AR053096A1 - BENCIMIDAZOL COMPOUNDS, COMPOSITIONS THAT CONTAIN THEM, PREPARATION OF THE SAME AND USES FOR THE PREPARATION OF MEDICINES - Google Patents
BENCIMIDAZOL COMPOUNDS, COMPOSITIONS THAT CONTAIN THEM, PREPARATION OF THE SAME AND USES FOR THE PREPARATION OF MEDICINESInfo
- Publication number
- AR053096A1 AR053096A1 ARP050104024A ARP050104024A AR053096A1 AR 053096 A1 AR053096 A1 AR 053096A1 AR P050104024 A ARP050104024 A AR P050104024A AR P050104024 A ARP050104024 A AR P050104024A AR 053096 A1 AR053096 A1 AR 053096A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- heterocyclyl
- bencimidazol
- medicines
- compositions
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Son utiles en terapia, en particular en el manejo del dolor, también en el tratamiento del cáncer, esclerosis multiple, enfermedad de Parkinson, Alzheimer, trastornos gastrointestinales y cardiovasculares. Reivindicacion 1. Un compuesto de formula (1), una sal del mismo aceptable para uso farmacéutico, diastereomeros, enantiomeros, mezclas de los mismos donde G se selecciona de -O-, -CHF- y -CF2-; R1 es un heterociclilo C2-6, donde dicho heterociclilo C2-6 incluye al menos un N en dicho anillo heterociclilo C2-6, uno de dichos al menos un N está directamente unido al grupo sulfonilo de la formula (1), y dicho heterociclilo C2-6 está sustituido en forma opcional con uno o más grupos seleccionados de halogeno, hidroxi, R5-C(=O)-, R5- C(=O)-NH-, R5R6-NH-C(=O)-, R5R6-NH-C(=O)-NH-, R5-O-C(=O)-NH-, alcoxi C1-6 y alquilamino C1-6, donde dichos R5, R6 se seleccionan en forma independiente de -H, alquilo C1-6, arilo C6-10, alquenilo C2-6, cicloalquilo C3-6, heterociclilo C2-6, alquilo C1-6 halogenado e hidroxialquilo C1-6; y R2, R3 y R4 se seleccionan en forma independiente de F y metilo.They are useful in therapy, particularly in pain management, also in the treatment of cancer, multiple sclerosis, Parkinson's disease, Alzheimer's, gastrointestinal and cardiovascular disorders. Claim 1. A compound of formula (1), a salt thereof acceptable for pharmaceutical use, diastereomers, enantiomers, mixtures thereof where G is selected from -O-, -CHF- and -CF2-; R1 is a C2-6 heterocyclyl, wherein said C2-6 heterocyclyl includes at least one N in said C2-6 heterocyclyl ring, one of said at least one N is directly attached to the sulfonyl group of the formula (1), and said heterocyclyl C2-6 is optionally substituted with one or more groups selected from halogen, hydroxy, R5-C (= O) -, R5- C (= O) -NH-, R5R6-NH-C (= O) -, R5R6-NH-C (= O) -NH-, R5-OC (= O) -NH-, C1-6 alkoxy and C1-6 alkylamino, wherein said R5, R6 are independently selected from -H, C1 alkyl -6, C6-10 aryl, C2-6 alkenyl, C3-6 cycloalkyl, C2-6 heterocyclyl, halogenated C1-6 alkyl and C1-6 hydroxyalkyl; and R2, R3 and R4 are independently selected from F and methyl.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2004/004124 WO2005030732A1 (en) | 2003-09-26 | 2004-09-24 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| PCT/GB2004/004112 WO2005030761A1 (en) | 2003-09-26 | 2004-09-24 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0500183 | 2005-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053096A1 true AR053096A1 (en) | 2007-04-25 |
Family
ID=38008106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104024A AR053096A1 (en) | 2004-09-24 | 2005-09-26 | BENCIMIDAZOL COMPOUNDS, COMPOSITIONS THAT CONTAIN THEM, PREPARATION OF THE SAME AND USES FOR THE PREPARATION OF MEDICINES |
Country Status (7)
| Country | Link |
|---|---|
| AR (1) | AR053096A1 (en) |
| BR (1) | BRPI0515876A (en) |
| IL (1) | IL182021A0 (en) |
| MX (1) | MX2007003121A (en) |
| NO (1) | NO20072090L (en) |
| TW (1) | TW200626577A (en) |
| UY (1) | UY29129A1 (en) |
-
2005
- 2005-09-22 MX MX2007003121A patent/MX2007003121A/en unknown
- 2005-09-22 BR BRPI0515876-1A patent/BRPI0515876A/en not_active Application Discontinuation
- 2005-09-23 TW TW094133192A patent/TW200626577A/en unknown
- 2005-09-23 UY UY29129A patent/UY29129A1/en not_active Application Discontinuation
- 2005-09-26 AR ARP050104024A patent/AR053096A1/en unknown
-
2007
- 2007-03-19 IL IL182021A patent/IL182021A0/en unknown
- 2007-04-23 NO NO20072090A patent/NO20072090L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200626577A (en) | 2006-08-01 |
| IL182021A0 (en) | 2007-07-24 |
| UY29129A1 (en) | 2006-04-28 |
| MX2007003121A (en) | 2007-07-18 |
| BRPI0515876A (en) | 2008-08-12 |
| NO20072090L (en) | 2007-06-25 |
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| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |