AR053849A1 - Antagonistas de receptores muscarinicos - Google Patents

Antagonistas de receptores muscarinicos

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Publication number
AR053849A1
AR053849A1 ARP060101563A ARP060101563A AR053849A1 AR 053849 A1 AR053849 A1 AR 053849A1 AR P060101563 A ARP060101563 A AR P060101563A AR P060101563 A ARP060101563 A AR P060101563A AR 053849 A1 AR053849 A1 AR 053849A1
Authority
AR
Argentina
Prior art keywords
alkyl
halogen
optionally substituted
independently selected
substituents independently
Prior art date
Application number
ARP060101563A
Other languages
English (en)
Inventor
Andrew Bailey
David Donald
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR053849A1 publication Critical patent/AR053849A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
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Abstract

Un proceso para su preparacion, composiciones farmacéuticas que los contienen, un proceso para preparar composiciones farmacéuticas, su uso en terapia e intermediarios que se utilizan en su preparacion. Reivindicacion 1: Un compuesto caracterizado porque responde a la formula (1) donde: 1 representa fenilo, bencimidazolilo, benzoxazolilo o un anillo heteroaromático de 5-6 miembros, donde cada uno de los cuales puede estar opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre halogeno, S(O)0-2R6, NR7R8, S(O)2NR9R10, C(O)NR11R12, C(O)R13, NR14S(O)2R15, NR16C(O)R17, NR18C(O)2R19, NR20C(O)NR21R22, OR23 y C1-6 alquilo, donde C1-6 alquilo puede estar opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre halogeno, hidroxilo, C1-6 alcoxi, NH2, NH(C1-6 alquilo) y N(C1-6 alquilo)2; R2 representa un anillo C3-8 cicloalquilo, donde el anillo cicloalquilo puede estar opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre halogeno, S(O)0-2R24, NR25R26, S(O)2NR27R28, C(O)NR29R30, NR31S(O)2R32, NR33C(O)R34, OR35 y C1-6 alquilo, donde C1-6 alquilo puede estar opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre halogeno, hidroxilo, C1-6 alcoxi, NH2, NH(C1-6 alquilo) y N(C1-6 alquilo)2; R4 representa H o C1-6 alquilo; R5 representa H o C1-6 alquilo; n es 1 o 2; R6, R13, R15, R17, R19, R23, R24, R32, R34 y R35 representan en forma independiente entre sí H o C1-6 alquilo, donde C1-6 alquilo puede estar opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre halogeno, hidroxilo, C1-6 alcoxi, NH2, NH(C1-6 alquilo) y N(C1-6 alquilo)2; R7, R8, R9, R10, R11, R12, R14, R16, R18, R20, R21, R22, R25, R26, R27, R28, R29, R30, R31 y R33 representan en forma independiente entre sí H, C2-6 hidroxialquilo o C1-6 alquilo, donde C1-6 alquilo puede estar opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre halogeno, hidroxilo, C1-6 alcoxi, NH2, NH(C1-6 alquilo) y N(C1-6 alquilo)2; o cualquiera de R7 y R8, R9 y R10, R11 y R12, R121 y R22, R25 y R26, R27 y R28, o R29 y R30, junto con el átomo de N al cual están unidos, pueden formar un anillo heterocíclico alifático de entre 4 y 8 miembros, donde el anillo heterocíclico puede estar opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre halogeno, hidroxilo, C1-6 alquilo, C1-6 hidroxialquilo y C1-6 haloalquilo, y X representa un anion aceptable para uso farmacéutico de un ácido mono o polivalente.
ARP060101563A 2005-04-20 2006-04-20 Antagonistas de receptores muscarinicos AR053849A1 (es)

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Application Number Priority Date Filing Date Title
SE0500893 2005-04-20
SE0502696 2005-12-07

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AR053849A1 true AR053849A1 (es) 2007-05-23

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ARP060101563A AR053849A1 (es) 2005-04-20 2006-04-20 Antagonistas de receptores muscarinicos

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US (1) US20090042942A1 (es)
EP (1) EP1874727A1 (es)
JP (1) JP2008538762A (es)
AR (1) AR053849A1 (es)
TW (1) TW200722418A (es)
UY (1) UY29485A1 (es)
WO (1) WO2006112778A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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JP2009534463A (ja) * 2006-04-24 2009-09-24 アストラゼネカ・アクチエボラーグ 例えば慢性気管支閉塞、喘息および過活動膀胱の処置に有用な、ムスカリンｍ３受容体アンタゴニスト活性を有する環状アミノアルコールの新規アルキルエステル
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
WO2008075006A1 (en) * 2006-12-19 2008-06-26 Astrazeneca Ab Piperldinum compounds for treatment of obstructive pulmonary diseases ( copd)
CA2672446A1 (en) * 2006-12-19 2008-06-26 Astrazeneca Ab Quinuclidinol derivatives as muscarinic receptor antagonists
GB0702416D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New combination
US20110136843A1 (en) * 2007-02-23 2011-06-09 Tomas Eriksson Novel Combination of Compounds to be Used in the Treatment of Airway Diseases, Especially Chronic Obstructive Pulmonary Disease (COPD) and Asthma
CA2723981A1 (en) 2008-05-13 2009-11-19 Astrazeneca Ab New compounds 273

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JP2001504459A (ja) * 1996-11-11 2001-04-03 ノエ・クリスティアン・エル 対掌体純粋な、塩基性アリール―シクロアルキル―ヒドロキシカルボン酸エステル、その製造方法及びこれを薬剤に使用する方法
CA2415468A1 (en) * 2000-07-11 2003-01-10 Yoshio Ogino Ester derivatives
ES2206021B1 (es) * 2002-04-16 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de pirrolidinio.

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UY29485A1 (es) 2006-11-30
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