AR043880A1 - Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas - Google Patents

Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas

Info

Publication number
AR043880A1
AR043880A1 ARP040101306A ARP040101306A AR043880A1 AR 043880 A1 AR043880 A1 AR 043880A1 AR P040101306 A ARP040101306 A AR P040101306A AR P040101306 A ARP040101306 A AR P040101306A AR 043880 A1 AR043880 A1 AR 043880A1
Authority
AR
Argentina
Prior art keywords
trans
phenyl
amino
pyrimidine
forms
Prior art date
Application number
ARP040101306A
Other languages
English (en)
Inventor
Axel Pahl
Bernd-Martin Luitjens
Emil Finner
Pieter C Verveer
Jan Zorgdrager
Heinrich Timo Dr
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of AR043880A1 publication Critical patent/AR043880A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mesilato ácido de 4-(4-trans-hidroxiciclohexil)amino-2-fenil-7H-pirrolo[2,3d]pirimidina, formas polimorfas alfa y beta del mismo, método para la producción de dichos compuestos y uso para el tratamiento de hipertensión esencial, insuficiencia cardíaca congestiva e insuficiencia renal.
ARP040101306A 2003-04-22 2004-04-19 Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas AR043880A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03101093 2003-04-22

Publications (1)

Publication Number Publication Date
AR043880A1 true AR043880A1 (es) 2005-08-17

Family

ID=36143550

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101306A AR043880A1 (es) 2003-04-22 2004-04-19 Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas

Country Status (26)

Country Link
US (1) US7381729B2 (es)
EP (1) EP1641797B1 (es)
JP (1) JP2006524214A (es)
KR (1) KR20060021296A (es)
CN (1) CN100360533C (es)
AR (1) AR043880A1 (es)
AT (1) ATE373002T1 (es)
AU (1) AU2004232495B2 (es)
BR (1) BRPI0409511A (es)
CA (1) CA2522810A1 (es)
DE (1) DE602004008919T2 (es)
DK (1) DK1641797T3 (es)
ES (1) ES2290696T3 (es)
HK (1) HK1089767A1 (es)
IL (1) IL171120A (es)
MX (1) MXPA05011348A (es)
NO (1) NO20055495L (es)
PL (1) PL1641797T3 (es)
PT (1) PT1641797E (es)
RU (1) RU2345994C2 (es)
SA (1) SA04250093B1 (es)
SI (1) SI1641797T1 (es)
TW (1) TWI324517B (es)
UA (1) UA81806C2 (es)
WO (1) WO2004094428A1 (es)
ZA (1) ZA200508519B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR043880A1 (es) 2003-04-22 2005-08-17 Solvay Pharm Gmbh Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas
WO2007073855A1 (en) * 2005-12-23 2007-07-05 Bayer Healthcare Ag Use of adenosine a1 receptor agonists for the protection of renal cells against toxic effects caused by aminoglycosides during treatment of infectious diseases
TW200808819A (en) * 2006-06-19 2008-02-16 Solvay Pharm Gmbh Use of adenosine A1 antagonists in radiocontrast media induced nephrophaty
TWI561520B (en) * 2012-09-27 2016-12-11 Sunshine Lake Pharma Co Ltd Crystalline forms of dihydropyrimidine derivatives

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1254569A (en) * 1982-08-19 1989-05-23 Ian C. Pattison Sulfonic acid salts of 6-amino-1,5-dihydro-4h- imidazo¬4,5-c|pyridin-4-one
CS249455B1 (en) * 1985-01-24 1987-03-12 Miroslav Protiva N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation
JP2815691B2 (ja) * 1990-09-20 1998-10-27 麒麟麦酒株式会社 Ｋｒｎ２３９１酸付加塩およびその用途
FR2708604B1 (fr) * 1993-07-30 1995-10-20 Sanofi Elf Utilisation de dérivés de benzènesulfonyl-indole pour la préparation de médicaments.
JPH08198876A (ja) * 1995-01-30 1996-08-06 Yoshitomi Pharmaceut Ind Ltd トランス−Ｎ−（１Ｈ−ピラゾロ〔３，４−ｂ〕ピリジン−４−イル）−４−グアニジノメチルシクロヘキサンカルボキサミド・１メタンスルホン酸塩・１水和物
JPH08337584A (ja) * 1995-04-10 1996-12-24 Dai Ichi Seiyaku Co Ltd 縮合六環式アミノ化合物、これを含有する医薬及びその製法
FR2749846B1 (fr) * 1996-06-17 1998-09-11 Pf Medicament Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
US6878716B1 (en) * 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
YU76100A (sh) 1998-06-02 2003-12-31 Osi Pharmaceuticals Inc. Pirolo(2,3-d) pirimidin preparati i njihova primena
TWI223598B (en) * 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
AU784878B2 (en) * 1999-12-02 2006-07-13 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 A2A and A3 receptors and uses thereof
AU779118B2 (en) * 2000-03-03 2005-01-06 Pfizer Inc. 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3, 4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline mesylate and polymorphs
AU2002226877B2 (en) * 2000-10-17 2006-01-12 Merck & Co., Inc. Orally active salts with tyrosine kinase activity
US6680324B2 (en) * 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en) * 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
AR043880A1 (es) 2003-04-22 2005-08-17 Solvay Pharm Gmbh Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas

Also Published As

Publication number Publication date
KR20060021296A (ko) 2006-03-07
US20040248912A1 (en) 2004-12-09
CN1777606A (zh) 2006-05-24
DK1641797T3 (da) 2007-10-29
CA2522810A1 (en) 2004-11-04
HK1089767A1 (en) 2006-12-08
WO2004094428A1 (en) 2004-11-04
DE602004008919T2 (de) 2008-06-19
RU2345994C2 (ru) 2009-02-10
PT1641797E (pt) 2007-12-21
BRPI0409511A (pt) 2006-04-18
AU2004232495B2 (en) 2010-04-22
SA04250093B1 (ar) 2008-07-12
TWI324517B (en) 2010-05-11
SI1641797T1 (sl) 2007-12-31
US7381729B2 (en) 2008-06-03
RU2005136215A (ru) 2006-03-20
JP2006524214A (ja) 2006-10-26
AU2004232495A1 (en) 2004-11-04
DE602004008919D1 (de) 2007-10-25
CN100360533C (zh) 2008-01-09
EP1641797B1 (en) 2007-09-12
NO20055495D0 (no) 2005-11-21
IL171120A (en) 2011-01-31
TW200505457A (en) 2005-02-16
MXPA05011348A (es) 2005-11-28
UA81806C2 (uk) 2008-02-11
ZA200508519B (en) 2007-04-25
EP1641797A1 (en) 2006-04-05
ATE373002T1 (de) 2007-09-15
NO20055495L (no) 2006-01-23
ES2290696T3 (es) 2008-02-16
PL1641797T3 (pl) 2008-01-31

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