AR036242A1 - PIRROLO NUCLEOSIDE ANALOG [2,3-D] PYRIMIDINE AND USE OF THE SAME TO PREPARE A PHARMACEUTICAL COMPOSITION - Google Patents
PIRROLO NUCLEOSIDE ANALOG [2,3-D] PYRIMIDINE AND USE OF THE SAME TO PREPARE A PHARMACEUTICAL COMPOSITIONInfo
- Publication number
- AR036242A1 AR036242A1 ARP020102803A AR036242A1 AR 036242 A1 AR036242 A1 AR 036242A1 AR P020102803 A ARP020102803 A AR P020102803A AR 036242 A1 AR036242 A1 AR 036242A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- nucleoside analog
- pyrimidine
- prepare
- pharmaceutical composition
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un análogo de nucleósido pirrolo[2,3-d]pirimidina de la fórmula (1), en donde: A es O, S, ó CH2; X es H, NH2 u OH; Y es H, halógeno o NH2; Z se selecciona del grupo que consiste en H, halógeno, R, OH, OR, SH, SR, NH2, NHR, NR2, CN, C(O)NH2, COOH, COOR, CH2NH2, C(=NOH)NH2, y C(=NH)NH2 en donde R es alquilo, alquenilo, alquinilo, o aralquilo; R2 y R3 se seleccionan independientemente del grupo que consiste de H, F, y OH; R4 se selecciona del grupo que consiste de un hidrógeno, un alquilo, un alquenilo, un alquinilo, y un aralquilo, en donde R4 opcionalmente posee por lo menos uno de un heteroátomo y un grupo funcional; R5 es H, OH, OP(O)(OH)2, P(O)(OH)2, OP(O)(OR')2, o P(O)(OR')2, en donde R' es un grupo de enmascaramiento; y R5 se selecciona del grupo que consiste de un alquilo, un alquenilo, un alquinilo, y un aralquilo, en donde R5 por lo menos tiene dos átomos de carbono, y opcionalmente tiene por lo menos uno de un heteroátomo y un grupo funcional. Uso del análogo de nucleósido para preparar una composición farmacéutica de utilidad para modificar la secreción de una citocina de una célula. El análogo de nucleósido presenta un efecto anticáncer y de inmunomodulación con una reducida citotoxicidad.A nucleoside analog pyrrolo [2,3-d] pyrimidine of the formula (1), wherein: A is O, S, or CH2; X is H, NH2 or OH; Y is H, halogen or NH2; Z is selected from the group consisting of H, halogen, R, OH, OR, SH, SR, NH2, NHR, NR2, CN, C (O) NH2, COOH, COOR, CH2NH2, C (= NOH) NH2, and C (= NH) NH2 where R is alkyl, alkenyl, alkynyl, or aralkyl; R2 and R3 are independently selected from the group consisting of H, F, and OH; R4 is selected from the group consisting of a hydrogen, an alkyl, an alkenyl, an alkynyl, and an aralkyl, wherein R4 optionally possesses at least one of a heteroatom and a functional group; R5 is H, OH, OP (O) (OH) 2, P (O) (OH) 2, OP (O) (OR ') 2, or P (O) (OR') 2, where R 'is a masking group; and R5 is selected from the group consisting of an alkyl, an alkenyl, an alkynyl, and an aralkyl, wherein R5 has at least two carbon atoms, and optionally has at least one of a heteroatom and a functional group. Use of the nucleoside analog to prepare a pharmaceutical composition useful for modifying the secretion of a cytokine from a cell. The nucleoside analog has an anti-cancer and immunomodulation effect with reduced cytotoxicity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP020102803 AR036242A1 (en) | 2002-07-25 | 2002-07-25 | PIRROLO NUCLEOSIDE ANALOG [2,3-D] PYRIMIDINE AND USE OF THE SAME TO PREPARE A PHARMACEUTICAL COMPOSITION |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP020102803 AR036242A1 (en) | 2002-07-25 | 2002-07-25 | PIRROLO NUCLEOSIDE ANALOG [2,3-D] PYRIMIDINE AND USE OF THE SAME TO PREPARE A PHARMACEUTICAL COMPOSITION |
Publications (1)
Publication Number | Publication Date |
---|---|
AR036242A1 true AR036242A1 (en) | 2004-08-25 |
Family
ID=42632554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020102803 AR036242A1 (en) | 2002-07-25 | 2002-07-25 | PIRROLO NUCLEOSIDE ANALOG [2,3-D] PYRIMIDINE AND USE OF THE SAME TO PREPARE A PHARMACEUTICAL COMPOSITION |
Country Status (1)
Country | Link |
---|---|
AR (1) | AR036242A1 (en) |
-
2002
- 2002-07-25 AR ARP020102803 patent/AR036242A1/en unknown
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