AR061642A1 - Derivados de ureas de tropano, su preparacion y su aplicacion en terapeu-tica, procesos de obtencion y composiciones farmaceuticas - Google Patents
Derivados de ureas de tropano, su preparacion y su aplicacion en terapeu-tica, procesos de obtencion y composiciones farmaceuticasInfo
- Publication number
- AR061642A1 AR061642A1 ARP070102821A ARP070102821A AR061642A1 AR 061642 A1 AR061642 A1 AR 061642A1 AR P070102821 A ARP070102821 A AR P070102821A AR P070102821 A ARP070102821 A AR P070102821A AR 061642 A1 AR061642 A1 AR 061642A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- conr6r7
- coor5
- nr6r7
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Procedimientos de preparacion y aplicacion en terapéutica. Reivindicacion 1: Compuesto que responde a la formula (1) en la que: X representa bien un átomo de carbono, de oxígeno, de azufre o de nitrogeno, o bien el grupo -SO2; el enlace punteado es un enlace simple o un enlace doble; R1a, b, c, d y R2a, b, idénticos o diferentes, representan cada uno un átomo de hidrogeno o de halogeno; un grupo alquilo C1-5; alcoxi C1-5; halogenoalquilo C1-5, hidroxi; hidroxialquilo C1-5, alcoxi C1-5-aIquilo C1-5; ciano; un grupo -COOR5; -NR6R7, -COOR5-alquilo C1-5, -NR6R7-alquilo C1-5, -CONR6R7, -CONR6R7-alquilo C1-5, -SO2NR6R7; -(R2a)p O (R2b)r también pueden formar junto con el átomo de carbono al que se unen un grupo C=O; R3 representa un átomo de hidrogeno, fluor o alquilo C1-5; alcoxi C1-5; alcoxialquilo C1-5; hidroxi; hidroxialquilo C1-5; halogenoalquilo C1-5; ciano; un grupo -COOR5, -NR6R7, -COOR5-alquilo C1-5, -NR6R7-alquilo C1-5, -CONR6R7, -CONR6R7-alquilo C1-5; R4 representa: o un átomo de hidrogeno, alquilo C1-5; cicloalquilo C3-6; heterociclo; arilo mono- o bicíclico que tiene de 5 a 10 átomos de carbono; o un grupo heteroarilo mono- o bicíclico que tiene de 2 a 9 átomos de carbono; estando el grupo arilo o heteroarilo opcionalmente sustituido por 1 a 4 sustituyentes elegidos entre los átomos de halogeno, alquilo C1-5; alcoxi C1-5; halogenoalquilo C1-5; hidroxi; hidroxialquilo C1-5, alcoxi C1-5-alquilo C1-5; ciano; fenilo opcionalmente sustituido; bencilo opcionalmente sustituido; -COOR5, -NR6R7, -COOR5-alquilo C1-5, -NR6R7-alquilo C1-5, -CONR6R7, -CONR6R7-alquilo C1-5, -SO2NR6R7, -NR6-COR5; p y r, idénticos o diferentes, son numeros enteros iguales a 1 o 2; R5 representa un átomo de hidrogeno, un grupo alquilo C1-5; cicloalquilo C3-6; R6 y R7, idénticos o diferentes, representan cada uno un átomo de hidrogeno, alquilo C1-5; cicloalquilo C3-6; alquilcarbonilo C1-5; hidroximetil-alquilo C1-5; alcoximetilo C1-5-alquilo C1-5; arilo; -SO2-R5 o pueden formar junto con el átomo de nitrogeno al que se unen un heterociclo opcionalmente sustituido; sus sales, solvatos e hidratos así como sus enantiomeros y diastereoisomeros, incluidas las mezclas racémicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0605785A FR2902791B1 (fr) | 2006-06-27 | 2006-06-27 | Derives d'urees de tropane,leur preparation et leur application en therapeutique |
FR0700507A FR2911874B1 (fr) | 2007-01-25 | 2007-01-25 | Derives d'urees de tropane, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
AR061642A1 true AR061642A1 (es) | 2008-09-10 |
Family
ID=38820110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070102821A AR061642A1 (es) | 2006-06-27 | 2007-06-26 | Derivados de ureas de tropano, su preparacion y su aplicacion en terapeu-tica, procesos de obtencion y composiciones farmaceuticas |
Country Status (23)
Country | Link |
---|---|
US (2) | US7897773B2 (es) |
EP (1) | EP2046791B1 (es) |
JP (1) | JP2009541464A (es) |
KR (1) | KR20090021193A (es) |
AR (1) | AR061642A1 (es) |
AT (1) | ATE461930T1 (es) |
AU (1) | AU2007264792A1 (es) |
CA (1) | CA2648769A1 (es) |
CL (1) | CL2007001885A1 (es) |
CY (1) | CY1110132T1 (es) |
DE (1) | DE602007005487D1 (es) |
DK (1) | DK2046791T3 (es) |
ES (1) | ES2342793T3 (es) |
IL (1) | IL195510A0 (es) |
MX (1) | MX277822B (es) |
PE (1) | PE20080344A1 (es) |
PL (1) | PL2046791T3 (es) |
PT (1) | PT2046791E (es) |
RU (1) | RU2009102535A (es) |
SI (1) | SI2046791T1 (es) |
TW (1) | TW200811170A (es) |
UY (1) | UY30447A1 (es) |
WO (1) | WO2008000951A2 (es) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS52307B (en) * | 2006-06-27 | 2012-12-31 | Takeda Pharmaceutical Company Limited | CONDENSED CYCLIC UNITS |
US8835426B2 (en) | 2007-02-26 | 2014-09-16 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
EP2183228B1 (en) * | 2007-07-26 | 2014-08-20 | Vitae Pharmaceuticals, Inc. | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
WO2009063061A2 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
JP5490020B2 (ja) * | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状カルバゼート及びセミカルバジドインヒビター |
FR2926817B1 (fr) * | 2008-01-28 | 2010-02-26 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
FR2934858B1 (fr) * | 2008-08-08 | 2010-08-27 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
TW200936136A (en) * | 2008-01-28 | 2009-09-01 | Sanofi Aventis | Tetrahydroquinoxaline urea derivatives, their preparation and their therapeutic application |
EP2245014B1 (en) * | 2008-02-12 | 2011-11-02 | Boehringer Ingelheim International GmbH | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
WO2009102460A2 (en) * | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
JP5301563B2 (ja) | 2008-05-01 | 2013-09-25 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター |
EP2291370B1 (en) | 2008-05-01 | 2013-11-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
CA2723039A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
CA2724214A1 (en) | 2008-05-13 | 2009-11-19 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
NZ590495A (en) | 2008-07-25 | 2012-10-26 | Vitae Pharmaceuticals Inc | Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
WO2010023161A1 (en) * | 2008-08-25 | 2010-03-04 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
CA2738453C (en) | 2008-10-23 | 2017-07-04 | Boehringer Ingelheim International Gmbh | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use |
CA2744946A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
US8703765B2 (en) | 2009-06-02 | 2014-04-22 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
WO2011011123A1 (en) | 2009-06-11 | 2011-01-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
EP2448928B1 (en) | 2009-07-01 | 2014-08-13 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
FR2948370B1 (fr) * | 2009-07-27 | 2013-04-05 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
FR2948369B1 (fr) * | 2009-07-27 | 2013-04-12 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
TWI531571B (zh) * | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基-及雜芳基羰基衍生物 |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
CN102947295B (zh) * | 2010-04-29 | 2016-01-20 | 爱丁堡大学 | 作为11β-HSD1抑制剂的3,3-二取代的-(8-氮杂双环[3.2.1]辛烷-8-基)-[5-(1H-吡唑-4基)-噻吩-3-基]-甲酮 |
US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための11−β−HSD1のインヒビターとしてのアザスピロヘキサノン |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
CA2813671A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基-及雜環芳基羰基衍生物 |
US8735585B2 (en) | 2011-08-17 | 2014-05-27 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2015074064A2 (en) | 2013-11-18 | 2015-05-21 | Bair Kenneth W | Tetrahydroquinoline compositions as bet bromodomain inhibitors |
EP3071205B1 (en) | 2013-11-18 | 2020-02-05 | Forma Therapeutics, Inc. | Benzopiperazine compositions as bet bromodomain inhibitors |
CA2981503C (en) | 2015-03-31 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
WO2017189663A1 (en) | 2016-04-26 | 2017-11-02 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
