AR037973A1 - 4-arilquinazolinas - Google Patents
4-arilquinazolinasInfo
- Publication number
- AR037973A1 AR037973A1 ARP020105062A ARP020105062A AR037973A1 AR 037973 A1 AR037973 A1 AR 037973A1 AR P020105062 A ARP020105062 A AR P020105062A AR P020105062 A ARP020105062 A AR P020105062A AR 037973 A1 AR037973 A1 AR 037973A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- hal
- compounds
- phenyl
- polysubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos de la fórmula (1), y al uso de los mismos como inhibidores de NHE-3, procedimiento de preparación, preparación farmacéutica, medicamentos. Reivindicación 1: Compuestos de la fórmula (1) donde: Ar es fenilo o naftilo X-sustituido, que está adicionalmente sustituido por R3 y R4, Y es fórmula (2), (3) ó (4); X es H, NR6R7 o un anillo saturado de 5-7 miembros que tiene dos átomos de N; R1, R2, R3 y R4 son cada uno, independientemente entre sí, H, A, OA, Hal, CF3, OH, NO2, NH2, NHA, NA2, NH-CO-A, NH-CO-Ph, SA, SO-A, SO2-A, SO2-Ph, CN, OCF3, CO-A, CO2H, CO2A, CO-NH2, CO-NHA, CO-NA2, SO2NH2, SO2NHA, SO2NA2 o fenilo que está insustituido ó monosustituido ó polisustituido por A, OA, Hal ó CF3; A es alquilo que tiene 1, 2, 3, 4, 5 ó 6 átomos de carbono; Hal es F, Cl, Br ó I; R5 es H, A, OH, NO2, fenilo que está insustituido ó monosustituido ó polisustituido por A, OA, Hal ó CF3, un grupo de protección amino ó fórmula (5); R6 y R7 son cada uno, independientemente entre sí, H, A, fenilo que está insustituido ó monosustituido ó polisustituido por A, OA, Hal ó CF3, bencilo, un grupo de protección amino ó -(CH2)nNR10R11; R8 y R9 son cada uno, independientemente entre sí, H ó A; R10 y R11 son cada uno, independientemente entre sí, H, A, fenilo que está insustituido ó monosustituido ó polisustituido por A, OA, Hal ó CF3, bencilo o un grupo de protección amino; z es 0 ó 1; y n es 2, 3 ó 4; y sales solvatos y estereoisómeros de los mismos, incluyendo las mezclas de los mismos en todas las relaciones, y derivados de los mismos de uso farmacéutico, en particular, sales y solvatos de los mismos de tolerancia fisiológica, con la condición de que queden excluidos los compuestos de la fórmula (1) donde X es H y, simultáneamente, z es 0. Reivindicación 15: Uso de los compuestos de la fórmula (1) de acuerdo con una o varias de las reivindicaciones 1 a 11 y/o sus sales y/o solvatos fisiológicamente aceptables para preparar un medicamento para el tratamiento y la profilaxis de hipertonía, trombosis, estados isquémicos del corazón, del sistema nervioso periférico y central y de apoplejías, estados isquémicos de órganos y miembros periféricos, y para el tratamiento de estados de shock. Reivindicación 16: Uso de los compuestos de la fórmula (1) de acuerdo con una o varias de las reivindicaciones 1 a 11 y/o sus sales y/o solvatos fisiológicamente aceptables para preparar un medicamento para usar en operaciones quirúrgicas y trasplantes de órganos y para preservar y almacenar trasplantes para medidas quirúrgicas. Reivindicación 17: Uso de los compuestos de la fórmula (1) de acuerdo con una o varias de las reivindicaciones 1 a 11 y/o sus sales y/o solvatos fisiológicamente aceptables para preparar un medicamento para el tratamiento y la profilaxis de enfermedades en las cuales la proliferación celular representa una causa primaria o secundaria, para el tratamiento o la profilaxis de trastornos del metabolismo de las grasas o el impulso respiratorio alterado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10163992A DE10163992A1 (de) | 2001-12-24 | 2001-12-24 | 4-Aryl-chinazoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037973A1 true AR037973A1 (es) | 2004-12-22 |
