AR057627A1 - Compuestos de carbamato como agonistas del receptor 5-ht4 - Google Patents

Compuestos de carbamato como agonistas del receptor 5-ht4

Info

Publication number
AR057627A1
AR057627A1 ARP060105125A ARP060105125A AR057627A1 AR 057627 A1 AR057627 A1 AR 057627A1 AR P060105125 A ARP060105125 A AR P060105125A AR P060105125 A ARP060105125 A AR P060105125A AR 057627 A1 AR057627 A1 AR 057627A1
Authority
AR
Argentina
Prior art keywords
alkyl
nrarb
compounds
formula
3alkyl
Prior art date
Application number
ARP060105125A
Other languages
English (en)
Inventor
Daniel D Long
Seok-Ki Choi
P Fatheree
Adam A Goldblum
D Marquess
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of AR057627A1 publication Critical patent/AR057627A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

También se proveen composiciones farmacéuticas como compuestos, métodos para utilizar dichos compuestos para tratar enfermedades asociadas con la actividad del receptor 5-HT4, y procesos e intermediarios utiles para preparar dichos compuestos. Reivindicacion 1: Un compuesto caracterizado porque es de formula (1) donde R1 es halo o C1-3 alquilo, donde C1-3 alquilo está opcionalmente sustituido con hidroxi o halo; R2 es H o C1-3 alquilo, donde C1-3 está opcionalmente sustituido con hidroxi; R3 es C1-3 alquilo o H; R4 es -(CH2)1-3C(O)NRaRb, o como se muestra en los compuestos de formulas (2), o R3 y R4 junto con el átomo de N al cual están unidos forman una porcion seleccionada entre: (i) una porcion de formula (3), (ii)una porcion de formula (4); y (iii) una porcion de formula (5), donde R5 es -OC(O)NRaRb, -C(O)NRaRb, -NRdS(O)2C1-3alquilo, -NRdC(O)Rc, -NRdS(O)2NRaRb, o -NRdC(O)ORe; R6 es -C(O)Rf, -(CH2)2ORg, -S(O)2NRaRb, -S(O)2C1-3alquilo, o -S(O)2(CH2)1-3S(O)2C1- 3alquilo; Ra, Rb, y Rc son en forma independiente H o C1-3 alquilo; Rd es H o C1-3 alquilo, donde C1-3 alquilo está opcionalmente sustituido con hidroxi; Re es C1-3 alquilo; Rf es H, C1-3 alquilo, tetrahidrofuranilo, o -NRaRb; Rg es H o C1-3 alquilo; a es 0, 1 o 2; b es 0, 1, 2 o 3, c es 0, 1 o 2; d es 1 o 2; y e es 1 o 2; con la condicion de que cuando c es 0, entonces d es 2, y R5 es -C(O)NRaRb; y cuando c es 2, entonces d es 1; o una sal o solvato o estereoisomero aceptable para uso farmacéutico del mismo.
ARP060105125A 2005-11-22 2006-11-22 Compuestos de carbamato como agonistas del receptor 5-ht4 AR057627A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73870205P 2005-11-22 2005-11-22

Publications (1)

Publication Number Publication Date
AR057627A1 true AR057627A1 (es) 2007-12-05

Family

ID=38067868

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105125A AR057627A1 (es) 2005-11-22 2006-11-22 Compuestos de carbamato como agonistas del receptor 5-ht4

Country Status (20)

Country Link
US (2) US7329752B2 (es)
EP (1) EP1960396B1 (es)
JP (1) JP2009516745A (es)
KR (1) KR20080072727A (es)
CN (1) CN101312967B (es)
AR (1) AR057627A1 (es)
AT (1) ATE448224T1 (es)
AU (1) AU2006318507A1 (es)
BR (1) BRPI0618835A2 (es)
CA (1) CA2630222A1 (es)
DE (1) DE602006010432D1 (es)
EA (1) EA014819B1 (es)
ES (1) ES2336952T3 (es)
MY (1) MY143574A (es)
NO (1) NO20082597L (es)
NZ (1) NZ567653A (es)
PE (1) PE20070954A1 (es)
TW (1) TW200804366A (es)
WO (1) WO2007062058A2 (es)
ZA (1) ZA200804010B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006094063A1 (en) * 2005-03-02 2006-09-08 Theravance, Inc. Quinolinone compounds as 5-ht4 receptor agonists
WO2007097976A1 (en) * 2006-02-16 2007-08-30 Theravance, Inc. Process for preparing intermediates to 5-ht4 receptor agonist compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223511A (en) * 1987-09-23 1993-06-29 Boehringer Ingelheim Italia S.P.A. Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists
IT1231413B (it) 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
JP3829879B2 (ja) * 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
IT1275903B1 (it) * 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
IT1298271B1 (it) 1998-02-18 1999-12-20 Boehringer Ingelheim Italia Esteri ed ammidi dell'acido 2-oxo-2,3-diidro-benzimidazol-1- carbossilico
CN1461216A (zh) * 1999-04-28 2003-12-10 呼吸器有限公司 用作治疗有关支气管收缩的机能障碍的药物的化合物
IT1313625B1 (it) * 1999-09-22 2002-09-09 Boehringer Ingelheim Italia Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina.
JP4181847B2 (ja) * 2002-10-25 2008-11-19 エルピーダメモリ株式会社 タイミング調整回路、半導体装置及びタイミング調整方法
ES2377484T3 (es) * 2003-09-03 2012-03-28 Pfizer, Inc. Compuestos de bencimidazolona que tiene actividad agonista del receptor 5-HT
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
ES2332808T3 (es) * 2004-11-05 2010-02-12 Theravance, Inc. Compuestos agonistas del receptor 5-ht4.
EP1807423B1 (en) * 2004-11-05 2009-05-20 Theravance, Inc. Quinolinone-carboxamide compounds
RU2404179C2 (ru) * 2004-12-22 2010-11-20 Тереванс, Инк. Индазол-карбоксамидные соединения
WO2006094063A1 (en) 2005-03-02 2006-09-08 Theravance, Inc. Quinolinone compounds as 5-ht4 receptor agonists
US7351304B2 (en) * 2005-05-24 2008-04-01 General Electric Company Method and apparatus for reducing surface defects
DE602006019595D1 (de) 2005-06-07 2011-02-24 Theravance Inc Benzimidazoloncarbonsäureamidverbindungen als agonisten des 5-ht4-rezeptors

Also Published As

Publication number Publication date
AU2006318507A1 (en) 2007-05-31
TW200804366A (en) 2008-01-16
WO2007062058A2 (en) 2007-05-31
CN101312967A (zh) 2008-11-26
ZA200804010B (en) 2009-02-25
US20080090811A1 (en) 2008-04-17
EP1960396A2 (en) 2008-08-27
ATE448224T1 (de) 2009-11-15
PE20070954A1 (es) 2007-09-10
US7851467B2 (en) 2010-12-14
WO2007062058A3 (en) 2007-09-07
US20070117796A1 (en) 2007-05-24
NZ567653A (en) 2011-06-30
CA2630222A1 (en) 2007-05-31
US7329752B2 (en) 2008-02-12
NO20082597L (no) 2008-06-10
DE602006010432D1 (de) 2009-12-24
BRPI0618835A2 (pt) 2011-09-13
CN101312967B (zh) 2011-08-24
EA200801402A1 (ru) 2008-10-30
KR20080072727A (ko) 2008-08-06
EA014819B1 (ru) 2011-02-28
EP1960396B1 (en) 2009-11-11
ES2336952T3 (es) 2010-04-19
MY143574A (en) 2011-05-31
JP2009516745A (ja) 2009-04-23

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