AR023271A1 - POLYMER CONJUGATE ABLE TO INHIBIT ONE OR MORE PROTEOLITICAL ENZYMES - Google Patents
POLYMER CONJUGATE ABLE TO INHIBIT ONE OR MORE PROTEOLITICAL ENZYMESInfo
- Publication number
- AR023271A1 AR023271A1 ARP000104756A ARP000104756A AR023271A1 AR 023271 A1 AR023271 A1 AR 023271A1 AR P000104756 A ARP000104756 A AR P000104756A AR P000104756 A ARP000104756 A AR P000104756A AR 023271 A1 AR023271 A1 AR 023271A1
- Authority
- AR
- Argentina
- Prior art keywords
- enzymes
- proteolitical
- inhibit
- polymeric
- polymer conjugate
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 241000264877 Hippospongia communis Species 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 206010040880 Skin irritation Diseases 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 230000002175 menstrual effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 abstract 1
- 230000036556 skin irritation Effects 0.000 abstract 1
- 231100000475 skin irritation Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Conjugados poliméricos apropiados para el uso en la prevencion de la irritacion cutánea que se produce por la exposicion de la piel a los fluidoscorporales, inter alia, el fluido menstrual. Conjugados poliméricos que tienen la formula (1), en donde Tes una unidad heterocíclica que es capaz de inhibiruna o más enzimas proteolíticas; L es un grupo de enlace; [Poli] es una unidad polimérica, i representa el numero de dichas unidades heterocíclicas quecomprenden el conjugado y tiene un valor desde1 hasta 100; z es 0 o 1, en donde los conjugados poliméricos. Campo de aplicacion: Panales, rellenos, toallassanitarias y artículos similares.Polymeric conjugates suitable for use in the prevention of skin irritation caused by exposure of the skin to body fluids, inter alia, menstrual fluid. Polymeric conjugates having the formula (1), wherein Tes a heterocyclic unit that is capable of inhibiting one or more proteolytic enzymes; L is a linking group; [Poly] is a polymeric unit, i represents the number of said heterocyclic units that comprise the conjugate and has a value from 1 to 100; z is 0 or 1, where the polymer conjugates. Field of application: Honeycombs, fillings, health class and similar items.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15341899P | 1999-09-10 | 1999-09-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR023271A1 true AR023271A1 (en) | 2002-09-04 |
Family
ID=22547144
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000104756A AR023271A1 (en) | 1999-09-10 | 2000-09-11 | POLYMER CONJUGATE ABLE TO INHIBIT ONE OR MORE PROTEOLITICAL ENZYMES |
ARP000104757A AR022655A1 (en) | 1999-09-10 | 2000-09-11 | COMPOSITIONS TO INHIBIT ENZYMES, APPLICABLE TO HUMAN SKIN AND TO PREVENT SKIN IRRITATION AND METHOD TO PREVENT SKIN IRRITATION. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000104757A AR022655A1 (en) | 1999-09-10 | 2000-09-11 | COMPOSITIONS TO INHIBIT ENZYMES, APPLICABLE TO HUMAN SKIN AND TO PREVENT SKIN IRRITATION AND METHOD TO PREVENT SKIN IRRITATION. |
Country Status (9)
Country | Link |
---|---|
US (1) | US6541629B1 (en) |
EP (2) | EP1438073B1 (en) |
JP (1) | JP5020451B2 (en) |
AR (2) | AR023271A1 (en) |
AT (2) | ATE309824T1 (en) |
AU (2) | AU7125700A (en) |
DE (2) | DE60044827D1 (en) |
PE (2) | PE20010586A1 (en) |
WO (2) | WO2001017564A2 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6803496B2 (en) * | 1997-09-10 | 2004-10-12 | The Procter & Gamble Company | Method for maintaining or improving skin health |
US8907154B2 (en) | 2001-10-01 | 2014-12-09 | The Procter & Gamble Company | Sanitary napkins with hydrophobic lotions |
US8795716B2 (en) | 2001-10-01 | 2014-08-05 | The Procter & Gamble Company | Skin care compositions on a thin sanitary napkin |
US9035123B2 (en) | 2002-10-01 | 2015-05-19 | The Procter & Gamble Company | Absorbent article having a lotioned topsheet |
US7285570B2 (en) | 2003-04-17 | 2007-10-23 | The Procter & Gamble Company | Compositions and methods for regulating mammalian keratinous tissue |
ES2341545T3 (en) * | 2003-06-06 | 2010-06-22 | Arexis Ab | USE OF CONDENSED HETEROCICLICAL COMPOUNDS AS SCCE INHIBITORS FOR THE TREATMENT OF SKIN DISEASES. |
US7384113B2 (en) * | 2004-04-19 | 2008-06-10 | Hewlett-Packard Development Company, L.P. | Fluid ejection device with address generator |
US7642397B2 (en) * | 2004-08-10 | 2010-01-05 | Kimberly-Clark Worldwide, Inc. | Absorbent articles comprising a bodily exudate modifying agent and a skin care formulation |
US7265257B2 (en) * | 2004-08-10 | 2007-09-04 | Kimberly-Clark Worldwide, Inc. | Absorbent articles comprising a bodily exudate modifying agent and a film-forming skin care formulation |
CA2715577A1 (en) * | 2008-02-15 | 2009-08-20 | The Proctor & Gamble Company | Absorbent article with lotion comprising a polypropylene glycol material |
EP2889306B1 (en) * | 2012-08-24 | 2018-09-19 | Ajinomoto Co., Inc. | Acyl dipeptide derivative |
JP7404031B2 (en) | 2019-10-29 | 2023-12-25 | 日本航空電子工業株式会社 | antenna |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2211469A1 (en) | 1972-12-21 | 1974-07-19 | Air Liquide | Enzyme purification, esp. ribonuclease, and (chymo) trypsin - by treatment with specific polyinhibitors and extraction or pptn of the complex formed |
DE2433883C2 (en) * | 1973-07-20 | 1986-03-27 | Research Corp., New York, N.Y. | Use of physiologically active polypeptides |
FR2252351A2 (en) | 1973-11-28 | 1975-06-20 | Air Liquide | Isolation of enzymes by selective extraction - partition of polyinhibitor-enzyme complex between water and polyethylene glycol |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US5162307A (en) | 1988-09-09 | 1992-11-10 | Board Of Trustees Of The University Of Kentucky | Polymer bound elastase inhibitors |
FR2651125B1 (en) * | 1989-08-23 | 1992-10-02 | Roussel Uclaf | PHARMACEUTICAL COMPOSITIONS OF THE "WATER PASTE" TYPE. |
EP0452179B1 (en) | 1990-03-28 | 1996-06-12 | Nippon Oil And Fats Company, Limited | Polymer-combined drug for gastric treatment and a method for producing the drug |
JPH04182423A (en) * | 1990-11-16 | 1992-06-30 | Shiseido Co Ltd | Cleaning and wiping agent composition |
US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
DE4342154A1 (en) | 1993-12-10 | 1995-06-14 | Behringwerke Ag | Amidinophenylalanine derivatives, process for their preparation, their use and agents containing them as anticoagulants |
JP3945544B2 (en) * | 1995-12-27 | 2007-07-18 | ピジョン株式会社 | Method for producing soybean extract |
EP0954572A1 (en) * | 1997-01-10 | 1999-11-10 | Novo Nordisk A/S | Enzyme coupled with polymeric molecules for skin care |
US5965119A (en) * | 1997-12-30 | 1999-10-12 | Enzon, Inc. | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents |
US6267952B1 (en) * | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
CA2322503A1 (en) * | 1998-03-12 | 1999-09-16 | Donald Carroll Roe | Disposable absorbent article having a skin care composition containing an enzyme inhibitor |
US6066673A (en) * | 1998-03-12 | 2000-05-23 | The Procter & Gamble Company | Enzyme inhibitors |
EP1061963B1 (en) * | 1998-03-12 | 2003-05-07 | The Procter & Gamble Company | Protease inhibitors in absorbent articles |
CA2358463A1 (en) | 1999-01-08 | 2000-07-13 | Virginia Commonwealth University | Polymeric delivery agents and delivery agent compounds |
JP2003508480A (en) * | 1999-09-10 | 2003-03-04 | ザ、プロクター、エンド、ギャンブル、カンパニー | Enzyme inhibitors |
WO2001018181A2 (en) * | 1999-09-10 | 2001-03-15 | The Procter & Gamble Company | Enzyme inhibitors |
-
2000
- 2000-09-08 PE PE2000000928A patent/PE20010586A1/en not_active Application Discontinuation
- 2000-09-08 AT AT00960035T patent/ATE309824T1/en not_active IP Right Cessation
- 2000-09-08 JP JP2001521353A patent/JP5020451B2/en not_active Expired - Fee Related
- 2000-09-08 PE PE2000000929A patent/PE20010587A1/en not_active Application Discontinuation
- 2000-09-08 AT AT00960049T patent/ATE476998T1/en not_active IP Right Cessation
- 2000-09-08 US US09/657,963 patent/US6541629B1/en not_active Expired - Fee Related
- 2000-09-08 EP EP00960049A patent/EP1438073B1/en not_active Expired - Lifetime
- 2000-09-08 AU AU71257/00A patent/AU7125700A/en not_active Abandoned
- 2000-09-08 DE DE60044827T patent/DE60044827D1/en not_active Expired - Lifetime
- 2000-09-08 WO PCT/US2000/024653 patent/WO2001017564A2/en active IP Right Grant
- 2000-09-08 DE DE60024101T patent/DE60024101T2/en not_active Expired - Lifetime
- 2000-09-08 EP EP00960035A patent/EP1212097B1/en not_active Expired - Lifetime
- 2000-09-08 WO PCT/US2000/024712 patent/WO2001017565A2/en active Application Filing
- 2000-09-08 AU AU71269/00A patent/AU7126900A/en not_active Abandoned
- 2000-09-11 AR ARP000104756A patent/AR023271A1/en not_active Application Discontinuation
- 2000-09-11 AR ARP000104757A patent/AR022655A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE309824T1 (en) | 2005-12-15 |
EP1212097B1 (en) | 2005-11-16 |
AU7126900A (en) | 2001-04-10 |
DE60024101T2 (en) | 2006-07-27 |
JP5020451B2 (en) | 2012-09-05 |
EP1438073B1 (en) | 2010-08-11 |
WO2001017565A3 (en) | 2002-01-17 |
JP2003508498A (en) | 2003-03-04 |
WO2001017565A2 (en) | 2001-03-15 |
EP1438073A2 (en) | 2004-07-21 |
WO2001017564A2 (en) | 2001-03-15 |
EP1212097A2 (en) | 2002-06-12 |
PE20010586A1 (en) | 2001-06-23 |
DE60024101D1 (en) | 2005-12-22 |
WO2001017564A3 (en) | 2002-01-24 |
ATE476998T1 (en) | 2010-08-15 |
AU7125700A (en) | 2001-04-10 |
US6541629B1 (en) | 2003-04-01 |
DE60044827D1 (en) | 2010-09-23 |
AR022655A1 (en) | 2002-09-04 |
PE20010587A1 (en) | 2001-07-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |