AR016264A1 - Construccion de adn que altera la expresion de un gen endogeno de ifna2 en celulas de mamifero al integrarse al genoma de la celula por medio derecombinacion homologa, celula homologamente recombinante, metodo para alterar la expresion del gen endogeno de ifn2 en una celula de mamifero, uso dedicha - Google Patents
Construccion de adn que altera la expresion de un gen endogeno de ifna2 en celulas de mamifero al integrarse al genoma de la celula por medio derecombinacion homologa, celula homologamente recombinante, metodo para alterar la expresion del gen endogeno de ifn2 en una celula de mamifero, uso dedichaInfo
- Publication number
- AR016264A1 AR016264A1 ARP990102133A ARP990102133A AR016264A1 AR 016264 A1 AR016264 A1 AR 016264A1 AR P990102133 A ARP990102133 A AR P990102133A AR P990102133 A ARP990102133 A AR P990102133A AR 016264 A1 AR016264 A1 AR 016264A1
- Authority
- AR
- Argentina
- Prior art keywords
- cell
- expression
- gene
- endogeno
- ifna2
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Una construccion de ADN que altera la expresion de un gen endogeno de IFNA2 en células de mamífero al integrarse al genoma de la célula por mediode recombinacion homologa; que comprende: (i) una secuencia objetivo que contiene al menos 20nucleotidos contiguos de una o más de SEQ ID NO.: 7, 8, 12, 16,17, 18 y 19; y (ii) una secuencia reguladora de la transcripcion; célula homologamente recombinante, método para alterar la expresion del gen endogenode IFNA2 en una célula de mamífero,uso de dicha célula para la manufactura de un medicamento, método para producir IFNA2 y molécula de ácido nucleicoaislado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8464898P | 1998-05-07 | 1998-05-07 | |
US8655598P | 1998-05-21 | 1998-05-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR016264A1 true AR016264A1 (es) | 2001-06-20 |
Family
ID=26771248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990102133A AR016264A1 (es) | 1998-05-07 | 1999-05-06 | Construccion de adn que altera la expresion de un gen endogeno de ifna2 en celulas de mamifero al integrarse al genoma de la celula por medio derecombinacion homologa, celula homologamente recombinante, metodo para alterar la expresion del gen endogeno de ifn2 en una celula de mamifero, uso dedicha |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1075531A1 (es) |
JP (1) | JP2002513580A (es) |
KR (1) | KR20010052278A (es) |
CN (1) | CN1309710A (es) |
AR (1) | AR016264A1 (es) |
AU (1) | AU3788899A (es) |
CA (1) | CA2328459A1 (es) |
CZ (1) | CZ299418B6 (es) |
HU (1) | HUP0102517A3 (es) |
IL (1) | IL139433A0 (es) |
NO (1) | NO20005585L (es) |
PL (1) | PL344517A1 (es) |
TR (1) | TR200003271T2 (es) |
WO (1) | WO1999057292A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1647501A (en) | 1999-12-10 | 2001-06-18 | Cytos Biotechnology Ag | Replicon based activation of endogenous genes |
FR2817559B1 (fr) * | 2000-12-06 | 2003-12-12 | Genodyssee | Procede de determination d'un ou plusieurs polymorphisme(s) fontionnel(s) dans la sequence nucleique d'un gene "candidat" fonctionnel preselectionne et ses applications |
US9085627B2 (en) * | 2011-04-13 | 2015-07-21 | National Research Council Of Canada | Expression system with SAR element from IFNα2 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5641670A (en) * | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
-
1999
- 1999-05-05 TR TR2000/03271T patent/TR200003271T2/xx unknown
- 1999-05-05 HU HU0102517A patent/HUP0102517A3/hu unknown
- 1999-05-05 PL PL99344517A patent/PL344517A1/xx not_active Application Discontinuation
- 1999-05-05 IL IL13943399A patent/IL139433A0/xx unknown
- 1999-05-05 CN CN99808195A patent/CN1309710A/zh active Pending
- 1999-05-05 EP EP99920375A patent/EP1075531A1/en not_active Withdrawn
- 1999-05-05 CZ CZ20003705A patent/CZ299418B6/cs not_active IP Right Cessation
- 1999-05-05 JP JP2000547246A patent/JP2002513580A/ja active Pending
- 1999-05-05 KR KR1020007012066A patent/KR20010052278A/ko not_active Application Discontinuation
- 1999-05-05 CA CA002328459A patent/CA2328459A1/en not_active Abandoned
- 1999-05-05 AU AU37888/99A patent/AU3788899A/en not_active Abandoned
- 1999-05-05 WO PCT/US1999/009925 patent/WO1999057292A1/en not_active Application Discontinuation
- 1999-05-06 AR ARP990102133A patent/AR016264A1/es not_active Application Discontinuation
-
2000
- 2000-11-06 NO NO20005585A patent/NO20005585L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU3788899A (en) | 1999-11-23 |
WO1999057292A9 (en) | 1999-12-16 |
NO20005585L (no) | 2001-01-05 |
EP1075531A1 (en) | 2001-02-14 |
JP2002513580A (ja) | 2002-05-14 |
PL344517A1 (en) | 2001-11-05 |
IL139433A0 (en) | 2001-11-25 |
HUP0102517A2 (hu) | 2001-11-28 |
CA2328459A1 (en) | 1999-11-11 |
CZ20003705A3 (cs) | 2001-04-11 |
HUP0102517A3 (en) | 2004-06-28 |
CN1309710A (zh) | 2001-08-22 |
CZ299418B6 (cs) | 2008-07-16 |
WO1999057292A1 (en) | 1999-11-11 |
NO20005585D0 (no) | 2000-11-06 |
TR200003271T2 (tr) | 2001-03-21 |
KR20010052278A (ko) | 2001-06-25 |
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