US10080741B2 (en) | 2016-04-26 | 2018-09-25 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
US10080742B2 (en) | 2016-04-26 | 2018-09-25 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
WO2017201152A1 (en) | 2016-05-18 | 2017-11-23 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
US10144729B2 (en) | 2016-05-18 | 2018-12-04 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as FXR agonists and methods of use thereof |
WO2017201155A1 (en) | 2016-05-18 | 2017-11-23 | Enanta Pharmaceuticals, Inc. | lSOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF |
KR20190056436A (ko) | 2016-10-04 | 2019-05-24 | 이난타 파마슈티칼스, 인코포레이티드 | Fxr 작용제로서의 이속사졸 유사체 및 그의 사용 방법 |
US10597391B2 (en) | 2016-10-26 | 2020-03-24 | Enanta Pharmaceuticals, Inc. | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof |
WO2019118571A1 (en) | 2017-12-12 | 2019-06-20 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as fxr agonists and methods of use thereof |
WO2019160813A1 (en) | 2018-02-14 | 2019-08-22 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
US11555032B2 (en) | 2019-05-13 | 2023-01-17 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE38835T1 (de) | 1983-07-05 | 1988-12-15 | Pfizer | Karbonsaeure-derivate verwendbar bei der verhuetung der zersetzung von knorpeln. |
EP0590022A1 (en) | 1991-06-14 | 1994-04-06 | PHARMACIA & UPJOHN COMPANY | IMIDAZO 1,5-a]QUINOXALINES |
CA2408913A1 (en) | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
ITMI20012060A1 (it) | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
HUP0202001A2 (hu) * | 2002-06-14 | 2005-08-29 | Sanofi-Aventis | DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok |
AU2003269242A1 (en) | 2002-10-11 | 2004-05-04 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors |
EP1615698B1 (en) * | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | New amide derivatives and pharmaceutical use thereof |
GB0325745D0 (en) | 2003-11-05 | 2003-12-10 | Astrazeneca Ab | Chemical compounds |
KR101368228B1 (ko) | 2004-11-10 | 2014-02-27 | 인사이트 코포레이션 | 락탐 화합물 및 약제로서의 이의 용도 |
WO2006055752A2 (en) | 2004-11-18 | 2006-05-26 | Incyte Corporation | INHIBITORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1 AND METHODS OF USING THE SAME |
WO2006105127A2 (en) | 2005-03-31 | 2006-10-05 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
WO2006132436A1 (ja) | 2005-06-08 | 2006-12-14 | Japan Tobacco Inc. | 複素環化合物 |
-
2007
- 2007-06-25 TW TW096122891A patent/TW200811170A/zh unknown
- 2007-06-25 PE PE2007000811A patent/PE20080344A1/es not_active Application Discontinuation
- 2007-06-26 MX MX2008016492A patent/MX277822B/es active IP Right Grant
- 2007-06-26 WO PCT/FR2007/001070 patent/WO2008000951A2/fr active Application Filing
- 2007-06-26 EP EP07803782A patent/EP2046791B1/fr active Active
- 2007-06-26 CA CA002648769A patent/CA2648769A1/fr not_active Abandoned
- 2007-06-26 ES ES07803782T patent/ES2342793T3/es active Active
- 2007-06-26 AU AU2007264792A patent/AU2007264792A1/en not_active Abandoned
- 2007-06-26 PL PL07803782T patent/PL2046791T3/pl unknown
- 2007-06-26 PT PT07803782T patent/PT2046791E/pt unknown
- 2007-06-26 AR ARP070102821A patent/AR061642A1/es not_active Application Discontinuation
- 2007-06-26 RU RU2009102535/04A patent/RU2009102535A/ru not_active Application Discontinuation
- 2007-06-26 AT AT07803782T patent/ATE461930T1/de active
- 2007-06-26 DK DK07803782.7T patent/DK2046791T3/da active
- 2007-06-26 DE DE602007005487T patent/DE602007005487D1/de active Active
- 2007-06-26 CL CL2007001885A patent/CL2007001885A1/es unknown
- 2007-06-26 JP JP2009517319A patent/JP2009541464A/ja not_active Withdrawn
- 2007-06-26 KR KR1020087031631A patent/KR20090021193A/ko not_active Application Discontinuation
- 2007-06-26 SI SI200730258T patent/SI2046791T1/sl unknown
- 2007-06-27 UY UY30447A patent/UY30447A1/es not_active Application Discontinuation
-
2008
- 2008-11-25 IL IL195510A patent/IL195510A0/en unknown
- 2008-12-11 US US12/332,547 patent/US7897773B2/en not_active Expired - Fee Related
-
2010
- 2010-06-21 CY CY20101100571T patent/CY1110132T1/el unknown
- 2010-08-30 US US12/871,403 patent/US20100324084A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20090170894A1 (en) | 2009-07-02 |
ATE461930T1 (de) | 2010-04-15 |
ES2342793T3 (es) | 2010-07-14 |
RU2009102535A (ru) | 2010-08-10 |
US20100324084A1 (en) | 2010-12-23 |
WO2008000951A3 (fr) | 2008-02-21 |
AU2007264792A1 (en) | 2008-01-03 |
WO2008000951A2 (fr) | 2008-01-03 |
PT2046791E (pt) | 2010-06-23 |
TW200811170A (en) | 2008-03-01 |
SI2046791T1 (sl) | 2010-07-30 |
PE20080344A1 (es) | 2008-06-09 |
MX277822B (es) | 2010-08-03 |
JP2009541464A (ja) | 2009-11-26 |
EP2046791B1 (fr) | 2010-03-24 |
MX2008016492A (es) | 2009-01-22 |
DK2046791T3 (da) | 2010-07-19 |
DE602007005487D1 (de) | 2010-05-06 |
CY1110132T1 (el) | 2015-01-14 |
PL2046791T3 (pl) | 2010-08-31 |
CL2007001885A1 (es) | 2008-01-25 |
KR20090021193A (ko) | 2009-02-27 |
US7897773B2 (en) | 2011-03-01 |
UY30447A1 (es) | 2008-01-31 |
IL195510A0 (en) | 2009-09-01 |
EP2046791A2 (fr) | 2009-04-15 |
CA2648769A1 (fr) | 2008-01-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR061642A1 (es) | Derivados de ureas de tropano, su preparacion y su aplicacion en terapeu-tica, procesos de obtencion y composiciones farmaceuticas | |
AR047456A1 (es) | Derivados de amidas, procesos para su preparacion y uso como insecticidas | |
AR056195A1 (es) | Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos | |
AR067646A1 (es) | Ariloxazoles sustituidos y su uso | |
AR061739A1 (es) | Nuevos derivados naftalenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
AR052568A1 (es) | Derivados de pirazolo -pirimidina como antagonstas de mglur2 | |
AR078462A1 (es) | Inhibidores macrociclicos de la replicacion de virus de la hepatitis c | |
AR078163A1 (es) | Utilizacion de aminodihidrotiazinas para el tratamiento o prevencion de la diabetes | |
PE20040373A1 (es) | Composiciones herbicidas que comprenden derivados de isoxazolina | |
AR055744A1 (es) | Derivados de acido pirimidincarboxilico, su uso para preparar medicamentos y preparacion de dicjhos compuestos | |
UY30105A1 (es) | Derivados nuevos azufrados de urea cíclica, su preparación y su utilización farmacéutica como inhibidores de quinasas. | |
PE20121695A1 (es) | 5-alquinil-pirimidinas | |
PE20060583A1 (es) | Tiazolil-dihidro-indazoles como inhibidores de pi3-quinasas | |
PE20060554A1 (es) | Saliciltiazoles sustituidos con difenilamina o derivados de difenilamina como inhibidores de la fosfotirosina fosfatasa 1b y procedimientos para su preparacion | |
ECSP088431A (es) | Derivados de pirazolo | |
AR072016A1 (es) | Derivados de isoxazol que funcionan como potenciadores de los receptores de glutamato | |
AR063101A1 (es) | Derivados de pirazina-2-carboxiamida, un proceso para su obtencion, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento o profilaxis de enfermedades asociadas con la modulacion de receptores del cb2. | |
AR068538A1 (es) | Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido | |
NI200800015A (es) | Derivados de n-(heteroaril)-1-heteroarilalquil - 1h - indol - 2 - carboxamidas, su preparación y su aplicación en terapéutica. | |
ECSP088805A (es) | 2-(piridin-2-il)-pirimidinas como fungicidas | |
PE20110196A1 (es) | 5-alquinil-pirimidinas | |
CY1117862T1 (el) | Ετεροκυκλικες ενωσεις βενζοδιοξολιου ή βενζοδιοξεπινης ως αναστολεις φωσφοδιεστερασης | |
AR103742A1 (es) | Derivados de trifluorometilpropanamida | |
CO6361956A2 (es) | Nuevos derivados de benzotiadiazepinas, su procedimiento de preparación y composiciones farmaceúticas que los contienen | |
CU23761B7 (es) | Nuevos derivados de diosmetina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |