AR047510A1 - Derivados de sulfonamida como agonistas de receptores adrenergicos ??2 - Google Patents

Derivados de sulfonamida como agonistas de receptores adrenergicos ??2

Info

Publication number
AR047510A1
AR047510A1 ARP050100206A ARP050100206A AR047510A1 AR 047510 A1 AR047510 A1 AR 047510A1 AR P050100206 A ARP050100206 A AR P050100206A AR P050100206 A ARP050100206 A AR P050100206A AR 047510 A1 AR047510 A1 AR 047510A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
sulfonamide derivatives
cycloalkyl
formulas
Prior art date
Application number
ARP050100206A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43063961&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR047510(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0406388A external-priority patent/GB0406388D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of AR047510A1 publication Critical patent/AR047510A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40Y being a hydrogen or a carbon atom
    • C07C323/42Y being a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente se refiere a derivados de sulfonamida como antagonistas de receptores adrenérgicos beta 2, procesos para su preparacion, composiciones farmacéuticas que los contienen y usos para trastornos y afecciones inflamatorios, alérgicos y respiratorios. Reivindicacion 1: Un compuesto de formula general (1) en la que el grupo (CH2)n-C(=O)Q1 está en posicion relativa meta o para, R1 y R2 se seleccionan independientemente de H y alquilo C1-4, n es 0, 1 o 2 y Q1 es un grupo que se selecciona entre las formulas (2) o (3) y un grupo *-NR11-Q2-A, en el que p es 1 o 2; Q2 es un alquileno C1-4 R11 es H o alquilo C1-4 y A es piridilo, cicloalquilo C3-10 siendo dicho cicloalquilo, opcionalmente esta puenteado por uno o más átomos de C, tetrahidropiranilo, piperidinilo opcionalmente sustituido con bencilo, tetrahidrotiopiranilo o un grupo de las formulas (4) o (5) en el que R3, R4, R5, R6 y R7 son iguales o diferentes y se seleccionan de H, alquilo C1-4, OR8, SR9, halo, CN, CF3, OCF3, COOR9, SO2NR9R10, CONR9R10, NR9R10, NHCOR10 y fenilo; en los que R8 es alquilo C1-4 y R9 y R10 son iguales o diferentes y se seleccionan de H o alquilo C1-4 y el * representa el punto de union al grupo carbonilo; o, si fuera apropiado, sus sales y/o isomeros, tautomeros, solvatos o variaciones isotopicas farmacéuticamente aceptables.
ARP050100206A 2004-01-22 2005-01-20 Derivados de sulfonamida como agonistas de receptores adrenergicos ??2 AR047510A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04290168 2004-01-22
GB0406388A GB0406388D0 (en) 2004-03-22 2004-03-22 Sulfonamide derivatives for the treatment of diseases
US60025904P 2004-08-09 2004-08-09

Publications (1)

Publication Number Publication Date
AR047510A1 true AR047510A1 (es) 2006-01-25

Family

ID=43063961

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050100206A AR047510A1 (es) 2004-01-22 2005-01-20 Derivados de sulfonamida como agonistas de receptores adrenergicos ??2

Country Status (41)

Country Link
US (1) US7351742B2 (es)
EP (1) EP1708992B1 (es)
JP (1) JP4036343B2 (es)
KR (1) KR100785580B1 (es)
CN (1) CN1910144B (es)
AP (1) AP2378A (es)
AR (1) AR047510A1 (es)
AT (1) ATE369333T1 (es)
AU (1) AU2005214154B2 (es)
BR (1) BRPI0507041A (es)
CA (1) CA2553293C (es)
CO (1) CO5720993A2 (es)
CY (1) CY1106894T1 (es)
DE (1) DE602005001929T2 (es)
DK (1) DK1708992T3 (es)
DO (1) DOP2005000004A (es)
EA (1) EA009735B1 (es)
EC (1) ECSP066701A (es)
ES (1) ES2289691T3 (es)
GE (1) GEP20084452B (es)
HK (1) HK1096083A1 (es)
HN (1) HN2005000030A (es)
HR (1) HRP20070452T3 (es)
IL (1) IL176629A (es)
MA (1) MA28303A1 (es)
ME (1) ME00557A (es)
MY (1) MY139690A (es)
NL (1) NL1028086C2 (es)
NO (1) NO20063761L (es)
NZ (1) NZ548235A (es)
OA (1) OA13361A (es)
PA (1) PA8621901A1 (es)
PE (1) PE20050765A1 (es)
PL (1) PL1708992T3 (es)
PT (1) PT1708992E (es)
RS (1) RS50538B (es)
SI (1) SI1708992T1 (es)
TW (1) TWI273099B (es)
UA (1) UA82283C2 (es)
UY (1) UY28724A1 (es)
WO (1) WO2005080324A1 (es)

