AR027399A1 - Compuestos heterociclicos utiles como inhibidores de la fosfodiesterasa iv, composiciones formuladas con dichos compuestos y uso de dichos compuestos parapreparar dichas composiciones - Google Patents

Compuestos heterociclicos utiles como inhibidores de la fosfodiesterasa iv, composiciones formuladas con dichos compuestos y uso de dichos compuestos parapreparar dichas composiciones

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Publication number
AR027399A1
AR027399A1 ARP010100598A ARP010100598A AR027399A1 AR 027399 A1 AR027399 A1 AR 027399A1 AR P010100598 A ARP010100598 A AR P010100598A AR P010100598 A ARP010100598 A AR P010100598A AR 027399 A1 AR027399 A1 AR 027399A1
Authority
AR
Argentina
Prior art keywords
compounds
compositions
phosphodesterase
preparate
inhibitors
Prior art date
Application number
ARP010100598A
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English (en)
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of AR027399A1 publication Critical patent/AR027399A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)

Abstract

Se trata de compuestos inhibidores de la fosfodiestersa, tienen utilidad terapéutica y tienen la formula general (1) donde R1 es C3-6 cicloalquilo o C1-3alquilo opcionalmente sustituido con uno o más átomos de fluor; R2 es C1-alquilo, C3-6 cicloalqui lo, CF3, CH2CF3, C2F5 o NR4R5; R3 es un grupo pirazol,imidazol o isoxazol de formula parcial (A), (B) o (C); NR4R5 es un anillo heterocíclico que contiene nitrogeno; R6 es C1-3 alquilo; y R7 y R8, que son igualeso diferentes, son cada uno H, C1-3 alq uilo, halogeno, CF3 o CN, siempre que ambos no sean H; o sales farmacéuticamente aceptables de los mismos.
ARP010100598A 2000-02-11 2001-02-09 Compuestos heterociclicos utiles como inhibidores de la fosfodiesterasa iv, composiciones formuladas con dichos compuestos y uso de dichos compuestos parapreparar dichas composiciones AR027399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0003254.0A GB0003254D0 (en) 2000-02-11 2000-02-11 Heterocyclic compounds and their therapeutic use

Publications (1)

Publication Number Publication Date
AR027399A1 true AR027399A1 (es) 2003-03-26

Family

ID=9885477

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100598A AR027399A1 (es) 2000-02-11 2001-02-09 Compuestos heterociclicos utiles como inhibidores de la fosfodiesterasa iv, composiciones formuladas con dichos compuestos y uso de dichos compuestos parapreparar dichas composiciones

Country Status (10)

Country Link
US (1) US6313116B1 (es)
EP (1) EP1263757B1 (es)
JP (1) JP2003522772A (es)
AR (1) AR027399A1 (es)
AT (1) ATE300537T1 (es)
AU (1) AU2001233837A1 (es)
DE (1) DE60112254T2 (es)
GB (1) GB0003254D0 (es)
PE (1) PE20011290A1 (es)
WO (1) WO2001058897A1 (es)

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NZ551017A (en) * 2004-05-18 2010-11-26 Schering Corp Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors
TWI306401B (en) 2004-08-13 2009-02-21 Nat Health Research Institutes Benzothiazolium compounds
US7643818B2 (en) * 2004-11-22 2010-01-05 Seven Networks, Inc. E-mail messaging to/from a mobile terminal
SE0403117D0 (sv) * 2004-12-21 2004-12-21 Astrazeneca Ab New compounds 1
EP1870401A4 (en) * 2005-04-06 2011-06-15 Msd Kk SUBSTITUTE DERIVATIVE PIPERAZINE IN 1,4
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CN101410385B (zh) 2006-03-28 2011-08-24 高点制药有限责任公司 具有组胺h3受体活性的苯并噻唑类
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
KR20090064418A (ko) * 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100111800A1 (en) * 2008-11-03 2010-05-06 Westinghouse Electric Company Llc PRODUCTION OF NUCLEAR GRADE ENRICHED GADOLINIUM AND ERBIUM USING VOLATILE Gd OR Er SPECIES USING AN AERODYNAMIC PROCESS
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
CN110367188A (zh) * 2019-04-04 2019-10-25 上海大学 心肌层转染慢病毒的小鼠模型的构建方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK283534B6 (sk) * 1996-11-15 2003-09-11 Darwin Discovery Limited Bicyklické arylkarboxamidy a farmaceutický prostriedok s ich obsahom
IL135176A0 (en) * 1997-11-10 2001-05-20 Bristol Myers Squibb Co Benzothiazole derivatives and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
US6313116B1 (en) 2001-11-06
DE60112254D1 (de) 2005-09-01
PE20011290A1 (es) 2001-12-20
JP2003522772A (ja) 2003-07-29
AU2001233837A1 (en) 2001-08-20
DE60112254T2 (de) 2006-05-24
ATE300537T1 (de) 2005-08-15
EP1263757A1 (en) 2002-12-11
WO2001058897A1 (en) 2001-08-16
GB0003254D0 (en) 2000-04-05
EP1263757B1 (en) 2005-07-27

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