AR023625A1 - NON-ESTEQUIOMETRIC COMPOUNDS FORMED BETWEEN PRIMICINE AND CYCLODEXTRINE - Google Patents

NON-ESTEQUIOMETRIC COMPOUNDS FORMED BETWEEN PRIMICINE AND CYCLODEXTRINE

Info

Publication number
AR023625A1
AR023625A1 ARP970101304A ARP970101304A AR023625A1 AR 023625 A1 AR023625 A1 AR 023625A1 AR P970101304 A ARP970101304 A AR P970101304A AR P970101304 A ARP970101304 A AR P970101304A AR 023625 A1 AR023625 A1 AR 023625A1
Authority
AR
Argentina
Prior art keywords
primicin
primicine
estequiometric
cyclodextrine
compounds formed
Prior art date
Application number
ARP970101304A
Other languages
Spanish (es)
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Medipharma Kutato Es Fejleszto Kft
Boulu Laurent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet, Medipharma Kutato Es Fejleszto Kft, Boulu Laurent filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of AR023625A1 publication Critical patent/AR023625A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

El campo de accion del presente lo constituyen los preparados farmacéuticos antibioticos, en particular de aplicacion local, basados en la primicina. Laprimicina tiene el inconveniente de ser poco soluble, tanto en agua como en alcohol. Paraaumentar la solubilidad de la primicina, el presente propone nuevoscompuestos no estequiométricos, formados entre primicina o sus componentes, y una ciclodextrina o un derivado de ciclodextrina o mezcla de ellos, en unarelacion molar comprendidaentre 1:0,3 y 1:4,0.The field of action of this is antibiotic pharmaceutical preparations, in particular of local application, based on primicin. Laprimycin has the disadvantage of being poorly soluble, both in water and in alcohol. To increase the solubility of primicin, the present proposes new non-stoichiometric compounds, formed between primicin or its components, and a cyclodextrin or a derivative of cyclodextrin or mixture thereof, in a molar ratio between 1: 0.3 and 1: 4.0.

ARP970101304A 1996-04-02 1997-04-02 NON-ESTEQUIOMETRIC COMPOUNDS FORMED BETWEEN PRIMICINE AND CYCLODEXTRINE AR023625A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9600847A HUP9600847A3 (en) 1996-04-02 1996-04-02 Nonstochiometric compds. of primycins with ciclodextrin derivatives, pharmaceutical compns. contg. the said compds. and process for preparing them

Publications (1)

Publication Number Publication Date
AR023625A1 true AR023625A1 (en) 2002-09-04

Family

ID=89993853

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101304A AR023625A1 (en) 1996-04-02 1997-04-02 NON-ESTEQUIOMETRIC COMPOUNDS FORMED BETWEEN PRIMICINE AND CYCLODEXTRINE

Country Status (4)

Country Link
AR (1) AR023625A1 (en)
AU (1) AU2173297A (en)
HU (1) HUP9600847A3 (en)
WO (1) WO1997036935A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030599A1 (en) * 1998-11-23 2000-06-02 The Procter & Gamble Company Skin deodorizing and sanitizing compositions
PE20020300A1 (en) 2000-08-22 2002-05-10 Pharmacia Corp COMPOSITION OF SOLUTION OF AN ANTIBIOTIC DRUG BASED ON OXAZOLIDINONE WITH IMPROVEMENT OF DRUG LOAD
EP1893174A2 (en) * 2005-05-10 2008-03-05 Cytophil, Inc. Injectable hydrogels and methods of making and using same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196822B (en) * 1984-07-03 1989-01-30 Chinoin Gyogyszer Es Vegyeszet Process for producing primicin salts

Also Published As

Publication number Publication date
HUP9600847A2 (en) 1998-01-28
HUP9600847A3 (en) 1999-08-30
WO1997036935A1 (en) 1997-10-09
AU2173297A (en) 1997-10-22
HU9600847D0 (en) 1996-05-28

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