AR036373A1 - PROCEDURE FOR THE PREPARATION OF COMPOUNDS OF 2- (4-ALQUIL-1-PIPERAZINIL) -BENZALDEHIDO AND BENCILIDENILO " - Google Patents
PROCEDURE FOR THE PREPARATION OF COMPOUNDS OF 2- (4-ALQUIL-1-PIPERAZINIL) -BENZALDEHIDO AND BENCILIDENILO "Info
- Publication number
- AR036373A1 AR036373A1 ARP020103228A ARP020103228A AR036373A1 AR 036373 A1 AR036373 A1 AR 036373A1 AR P020103228 A ARP020103228 A AR P020103228A AR P020103228 A ARP020103228 A AR P020103228A AR 036373 A1 AR036373 A1 AR 036373A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compounds
- alkyl
- preparation
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Un procedimiento para la preparación de un compuesto de 2-(4-alquil-1-piperazinil)-benzaldehído de fórmula (1) en la que R1 es alquilo C1-6; que comprende la etapa de dejar que un compuesto de fórmula (3) reaccione con un compuesto de fórmula (4) en presencia de agua y un carbonato de metal. Los compuestos de fórmula (1) son útiles para la preparación de los compuestos de fórmula (2), en la que R1 es alquilo C1-6 y R2 es -(CH2)mB, siendo m 0, 1, 2 ó 3 y B es fenilo o naftilo, pudiendo estar cada uno de los grupos fenilo y naftilo anteriores opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente de cloro, fluoro, bromo, yodo, alquilo C1-6, alcoxi C1-6, alcoxi C1-6-alquilo C1-6, trifluorometilo, trifluorometoxi y ciano; los cuales son antagonistas selectivos de los receptores de serotonina 1 (5-HT) y por compuestos útiles para tratar hipertensión, depresión, trastornos bipolar, ansiedad, obesidad, fobias entre otras condiciones.A process for the preparation of a 2- (4-alkyl-1-piperazinyl) -benzaldehyde compound of formula (1) in which R 1 is C 1-6 alkyl; which comprises the step of allowing a compound of formula (3) to react with a compound of formula (4) in the presence of water and a metal carbonate. The compounds of formula (1) are useful for the preparation of the compounds of formula (2), wherein R 1 is C 1-6 alkyl and R 2 is - (CH 2) mB, where m 0, 1, 2 or 3 and B it is phenyl or naphthyl, each of the above phenyl and naphthyl groups being optionally substituted with one or more substituents independently selected from chloro, fluoro, bromo, iodo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy C1-6, trifluoromethyl, trifluoromethoxy and cyano; which are selective antagonists of serotonin 1 (5-HT) receptors and by compounds useful for treating hypertension, depression, bipolar disorders, anxiety, obesity, phobias among other conditions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31601001P | 2001-08-30 | 2001-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036373A1 true AR036373A1 (en) | 2004-09-01 |
Family
ID=23227067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103228A AR036373A1 (en) | 2001-08-30 | 2002-08-28 | PROCEDURE FOR THE PREPARATION OF COMPOUNDS OF 2- (4-ALQUIL-1-PIPERAZINIL) -BENZALDEHIDO AND BENCILIDENILO " |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6608195B2 (en) |
| EP (1) | EP1288208B1 (en) |
| JP (1) | JP3902751B2 (en) |
| KR (1) | KR100503518B1 (en) |
| CN (1) | CN1172920C (en) |
| AR (1) | AR036373A1 (en) |
| AT (1) | ATE332897T1 (en) |
| AU (1) | AU2002300770B2 (en) |
| BR (1) | BR0203426A (en) |
| CA (1) | CA2399970A1 (en) |
| CY (1) | CY1106126T1 (en) |
| DE (1) | DE60213043T2 (en) |
| DK (1) | DK1288208T3 (en) |
| ES (1) | ES2266416T3 (en) |
| HK (1) | HK1051190A1 (en) |
| HU (1) | HUP0202907A3 (en) |
| IL (1) | IL151430A0 (en) |
| MX (1) | MXPA02008538A (en) |
| PL (1) | PL355799A1 (en) |
| PT (1) | PT1288208E (en) |
| RU (1) | RU2222533C1 (en) |
| TW (1) | TWI234563B (en) |
| YU (1) | YU62302A (en) |
| ZA (1) | ZA200206888B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