Family
ID=7710890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020105062A AR037973A1 (es) | 2001-12-24 | 2002-12-20 | 4-arilquinazolinas |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050020612A1 (es) |
| EP (1) | EP1458396A1 (es) |
| KR (1) | KR20040066856A (es) |
| AR (1) | AR037973A1 (es) |
| AU (1) | AU2002356762A1 (es) |
| BR (1) | BR0215294A (es) |
| CA (1) | CA2471524A1 (es) |
| DE (1) | DE10163992A1 (es) |
| MX (1) | MXPA04006193A (es) |
| PL (1) | PL369855A1 (es) |
| WO (1) | WO2003055490A1 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10043667A1 (de) * | 2000-09-05 | 2002-03-14 | Merck Patent Gmbh | 2-Guanidino-4-aryl-chinazoline |
| US8508508B2 (en) | 2003-02-14 | 2013-08-13 | Next Holdings Limited | Touch screen signal processing with single-point calibration |
| US7629967B2 (en) * | 2003-02-14 | 2009-12-08 | Next Holdings Limited | Touch screen signal processing |
| US8456447B2 (en) | 2003-02-14 | 2013-06-04 | Next Holdings Limited | Touch screen signal processing |
| DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| US7241775B2 (en) | 2003-03-24 | 2007-07-10 | Sanofi-Aventis Deutschland Gmbh | Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines |
| US7538759B2 (en) | 2004-05-07 | 2009-05-26 | Next Holdings Limited | Touch panel display system with illumination and detection provided from a single edge |
| GB0526515D0 (en) * | 2005-12-28 | 2006-02-08 | Merck Sharp & Dohme | Modulation of signalling pathways |
| WO2008094706A2 (en) * | 2007-02-01 | 2008-08-07 | Cook Incorporated | Closure device and method of closing a bodily opening |
| US8115753B2 (en) * | 2007-04-11 | 2012-02-14 | Next Holdings Limited | Touch screen system with hover and click input methods |
| US8432377B2 (en) * | 2007-08-30 | 2013-04-30 | Next Holdings Limited | Optical touchscreen with improved illumination |
| KR20100075460A (ko) | 2007-08-30 | 2010-07-02 | 넥스트 홀딩스 인코포레이티드 | 저 프로파일 터치 패널 시스템 |
| US20090213093A1 (en) * | 2008-01-07 | 2009-08-27 | Next Holdings Limited | Optical position sensor using retroreflection |
| US20090207144A1 (en) * | 2008-01-07 | 2009-08-20 | Next Holdings Limited | Position Sensing System With Edge Positioning Enhancement |
| US8405636B2 (en) * | 2008-01-07 | 2013-03-26 | Next Holdings Limited | Optical position sensing system and optical position sensor assembly |
| WO2010039663A2 (en) * | 2008-10-02 | 2010-04-08 | Next Holdings, Inc. | Stereo optical sensors for resolving multi-touch in a touch detection system |
| JP5502106B2 (ja) | 2008-12-31 | 2014-05-28 | アーデリクス，インコーポレーテッド | 体液貯留または塩分過負荷と関連する障害および消化管障害の治療におけるｎｈｅ媒介性アンチポートを阻害するための組成物および方法 |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US20120088737A2 (en) * | 2009-10-02 | 2012-04-12 | Ajinomoto Co., Inc | Novel acyl guanidine derivatives |
| US20110199387A1 (en) * | 2009-11-24 | 2011-08-18 | John David Newton | Activating Features on an Imaging Device Based on Manipulations |
