AR033879A1 - Compuesto sulfonamida, composicion farmaceutica que lo comprende, su uso para preparar dicha composicion y procedimiento para la obtencion de dicho compuesto - Google Patents

Compuesto sulfonamida, composicion farmaceutica que lo comprende, su uso para preparar dicha composicion y procedimiento para la obtencion de dicho compuesto

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Publication number
AR033879A1
AR033879A1 ARP020101651A ARP020101651A AR033879A1 AR 033879 A1 AR033879 A1 AR 033879A1 AR P020101651 A ARP020101651 A AR P020101651A AR P020101651 A ARP020101651 A AR P020101651A AR 033879 A1 AR033879 A1 AR 033879A1
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AR
Argentina
Prior art keywords
compound
alkyl
formula
pharmaceutical composition
prepare
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Application number
ARP020101651A
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English (en)
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Smithkline Beecham Corp
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Publication of AR033879A1 publication Critical patent/AR033879A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/04—Antibacterial agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/06—Antiarrhythmics
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    • A61P9/08—Vasodilators for multiple indications
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12—Antihypertensives
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un compuesto sulfamida que responde a la fórmula (1): en la que R1 es fenilo sin sustituir o sustituido con uno, dos, tres, cuatro o cinco de cualquiera de los siguientes: halógeno, CF3, OCF3, SCF3, NO2, CN, alquilo C1-6, alcoxi C1-6, NR5R6, CONR7R8, S-alquilo C1-6, CO2(alquilo C1-6), (alquil C1-6)-CO2-(alquilo C1-6); R2 es hidrógeno, halógeno, CF3, CN o alquilo C1-4; R3, R4, R7 y R8 son independientemente hidrógeno, alquilo C1-6, o bencilo; R5, R6 y R9 son independientemente hidrógeno o alquilo C1-6; X es O, S ó CH2; n es 1; o una de sus sales farmacéuticamente aceptables. Una composición farmacéutica que comprende un compuesto de la fórmula (1) y un vehículo o excipiente farmacéuticamente aceptable. Uso de un compuesto de la fórmula (1) para preparar una composición farmacéutica para tratar enfermedades asociadas con el equilibrio de la urotensina II antagonizando el receptor de la urotesina-II, mediante la administración a un paciente que lo necesite de dicho compuesto. Un procedimiento para la obtención de un compuesto de fórmula (1) o una de sus sales farmacéuticamente aceptables que comprende la hidrogenación de un compuesto e la fórmula (2) en la que R9 y n son como se describe en la reivindicación 1, o un grupo convertible en los mismos, para dar un compuesto de la fórmula (3), que se hace reaccionar con un compuesto de la fórmula: R1-SO2Cl, en la que R1 es como se describen en la reivindicación 1, o un grupo convertible en el mismo, y cuando se desee o sea necesario, conversión de R1 y/o R9.
ARP020101651A 2001-05-07 2002-05-06 Compuesto sulfonamida, composicion farmaceutica que lo comprende, su uso para preparar dicha composicion y procedimiento para la obtencion de dicho compuesto AR033879A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28932701P 2001-05-07 2001-05-07

Publications (1)

Publication Number Publication Date
AR033879A1 true AR033879A1 (es) 2004-01-07

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ID=23111049

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ARP020101651A AR033879A1 (es) 2001-05-07 2002-05-06 Compuesto sulfonamida, composicion farmaceutica que lo comprende, su uso para preparar dicha composicion y procedimiento para la obtencion de dicho compuesto

Country Status (21)

Country Link
US (2) US7091204B2 (es)
EP (2) EP1385507A4 (es)
JP (2) JP2004529939A (es)
KR (1) KR20030094384A (es)
CN (1) CN1516580A (es)
AR (1) AR033879A1 (es)
AT (1) ATE341544T1 (es)
BR (1) BR0209440A (es)
CA (1) CA2446365A1 (es)
CO (1) CO5540284A2 (es)
CZ (1) CZ20033018A3 (es)
DE (1) DE60215145T2 (es)
ES (1) ES2272705T3 (es)
HU (1) HUP0400040A2 (es)
IL (1) IL158626A0 (es)
MX (1) MXPA03010158A (es)
NO (1) NO20034949L (es)
NZ (1) NZ528997A (es)
PL (1) PL366641A1 (es)
WO (2) WO2002089792A1 (es)
ZA (1) ZA200308133B (es)

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WO2004078114A2 (en) 2003-02-28 2004-09-16 Encysive Pharmaceuticals Inc. Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-ii receptor antagonists.
AU2004226197B2 (en) * 2003-03-25 2009-12-03 Laboratoires Fournier S.A. Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain
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JP4851328B2 (ja) 2003-09-26 2012-01-11 アクテリオン ファーマシューティカルズ リミテッド 新規なピリジン誘導体
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CA2583845C (en) 2004-10-12 2013-03-26 Actelion Pharmaceuticals Ltd 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as crystalline sulfate salt
CL2007002097A1 (es) * 2006-07-20 2008-01-18 Smithkline Beecham Corp Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras.
FR2904827B1 (fr) * 2006-08-11 2008-09-19 Sanofi Aventis Sa Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii
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CN101525307A (zh) * 2009-04-17 2009-09-09 大连凯飞精细化工有限公司 对磺酰氯苯丙酸甲酯的合成方法
EP2617415B1 (en) * 2010-09-16 2016-04-20 Catholic Kwandong University Industry Foundation Use of a compound for inducing differentiation of mesenchymal stem cells into cartilage cells
DE102011104267A1 (de) 2011-06-06 2012-12-06 Philipps-Universität Marburg Verbindungen als PPAR beta/delta Inhibitoren für die Behandlung von PPAR beta/delta-vermittelten Erkrankungen
DE102011118606A1 (de) 2011-11-15 2013-05-16 Philipps-Universität Marburg Stilben-Verbindungen als PPAR beta/delta Inhibitoren für die Behandlung von PPAR beta/delta-vermittelten Erkrankungen
EP3594203B1 (en) * 2017-03-08 2021-08-04 Takeda Pharmaceutical Company Limited Substituted pyrrolidine compound and use thereof
KR102278691B1 (ko) * 2019-08-09 2021-07-16 한국화학연구원 신규한 피리미딘 설폰아마이드 유도체
US11773603B2 (en) 2021-09-23 2023-10-03 Tile Redi, Llc Reinforced floors for modular bathrooms

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JP3637974B2 (ja) * 1993-03-25 2005-04-13 エーザイ株式会社 ピロリジン誘導体
DZ2376A1 (fr) * 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
JP4253126B2 (ja) 1998-01-29 2009-04-08 アムジェン インコーポレイテッド Ｐｐａｒ−ガンマ調節剤
WO2002089785A1 (en) * 2001-05-07 2002-11-14 Smithkline Beecham Corporation Sulfonamides

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