AR046310A1 - Compuestos nucleosidicos para el tratamiento de enfermedades virales. composiciones farmaceuticas. - Google Patents

Compuestos nucleosidicos para el tratamiento de enfermedades virales. composiciones farmaceuticas.

Info

Publication number
AR046310A1
AR046310A1 ARP040103898A ARP040103898A AR046310A1 AR 046310 A1 AR046310 A1 AR 046310A1 AR P040103898 A ARP040103898 A AR P040103898A AR P040103898 A ARP040103898 A AR P040103898A AR 046310 A1 AR046310 A1 AR 046310A1
Authority
AR
Argentina
Prior art keywords
substituted
alkyl
heteroaryl
amino
group
Prior art date
Application number
ARP040103898A
Other languages
English (en)
Original Assignee
Genelabs Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34658262&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR046310(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/861,090 external-priority patent/US7202223B2/en
Priority claimed from US10/861,311 external-priority patent/US7144868B2/en
Application filed by Genelabs Tech Inc filed Critical Genelabs Tech Inc
Publication of AR046310A1 publication Critical patent/AR046310A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Abstract

El presente se refiere a composiciones farmacéuticas que las contienen. Reivindicación 1: Un compuesto de fórmula (1), caracterizado porque Y se selecciona entre el grupo que consiste en una unión, -CH2- u -O-; cada uno de W, W1, y W2 se selecciona independientemente entre el grupo que consiste en hidrógeno y una prodroga aceptable para uso farmacéutico; y T se selecciona entre el grupo que consiste en: a) -C:::C-R, donde R se selecciona entre el grupo que consiste en i) tri[alquil(C1- 4)]sililo, -C(O)NR1R2, alcoxialquilo, heteroarilo, y heteroarilo sustituido, y fenilo sustituido con entre 1 y 3 sustituyentes que se seleccionan entre el grupo que consiste en alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, alcoxi, alcoxi sustituido, acilo, acilamino, aciloxi, aminoacilo, amidino, amino, amino sustituido, carboxilo, éster carboxílico, ciano, cicloalquilo, cicloalquilo sustituido, cicloalcoxi, cicloalcoxi sustituido, guanidino, halo, heteroarilo, heteroarilo sustituido, hidrazino, hidroxilo, nitro, tiol, y -S(O)mR3; donde R1 y R2 se seleccionan independientemente entre el grupo que consiste en hidrógeno, alquilo, alquilo sustituido, amino, amino sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterocíclico y heterocíclico sustituido siempre y cuando solamente uno de R1 y R2 sea amino o amino sustituido, y además donde R1 y R2, junto con el átomo de nitrógeno al que están unidos, forman un heterociclo o un heterociclo sustituido; R3 se selecciona entre el grupo que consiste en alquilo, alquilo sustituido, amino, amino sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterocíclico y heterocíclico sustituido; y m es un entero igual a 0, 1 ó 2; ii) -C(O)OR14, donde R14 es hidrógeno, alquilo o alquilo sustituido; b) -CH=CH-Q2, donde Q2 se selecciona entre hidrógeno o cis-metoxi; c) -C(O)H; d) -CH=NNHR15, donde R15 es H o alquilo; e) -CH=N(OR15), donde R15 es según se definió antes; f) -CH(OR16)2, donde R16 es alquilo (C3-6) y g) -B(OR15)2, donde R15 es según se definió antes; y sales o sales parciales de los mismos aceptables para uso farmacéutico.
ARP040103898A 2003-10-27 2004-10-26 Compuestos nucleosidicos para el tratamiento de enfermedades virales. composiciones farmaceuticas. AR046310A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US51515303P 2003-10-27 2003-10-27
US10/861,090 US7202223B2 (en) 2003-10-27 2004-06-04 Nucleoside compounds for treating viral infections
US10/861,311 US7144868B2 (en) 2003-10-27 2004-06-04 Nucleoside compounds for treating viral infections
US10/861,219 US7151089B2 (en) 2003-10-27 2004-06-04 Nucleoside compounds for treating viral infections
US60281504P 2004-08-18 2004-08-18

Publications (1)

Publication Number Publication Date
AR046310A1 true AR046310A1 (es) 2005-11-30

Family

ID=34658262

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103898A AR046310A1 (es) 2003-10-27 2004-10-26 Compuestos nucleosidicos para el tratamiento de enfermedades virales. composiciones farmaceuticas.

Country Status (10)

Country Link
US (2) US7244713B2 (es)
EP (1) EP1687321A1 (es)
JP (1) JP2007509943A (es)
AR (1) AR046310A1 (es)
AU (1) AU2004295291A1 (es)
CA (1) CA2543090A1 (es)
IL (1) IL174684A0 (es)
NZ (1) NZ546201A (es)
SV (1) SV2005001919A (es)
WO (1) WO2005054268A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EA200601591A1 (ru) 2000-05-26 2007-02-27 Айденикс (Кайман) Лимитед Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
BR0312278A (pt) 2002-06-28 2007-06-19 Idenix Cayman Ltd éster 2'-c-metil-3'-o-l-valina de ribofuranosil citidina para tratamento de infecções por flaviviridae
EP1576138B1 (en) 2002-11-15 2017-02-01 Idenix Pharmaceuticals LLC. 2'-methyl nucleosides in combination with interferon and flaviviridae mutation
AU2004295291A1 (en) * 2003-10-27 2005-06-16 Smithkline Beecham Corporation Nucleoside compounds for treating viral infections
US7405204B2 (en) * 2005-04-25 2008-07-29 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
EP2385053B1 (en) * 2005-11-17 2013-10-02 OSI Pharmaceuticals, Inc. Intermediates for the preparation of fused bicyclic mTOR inhibitors
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
EP1981890A2 (en) * 2006-01-25 2008-10-22 OSI Pharmaceuticals, Inc. UNSATURATED mTOR INHIBITORS
WO2008005542A2 (en) 2006-07-07 2008-01-10 Gilead Sciences, Inc., Antiviral phosphinate compounds
KR20110017845A (ko) * 2008-03-19 2011-02-22 오에스아이 파마슈티컬스, 인코포레이티드 Ｍｔｏｒ 억제자 염 형태
US8809344B2 (en) 2008-10-29 2014-08-19 Apath, Llc Compounds, compositions, and methods for control of hepatitis C viral infections
JP5499037B2 (ja) * 2009-08-14 2014-05-21 株式会社日立製作所 遺伝子配列解析法及び試薬

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140851A (en) 1977-11-21 1979-02-20 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis and antitumor activity of 2,4,5-trisubstituted-pyrrolo2,3-d]-pyrimidine nucleosides
JPS61229897A (ja) 1985-04-05 1986-10-14 Nippon Zoki Pharmaceut Co Ltd 新規ヌクレオシド化合物
US6211158B1 (en) 1987-04-10 2001-04-03 Roche Diagnostics Gmbh Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents
US4892865A (en) 1987-12-01 1990-01-09 The Regents Of The University Of Michigan Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents
US4968686A (en) 1988-04-08 1990-11-06 The Regents Of The University Of Michigan Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents
US4927830A (en) 1988-04-08 1990-05-22 The Regents Of The University Of Michigan Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents
US5824796A (en) 1988-09-28 1998-10-20 Epoch Pharmaceuticals, Inc. Cross-linking oligonucleotides
US5763597A (en) 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. Orally active adenosine kinase inhibitors
DE69133405T2 (de) 1990-01-11 2005-07-07 Isis Pharmaceutical, Inc., Carlsbad Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression
US5681941A (en) 1990-01-11 1997-10-28 Isis Pharmaceuticals, Inc. Substituted purines and oligonucleotide cross-linking
WO1994018215A1 (en) 1993-02-03 1994-08-18 Gensia, Inc. Adenosine kinase inhibitors comprising lyxofuranosyl derivatives
AU6632094A (en) 1993-04-19 1994-11-08 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
AU690587B2 (en) 1993-09-17 1998-04-30 Gilead Sciences, Inc. Method for dosing therapeutic compounds
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
DE4438918A1 (de) 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
AU6485996A (en) 1995-07-06 1997-02-05 Board Of Regents, The University Of Texas System Methods and compositions for modulation and inhibition of teomerase
US6004939A (en) 1995-07-06 1999-12-21 Ctrc Research Foundation Board Of Regents Methods for modulation and inhibition of telomerase
FR2750435B1 (fr) 1996-06-27 1998-08-28 Appligene Oncor Procede de formation de complexes d'hybridation dont la stabilite depend peu de la composition en base des deux molecules d'acides nucleiques hybridees
US6831069B2 (en) 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
EP1138689A1 (en) 2000-03-28 2001-10-04 Roche Diagnostics GmbH N8- and C8-linked purine bases as universal nucleosides used for oligonucleotide hybridization
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
WO2002057287A2 (en) * 2001-01-22 2002-07-25 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
AU2002353165A1 (en) 2001-12-17 2003-06-30 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
WO2003055896A2 (en) 2001-12-21 2003-07-10 Micrologix Biotech Inc. Anti-viral 7-deaza l-nucleosides
WO2003062256A1 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
CA2474563C (en) * 2002-02-13 2010-11-09 Merck & Co., Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
AU2003241621A1 (en) 2002-05-24 2003-12-12 Isis Pharmaceuticals, Inc. Oligonucleotides having modified nucleoside units
US20040014957A1 (en) 2002-05-24 2004-01-22 Anne Eldrup Oligonucleotides having modified nucleoside units
US20060264389A1 (en) 2002-07-16 2006-11-23 Balkrishen Bhat Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
CA2492607A1 (en) 2002-07-25 2004-02-05 Micrologix Biotech Inc. Anti-viral 7-deaza d-nucleosides and uses thereof
US7094768B2 (en) * 2002-09-30 2006-08-22 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis C virus infection
TW200418498A (en) 2002-09-30 2004-10-01 Genelabs Tech Inc Nucleoside derivatives for treating hepatitis C virus infection
WO2004043978A2 (en) 2002-11-05 2004-05-27 Isis Pharmaceuticals, Inc. 2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
US7144868B2 (en) * 2003-10-27 2006-12-05 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
US7202223B2 (en) * 2003-10-27 2007-04-10 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
AU2004295291A1 (en) * 2003-10-27 2005-06-16 Smithkline Beecham Corporation Nucleoside compounds for treating viral infections

Also Published As

Publication number Publication date
EP1687321A1 (en) 2006-08-09
US7244713B2 (en) 2007-07-17
AU2004295291A1 (en) 2005-06-16
US20070167383A1 (en) 2007-07-19
SV2005001919A (es) 2005-08-18
CA2543090A1 (en) 2005-06-16
IL174684A0 (en) 2006-08-20
WO2005054268A1 (en) 2005-06-16
US20050215511A1 (en) 2005-09-29
NZ546201A (en) 2009-05-31
JP2007509943A (ja) 2007-04-19

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