AR036354A1 - Preparacion solida - Google Patents
Preparacion solidaInfo
- Publication number
- AR036354A1 AR036354A1 ARP020103187A ARP020103187A AR036354A1 AR 036354 A1 AR036354 A1 AR 036354A1 AR P020103187 A ARP020103187 A AR P020103187A AR P020103187 A ARP020103187 A AR P020103187A AR 036354 A1 AR036354 A1 AR 036354A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- magnesium
- optionally substituted
- aluminum hydroxide
- coprecipitate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Una preparación sólida desintegrable gástrica que comprende un ingrediente activo inactivador del ácido de acción antiulcerosa y neutralizante rápido del ácido estomacal que suprime la generación de anhídrido carbónico permitiendo el efecto farmacológico del ingrediente activo, y por lo menos un componente seleccionado de los óxidos de metal e hidróxidos de metal, cuyo tiempo de desintegración preferentemente está dentro de los 7 minutos. Además, dicha preparación no posee capa entérica. La preparación comprende adicionalmente por lo menos un componente seleccionado de los carbonatos de metal alcalino y térreo y los aditivos básicos que poseen una elevada solubilidad en agua. El ingrediente activo inactivador del ácido es un compuesto representado por la fórmula (1) en donde el anillo A es un anillo de benceno opcionalmente sustituido, R1 es átomo de hidrógeno, un grupo aralquilo opcionalmente sustituido, grupo acilo o grupo aciloxilo, R2, R3 y R4 son iguales o diferentes y cada uno representa un átomo de hidrógeno, un grupo alquilo opcionalmente sustituido, un grupo alcoxilo opcionalmente sustituido o un grupo amino opcionalmente sustituido, e Y representa un átomo de nitrógeno o CH, o una sal del mismo. El óxido de metal se selecciona del grupo que consiste en óxido de magnesio, silicato de magnesio, gel de hidróxido de aluminio seca y aluminato de metasilicato de magnesio y el hidróxido de metal se selecciona del grupo que consiste en hidrato de magnesio, hidróxido de aluminio, hidrotalcita sintética, coprecipitado de hidróxido de aluminio e hidróxido de magnesio, coprecipitado de hidróxido de aluminio, carbonato de magnesio y carbonato de calcio, y coprecipitado de hidróxido de aluminio y bicarbonato de sodio.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001263481 | 2001-08-31 | ||
JP2001341477 | 2001-11-07 | ||
JP2002060006 | 2002-03-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR036354A1 true AR036354A1 (es) | 2004-09-01 |
Family
ID=27347410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020103187A AR036354A1 (es) | 2001-08-31 | 2002-08-26 | Preparacion solida |
Country Status (6)
Country | Link |
---|---|
US (1) | US20040248939A1 (es) |
EP (1) | EP1420763A1 (es) |
AR (1) | AR036354A1 (es) |
CA (1) | CA2448760A1 (es) |
PE (1) | PE20030436A1 (es) |
WO (1) | WO2003017980A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
GB9720061D0 (en) | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
SE0000774D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
EA006398B1 (ru) | 2001-06-01 | 2005-12-29 | Поузен Инк. | Фармацевтические композиции для координированной доставки нестероидных противовоспалительных лекарственных средств |
US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
SE0102993D0 (sv) | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
ES2534713T3 (es) | 2002-10-16 | 2015-04-27 | Takeda Pharmaceutical Company Limited | Preparaciones sólidas estables |
US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
ES2283172B1 (es) * | 2005-01-21 | 2008-08-16 | Universidad De Granada | Suspension extemporanea de omeprazol para via oral. |
EP1901719A2 (en) * | 2005-07-11 | 2008-03-26 | Nycomed Danmark ApS | Benzimidazole formulation |
US20070020334A1 (en) * | 2005-07-11 | 2007-01-25 | Poul Bertelsen | Benzimidazole formulation |
