AR059916A1 - Procesos y productos intermedios para preparar compuestos esterico - Google Patents
Procesos y productos intermedios para preparar compuestos estericoInfo
- Publication number
- AR059916A1 AR059916A1 ARP070101077A ARP070101077A AR059916A1 AR 059916 A1 AR059916 A1 AR 059916A1 AR P070101077 A ARP070101077 A AR P070101077A AR P070101077 A ARP070101077 A AR P070101077A AR 059916 A1 AR059916 A1 AR 059916A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- esteric
- prepare
- compounds
- processes
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000013067 intermediate product Substances 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/20—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
- C07C247/06—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
- C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Abstract
Reivindicacion 1: Un proceso para preparar un compuesto opticamente enriquecido de la formula 1 en donde: los átomos de carbono alfa y beta respecto del grupo carboxi son estereocentros; R1 y R'1 son cada uno, de modo independiente H, alifático opcionalmente sustituido, cicloalifático opcionalmente sustituido, arilalifático opcionalmente sustituido, heteroalifático opcionalmente sustituido o heteroarilalifático opcionalmente sustituido, R'2 es -NHR2 o -OE; R2 es H, alifático opcionalmente sustituido, cicloalifático opcionalmente sustituido, arilalifático opcionalmente sustituido, heteroalifático opcionalmente sustituido o heteroarilalifático opcionalmente sustituido; y E es alquilo C1-6 o bencilo; que comprende las etapas de: a) formar una sal de un compuesto de la formula 1; b) cristalizar dicha sal para dar un compuesto superior al 55% de exceso enantiomérico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78297606P | 2006-03-16 | 2006-03-16 | |
US84477106P | 2006-09-15 | 2006-09-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR059916A1 true AR059916A1 (es) | 2008-05-07 |
Family
ID=38222510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070101077A AR059916A1 (es) | 2006-03-16 | 2007-03-16 | Procesos y productos intermedios para preparar compuestos esterico |
Country Status (15)
Country | Link |
---|---|
US (3) | US20070244334A1 (es) |
EP (3) | EP2295401A3 (es) |
JP (1) | JP5313124B2 (es) |
KR (1) | KR101398259B1 (es) |
AR (1) | AR059916A1 (es) |
AU (1) | AU2007227580A1 (es) |
BR (1) | BRPI0709568A2 (es) |
CA (1) | CA2646123A1 (es) |
HK (1) | HK1132988A1 (es) |
MX (1) | MX2008011869A (es) |
NZ (1) | NZ571281A (es) |
RU (1) | RU2013105768A (es) |
SG (1) | SG170729A1 (es) |
TW (2) | TW201416341A (es) |
WO (1) | WO2007109023A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL129407A0 (en) | 1996-10-18 | 2000-02-17 | Vertex Pharma | Inhibitors of serine proteases particularly hepatitis C virus NS3 protease pharmaceutical compositions containing the same and the use thereof |
SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
MY148123A (en) | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
US8399615B2 (en) * | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
AU2007217355B2 (en) | 2006-02-27 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same |
CA2646229A1 (en) * | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
US7834190B2 (en) * | 2006-05-26 | 2010-11-16 | Kaneka Corporation | Process for production of optically active-3-amino-2-hydroxypropionic cyclopropylamide derivatives and salts thereof |
DE102006059317A1 (de) | 2006-07-04 | 2008-01-10 | Evonik Degussa Gmbh | Verfahren zur Herstellung von β-Amino-α-hydroxy-carbonsäureamiden |
DE102006042147A1 (de) * | 2006-09-06 | 2008-03-27 | Dynamit Nobel Gmbh Explosivstoff- Und Systemtechnik | Hydrochloride von 3-Amino-2-hydroxycarbonsäureamiden |
TW200846343A (en) | 2007-02-27 | 2008-12-01 | Vertex Pharma | Co-crystals and pharmaceutical compositions comprising the same |
WO2008106058A2 (en) | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
ATE530546T1 (de) | 2007-08-30 | 2011-11-15 | Vertex Pharma | Kokristalle und pharmazeutische zusammensetzungen damit |
EP2861557A1 (en) | 2012-06-13 | 2015-04-22 | Janssen Pharmaceutica, N.V. | A method for the preparation of 3-amino-n-cyclopropyl-2-hydroxyl-hexanamide |
CN103508918B (zh) * | 2012-06-18 | 2015-09-09 | 上海医药工业研究院 | 带有环丁基的α-羟基β-氨基酯类化合物及其制备方法 |
WO2013189978A1 (en) | 2012-06-20 | 2013-12-27 | Sandoz Ag | PROCESS FOR PREPARING ß-AMINO ACID DERIVATIVES AND USE OF SAID PROCESS FOR PREPARING TELAPREVIR |
US9346853B2 (en) | 2012-06-20 | 2016-05-24 | Sandoz Ag | Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including β-amino acids prepared via Mukaiyama aldol addition |
WO2014033667A1 (en) | 2012-08-30 | 2014-03-06 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir |
WO2014083582A2 (en) * | 2012-11-29 | 2014-06-05 | Msn Laboratories Limited | Novel process for the preparation of (1s,3ar,6as)-2-[(2s)-2-({(2s)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-n-[(3s)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c] pyrrole-1-carboxamide and its intermediates |
WO2014203208A1 (en) | 2013-06-21 | 2014-12-24 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir and intermediates thereof |
WO2014203224A1 (en) | 2013-06-21 | 2014-12-24 | Ranbaxy Laboratories Limited | Process for the preparation of telaprevir and its intermediates |
CN104926831A (zh) * | 2014-03-20 | 2015-09-23 | 上海医药工业研究院 | 合成特拉匹韦的中间体及其制备方法 |
CN110577506B (zh) * | 2018-06-07 | 2023-04-07 | 中国科学院上海有机化学研究所 | (﹣)-三尖杉碱的酯类衍生物的合成方法及其中间体 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US711530A (en) | 1902-07-30 | 1902-10-21 | Kempshall Mfg Co | Playing-ball. |
US782976A (en) | 1904-05-21 | 1905-02-21 | Patrick Thomas Lyons | Water-heater. |
US782778A (en) | 1904-06-04 | 1905-02-14 | Gas And Electric Protective Company | Emergency fire apparatus for buildings. |
US844771A (en) | 1906-09-07 | 1907-02-19 | Horace M Bellows | Aerial navigation. |
DE2136067C3 (de) * | 1970-08-03 | 1980-09-11 | Merck & Co., Inc., Rahway, N.J. (V.St.A.) | 3-Fluor-D-alanin, 3-Fluor-D-alanin-2-d, deren Salze und diese Verbindungen enthaltende Arzneimittel |
JPS54163544A (en) * | 1978-06-09 | 1979-12-26 | Nippon Kayaku Kk | Dllthreo and dllerythroo 33aminoo22hydroxyy44 phenylbutanoic acid amide and method |
JPS5557547A (en) * | 1978-10-25 | 1980-04-28 | Nippon Kayaku Co Ltd | Dl-threo- and dl-erythro-3-amino-2-hydroxy-5- methylhexanoic acid amides and their preparation |
JP3046369B2 (ja) * | 1990-03-15 | 2000-05-29 | エーザイ株式会社 | 光学異性体分離剤 |
JP3863230B2 (ja) | 1996-08-16 | 2006-12-27 | 株式会社カネカ | β−アミノ−α−ヒドロキシ酸誘導体の製造方法 |
DE69725023T2 (de) | 1996-10-08 | 2004-08-05 | Colorado State University Research Foundation, Fort Collins | Katalytische asymmetrische epoxidierung |
EP0978508B1 (de) * | 1998-08-05 | 2005-12-14 | DSM IP Assets B.V. | Herstellung von 4,4'-Diketo-carotinoiden |
US6025516A (en) * | 1998-10-14 | 2000-02-15 | Chiragene, Inc. | Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes |
AU2943400A (en) | 1999-03-12 | 2000-10-04 | Ajinomoto Co., Inc. | Process for the preparation of alpha-aminoketone derivatives |
JP4421141B2 (ja) * | 2000-06-30 | 2010-02-24 | 生化学工業株式会社 | アジド誘導体 |
WO2002002546A1 (fr) * | 2000-06-30 | 2002-01-10 | Seikagaku Corporation | Amides d'acide carboxylique, azides et amino-alcools et procedes de preparation de $g(a)-ceto amides a l'aide de ces derniers |
JP4666440B2 (ja) * | 2000-06-30 | 2011-04-06 | 生化学工業株式会社 | アミノアルコール誘導体 |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
JP2005500322A (ja) * | 2001-07-03 | 2005-01-06 | アルタナ ファルマ アクチエンゲゼルシャフト | 3−フェニルイソセリンの製法 |
JP2003055389A (ja) * | 2001-08-09 | 2003-02-26 | Univ Tokyo | 錯体及びそれを用いたエポキシドの製法 |
JP3924613B2 (ja) * | 2002-11-06 | 2007-06-06 | 国立大学法人 東京大学 | α,β−エポキシアミドの製法 |
JP4239622B2 (ja) * | 2003-03-11 | 2009-03-18 | 東ソー株式会社 | 不斉エポキシ触媒及びそれを用いた光学活性エポキシドの製造方法 |
MY145081A (en) | 2004-02-27 | 2011-12-15 | Schering Corp | Sulfur compounds as inhibitors of hepatitis c virus ns3 serine protease |
EP1831150A1 (en) | 2004-07-23 | 2007-09-12 | DSMIP Assets B.V. | Process for the preparation of (2r, 3r)-2-hydroxy-3-amino-3-aryl-propionamide and (2r, 3r)-2-hydroxy-3-amino-3-aryl-propionic acid alkyl ester |
US7441786B2 (en) * | 2005-03-07 | 2008-10-28 | Stryker Corporation | Convertible low profile roller and support base |
AU2006262386B2 (en) * | 2005-06-20 | 2012-02-02 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use |
ES2344156T3 (es) | 2005-08-19 | 2010-08-19 | Vertex Pharmaceuticals Incorporated | Procedimientos e intermedios. |
JP4851804B2 (ja) | 2006-02-13 | 2012-01-11 | 株式会社日立ハイテクノロジーズ | 集束イオンビーム加工観察装置、集束イオンビーム加工観察システム及び加工観察方法 |
JP2009132621A (ja) * | 2006-03-13 | 2009-06-18 | Ajinomoto Co Inc | シクロプロピルアミド化合物の製造方法 |
DE102006059317A1 (de) * | 2006-07-04 | 2008-01-10 | Evonik Degussa Gmbh | Verfahren zur Herstellung von β-Amino-α-hydroxy-carbonsäureamiden |
-
2007
- 2007-03-14 MX MX2008011869A patent/MX2008011869A/es active IP Right Grant
- 2007-03-14 CA CA002646123A patent/CA2646123A1/en not_active Abandoned
- 2007-03-14 KR KR1020087025193A patent/KR101398259B1/ko not_active IP Right Cessation
- 2007-03-14 US US11/724,002 patent/US20070244334A1/en not_active Abandoned
- 2007-03-14 NZ NZ571281A patent/NZ571281A/en not_active IP Right Cessation
- 2007-03-14 JP JP2009500435A patent/JP5313124B2/ja not_active Expired - Fee Related
- 2007-03-14 AU AU2007227580A patent/AU2007227580A1/en not_active Abandoned
- 2007-03-14 EP EP10177438A patent/EP2295401A3/en not_active Withdrawn
- 2007-03-14 EP EP07752981A patent/EP1993993A1/en not_active Withdrawn
- 2007-03-14 SG SG201101886-8A patent/SG170729A1/en unknown
- 2007-03-14 WO PCT/US2007/006320 patent/WO2007109023A1/en active Application Filing
- 2007-03-14 EP EP11172239A patent/EP2407448A3/en not_active Withdrawn
- 2007-03-14 BR BRPI0709568-6A patent/BRPI0709568A2/pt not_active IP Right Cessation
- 2007-03-16 TW TW102145986A patent/TW201416341A/zh unknown
- 2007-03-16 TW TW96109169A patent/TWI466851B/zh not_active IP Right Cessation
- 2007-03-16 AR ARP070101077A patent/AR059916A1/es unknown
-
2009
- 2009-11-18 HK HK09110787.7A patent/HK1132988A1/xx not_active IP Right Cessation
-
2010
- 2010-08-04 US US12/806,014 patent/US8383858B2/en not_active Expired - Fee Related
-
2013
- 2013-01-14 US US13/740,707 patent/US20130131359A1/en not_active Abandoned
- 2013-02-12 RU RU2013105768/04A patent/RU2013105768A/ru unknown
Also Published As
Publication number | Publication date |
---|---|
EP1993993A1 (en) | 2008-11-26 |
TW200812941A (en) | 2008-03-16 |
KR101398259B1 (ko) | 2014-05-26 |
BRPI0709568A2 (pt) | 2011-07-12 |
HK1132988A1 (en) | 2010-03-12 |
EP2295401A2 (en) | 2011-03-16 |
US20100298568A1 (en) | 2010-11-25 |
TWI466851B (zh) | 2015-01-01 |
AU2007227580A1 (en) | 2007-09-27 |
CA2646123A1 (en) | 2007-09-27 |
WO2007109023A1 (en) | 2007-09-27 |
JP2009530282A (ja) | 2009-08-27 |
RU2013105768A (ru) | 2014-08-20 |
SG170729A1 (en) | 2011-05-30 |
EP2407448A2 (en) | 2012-01-18 |
MX2008011869A (es) | 2008-12-03 |
TW201416341A (zh) | 2014-05-01 |
US20130131359A1 (en) | 2013-05-23 |
RU2008140942A (ru) | 2010-04-27 |
EP2407448A3 (en) | 2012-07-25 |
JP5313124B2 (ja) | 2013-10-09 |
EP2295401A3 (en) | 2012-07-25 |
US8383858B2 (en) | 2013-02-26 |
KR20080109028A (ko) | 2008-12-16 |
US20070244334A1 (en) | 2007-10-18 |
NZ571281A (en) | 2011-11-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR059916A1 (es) | Procesos y productos intermedios para preparar compuestos esterico | |
CO6280583A2 (es) | Pirido[2,3-b]pirazinas herbicidas, procesos para su preparación, composiciones que comprenden estos compuestos, y métodos para controlar plantas usando estos compuestos. | |
PH12018500106A1 (en) | Ethynyl derivatives as metabotropic glutamate receptor modulators | |
AR061924A1 (es) | Proceso para elaborar 2- amino -5 - halobenzamidas 3- sustituidas | |
ATE549343T1 (de) | Verfahren zur herstellung von (alpha s, beta r)-6-brom-alpha-ä2-(dimethylamino)ethylü-2-meth xy- alpha-1-naphthalinyl-beta-phenyl-3- chinolinethanol | |
AR061112A1 (es) | Procedimientos para la produccion de derivados de benzopiran-2-ol, fesoterodina y un derivado de la tolterodina e intermediarios de sintesis de los citados procesos. | |
BR112014014148A2 (pt) | misturas de ácidos difosfínicos e dialquilfosfínicos, processo para produção das mesmas e uso das mesmas | |
DE602006021411D1 (de) | Verfahren zur herstellung von optional 2-substituierten 1,6-dihydro-6-oxo-4-pyrimidincarboxylsäuren | |
BRPI0607092A2 (pt) | polimorfo cristalino de monoidrato de sal monossódico de ácido 3-(n-metil-n-pentil) amino-1-hidroxipropano-1, 1-difosfÈnico, ibandronato, processo para a preparação de um polimorfo de ibandronato cristalino, e composição farmacêutica que o compreende | |
ATE441627T1 (de) | Verfahren zur herstellung von valsartan | |
BRPI0817747A8 (pt) | Processo para a preparação de derivados de ácido 2-di-halogenoacil-3-amino-acrílico | |
AR057022A1 (es) | Proceso para resolver un r o s acido mandelico a partir de su mezcla racemica | |
BR112018073490A2 (pt) | 6.7.beta-epóxidos esteroides como intermediários químicos | |
SI2183201T1 (sl) | Postopek za resolucijo zopiklona in intermediatnespojine | |
BR112013023921A2 (pt) | (3r,4r) -4-ciano-3, 4-difenilbutanoatos substituídos, processos para a sua preparação e sua utilização como herbecidas e reguladores de crescimento de plantas | |
AR083718A1 (es) | Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas | |
MX2021005343A (es) | Proceso para la preparacion de isoxazolinas opticamente enriquecidas. | |
ATE549315T1 (de) | Verfahren zur herstellung von kristallinem perindopril | |
DE602006015458D1 (de) | Verfahren zur herstellung eines carbonsäureamidderivats | |
DE602006008335D1 (de) | Neuartiges verfahren zur herstellung von quaternärer säure und ammoniumsalzen | |
DE602005013007D1 (de) | Verfahren zur herstellung von lactonen | |
BR112017021824A2 (pt) | composto enantiomericamente puro, processo de fabricação dos compostos, e, método para regular o crescimento de plantas | |
BR112022002990A2 (pt) | Processo para a preparação de derivados de ácido carboxílico de 3-bromo-4,5-di-hidro-1h-pirazóis | |
AR057333A1 (es) | Proceso para la preparacion de 3,3-diarilpropilaminas | |
WO2012070896A3 (en) | Synthetic method of enantiomerically pure 2,2'-dihydroxy-1,1'-binaphthyl-3-carboxylic acid |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |