AR043823A1 - COMPOUNDS DERIVED FROM OXIMA, ITS PREPARATION AND PREPARATION OF MEDICINES CONTAINING THEM - Google Patents

COMPOUNDS DERIVED FROM OXIMA, ITS PREPARATION AND PREPARATION OF MEDICINES CONTAINING THEM

Info

Publication number
AR043823A1
AR043823A1 ARP040101103A ARP040101103A AR043823A1 AR 043823 A1 AR043823 A1 AR 043823A1 AR P040101103 A ARP040101103 A AR P040101103A AR P040101103 A ARP040101103 A AR P040101103A AR 043823 A1 AR043823 A1 AR 043823A1
Authority
AR
Argentina
Prior art keywords
alkyl
preparation
compounds derived
oxima
manufacture
Prior art date
Application number
ARP040101103A
Other languages
Spanish (es)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR043823A1 publication Critical patent/AR043823A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos derivados de oxima, sus sales farmacéuticamente aceptables así como sus formas enantioméricas, sus diastereoisómeros y sus racematos; la obtención de los compuestos recién mencionados, los medicamentos que los contienen y su fabricación así como el uso de los compuestos recién mencionados como inhibidores de desacetilasa de histona (HDAC), para la inhibición del crecimiento tumoral o el tratamiento del cáncer, o para la fabricación de los medicamentos correspondientes. Reivindicación 1: Un compuesto de la fórmula (1) en la que R1 es H o alquilo C1-4; R2 es arilo, heteroarilo o heterociclilo; todos ellos pueden estar opcionalmente sustituidos una o varias veces con alquilo; halógeno; -O-alquilo; -NH(alquilo); -N(alquilo)2; o R1 y R2 junto con el átomo de C al que están unidos forman un hidrocarburo cíclico; y sales farmacéuticamente aceptables del mismo.Compounds derived from oxime, their pharmaceutically acceptable salts as well as their enantiomeric forms, their diastereoisomers and their racemates; obtaining the aforementioned compounds, the medications containing them and their manufacture, as well as the use of the aforementioned compounds as histone deacetylase inhibitors (HDAC), for tumor growth inhibition or cancer treatment, or for the manufacture of the corresponding medications. Claim 1: A compound of the formula (1) wherein R1 is H or C1-4 alkyl; R2 is aryl, heteroaryl or heterocyclyl; all of them can be optionally substituted once or several times with alkyl; halogen; -O-alkyl; -NH (alkyl); -N (alkyl) 2; or R1 and R2 together with the C atom to which they are attached form a cyclic hydrocarbon; and pharmaceutically acceptable salts thereof.

ARP040101103A 2003-04-04 2004-04-01 COMPOUNDS DERIVED FROM OXIMA, ITS PREPARATION AND PREPARATION OF MEDICINES CONTAINING THEM AR043823A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03007829 2003-04-04

Publications (1)

Publication Number Publication Date
AR043823A1 true AR043823A1 (en) 2005-08-17

Family

ID=33104054

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101103A AR043823A1 (en) 2003-04-04 2004-04-01 COMPOUNDS DERIVED FROM OXIMA, ITS PREPARATION AND PREPARATION OF MEDICINES CONTAINING THEM

Country Status (14)

Country Link
US (1) US7173060B2 (en)
EP (1) EP1613622A1 (en)
JP (1) JP2006515345A (en)
KR (1) KR100733757B1 (en)
CN (1) CN1771247A (en)
AR (1) AR043823A1 (en)
AU (1) AU2004226215A1 (en)
BR (1) BRPI0409182A (en)
CA (1) CA2519301A1 (en)
CL (1) CL2004000732A1 (en)
MX (1) MXPA05010424A (en)
RU (1) RU2005133994A (en)
TW (1) TW200424187A (en)
WO (1) WO2004087693A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040094672A (en) 2002-03-13 2004-11-10 얀센 파마슈티카 엔.브이. Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
WO2003076438A1 (en) 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase
CA2476067C (en) 2002-03-13 2011-09-20 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
PL212089B1 (en) 2002-03-13 2012-08-31 Janssen Pharmaceutica Nv New inhibitors of histone deacetylase
WO2006010750A1 (en) 2004-07-28 2006-02-02 Janssen Pharmaceutica N.V. Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
US20080213399A1 (en) 2005-02-03 2008-09-04 Topotarget Uk Limited Combination Therapies Using Hdac Inhibitors
NZ563236A (en) 2005-05-13 2010-12-24 Topotarget Uk Ltd Pharmaceutical formulations of N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide, aka PXD-101, and arginine
CA2605272C (en) 2005-05-18 2013-12-10 Janssen Pharmaceutica N.V. Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
WO2007011626A2 (en) 2005-07-14 2007-01-25 Takeda San Diego, Inc. Histone deacetylase inhibitors
US8828392B2 (en) 2005-11-10 2014-09-09 Topotarget Uk Limited Histone deacetylase (HDAC) inhibitors (PXD101) for the treatment of cancer alone or in combination with chemotherapeutic agent
DK1981871T3 (en) 2006-01-19 2012-02-13 Janssen Pharmaceutica Nv Heterocyclyl alkyl derivatives as novel inhibitors of histone deacetylase
EP1979326B1 (en) 2006-01-19 2012-10-03 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
US8101616B2 (en) 2006-01-19 2012-01-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
DK1981874T3 (en) 2006-01-19 2009-09-28 Janssen Pharmactuica N V Aminophenyl derivatives as novel inhibitors of histone deacetylase
AU2007206950B2 (en) 2006-01-19 2012-02-02 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
US7888360B2 (en) 2006-01-19 2011-02-15 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
US20100056522A1 (en) 2007-03-28 2010-03-04 Santen Pharmaceutical Co., Ltd. Intraocular pressure-lowering agent comprising compound having histone deacetylase inhibitor effect as active ingredient
CN101868446A (en) 2007-09-25 2010-10-20 托波塔吉特英国有限公司 The synthetic method of some hydroxamic acid compound
US8426449B2 (en) * 2008-04-02 2013-04-23 Panmira Pharmaceuticals, Llc Aminoalkylphenyl antagonists of prostaglandin D2 receptors
US9149459B2 (en) 2008-07-23 2015-10-06 Novartis Ag Sphingosine 1 phosphate receptor modulators and their use to treat muscle inflammation
WO2010028192A1 (en) 2008-09-03 2010-03-11 Repligen Corporation Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
PT2680694T (en) 2011-02-28 2019-03-14 Biomarin Pharm Inc Histone deacetylase inhibitors
AU2014228344C1 (en) 2013-03-15 2019-02-07 Biomarin Pharmaceutical Inc. HDAC inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1033046B (en) 1970-10-31 1979-07-10 Finotto Martino PROCESS FOR MANUFACTURING SUBSTITUTED BENZIMIDAZOLES
DE2201062A1 (en) 1972-01-11 1973-07-26 Bayer Ag N-ALKOXYCARBONYL- OR N-ALKYLTHIOCARBONYL-2- (2'-THIENYL) -ENZIMIDAZOLE, A METHOD FOR THEIR PRODUCTION AND USE AS FUNGICIDES
NZ219974A (en) * 1986-04-22 1989-08-29 Goedecke Ag N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases
JPH0692398B2 (en) * 1987-07-07 1994-11-16 日本農薬株式会社 Pyrazol oxime derivative and bactericidal insecticide, acaricide containing the compound
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
US20020103192A1 (en) 2000-10-26 2002-08-01 Curtin Michael L. Inhibitors of histone deacetylase
US6784173B2 (en) * 2001-06-15 2004-08-31 Hoffmann-La Roche Inc. Aromatic dicarboxylic acid derivatives
JP4641670B2 (en) * 2001-06-28 2011-03-02 株式会社フジタ Water purification structure
AR034897A1 (en) * 2001-08-07 2004-03-24 Hoffmann La Roche N-MONOACILATED DERIVATIVES OF O-PHENYLENDIAMINS, THEIR HETEROCICLICAL ANALOGS OF SIX MEMBERS AND THEIR USE AS PHARMACEUTICAL AGENTS

Also Published As

Publication number Publication date
CL2004000732A1 (en) 2005-02-04
US20040214880A1 (en) 2004-10-28
CN1771247A (en) 2006-05-10
KR20060011947A (en) 2006-02-06
EP1613622A1 (en) 2006-01-11
KR100733757B1 (en) 2007-06-29
WO2004087693A1 (en) 2004-10-14
RU2005133994A (en) 2006-06-27
US7173060B2 (en) 2007-02-06
JP2006515345A (en) 2006-05-25
MXPA05010424A (en) 2005-11-04
CA2519301A1 (en) 2004-10-14
AU2004226215A1 (en) 2004-10-14
BRPI0409182A (en) 2006-04-11
TW200424187A (en) 2004-11-16

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