AR025694A1 - Composiciones de condrocitos, preparacion y usos. - Google Patents
Composiciones de condrocitos, preparacion y usos.Info
- Publication number
- AR025694A1 AR025694A1 ARP000104869A ARP000104869A AR025694A1 AR 025694 A1 AR025694 A1 AR 025694A1 AR P000104869 A ARP000104869 A AR P000104869A AR P000104869 A ARP000104869 A AR P000104869A AR 025694 A1 AR025694 A1 AR 025694A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- refers
- defects
- cartilaginous
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3852—Cartilage, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se refiere a composiciones de células condrocitarias, en especial humanas, y también se refiere a métodos para su preparacion y a sus utilizaciones. Másparticularmente, describe la produccion de suspensiones de condrocitos humanos autologos, en la cual se utilizan enzimas recombinantes y/o medios compatiblescon un uso farmacéutico. Los condrocitos producidos pueden ser utilizados in vivo para restaurar estructuras cartilaginosas afectadas, tales como los defectoscartilaginosos post-traumáticoso la osteocondritris disecante de las rodillas o, en términos más generales, para el tratamiento y retencion de los defectossignificativos del cartílago, en especial de cartílago articular.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9911564A FR2798671A1 (fr) | 1999-09-16 | 1999-09-16 | Compositions de chondrocytes, preparation et utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
AR025694A1 true AR025694A1 (es) | 2002-12-11 |
Family
ID=9549897
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000104868A AR025693A1 (es) | 1999-09-16 | 2000-09-15 | Composiciones de condrocitos, preparacion y usos |
ARP000104869A AR025694A1 (es) | 1999-09-16 | 2000-09-15 | Composiciones de condrocitos, preparacion y usos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000104868A AR025693A1 (es) | 1999-09-16 | 2000-09-15 | Composiciones de condrocitos, preparacion y usos |
Country Status (7)
Country | Link |
---|---|
US (1) | US6365405B1 (es) |
EP (2) | EP1085082A1 (es) |
AR (2) | AR025693A1 (es) |
AU (2) | AU7429200A (es) |
CA (1) | CA2384768A1 (es) |
FR (1) | FR2798671A1 (es) |
WO (2) | WO2001019965A1 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8545569B2 (en) | 2001-05-25 | 2013-10-01 | Conformis, Inc. | Patient selectable knee arthroplasty devices |
US8771365B2 (en) | 2009-02-25 | 2014-07-08 | Conformis, Inc. | Patient-adapted and improved orthopedic implants, designs, and related tools |
US8083745B2 (en) | 2001-05-25 | 2011-12-27 | Conformis, Inc. | Surgical tools for arthroplasty |
US8556983B2 (en) | 2001-05-25 | 2013-10-15 | Conformis, Inc. | Patient-adapted and improved orthopedic implants, designs and related tools |
US7468075B2 (en) | 2001-05-25 | 2008-12-23 | Conformis, Inc. | Methods and compositions for articular repair |
US7799077B2 (en) | 2002-10-07 | 2010-09-21 | Conformis, Inc. | Minimally invasive joint implant with 3-dimensional geometry matching the articular surfaces |
US20070100462A1 (en) | 2001-05-25 | 2007-05-03 | Conformis, Inc | Joint Arthroplasty Devices |
US8480754B2 (en) | 2001-05-25 | 2013-07-09 | Conformis, Inc. | Patient-adapted and improved articular implants, designs and related guide tools |
US8882847B2 (en) | 2001-05-25 | 2014-11-11 | Conformis, Inc. | Patient selectable knee joint arthroplasty devices |
US8735773B2 (en) | 2007-02-14 | 2014-05-27 | Conformis, Inc. | Implant device and method for manufacture |
US7534263B2 (en) | 2001-05-25 | 2009-05-19 | Conformis, Inc. | Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty |
US8617242B2 (en) | 2001-05-25 | 2013-12-31 | Conformis, Inc. | Implant device and method for manufacture |
