AR017971A1 -
TRICYCLIC DERIVATIVES OF TRIAZOLBENZAZEPINAS, PROCEDURE TO PRODUCE THE SAME, PHARMACEUTICAL COMPOSITIONS FORMULATED WITH SUCH COMPOUNDS AND INTERMEDIARY COMPOUNDS OF APPLICATION IN SUCH PROCEDURE AND THE PEPARATION OF THE SAME.
- Google Patents
TRICYCLIC DERIVATIVES OF TRIAZOLBENZAZEPINAS, PROCEDURE TO PRODUCE THE SAME, PHARMACEUTICAL COMPOSITIONS FORMULATED WITH SUCH COMPOUNDS AND INTERMEDIARY COMPOUNDS OF APPLICATION IN SUCH PROCEDURE AND THE PEPARATION OF THE SAME.
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Application filed by Meiji Seika KaishafiledCriticalMeiji Seika Kaisha
Publication of AR017971A1publicationCriticalpatent/AR017971A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Nitrogen Condensed Heterocyclic Rings
(AREA)
Abstract
Se proveen derivados tricíclicos de triazolbenzazepina en forma de profármaco. Los compuestos conformes a la presente invencion son aquéllosrepresentados por la formula (I) y sales y solvatos farmacologicamente aceptables de los mismos. Loscompuesto s son utiles como agentes antialérgicosy presentan una excelente biodisponibilidad, donde R1 representa hidrogeno, OH, alquilo o fenilalquilo; R2, R3, R4 y R5 representa hidrogeno,halogeno, hidroxilo opcionalmente protegido, formilo,alquilo opcional mente sustituido, alquenilo, alcoxi o similares, y Q presenta un grupo seleccionadoentre los grupos (i) a (iv), halogeno o alcoxi. También se proponen composicion farmacéuticas formuladas con dichos derivados y los objetosrestantesmencionados en el título de la solicitud.Tricyclic derivatives of triazolbenzazepine in the form of a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and have excellent bioavailability, where R 1 represents hydrogen, OH, alkyl or phenylalkyl; R2, R3, R4 and R5 represents hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, and Q has a group selected from groups (i) to (iv), halogen or alkoxy. Pharmaceutical compositions formulated with such derivatives and the objects listed in the application title are also proposed.
ARP9901000891998-03-041999-01-11
TRICYCLIC DERIVATIVES OF TRIAZOLBENZAZEPINAS, PROCEDURE TO PRODUCE THE SAME, PHARMACEUTICAL COMPOSITIONS FORMULATED WITH SUCH COMPOUNDS AND INTERMEDIARY COMPOUNDS OF APPLICATION IN SUCH PROCEDURE AND THE PEPARATION OF THE SAME.
AR017971A1
(en)
TRICYCLIC DERIVATIVES OF TRIAZOLBENZAZEPINAS, PROCEDURE TO PRODUCE THE SAME, PHARMACEUTICAL COMPOSITIONS FORMULATED WITH SUCH COMPOUNDS AND INTERMEDIARY COMPOUNDS OF APPLICATION IN SUCH PROCEDURE AND THE PEPARATION OF THE SAME.
NON-PEPTIDIC INHIBITING COMPOUNDS OF THE VLA-4 DEPENDENT CELL UNION IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE AND RESPIRATORY DISEASES; PHARMACEUTICAL COMPOSITION AND TREATMENT PROCEDURE
A COMPOUND, WHICH IS A DERIVATIVE OF BENZOHETEROCICLICO DISTAMICINA, ITS USE, A PROCEDURE TO PRODUCE IT AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT
PIPERIDINE COMPOUNDS, A PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS, AND THE USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR USE AS CCR-3 INHIBITORS
ANTI-TUMOR AND ANTIVIRAL RENTAL AGENTS, PROCEDURE FOR THEIR PREPARATION, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH AGENTS.
TRICYCLIC DERIVATIVES OF TRIAZOLBENZAZEPINAS, PROCEDURE TO PRODUCE THE SAME, PHARMACEUTICAL COMPOSITIONS FORMULATED WITH SUCH COMPOUNDS AND INTERMEDIARY COMPOUNDS OF APPLICATION IN SUCH PROCEDURE AND THE PEPARATION OF THE SAME.
DERIVATIVES OF BETA-ALANINA, USEFUL AS RECEIVER ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE USE OF THEM FOR THE PREPARATION OF MEDICINES