AR045341A1 - ACILUREA COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS, USE OF THE COMPOUNDS IN THE PREPARATION OF MEDICINES, AND PROCESSES FOR THE PREPARATION OF THE COMPOUNDS - Google Patents
ACILUREA COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS, USE OF THE COMPOUNDS IN THE PREPARATION OF MEDICINES, AND PROCESSES FOR THE PREPARATION OF THE COMPOUNDSInfo
- Publication number
- AR045341A1 AR045341A1 ARP040102812A ARP040102812A AR045341A1 AR 045341 A1 AR045341 A1 AR 045341A1 AR P040102812 A ARP040102812 A AR P040102812A AR P040102812 A ARP040102812 A AR P040102812A AR 045341 A1 AR045341 A1 AR 045341A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- preparation
- processes
- pharmaceutical compositions
- pyrrolidin
- Prior art date
Links
Abstract
Compuestos de acilurea de fórmula A y de fórmula B y sus sales farmacéuticamente aceptables; en donde: m es 1, 2 o 3(excepto que cuando X es CH2, m es 1):; n es 4 o 5; p es 0 o 1; R1 es pirrolidin-1-ilo, piperidin-1-ilo, morfolin-4-ilo, piperazin-1-ilo, 4-metilpiperazin-1-ilo o hexahidroazepin-1-ilo; R2 es dimetilamino, etilmetilamino, dietilamino, pirrolidin-1-ilo o piperidín-1-ilo; y X es O, CH2, NH, o N(CH3). Los compuestos son antagonistas de la función MCP-1, y son útiles en la prevención y tratamiento de enfermedades autoinmunitarias e inflamatorias crónicas o agudas tales como ateroesclerosis, enfermedad de Crohn, nefropatía diabética, enfermedad intestinal inflamatoria, esclerosis múltiple, nefritis, pancreatitis, fibrosis pulmonar, soriasis, restenosis, artritis reumatoide y rechazo de trasplantes; y de enfermedades de hipersensibilidad alérgica tales como rinitis alérgica y asma. Además se describen composiciones farmacéuticas que comprenden los compuestos, el uso de estos compuestos en la elaboración de medicamentos, y procesos para la preparación de los compuestos.Acylurea compounds of formula A and formula B and their pharmaceutically acceptable salts; where: m is 1, 2 or 3 (except that when X is CH2, m is 1) :; n is 4 or 5; p is 0 or 1; R1 is pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, piperazin-1-yl, 4-methylpiperazin-1-yl or hexahydroazepin-1-yl; R2 is dimethylamino, ethylmethylamino, diethylamino, pyrrolidin-1-yl or piperidin-1-yl; and X is O, CH2, NH, or N (CH3). The compounds are antagonists of the MCP-1 function, and are useful in the prevention and treatment of chronic or acute autoimmune and inflammatory diseases such as atherosclerosis, Crohn's disease, diabetic nephropathy, inflammatory bowel disease, multiple sclerosis, nephritis, pancreatitis, fibrosis pulmonary, psoriasis, restenosis, rheumatoid arthritis and transplant rejection; and of allergic hypersensitivity diseases such as allergic rhinitis and asthma. In addition, pharmaceutical compositions comprising the compounds, the use of these compounds in the preparation of medicaments, and processes for the preparation of the compounds are described.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/060,967 US6670364B2 (en) | 2001-01-31 | 2002-01-29 | Antagonists of MCP-1 function and methods of use thereof |
| US10/637,746 US6962926B2 (en) | 2001-01-31 | 2003-08-08 | Antagonist of MCP-1 function, and compositions and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045341A1 true AR045341A1 (en) | 2005-10-26 |
Family
ID=43014121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102812A AR045341A1 (en) | 2002-01-29 | 2004-08-06 | ACILUREA COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS, USE OF THE COMPOUNDS IN THE PREPARATION OF MEDICINES, AND PROCESSES FOR THE PREPARATION OF THE COMPOUNDS |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR045341A1 (en) |
-
2004
- 2004-08-06 AR ARP040102812A patent/AR045341A1/en unknown
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