| WO2005113526A2 (en) * | 2004-05-21 | 2005-12-01 | Pfizer Products Inc. | Metabolites of 4-(3,4-dichloro-phenyl)-2-[2-(4-methyl-piperazin-1-yl)-benzylidene]-thiomorpholin-3-one |
| CN111269585B (en) * | 2020-03-11 | 2021-10-08 | 苏州根岸生物科技有限责任公司 | Fluorescent dye and preparation method and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA56185C2 (en) * | 1996-09-30 | 2003-05-15 | Пфайзер Інк. | Aralkyl- and aralkylidene heterocyclic lactams and imids, a pharmaceutical composition and a treatment method |
| US6248888B1 (en) * | 1997-11-14 | 2001-06-19 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of terazosin hydrochloride dihydrate |
| TW426667B (en) | 1997-11-19 | 2001-03-21 | Pfizer | Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists |
-
2002
- 2002-08-15 EP EP02255713A patent/EP1288208B1/en not_active Expired - Lifetime
- 2002-08-15 DE DE60213043T patent/DE60213043T2/en not_active Expired - Fee Related
- 2002-08-15 DK DK02255713T patent/DK1288208T3/en active
- 2002-08-15 PT PT02255713T patent/PT1288208E/en unknown
- 2002-08-15 ES ES02255713T patent/ES2266416T3/en not_active Expired - Lifetime
- 2002-08-15 AT AT02255713T patent/ATE332897T1/en not_active IP Right Cessation
- 2002-08-21 YU YU62302A patent/YU62302A/en unknown
- 2002-08-22 IL IL15143002A patent/IL151430A0/en unknown
- 2002-08-26 TW TW091119264A patent/TWI234563B/en not_active IP Right Cessation
- 2002-08-27 JP JP2002246898A patent/JP3902751B2/en not_active Expired - Fee Related
- 2002-08-27 CN CNB021418624A patent/CN1172920C/en not_active Expired - Fee Related
- 2002-08-28 ZA ZA200206888A patent/ZA200206888B/en unknown
- 2002-08-28 BR BR0203426-3A patent/BR0203426A/en not_active IP Right Cessation
- 2002-08-28 AU AU2002300770A patent/AU2002300770B2/en not_active Ceased
- 2002-08-28 CA CA002399970A patent/CA2399970A1/en not_active Abandoned
- 2002-08-28 AR ARP020103228A patent/AR036373A1/en unknown
- 2002-08-29 MX MXPA02008538A patent/MXPA02008538A/en active IP Right Grant
- 2002-08-29 US US10/230,945 patent/US6608195B2/en not_active Expired - Fee Related
- 2002-08-29 HU HU0202907A patent/HUP0202907A3/en unknown
- 2002-08-29 RU RU2002123289/04A patent/RU2222533C1/en not_active IP Right Cessation
- 2002-08-29 KR KR10-2002-0051374A patent/KR100503518B1/en not_active IP Right Cessation
- 2002-08-30 PL PL02355799A patent/PL355799A1/en not_active Application Discontinuation
-
2003
- 2003-05-13 HK HK03103338A patent/HK1051190A1/en not_active IP Right Cessation
-
2006
- 2006-07-25 CY CY20061101030T patent/CY1106126T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2266416T3 (en) | 2007-03-01 |
| CN1403448A (en) | 2003-03-19 |
| MXPA02008538A (en) | 2003-03-05 |
| HU0202907D0 (en) | 2002-10-28 |
| AU2002300770B2 (en) | 2007-06-07 |
| ATE332897T1 (en) | 2006-08-15 |
| EP1288208A1 (en) | 2003-03-05 |
| DE60213043D1 (en) | 2006-08-24 |
| ZA200206888B (en) | 2004-03-01 |
| BR0203426A (en) | 2003-05-13 |
| HUP0202907A2 (en) | 2003-06-28 |
| RU2222533C1 (en) | 2004-01-27 |
| HUP0202907A3 (en) | 2004-06-28 |
| EP1288208B1 (en) | 2006-07-12 |
| US6608195B2 (en) | 2003-08-19 |
| CA2399970A1 (en) | 2003-02-28 |
| DE60213043T2 (en) | 2007-01-04 |
| RU2002123289A (en) | 2004-03-10 |
| DK1288208T3 (en) | 2006-10-16 |
| CN1172920C (en) | 2004-10-27 |
| YU62302A (en) | 2005-03-15 |
| PL355799A1 (en) | 2003-03-10 |
| KR20030019190A (en) | 2003-03-06 |
| KR100503518B1 (en) | 2005-07-25 |
| TWI234563B (en) | 2005-06-21 |
| CY1106126T1 (en) | 2011-06-08 |
| PT1288208E (en) | 2006-09-29 |
| US20030087914A1 (en) | 2003-05-08 |
| JP3902751B2 (en) | 2007-04-11 |
| IL151430A0 (en) | 2003-04-10 |
| HK1051190A1 (en) | 2003-07-25 |
| JP2003096060A (en) | 2003-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |