AR057770A1 - Inhibidores de la p38-map-quinasa y composicion farmaceutica - Google Patents
Inhibidores de la p38-map-quinasa y composicion farmaceuticaInfo
- Publication number
- AR057770A1 AR057770A1 ARP060103659A ARP060103659A AR057770A1 AR 057770 A1 AR057770 A1 AR 057770A1 AR P060103659 A ARP060103659 A AR P060103659A AR P060103659 A ARP060103659 A AR P060103659A AR 057770 A1 AR057770 A1 AR 057770A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- aryl
- heteroalkyl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Se describen el compuesto y usos de éste para métodos para la obtencion de medicamentos. Estos compuestos pueden utilizarse en el tratamiento de enfermedades mediadas por la p38, como enfermedades inflamatorias (artritis reumatoide). Reivindicacion 1: Un compuesto de la formula (1) o (2), o una sal farmacéuticamente aceptable del mismo, en la que: R1 es arilo, heteroarilo, aralquilo o cicloalquilo; R2 es arilo, heteroarilo, cicloalquilo, alquilo ramificado o heterociclilo; R3 es hidrogeno o alquilo; R4 es hidrogeno, alquilo, hidroxi, amino, heteroalquilo, heterociclilo, heterociclilalquilo, hidroxicicloalquilo, cicloalquilalquilo, alquilsulfonilo, alquilsulfonamido, arilo, heteroarilo, aralquilo, heteroaralquilo, -(CHRa)r-C(=O)-Rb, - (CHRa)r-O-C(=O)-Rb, -(CHRa)r-NH-C(=O)-Rb o -SO2-Rb, en los que: Ra es hidrogeno, alquilo o heteroalquilo, Rb es alquilo, hidroxi, amino, heteroalquilo, arilo, aralquilo, heteroarilo, o heterociclilo, y r es numero de 0 a 4; R5es hidrogeno o alquilo; W es un enlace, O, S(O)m, CH2 o NRc, en los que m numero de 0 a 2; y Rc es hidrogeno, alquilo, heteroalquilo, heterociclilo, hidroxicicloalquilo, -C(=O)-Rd o -SO2-Rd, en los que Rd es alquilo, arilo, aralquilo, heteroarilo, heteroalquilo o heterociclilo; o R4 y Rc junto con los átomos a los que están unidos pueden formar un anillo heterocíclico; X e Y con independencia entre sí son nitrogeno o CRe, en el que: Re es hidrogeno, alquilo, hidroxi, alcoxi, amino, haloalquilo, ciano, halogeno, heteroalquilo, C(=O)-Rf o -SO2-Rf, en los que Rf es hidrogeno, hidroxi o alquilo; k es 0 o 1; y B es O, S(O)j, CH(ORg), NRh, C(=O), o NRiC(=O), en los que j es 0, 1 o 2; Rg es hidrogeno o alquilo; Rh es hidrogeno, alquilo, -C(=O)-Rj, o - SO2Rk, en los que Rj es alquilo, arilo o aralquilo; y Rk es alquilo, y Ri es alquilo, ciclo alquilo, arilo o heteroarilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71202105P | 2005-08-25 | 2005-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057770A1 true AR057770A1 (es) | 2007-12-19 |
Family
ID=37429246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103659A AR057770A1 (es) | 2005-08-25 | 2006-08-23 | Inhibidores de la p38-map-quinasa y composicion farmaceutica |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7517901B2 (es) |
| EP (1) | EP1919877A1 (es) |
| JP (1) | JP2009506008A (es) |
| KR (1) | KR20080031460A (es) |
| CN (1) | CN101243051A (es) |
| AR (1) | AR057770A1 (es) |
| AU (1) | AU2006283944A1 (es) |
| BR (1) | BRPI0615094A2 (es) |
| CA (1) | CA2620257A1 (es) |
| IL (1) | IL189381A0 (es) |
| MX (1) | MX2008002587A (es) |
| TW (1) | TW200800171A (es) |
| WO (1) | WO2007023114A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
| TW201811766A (zh) | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| WO2018049191A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridone derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| TW201811799A (zh) | 2016-09-09 | 2018-04-01 | 美商英塞特公司 | 吡唑并嘧啶化合物及其用途 |
| US10266530B2 (en) | 2016-09-09 | 2019-04-23 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| CN108570052A (zh) * | 2017-03-13 | 2018-09-25 | 中国科学院上海药物研究所 | 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用 |
| WO2019051199A1 (en) | 2017-09-08 | 2019-03-14 | Incyte Corporation | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS |
| DK3691620T3 (da) | 2017-10-05 | 2022-10-03 | Fulcrum Therapeutics Inc | P38-kinaseinhibitor reducerer dux4- og downstream-gen-ekspression til behandling af fshd |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| US10752635B2 (en) | 2018-02-20 | 2020-08-25 | Incyte Corporation | Indazole compounds and uses thereof |
| LT3755703T (lt) | 2018-02-20 | 2022-10-10 | Incyte Corporation | N-(fenil)-2-(fenil)pirimidin-4-karboksamido dariniai ir susiję junginiai, kaip hpk1 inhibitoriai, skirti vėžio gydymui |
| US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| JP7399968B2 (ja) | 2018-09-25 | 2023-12-18 | インサイト・コーポレイション | Ａｌｋ２及び／またはｆｇｆｒ調節剤としてのピラゾロ［４，３－ｄ］ピリミジン化合物 |
| US11066394B2 (en) | 2019-08-06 | 2021-07-20 | Incyte Corporation | Solid forms of an HPK1 inhibitor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2478048A (en) * | 1943-01-23 | 1949-08-02 | Winthrop Stearns Inc | Sulfanilamidoindazoles and method of production |
| JP2004536113A (ja) * | 2001-07-03 | 2004-12-02 | カイロン コーポレイション | チロシンキナーゼおよびセリン／スレオニンキナーゼのインヒビターとしてのインダゾールベンズイミダゾール化合物 |
| FR2836914B1 (fr) * | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
| CN100432073C (zh) * | 2002-08-06 | 2008-11-12 | 霍夫曼-拉罗奇有限公司 | 作为p-38map激酶抑制剂的6-烷氧基-吡啶并-嘧啶 |
| RU2006134020A (ru) * | 2004-02-27 | 2008-04-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Конденсированные производные пиразола |
-
2006
- 2006-08-16 CA CA002620257A patent/CA2620257A1/en not_active Abandoned
- 2006-08-16 WO PCT/EP2006/065334 patent/WO2007023114A1/en active Application Filing
- 2006-08-16 CN CNA2006800302236A patent/CN101243051A/zh active Pending
- 2006-08-16 JP JP2008527441A patent/JP2009506008A/ja active Pending
- 2006-08-16 MX MX2008002587A patent/MX2008002587A/es not_active Application Discontinuation
- 2006-08-16 AU AU2006283944A patent/AU2006283944A1/en not_active Abandoned
- 2006-08-16 BR BRPI0615094-2A patent/BRPI0615094A2/pt not_active Application Discontinuation
- 2006-08-16 EP EP06792822A patent/EP1919877A1/en not_active Withdrawn
- 2006-08-16 KR KR1020087004485A patent/KR20080031460A/ko not_active Application Discontinuation
- 2006-08-22 TW TW095130749A patent/TW200800171A/zh unknown
- 2006-08-23 AR ARP060103659A patent/AR057770A1/es not_active Application Discontinuation
- 2006-08-23 US US11/509,501 patent/US7517901B2/en not_active Expired - Fee Related
-
2008
- 2008-02-07 IL IL189381A patent/IL189381A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200800171A (en) | 2008-01-01 |
| US20070049633A1 (en) | 2007-03-01 |
| EP1919877A1 (en) | 2008-05-14 |
| MX2008002587A (es) | 2008-03-18 |
| KR20080031460A (ko) | 2008-04-08 |
| JP2009506008A (ja) | 2009-02-12 |
| WO2007023114A1 (en) | 2007-03-01 |
| BRPI0615094A2 (pt) | 2011-05-03 |
| IL189381A0 (en) | 2008-06-05 |
| US7517901B2 (en) | 2009-04-14 |
| AU2006283944A1 (en) | 2007-03-01 |
| CA2620257A1 (en) | 2007-03-01 |
| CN101243051A (zh) | 2008-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |