AR061655A1 - COMPOSITION OF DEGRADABLE POLYMER MICROSPHERES - Google Patents

COMPOSITION OF DEGRADABLE POLYMER MICROSPHERES

Info

Publication number
AR061655A1
AR061655A1 ARP070102834A ARP070102834A AR061655A1 AR 061655 A1 AR061655 A1 AR 061655A1 AR P070102834 A ARP070102834 A AR P070102834A AR P070102834 A ARP070102834 A AR P070102834A AR 061655 A1 AR061655 A1 AR 061655A1
Authority
AR
Argentina
Prior art keywords
microspheres
biologically active
incorporated
composition
active agent
Prior art date
Application number
ARP070102834A
Other languages
Spanish (es)
Original Assignee
Labopharm Inc
Labopharm Europe Ltd
Labopharm Barbados Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Inc, Labopharm Europe Ltd, Labopharm Barbados Ltd filed Critical Labopharm Inc
Publication of AR061655A1 publication Critical patent/AR061655A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

Una composicion de microesferas biodegradables para la entrega mediante liberacion prolongada y controlada de por lo menos un agente biologicamente activo in vivo, proporciona microesferas preparadas con copolímeros anfifílicos, injertados o en forma de estrella, en bloque, hechos de segmento/s de poli(N-vinil-2-pirrolidona) y segmento/s biodegradable/s, las microesferas incorporan por lo menos un agente biologicamente activo como por ejemplo, simvastatina y se adaptan para la entrega controlada del agente activo a un mamífero. Se incorporan agentes biologicamente activos de escasa solubilidad en agua en las microesferas mediante un método de emulsion simple. Se incorporan agentes hidrofílicos biologicamente activos en las microesferas mediante un método de emulsion doble. Se incorporan agentes anfifílicos biologicamente activos en las microesferas mediante un método de emulsion simple o bien doble. Su uso y método de preparacionA composition of biodegradable microspheres for delivery by prolonged and controlled release of at least one biologically active agent in vivo, provides microspheres prepared with amphiphilic, grafted or star-shaped, block-shaped copolymers, made of poly segment (s). -vinyl-2-pyrrolidone) and biodegradable segment (s), the microspheres incorporate at least one biologically active agent such as simvastatin and are adapted for controlled delivery of the active agent to a mammal. Biologically active agents of low water solubility are incorporated into the microspheres by a simple emulsion method. Biologically active hydrophilic agents are incorporated into the microspheres by a double emulsion method. Biologically active amphiphilic agents are incorporated into the microspheres by a simple or double emulsion method. Its use and method of preparation

ARP070102834A 2005-12-27 2007-06-26 COMPOSITION OF DEGRADABLE POLYMER MICROSPHERES AR061655A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75339405P 2005-12-27 2005-12-27
PCT/CA2006/002078 WO2007073596A1 (en) 2005-12-27 2006-12-21 Degradable polymeric microsphere composition

Publications (1)

Publication Number Publication Date
AR061655A1 true AR061655A1 (en) 2008-09-10

Family

ID=38217646

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102834A AR061655A1 (en) 2005-12-27 2007-06-26 COMPOSITION OF DEGRADABLE POLYMER MICROSPHERES

Country Status (4)

Country Link
AR (1) AR061655A1 (en)
CA (1) CA2634830A1 (en)
CL (1) CL2007001878A1 (en)
WO (1) WO2007073596A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060198891A1 (en) 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
US8580307B2 (en) * 2006-06-22 2013-11-12 Ethicon, Inc. High glass transition temperature absorbable microspheres
US9714318B2 (en) * 2013-07-26 2017-07-25 Stratasys, Inc. Polyglycolic acid support material for additive manufacturing systems
CN104072698A (en) * 2014-07-08 2014-10-01 成都市绿科华通科技有限公司 Drug-carrying block macromolecular material with star-shaped and porous structure
WO2016197262A1 (en) * 2015-06-12 2016-12-15 Bayer Pharma Aktiengesellschaft Process for the preparation of porous microparticles
CN114917411A (en) * 2022-05-31 2022-08-19 常州药物研究所有限公司 Mixed gel containing amphiphilic microspheres and preparation method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA41995C2 (en) * 1994-05-06 2001-10-15 Пфайзер Інк. Sustained release dosage form of azithromycin (variants), method of use, method of manufacture and method for treating infectious diseases in mammals (variants)
CA2248592A1 (en) * 1998-08-31 2000-02-29 Christopher D. Batich Microspheres for use in the treatment of cancer
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
US6579519B2 (en) * 2000-09-18 2003-06-17 Registrar, University Of Delhi Sustained release and long residing ophthalmic formulation and the process of preparing the same
US20030152622A1 (en) * 2001-10-25 2003-08-14 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral diuretic
US20040092577A1 (en) * 2002-04-26 2004-05-13 Lerner E. Itzhak Microparticle pharmaceutical compositions for intratumoral delivery
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents

Also Published As

Publication number Publication date
CL2007001878A1 (en) 2008-01-18
WO2007073596A1 (en) 2007-07-05
CA2634830A1 (en) 2007-07-05

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