| US20110221666A1 (en) * | 2009-11-24 | 2011-09-15 | Not Yet Assigned | Methods and Apparatus For Gesture Recognition Mode Control |
| EP2507683A1 (en) * | 2009-12-04 | 2012-10-10 | Next Holdings Limited | Methods and systems for position detection using an interactive volume |
| US20110234542A1 (en) * | 2010-03-26 | 2011-09-29 | Paul Marson | Methods and Systems Utilizing Multiple Wavelengths for Position Detection |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| CA2880338A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| CA2909169A1 (en) | 2013-04-12 | 2014-10-16 | Ardelyx, Inc. | Nhe3-binding compounds and methods for inhibiting phosphate transport |
| RS58378B1 (sr) | 2014-07-25 | 2019-04-30 | Taisho Pharmaceutical Co Ltd | Fenil tetrahidroizokvinolinsko jedinjenje supstituisano heteroarilom |
| UA126283C2 (uk) | 2017-01-09 | 2022-09-14 | Арделікс, Інк. | Сполуки, придатні для лікування розладів шлунково-кишкового тракту |
| MX2019008171A (es) | 2017-01-09 | 2020-02-05 | Ardelyx Inc | Inhibidores del antiporte mediado por nhe. |
| EP4397366A2 (en) | 2017-08-04 | 2024-07-10 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for treating hyperkalemia |
| CA3129233A1 (en) | 2019-02-07 | 2020-08-13 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for use in treating hyperkalemia |
| JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3131187A (en) * | 1964-04-28 | Certain z-guantoino-x-aryl-quinazolines | ||
| FR2460224A1 (fr) * | 1979-06-29 | 1981-01-23 | Renault | Regulateur d'allure pour vehicule automobile |
| FR2685667B1 (fr) * | 1991-12-26 | 1994-07-29 | Landerretche Alain | Dispositif d'assistance au controle de la puissance de vehicules equipes d'un moteur a combustion interne. |
| DE10019062A1 (de) * | 2000-04-18 | 2001-10-25 | Merck Patent Gmbh | 2-Guanidino-4-aryl-chinazoline als NHE-3 Inhibitoren |
| DE10043667A1 (de) * | 2000-09-05 | 2002-03-14 | Merck Patent Gmbh | 2-Guanidino-4-aryl-chinazoline |
-
2001
- 2001-12-24 DE DE10163992A patent/DE10163992A1/de not_active Withdrawn
-
2002
- 2002-11-29 AU AU2002356762A patent/AU2002356762A1/en not_active Abandoned
- 2002-11-29 CA CA002471524A patent/CA2471524A1/en not_active Abandoned
- 2002-11-29 PL PL02369855A patent/PL369855A1/xx unknown
- 2002-11-29 BR BR0215294-0A patent/BR0215294A/pt not_active Application Discontinuation
- 2002-11-29 EP EP02805750A patent/EP1458396A1/de not_active Withdrawn
- 2002-11-29 US US10/499,972 patent/US20050020612A1/en not_active Abandoned
- 2002-11-29 MX MXPA04006193A patent/MXPA04006193A/es unknown
- 2002-11-29 KR KR10-2004-7008400A patent/KR20040066856A/ko not_active Application Discontinuation
- 2002-11-29 WO PCT/EP2002/013530 patent/WO2003055490A1/de not_active Application Discontinuation
- 2002-12-20 AR ARP020105062A patent/AR037973A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20050020612A1 (en) | 2005-01-27 |
| EP1458396A1 (de) | 2004-09-22 |
| BR0215294A (pt) | 2005-02-09 |
| KR20040066856A (ko) | 2004-07-27 |
| MXPA04006193A (es) | 2004-12-06 |
| AU2002356762A1 (en) | 2003-07-15 |
| PL369855A1 (en) | 2005-05-02 |
| WO2003055490A1 (de) | 2003-07-10 |
| DE10163992A1 (de) | 2003-07-03 |
| CA2471524A1 (en) | 2003-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |