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Application filed by Wyeth Corp, Elan Pharm IncfiledCriticalWyeth Corp
Publication of AR026105A1publicationCriticalpatent/AR026105A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Se describen compuestos que se adhieren a VLA-4. Algunos de estos compuestos inhiben también la adhesion de leucocitos, y un particular, la adhesion deleucocitos intermedia por VLA-4 de los compuestos utiles para el tratamiento de enfermedades inflam atorias en un paciente mamífero, por ejemplo en un serhumano, tales como asma, enfermedad de Alzheimer, ateroes-clerosis, demencia causada por SIDA, diabetes, enfermedad inflamatoria del intestino, artritisreumatoide, transplante de tejidos, metástas is de tumores e isquemia de miocardio. Los compuestos pueden suministrarse también para el tratamiento deenfermedades cerebrales inflamatorias tales como esclerosis multiple.Compounds that adhere to VLA-4 are described. Some of these compounds also inhibit the adhesion of leukocytes, and in particular, the adhesion deleucocytes intermediate by VLA-4 of the compounds useful for the treatment of inflammatory diseases in a mammalian patient, for example in a human being, such as asthma, disease Alzheimer's disease, atherosclerosis, dementia caused by AIDS, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastases and myocardial ischemia. The compounds can also be supplied for the treatment of inflammatory brain diseases such as multiple sclerosis.
ARP000100287A1996-04-092000-01-24
HETEROARILO, HETEROCICLICO AND ILO COMPUTERS THAT
AR026105A1
(en)
DERIVATIVES OF PYROGLUTAMIC ACID AND RELATED COMPOUNDS THAT INHIBIT THE ADHESION OF LEUCOCITS INTERMEDIATED BY VLA-4, PHARMACEUTICAL COMPOSITIONS AND THE USE OF THE SAME FOR THE MANUFACTURE OF AGENTS AND MEDICINES