AR028475A1 - DERIVATIVES OF AZAINDOL AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION. - Google Patents

DERIVATIVES OF AZAINDOL AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION.

Info

Publication number
AR028475A1
AR028475A1 ARP000101879A ARP000101879A AR028475A1 AR 028475 A1 AR028475 A1 AR 028475A1 AR P000101879 A ARP000101879 A AR P000101879A AR P000101879 A ARP000101879 A AR P000101879A AR 028475 A1 AR028475 A1 AR 028475A1
Authority
AR
Argentina
Prior art keywords
depression
manufacture
treatment
azaindol
derivatives
Prior art date
Application number
ARP000101879A
Other languages
Spanish (es)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR028475A1 publication Critical patent/AR028475A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

Compuestos derivados de azaindol y el uso de los mismos para la manufactura de un medicamento para el tratamiento de enfermedades afectadas por trastornos de los sistemas neurologicos afectados por la serotonina, como por ejemplo, la depresion y la ansiedad, que tienen la formula (1), donde: R1 y R2 forman un anillo carbocíclico de entre 5 y 7 átomos de carbono, donde dicho anillo puede estar saturado o no saturado y puede contener uno o más heteroátomos; y X es independientemente hidrogeno, ciano, carbamoílo, halogeno o alcoxi; o sus sales farmacéuticamente aceptables.Compounds derived from azaindole and their use for the manufacture of a medicine for the treatment of diseases affected by disorders of the neurological systems affected by serotonin, such as depression and anxiety, which have the formula (1) , where: R1 and R2 form a carbocyclic ring of between 5 and 7 carbon atoms, where said ring may be saturated or unsaturated and may contain one or more heteroatoms; and X is independently hydrogen, cyano, carbamoyl, halogen or alkoxy; or its pharmaceutically acceptable salts.

ARP000101879A 1999-04-22 2000-04-19 DERIVATIVES OF AZAINDOL AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION. AR028475A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29673699A 1999-04-22 1999-04-22

Publications (1)

Publication Number Publication Date
AR028475A1 true AR028475A1 (en) 2003-05-14

Family

ID=23143341

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000101879A AR028475A1 (en) 1999-04-22 2000-04-19 DERIVATIVES OF AZAINDOL AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION.

Country Status (8)

Country Link
EP (1) EP1171439A1 (en)
JP (1) JP2002543079A (en)
CN (1) CN1348451A (en)
AR (1) AR028475A1 (en)
AU (1) AU4364400A (en)
BR (1) BR0010693A (en)
CA (1) CA2367681A1 (en)
WO (1) WO2000064898A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100338062C (en) * 2002-03-28 2007-09-19 卫材株式会社 Azaindoles as inhibitors of c-Jun N-terminal kinases
JP2008521771A (en) 2004-11-26 2008-06-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Isoxazoline-indole derivatives having improved antipsychotic and anxiolytic activity
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CR20170089A (en) 2009-04-03 2017-07-17 Plexxikon Inc PROPANE-ACID COMPOSITIONS-1 - SULFONIC {3- [5- (4-CHLORINE-PHENYL) -1H-PIRROLO [2,3-B] PIRIDINA-3-CARBONIL] -2,4-DIFLUORO-PHENIL} -AMIDA AND THE USE OF THE SAME
RS57869B1 (en) 2009-06-17 2018-12-31 Vertex Pharma Inhibitors of influenza viruses replication
NZ599866A (en) 2009-11-06 2014-09-26 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
KR20140014110A (en) 2010-12-16 2014-02-05 버텍스 파마슈티칼스 인코포레이티드 Inhibitors of influenza viruses replication
MA34948B1 (en) 2011-02-07 2014-03-01 Plexxikon Inc COMPOUNDS AND METHODS FOR MODULATING KINASE, AND INDICATIONS THEREOF
TWI558702B (en) 2011-02-21 2016-11-21 普雷辛肯公司 Solid forms of a pharmaceutically active substance
UA118010C2 (en) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед INFLUENCES OF INFLUENZA VIRUS REPLICATION
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
JP6615755B2 (en) 2013-11-13 2019-12-04 バーテックス ファーマシューティカルズ インコーポレイテッド Inhibitors of influenza virus replication
SI3068782T1 (en) 2013-11-13 2018-10-30 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
JP6857617B2 (en) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Influenza virus replication inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
US5627196A (en) * 1995-01-17 1997-05-06 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems

Also Published As

Publication number Publication date
BR0010693A (en) 2002-02-05
JP2002543079A (en) 2002-12-17
CN1348451A (en) 2002-05-08
AU4364400A (en) 2000-11-10
CA2367681A1 (en) 2000-11-02
EP1171439A1 (en) 2002-01-16
WO2000064898A1 (en) 2000-11-02

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