AR059094A1 - Derivados de ciclohexil - sulfonamida - Google Patents

Derivados de ciclohexil - sulfonamida

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Publication number
AR059094A1
AR059094A1 ARP070100244A ARP070100244A AR059094A1 AR 059094 A1 AR059094 A1 AR 059094A1 AR P070100244 A ARP070100244 A AR P070100244A AR P070100244 A ARP070100244 A AR P070100244A AR 059094 A1 AR059094 A1 AR 059094A1
Authority
AR
Argentina
Prior art keywords
halogenoalkyl
alkyl
group
unsubstituted
substituted
Prior art date
Application number
ARP070100244A
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English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR059094A1 publication Critical patent/AR059094A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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Abstract

Estos compuestos son utiles para el tratamiento y/o prevencion de enfermedades asociadas con la modulacion de los receptores de H3. Enfermedades de la obesidad. Reivindicacion 1: Compuestos de la formula general (1) en la que R1 se selecciona entre el grupo formado por alquilo inferior, cicloalquilo, cicloalquilalquilo inferior y tetrahidropiranilo; R2 se selecciona entre el grupo formado por H, alquilo inferior, cicloalquilo, cicloalquilalquilo inferior, halogenoalquilo inferior, alcoxialquilo inferior y cianoalquilo inferior; R3 se selecciona entre el grupo formado por alquilo inferior, (CH2)m-arilo, en el que m es el numero 0, 1 o 2 y en el que el anillo arilo está sin sustituir o sustituido con uno, dos o tres grupos seleccionados independientemente entre alquilo inferior, halogeno, halogenoalquilo inferior, ciano, cianoalquilo inferior, alcoxi inferior, alcanoílo inferior, benzoílo, halogenoalcoxi inferior, hidroxialquilo inferior, alcanoilamino inferior y alquilsulfonilo inferior, -(CH2)n-heteroarilo, en el que n es el numero 0, 1 o 2 y en el que el anillo heteroarilo está sin sustituir o sustituido con uno, dos o tres grupos seleccionados independientemente entre alquilo inferior, halogenoalquilo inferior, ciano, cianoalquilo inferior, alcoxi inferior, alcanoílo inferior, benzoílo, halogenoalcoxi inferior, hidroxialquilo inferior, alcanoilamino inferior y alquilsulfonilo inferior y -NR4R5, R4 se selecciona entre el grupo formado por hidrogeno, alquilo inferior, halogenoalquilo inferior, alcoxialquilo inferior y cianoalquilo inferior; R5 se selecciona entre el grupo formado por alquilo inferior, halogenoalquilo inferior, alcoxialquilo inferior, cianoalquilo inferior, fenilo sin sustituir o sustituido con uno, dos o tres grupos seleccionados independientemente entre alquilo inferior, halogeno, halogenoalquilo inferior, ciano, alcoxi inferior, alcanoílo inferior, benzoílo, halogenoalcoxi inferior e hidroxialquilo inferior y fenilalquilo inferior, cuyo anillo fenilo puede estar sin sustituir o sustituido con uno o dos grupos seleccionados independientemente entre alquilo inferior, halogeno, halogenoalquilo inferior, ciano, alcoxi inferior, alcanoílo inferior, benzoílo, halogenoalcoxi inferior e hidroxialquilo inferior; o R4 y R5 junto con el átomo de nitrogeno al que están unidos forman un anillo heterocíclico de 4, 5, 6 o 7 miembros que contiene opcionalmente otro heteroátomo seleccionado entre nitrogeno, oxígeno o azufre, un grupo sulfinilo o un grupo sulfonilo, dicho anillo heterocíclico está sin sustituir o sustituido con uno, dos o tres grupos seleccionados independientemente entre alquilo inferior, halogeno, halogenoalquilo, ciano, hidroxi, hidroxialquilo inferior, alcoxi inferior, oxo, fenilo, bencilo, piridilo y carbamoilo o está condensado con un anillo fenilo, dicho anillo fenilo está sin sustituir o sustituido con uno, dos o tres grupos seleccionados independientemente entre alquilo inferior, alcoxi inferior y halogeno; y las sales farmacéuticamente aceptables de los mismos.
ARP070100244A 2006-01-23 2007-01-19 Derivados de ciclohexil - sulfonamida AR059094A1 (es)

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US (2) US20070173511A1 (es)
EP (1) EP1979322B1 (es)
JP (1) JP5031771B2 (es)
KR (1) KR101047274B1 (es)
CN (1) CN101370779B (es)
AR (1) AR059094A1 (es)
AT (1) ATE479656T1 (es)
AU (1) AU2007206997B2 (es)
BR (1) BRPI0706716A2 (es)
CA (1) CA2637449A1 (es)
DE (1) DE602007008831D1 (es)
ES (1) ES2349160T3 (es)
IL (1) IL192632A0 (es)
NO (1) NO20083058L (es)
RU (1) RU2008134315A (es)
TW (1) TWI338001B (es)
WO (1) WO2007082840A1 (es)
ZA (1) ZA200806236B (es)

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CA2688585A1 (en) 2007-06-11 2008-12-18 F. Hoffmann-La Roche Ag Cyclohexyl derivatives
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
KR101229603B1 (ko) * 2008-02-12 2013-02-04 에프. 호프만-라 로슈 아게 피페리딘 설폰아미드 유도체
US8394858B2 (en) 2009-12-03 2013-03-12 Novartis Ag Cyclohexane derivatives and uses thereof
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
RS59411B1 (sr) 2013-03-13 2019-11-29 Forma Therapeutics Inc Derivati 2-hidroksi-1-{4-[(4-fenilfenil)karbonil]piperazin-1-il}etan-1-ona i srodna jedinjenja kao inhibitori sintaze masnih kiselina (fasn) za lečenje kancera
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
WO2020092395A1 (en) 2018-10-29 2020-05-07 Forma Therapeutics, Inc. SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247547A (en) * 1983-06-22 1988-12-28 Paul Hadvary Leucine derivatives
US5246960A (en) * 1984-12-21 1993-09-21 Hoffmann-La Roche Inc. Oxetanones
CA1328881C (en) * 1984-12-21 1994-04-26 Pierre Barbier Process for the manufacture of oxetanones
CA1270837A (en) * 1984-12-21 1990-06-26 Hoffmann-La Roche Limited Oxetanones
CA2035972C (en) * 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones
US6004996A (en) * 1997-02-05 1999-12-21 Hoffman-La Roche Inc. Tetrahydrolipstatin containing compositions
CN1997370B (zh) * 2004-05-19 2011-06-01 索尔瓦药物有限公司 N-氨磺酰-n＇-芳基哌嗪类化合物在制备用于预防或治疗肥胖和相关疾病的药物中的用途

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US20070173511A1 (en) 2007-07-26
AU2007206997A1 (en) 2007-07-26
EP1979322B1 (en) 2010-09-01
WO2007082840A1 (en) 2007-07-26
ATE479656T1 (de) 2010-09-15
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