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GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
EP1999107A2 (en) 2006-03-20 2008-12-10 Pfizer Limited Amine derivatives
ATE549337T1 (de) 2006-04-21 2012-03-15 Novartis Ag Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten
EP2074094A1 (en) * 2006-10-04 2009-07-01 Pfizer Limited Sulfonamide derivatives as adrenergic agonists and muscarinic antagonists
DE102007018151A1 (de) 2007-04-16 2008-10-23 Günenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
US7713463B1 (en) * 2007-11-13 2010-05-11 Nuvasive, Inc. Method of manufacturing embroidered surgical implants
PT2231642E (pt) 2008-01-11 2014-03-12 Novartis Ag Pirimidinas como inibidores de quinase
US8263623B2 (en) * 2008-07-11 2012-09-11 Pfizer Inc. Triazol derivatives useful for the treatment of diseases
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EA019441B1 (ru) 2008-12-30 2014-03-31 Палмаджен Терепьютикс (Инфлеммейшн) Лимитед Сульфонамиды, предназначенные для лечения респираторных нарушений
EP3210981B1 (en) 2009-04-23 2019-01-02 Theravance Respiratory Company, LLC Diamide compounds having muscarinic receptor antagonist and beta 2 adrenergic receptor agonist activity
JP2012528140A (ja) 2009-05-29 2012-11-12 ファイザー・リミテッド 新規なグルココルチコイド受容体アゴニスト
WO2010150014A1 (en) 2009-06-24 2010-12-29 Pulmagen Therapeutics (Inflammation) Limited 5r- 5 -deuterated glitazones for respiratory disease treatment
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JP6421989B2 (ja) 2012-12-06 2018-11-14 チエシ ファルマスティスィ エス.ピー.エー. ムスカリン受容体アンタゴニストおよびβ2アドレナリン受容体アゴニスト活性を有する化合物
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Also Published As

Publication number Publication date
NL1028086C2 (nl) 2006-05-09
CY1106894T1 (el) 2012-09-26
AP2378A (en) 2012-03-08
NO20063761L (no) 2006-10-23
ES2289691T3 (es) 2008-02-01
GEP20084452B (en) 2008-08-10
KR100785580B1 (ko) 2007-12-13
DOP2005000004A (es) 2005-07-31
DE602005001929D1 (de) 2007-09-20
EP1708992A1 (en) 2006-10-11
JP2007518790A (ja) 2007-07-12
UY28724A1 (es) 2005-08-31
DE602005001929T2 (de) 2007-12-06
AU2005214154A1 (en) 2005-09-01
EA200601141A1 (ru) 2007-02-27
WO2005080324A1 (en) 2005-09-01
OA13361A (en) 2007-04-13
TW200530164A (en) 2005-09-16
NZ548235A (en) 2010-05-28
AU2005214154B2 (en) 2008-01-24
US7351742B2 (en) 2008-04-01
PE20050765A1 (es) 2005-10-31
CA2553293C (en) 2010-12-14
SI1708992T1 (sl) 2007-12-31
KR20060127073A (ko) 2006-12-11
HN2005000030A (es) 2009-04-20
CN1910144B (zh) 2010-06-09
RS50538B (sr) 2010-05-07
ECSP066701A (es) 2006-10-31
MA28303A1 (fr) 2006-11-01
CA2553293A1 (en) 2005-09-01
MY139690A (en) 2009-10-30
PT1708992E (pt) 2007-11-16
NL1028086A1 (nl) 2005-07-25
EP1708992B1 (en) 2007-08-08
TWI273099B (en) 2007-02-11
AP2006003671A0 (en) 2006-06-30
CO5720993A2 (es) 2007-01-31
WO2005080324A8 (en) 2006-02-23
US20050171147A1 (en) 2005-08-04
HRP20070452T3 (en) 2008-02-29
IL176629A0 (en) 2006-10-31
BRPI0507041A (pt) 2007-06-12
PA8621901A1 (es) 2006-03-24
HK1096083A1 (en) 2007-05-25
CN1910144A (zh) 2007-02-07
IL176629A (en) 2011-04-28
DK1708992T3 (da) 2007-11-05
EA009735B1 (ru) 2008-02-28
PL1708992T3 (pl) 2007-12-31
ME00557A (en) 2011-12-20
ATE369333T1 (de) 2007-08-15
UA82283C2 (uk) 2008-03-25
JP4036343B2 (ja) 2008-01-23

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