US9603711B2 (en) | 2001-05-25 | 2017-03-28 | Conformis, Inc. | Patient-adapted and improved articular implants, designs and related guide tools |
ATE439806T1 (de) | 1998-09-14 | 2009-09-15 | Univ Leland Stanford Junior | Zustandsbestimmung eines gelenks und schadenvorsorge |
US9289153B2 (en) * | 1998-09-14 | 2016-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Joint and cartilage diagnosis, assessment and modeling |
US7239908B1 (en) | 1998-09-14 | 2007-07-03 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and devising treatment |
US7184814B2 (en) | 1998-09-14 | 2007-02-27 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and assessing cartilage loss |
DE10038700B4 (de) * | 2000-07-31 | 2006-09-07 | Michael Priv.-Doz. Dr. Sittinger | Autologe Bindegewebe, Verfahren zu ihrer Herstellung und ihre Verwendung |
ATE426357T1 (de) | 2000-09-14 | 2009-04-15 | Univ Leland Stanford Junior | Beurteilung des zustandes eines gelenkes und planung einer behandlung |
US8439926B2 (en) | 2001-05-25 | 2013-05-14 | Conformis, Inc. | Patient selectable joint arthroplasty devices and surgical tools |
DE60239674D1 (de) | 2001-05-25 | 2011-05-19 | Conformis Inc | Verfahren und zusammensetzungen zur reparatur der oberfläche von gelenken |
WO2003064598A2 (en) * | 2002-01-25 | 2003-08-07 | Genzyme Corporation | Serum-free media for chondrocytes and methods of use thereof |
US20050147959A1 (en) * | 2002-03-25 | 2005-07-07 | Frondoza Carmelita G. | Tissue analogs for in vitro testing and method of use therefor |
US20040078090A1 (en) | 2002-10-18 | 2004-04-22 | Francois Binette | Biocompatible scaffolds with tissue fragments |
EP1558181B1 (en) | 2002-11-07 | 2015-08-26 | ConforMIS, Inc. | Methods for determining meniscal size and shape and for devising treatment |
US7642092B2 (en) * | 2003-03-03 | 2010-01-05 | Technion Research & Development Foundation Ltd. | Cultured cartilage/bone cells/tissue, method of generating same and uses thereof |
US7067123B2 (en) * | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
EP1529543A1 (fr) * | 2003-11-04 | 2005-05-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Utilisation d'un hydrogel pour la culture de chondrocytes |
US20060063141A1 (en) * | 2004-09-17 | 2006-03-23 | Mcgann Locksley E | Method of cryopreserving cells |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
US7837740B2 (en) * | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US20090319045A1 (en) * | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
CN102688524A (zh) * | 2005-10-31 | 2012-09-26 | 株式会社现代组织工学 | 包含获得自肋软骨的软骨细胞的人工软骨及其制备方法 |
EP2302037A1 (en) * | 2005-11-10 | 2011-03-30 | Carticure Ltd. | Method for non-autologous cartilage regeneration |
EP2520255B1 (en) | 2005-11-21 | 2016-06-15 | Vertegen, Inc. | Methods for treating facet joints, uncovertebral joints, costovertebral joints and other joints |
JP2007191467A (ja) * | 2005-12-20 | 2007-08-02 | Pentax Corp | 肥大化能を有する軟骨細胞の産生する新しい細胞機能調節因子 |
EP2671521A3 (en) | 2006-02-06 | 2013-12-25 | ConforMIS, Inc. | Patient selectable joint arthroplasty devices and surgical tools |
US8500740B2 (en) * | 2006-02-06 | 2013-08-06 | Conformis, Inc. | Patient-specific joint arthroplasty devices for ligament repair |
US8623026B2 (en) | 2006-02-06 | 2014-01-07 | Conformis, Inc. | Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief |
ITTO20060282A1 (it) * | 2006-04-14 | 2007-10-15 | Univ Degli Studi Torino | Mezzo di coltura e composizione farmaceutica per la rigenerazione del tessuto cartilagineo relativo procedimento relativi usi e prodotti |
WO2008157412A2 (en) | 2007-06-13 | 2008-12-24 | Conformis, Inc. | Surgical cutting guide |
US8682052B2 (en) | 2008-03-05 | 2014-03-25 | Conformis, Inc. | Implants for altering wear patterns of articular surfaces |
AU2009246474B2 (en) | 2008-05-12 | 2015-04-16 | Conformis, Inc. | Devices and methods for treatment of facet and other joints |
EP2405865B1 (en) | 2009-02-24 | 2019-04-17 | ConforMIS, Inc. | Automated systems for manufacturing patient-specific orthopedic implants and instrumentation |
US8808297B2 (en) | 2009-02-24 | 2014-08-19 | Microport Orthopedics Holdings Inc. | Orthopedic surgical guide |
US8808303B2 (en) | 2009-02-24 | 2014-08-19 | Microport Orthopedics Holdings Inc. | Orthopedic surgical guide |
US9017334B2 (en) | 2009-02-24 | 2015-04-28 | Microport Orthopedics Holdings Inc. | Patient specific surgical guide locator and mount |
EP2509539B1 (en) | 2009-12-11 | 2020-07-01 | ConforMIS, Inc. | Patient-specific and patient-engineered orthopedic implants |
WO2012112702A2 (en) | 2011-02-15 | 2012-08-23 | Conformis, Inc. | Patient-adapted and improved articular implants, designs and related guide tools |
US9486226B2 (en) | 2012-04-18 | 2016-11-08 | Conformis, Inc. | Tibial guides, tools, and techniques for resecting the tibial plateau |
US20150079069A1 (en) | 2012-04-30 | 2015-03-19 | Elastomics Ab | Methods for modification of tissues |
US9675471B2 (en) | 2012-06-11 | 2017-06-13 | Conformis, Inc. | Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components |
CN110292038B (zh) * | 2018-03-23 | 2021-08-24 | 北京世纪劲得生物技术有限公司 | 间充质干细胞的冷冻保护液及其制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4846835A (en) * | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
JP3022984B2 (ja) * | 1989-11-28 | 2000-03-21 | サントリー株式会社 | 細菌コラゲナーゼ遺伝子 |
US5478739A (en) * | 1992-10-23 | 1995-12-26 | Advanced Tissue Sciences, Inc. | Three-dimensional stromal cell and tissue culture system |
US5543316A (en) * | 1994-04-20 | 1996-08-06 | Diacrin, Inc. | Injectable culture medium for maintaining viability of myoblast cells |
WO1995030742A1 (en) * | 1994-05-05 | 1995-11-16 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
US5842477A (en) * | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
FR2746109B1 (fr) * | 1996-03-12 | 1998-04-17 | Rhone Poulenc Rorer Sa | Milieu pour la conservation de materiel biologique |
US5993810A (en) * | 1996-03-15 | 1999-11-30 | Lebovitz; Shamir Israel | Method of softening or ripening the cervix of a female mammal using collagenase |
US5747322A (en) * | 1996-05-09 | 1998-05-05 | The Regents Of The University Of California | Recombinant crab collagenase |
JP3638614B2 (ja) * | 1996-07-25 | 2005-04-13 | ジェンザイム・コーポレーション | 軟骨細胞培地組成および培養方法 |
US6001352A (en) * | 1997-03-31 | 1999-12-14 | Osteobiologics, Inc. | Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor |
-
1999
- 1999-09-16 FR FR9911564A patent/FR2798671A1/fr not_active Withdrawn
-
2000
- 2000-09-14 EP EP00402537A patent/EP1085082A1/fr not_active Withdrawn
- 2000-09-14 WO PCT/FR2000/002536 patent/WO2001019965A1/fr active Application Filing
- 2000-09-14 EP EP00402536A patent/EP1085084A1/fr not_active Withdrawn
- 2000-09-14 WO PCT/FR2000/002535 patent/WO2001019964A1/fr active Application Filing
- 2000-09-14 AU AU74292/00A patent/AU7429200A/en not_active Abandoned
- 2000-09-14 AU AU74291/00A patent/AU7429100A/en not_active Abandoned
- 2000-09-14 CA CA002384768A patent/CA2384768A1/fr not_active Abandoned
- 2000-09-15 AR ARP000104868A patent/AR025693A1/es unknown
- 2000-09-15 US US09/662,469 patent/US6365405B1/en not_active Expired - Lifetime
- 2000-09-15 AR ARP000104869A patent/AR025694A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AR025693A1 (es) | 2002-12-11 |
WO2001019965A1 (fr) | 2001-03-22 |
FR2798671A1 (fr) | 2001-03-23 |
EP1085082A1 (fr) | 2001-03-21 |
CA2384768A1 (fr) | 2001-03-22 |
US6365405B1 (en) | 2002-04-02 |
EP1085084A1 (fr) | 2001-03-21 |
AU7429100A (en) | 2001-04-17 |
WO2001019964A1 (fr) | 2001-03-22 |
AU7429200A (en) | 2001-04-17 |
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