WO2007041790A1 (en) * | 2005-10-14 | 2007-04-19 | Jon Pty Limited | Salts of proton pump inhibitors and process for preparing same |
EP1967184A4 (en) * | 2005-12-28 | 2011-02-16 | Takeda Pharmaceutical | SOLID PREPARATION WITH CONTROLLED RELEASE |
CA2634969A1 (en) * | 2005-12-28 | 2007-07-05 | Takeda Pharmaceutical Company Limited | Controlled release solid preparation |
MY157620A (en) | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
US20080103169A1 (en) | 2006-10-27 | 2008-05-01 | The Curators Of The University Of Missouri | Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same |
GB0714670D0 (en) | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
GB0720220D0 (en) | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
EP2252274A4 (en) | 2008-02-20 | 2011-05-11 | Univ Missouri | COMPOSITION COMPRISING A COMBINATION OF OMEPRAZOLE AND LANSOPRAZOLE, AND A BUFFER AGENT, AND METHODS OF USING THE SAME |
KR20110079641A (ko) | 2008-09-09 | 2011-07-07 | 아스트라제네카 아베 | 제약 조성물을 이를 필요로 하는 환자에게 전달하는 방법 |
SG176724A1 (en) | 2009-06-25 | 2012-01-30 | Astrazeneca Ab | Method for treating a patient at risk for developing an nsaid-associated ulcer |
GB0913525D0 (en) | 2009-08-03 | 2009-09-16 | Ineos Healthcare Ltd | Method |
GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
US9539214B2 (en) | 2011-12-28 | 2017-01-10 | Pozen Inc. | Compositions and methods for delivery of omeprazole plus acetylsalicylic acid |
KR101841662B1 (ko) * | 2016-06-02 | 2018-03-23 | 동화약품주식회사 | 프로톤 펌프 저해제의 고체분산체 및 이를 포함하는 약제학적 조성물 |
EP4023216A4 (en) * | 2019-10-17 | 2023-05-10 | Hanmi Pharm. Co., Ltd. | PHARMACEUTICAL COMPOSITION WITH PROTON PUMP INHIBITOR AND ANTACID |
MX2022004464A (es) * | 2019-10-17 | 2022-05-03 | Hanmi Pharm Ind Co Ltd | Composicion farmaceutica que comprende un inhibidor de la bomba de protones y un antiacido. |
WO2021150050A1 (ko) * | 2020-01-23 | 2021-07-29 | 한미약품 주식회사 | 프로톤 펌프 저해제 및 제산제를 포함하는 약제학적 복합제제 |
CN111281855B (zh) * | 2020-03-23 | 2021-09-24 | 乐普制药科技有限公司 | 一种雷贝拉唑肠溶片及其制备方法 |
KR102608889B1 (ko) * | 2020-07-14 | 2023-12-04 | 한미약품 주식회사 | 프로톤 펌프 저해제 및 제산제를 포함하는 약제학적 복합제제 및 그의 제조방법 |
CN113384547B (zh) * | 2021-06-25 | 2024-03-19 | 上海信谊万象药业股份有限公司 | 一种奥美拉唑铝碳酸镁复合片及其制备工艺 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3316703A1 (de) * | 1983-05-04 | 1984-11-08 | Schering AG, 1000 Berlin und 4709 Bergkamen | Orales kontrastmittel fuer die kernspintomographie und dessen herstellung |
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) * | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
SE9600071D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients I |
US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
US20020039597A1 (en) * | 1998-04-20 | 2002-04-04 | Koji Ukai | Stabilized compositions containing benzimidazole-type compounds |
JP4127740B2 (ja) * | 1998-04-20 | 2008-07-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 安定化したベンズイミダゾール系化合物含有組成物 |
EP1222922B1 (en) * | 1999-10-20 | 2007-08-15 | Eisai R&D Management Co., Ltd. | Method for stabilizing benzimidazole compounds |
-
2002
- 2002-08-26 AR ARP020103187A patent/AR036354A1/es not_active Application Discontinuation
- 2002-08-28 PE PE2002000828A patent/PE20030436A1/es not_active Application Discontinuation
- 2002-08-29 US US10/487,809 patent/US20040248939A1/en not_active Abandoned
- 2002-08-29 CA CA002448760A patent/CA2448760A1/en not_active Abandoned
- 2002-08-29 EP EP02765367A patent/EP1420763A1/en not_active Withdrawn
- 2002-08-29 WO PCT/JP2002/008704 patent/WO2003017980A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20040248939A1 (en) | 2004-12-09 |
EP1420763A1 (en) | 2004-05-26 |
CA2448760A1 (en) | 2003-03-06 |
PE20030436A1 (es) | 2003-07-04 |
WO2003017980A1 (en) | 2003-03-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |