) | 2008-08-14 |
CN101573622A (zh) | 2009-11-04 |
FR2910969A1 (fr) | 2008-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |