AR054616A1 - Tetrahidroquinolinas sustituidas - Google Patents
Tetrahidroquinolinas sustituidasInfo
- Publication number
- AR054616A1 AR054616A1 ARP060102412A ARP060102412A AR054616A1 AR 054616 A1 AR054616 A1 AR 054616A1 AR P060102412 A ARP060102412 A AR P060102412A AR P060102412 A ARP060102412 A AR P060102412A AR 054616 A1 AR054616 A1 AR 054616A1
- Authority
- AR
- Argentina
- Prior art keywords
- naryl
- nnr2
- nheteroaryl
- aryl
- nxr
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de formula (1), donde W es CH o N; R 1, R2, R3 independientemente entre sí, H, A, arilo, heteroarilo, Hal, -(CY2)n-SA, -(CY2)n-SCF3, -(CY2)n-SCN, -(CY2)n-CF3, -(CY2)n-OCF3, R, NR-NR2, X-(CY2)n-XR, X-(CY2)n-Y, -(CY2)n-cicloalquilo, -(CY2)n- CH=CH2, cicloalquilo, -SCH3, -SCN, -CF3, -OCF3, -OA, -(CY2)n-OH, -(CY2)n-CO2R, -(CY2)n-CN, -(CY2)n-Hal, -(CY2)n-Y, -(CY2)n-Ra, -(CY2)n-NR2, -(CY2)n-OA, -(CY2)n-OCOA, -SCF3, -(CY2)n-CONR2, -(CY2)n-NHCOA, -(CY2)n-NHSO2A, SF5, Si(CH3)3, CO-(CY2)n-CH3, - (CY2)n-N-pirrolidona, -(CH2)nNRCOOR, NRCOOR, NCO, (CH2)nCOOR, NHCOOR, -(CH2)n-OH, -NR(CH2)nNR2, C(OH)R2, -NR(CH2)nOR, NCOR, (CH2)narilo, (CH2)nheteroarilo, (CH2)nR1, (CH2)nX(CH2)narilo, (CH2)nX(CH2)nheteroarilo, (CH2)nCONR2, XCONR(CH2)nNR2, N[(CH2)nXCOOR]CO(CH2)narilo, N[(CH2)nXR]CO(CH2)narilo, N[(CH2)nXR]CO(CH2)nX-arilo, N[(CH2)nXR]SO2(CH2)narilo, N[(CH2)nNRCOOR]CO(CH2)narilo, N[(CH2)nNR2]CO(CH2)narilo, N[(CH2)nNR2]CO(CH2)nNR-arilo, N[(CH2)nNR2]SO2(CH2)narilo, N[(CH2)nXR]CO(CH2)nheteroarilo, N[(CH2)nXR]CO(CH2)nX-heteroarilo, CO-arilo, SO2-heteroarilo, N[(CH2)nXR]SO2(CH2)nheteroarilo, N[(CH2)nNRCOOR]CO(CH2)nheteroarilo, N[(CH2)nNR2]CO(CH2)nheteroarilo, N[(CH2)nNR2]CO(CH2)nNR-heteroarilo, R1, y R3 conjuntamente también pueden significar -N-C(CF3)=N-, -N-CR=N-, -N-N=N-, y en donde los grupos no adyacentes CY2 también pueden estar reemplazados por X; Y es H, A, Hal, OR, E-R1; E es -NR1SO2-, -SO2NR1, -CONR1, -NR1CO-, -COO-, -OOC-, -CO-, -SO2-, - X-, -NR1CONR1, -OCONR1, -NR1COO-, -CSNR1, NR1CS-, -NR1CSNR1-, -SCONR1, -NR1COS-, -OCSNR1, NR1CSO-, -SCSNR1, -NR1CSS o un enlace simple; A es alquilo o cicloalquilo, donde uno o varios átomos de H pueden estar reemplazados por Hal; Hal es F, Cl, Br o I; R es H o A, en caso de radicales geminales también son juntos -(CH2)5-, -(CH2)4-, o -(CH2)n-X-(CH2)n, o -(CH2)n-Z-(CH2)n; R4, R4', R5, R5' son de modo independiente entre sí, H o N-pirrolidona no substituida o mono- o polisubstituida con OR, NO2, Hal, CF3, OCF3, CN, NR2, o SR, arilo o heteroarilo, Q, -(CY2)n-E-CR2R1, -(CY2)n-E-CR2XR1, -(CY2)n-E-(CY2)n-XR1 o -(CY2)n-E-(CY2)n-XRa, -X-(CH2)2OR, -X-CO(CH2)nCH3, -X-CO(CH2)2NR2, R1, S-arilo, O-arilo, CH2Si(CH3)3, o juntos son -X(CR2)2, -X-(CR2)3-, -X-CHQXY2-, -X-CH(CH2OR)(CY2)2-, -X-CH(CH2NR2)(CY2)2-, -X-CH=CQ-CH2-, -X-CQ=CH-CH2-, -X(CH2)2NR2, -(CR2)3-, -(CR2)4-, -CR=CR-CR=CR-, -XCHQ(CY2)2-, -XCHQCR2-, -R-N-(C=X)-N-R, -XC[(CH2)nOR]2CH2CH2-, -X-CY2CH(CH2OR)CY2, -XCY2CH(CH2NR2)CY2-, -X-CY2CHQ- CY2-, -XCHQCY2-, -XCY2CHQ-, -XCHQ(CY2)3-, -XCHQ(CY2)4-, -XCY2CHQ(CY2)2-, -XCY2CHQ(CY2)3-; X es O, S, o NR1; Q es (CH2)p-E-(CH2)pR1, (CH2)p-E-(CH2)pRa, (CH2)pHal, CHO, (CH2)pSR1, CORa, (CH2)pRa, (CH2)pOCORa, (CH2)pNCOR1, (CH2)pN(R1)2, (CH2)pOR1, (CH2)pOCON(R1)2, (CH2)pOCOOR1, (CH2)pNHCON(R1)2, (CH2)pNHCOOR1, (CH2)pCN, (CH2)pCOOR1, un resto seleccionado del grupo de formulas (2), OR, NHR, NR2, NR(CH2)narilo, NR(CH2)nOR, COOR, N-residuo de pirrolidona, OCOR, NR(CH2)nR2, (CY2)n-arilo, (CY2)2- heteroarilo, N[(CH2)nNR2]CO(CH2)narilo, N[(CH2)nNHCOOR]CO-arilo, R1, N[CH2(CH2)nOR]2, NR(CH2)nNCOOR, X (CH2)nX(CH2)nXR, NR(CH2)nX(CH2)nOH, NR(CH2)nO(CH2)nOH, (CH2)nCOOR, O(CO)NR(CH2)nOR, O(CO)(CH2)nNR2, NR(CH2)nNR2, N[(CH2)nNR2]CO(CH2)narilo, N[(CH2)nXR]CO(CH2)narilo, N[(CH2)nXR]CO(CH2)nheteroarilo, N[(CH2)nNR2]CO(CH2)nheteroarilo, N[(CH2)nNR2]CO(CH2)nR1, N(R)(CH2)nN(R)COOR, XCOO(CH2)nNR2, OSO2A, OSO2CF3, OSO2Ar, OCONR2, OCH2(CH2)nNR2, CONR1, COR1; Z es CH2, X, CHCONH2, CH(CH2)nNR1COOR1, CHNR1COOR1, NCHO, CHCON(R1)2, CH(CH2)nCOOR1, NCOOR1, CH(CH2)nOH, N(CH2)nOH, CHNH2, CH(CH2)nN(R1)2, C(OH)R1, CHNCOR1, NCOR1, N(CH2)narilo, N(CH2)nheteroarilo, CHR1, NR1, CH(CH2)narilo, CH(CH2)nheteroarilo, CH(CH2)nR1, N(CH2)nCOOR1, CH(CH2)nX(CH2)narilo, CH(CH2)nX(CH2)nheteroarilo, N(CH2)nCON(R1)2, NSO2R1, CHSO2N(R1)2, XCONR1(CH2)nN(R1)2, NCO(CH2)narilo, NCO(CH2)nXarilo, NSO2(CH2)narilo, NCO(CH2)nNR1arilo, NCO(CH2)nheteroarilo, NCO(CH2)nXheteroarilo, NSO2(CH2)nheteroarilo, NCO(CH2)nNR1heteroarilo, N(CH2)nNR2CH, CHO(CH2)nN(R1)2, CHX(CH2)nN(R1)2, NCO(CH2)nNR2, CHRa, NRa, C(OH)CY3, C(OH)arilo, C(NR2)arilo; R6 es arilo o héteroarilo no substituido o mono-, o polisubstituido con arilo o héteroarilo, que puede estar substituido con Hal, NO2, CN, A, OR, OCOR, COR, NR2, CF3, OCF3, OCH(CF3)2, -(CY2)n-OR, -OCOR, -(CY2)n-CO2R, -(CY2)n-CN, -NCOR, -COR o -(CY2)n-NR2; R6' es H o R6; R7 es (C=O)-R, (C=O)-NR2, (C=O)-OR, H o A; m es 0, 1 o 2, y n es 0, 1, 2, 3, 4, 5, 6 o 7, p es 0, 1, 2, 3, 4 o 5, con preferencia 1 o 2; s es 0, 1, 2, 3, 4, 5, 6 o 7, en especial 0, así como sus derivados, solvatos, tautomeros, sales y estereoisomeros de utilidad farmacéutica, así como sus mezclas en todas las proporciones. Pueden ser utilizados, por ejemplo, para el tratamiento de tumores.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005027170A DE102005027170A1 (de) | 2005-06-13 | 2005-06-13 | Substituierte Tetrahydrochinoline |
Publications (1)
Publication Number | Publication Date |
