AR031374A1 - FORMULATION AGONIST ORAL OPIACEO RESISTANT TO HANDLING - Google Patents
FORMULATION AGONIST ORAL OPIACEO RESISTANT TO HANDLINGInfo
- Publication number
- AR031374A1 AR031374A1 ARP010100556A ARP010100556A AR031374A1 AR 031374 A1 AR031374 A1 AR 031374A1 AR P010100556 A ARP010100556 A AR P010100556A AR P010100556 A ARP010100556 A AR P010100556A AR 031374 A1 AR031374 A1 AR 031374A1
- Authority
- AR
- Argentina
- Prior art keywords
- dosage form
- agonist
- released
- opiaceo
- formulation
- Prior art date
Links
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se revela una forma de dosificacion oral caracterizado por (i) un agonista opiáceo en forma liberable y (ii) un antagonista opiáceo secuestrado sustancialmente no liberado cuando la forma de dosificacion se administra intacta, tal que la relacion de la cantidad de antagonistas liberado de dicha forma de dosificacion después de la alteracion a la cantidad de dicho antagonista liberado de dicha forma de dosificacion intacta es de aproximadamente 4:1 o mayor, basado sobre la disolucion in-vitro después de 1 hora de dicha forma de dosificacion entre 900 ml de Fluido Gástrico Simulado utilizando un aparato USP tipo II (paleta) a 75 rpm a 37 degree C en donde dicho agonista y antagonista se dispersan a través de la forma de dosificacion y no se encuentran aislados uno de otro en dos capas diferentes.An oral dosage form is revealed characterized by (i) an opioid agonist in releasable form and (ii) a sequestered opioid antagonist substantially not released when the dosage form is administered intact, such that the ratio of the amount of antagonists released from said Dosage form after alteration to the amount of said antagonist released from said intact dosage form is approximately 4: 1 or greater, based on the in-vitro solution after 1 hour of said dosage form between 900 ml of Fluid Gastric Simulated using a USP type II device (paddle) at 75 rpm at 37 degree C where said agonist and antagonist are dispersed through the dosage form and are not isolated from each other in two different layers.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP010100556A AR031374A1 (en) | 2001-02-07 | 2001-02-07 | FORMULATION AGONIST ORAL OPIACEO RESISTANT TO HANDLING |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP010100556A AR031374A1 (en) | 2001-02-07 | 2001-02-07 | FORMULATION AGONIST ORAL OPIACEO RESISTANT TO HANDLING |
Publications (1)
Publication Number | Publication Date |
---|---|
AR031374A1 true AR031374A1 (en) | 2003-09-24 |
Family
ID=37516039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010100556A AR031374A1 (en) | 2001-02-07 | 2001-02-07 | FORMULATION AGONIST ORAL OPIACEO RESISTANT TO HANDLING |
Country Status (1)
Country | Link |
---|---|
AR (1) | AR031374A1 (en) |
-
2001
- 2001-02-07 AR ARP010100556A patent/AR031374A1/en unknown
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