---|---|
AR054616A1 true AR054616A1 (es) | 2007-07-04 |
Family
ID=36699028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060102412A AR054616A1 (es) | 2005-06-13 | 2006-06-09 | Tetrahidroquinolinas sustituidas |
Country Status (15)
Country | Link |
---|---|
US (1) | US7893082B2 (es) |
EP (1) | EP1891076B1 (es) |
JP (1) | JP5180070B2 (es) |
KR (1) | KR20080030015A (es) |
CN (2) | CN102010416A (es) |
AR (1) | AR054616A1 (es) |
AU (1) | AU2006312800B2 (es) |
BR (1) | BRPI0611613A2 (es) |
CA (1) | CA2611889C (es) |
DE (1) | DE102005027170A1 (es) |
ES (1) | ES2566729T3 (es) |
MX (1) | MX2007015782A (es) |
RU (1) | RU2007147925A (es) |
WO (1) | WO2007054138A1 (es) |
ZA (1) | ZA200800365B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005027168A1 (de) * | 2005-06-13 | 2006-12-14 | Merck Patent Gmbh | Tetrahydrochinoline |
DE102005027169A1 (de) * | 2005-06-13 | 2006-12-14 | Merck Patent Gmbh | Tetrahydrochinolinderivate |
DE102007013855A1 (de) * | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Substituierte Tetrahydrochinoline |
WO2009052288A1 (en) | 2007-10-19 | 2009-04-23 | Schering Corporation | Spiro-condensed 1, 3, 4-thiadiazole derivatives for inhibiting ksp kinesin activity |
WO2009077052A2 (en) * | 2007-12-18 | 2009-06-25 | Merck Patent Gmbh | Process for preparing tetrahydroquinoline derivatives |
EP3703692A4 (en) * | 2017-11-01 | 2021-04-28 | Merck Sharp & Dohme Corp. | NEW SUBSTITUTED TETRAHYDROQUINOLINE COMPOUNDS USED AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS |
WO2022138888A1 (ja) | 2020-12-25 | 2022-06-30 | 東レ株式会社 | テトラヒドロキノリン誘導体及びその医薬用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998027093A1 (en) * | 1996-12-18 | 1998-06-25 | Eli Lilly And Company | Combinatorial process for preparing hydrofuroquinoline libraries |
US6288075B1 (en) * | 1998-02-26 | 2001-09-11 | Rhone-Poulenc Rorer S.A. | Thiazolo[5,4,3-ij]quinolines, preparation and medicines containing the same |
US7250423B2 (en) | 2001-09-24 | 2007-07-31 | Chao-Jun Li | Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers |
WO2005016255A2 (en) * | 2003-07-16 | 2005-02-24 | Ligand Pharmaceuticals Incorporated | Substituted tetrahydroquinolines, phenylacetic acids and benzoic acids as hepatocyte nuclear factor 4 (hnf-4 ) modulator compounds |
JP5237555B2 (ja) * | 2003-12-20 | 2013-07-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 2−(ヘテロ)アリール置換テトラヒドロキノリン誘導体 |
SE0400285D0 (sv) * | 2004-02-10 | 2004-02-10 | Astrazeneca Ab | Pyrroloquinoline and piperidoquinoline derivatives, preparation thereof, compositions containing them and uses thereof |
BRPI0510365A (pt) * | 2004-04-28 | 2007-11-06 | Takeda Pharmaceutical | composto, método de produção de um composto, antagonista do receptor nk2, pró-droga, agente farmacêutico, métodos para antagonizar um recpetor nk2 e para evitar ou tratar doenças gastrintestinais funcionais, e, uso do composto ou uma pró-droga do mesmo |
DE102005027168A1 (de) * | 2005-06-13 | 2006-12-14 | Merck Patent Gmbh | Tetrahydrochinoline |
DE102005027169A1 (de) * | 2005-06-13 | 2006-12-14 | Merck Patent Gmbh | Tetrahydrochinolinderivate |
ES2537759T3 (es) * | 2006-06-19 | 2015-06-11 | Merck Patent Gmbh | Compuestos enriquecidos enantioméricamente y proceso |
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2005
- 2005-06-13 DE DE102005027170A patent/DE102005027170A1/de not_active Withdrawn
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2006
- 2006-05-17 KR KR1020087000901A patent/KR20080030015A/ko not_active Application Discontinuation
- 2006-05-17 JP JP2008516155A patent/JP5180070B2/ja not_active Expired - Fee Related
- 2006-05-17 CA CA2611889A patent/CA2611889C/en not_active Expired - Fee Related
- 2006-05-17 MX MX2007015782A patent/MX2007015782A/es active IP Right Grant
- 2006-05-17 CN CN2010105171785A patent/CN102010416A/zh active Pending
- 2006-05-17 RU RU2007147925/04A patent/RU2007147925A/ru not_active Application Discontinuation
- 2006-05-17 CN CNA200680021167XA patent/CN101198613A/zh active Pending
- 2006-05-17 ES ES06840909.3T patent/ES2566729T3/es active Active
- 2006-05-17 US US11/916,952 patent/US7893082B2/en not_active Expired - Fee Related
- 2006-05-17 EP EP06840909.3A patent/EP1891076B1/de not_active Not-in-force
- 2006-05-17 WO PCT/EP2006/004656 patent/WO2007054138A1/de active Application Filing
- 2006-05-17 AU AU2006312800A patent/AU2006312800B2/en not_active Ceased
- 2006-05-17 BR BRPI0611613-2A patent/BRPI0611613A2/pt not_active IP Right Cessation
- 2006-06-09 AR ARP060102412A patent/AR054616A1/es not_active Application Discontinuation
-
2008
- 2008-01-11 ZA ZA200800365A patent/ZA200800365B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1891076A1 (de) | 2008-02-27 |
KR20080030015A (ko) | 2008-04-03 |
AU2006312800A1 (en) | 2007-05-18 |
ES2566729T3 (es) | 2016-04-15 |
AU2006312800B2 (en) | 2011-08-25 |
CA2611889A1 (en) | 2007-05-18 |
CN101198613A (zh) | 2008-06-11 |
US20080194615A1 (en) | 2008-08-14 |
CA2611889C (en) | 2013-05-14 |
CN102010416A (zh) | 2011-04-13 |
BRPI0611613A2 (pt) | 2010-09-21 |
US7893082B2 (en) | 2011-02-22 |
MX2007015782A (es) | 2008-02-22 |
JP2008545803A (ja) | 2008-12-18 |
DE102005027170A1 (de) | 2006-12-14 |
ZA200800365B (en) | 2009-05-27 |
WO2007054138A1 (de) | 2007-05-18 |
EP1891076B1 (de) | 2016-01-27 |
RU2007147925A (ru) | 2009-07-20 |
JP5180070B2 (ja) | 2013-04-10 |
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