AR015035A1 - SEROTONERGIC AGENTS, PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT - Google Patents

SEROTONERGIC AGENTS, PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT

Info

Publication number
AR015035A1
AR015035A1 ARP990101974A ARP990101974A AR015035A1 AR 015035 A1 AR015035 A1 AR 015035A1 AR P990101974 A ARP990101974 A AR P990101974A AR P990101974 A ARP990101974 A AR P990101974A AR 015035 A1 AR015035 A1 AR 015035A1
Authority
AR
Argentina
Prior art keywords
manufacture
pharmaceutical composition
serotonergic agents
alkyl
medicinal product
Prior art date
Application number
ARP990101974A
Other languages
Spanish (es)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of AR015035A1 publication Critical patent/AR015035A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Agentes serotonérgicos representados por la formula general (1) en donde: R1 se selecciona entre H, OH, OR2, o halogeno (F, Cl, Br, I); R3 es alquiloinferior C1-6; (CH2)nAr; n es un numero entero seleccionado entre 0, 1 o 2; X es CH o CH2; R2 es H oen conjunto es O; Ar se selecciona entre fenilo, bencilo,piridinilo, pirimidinilo, pirazinilo, furilo, tienilo, pirrolilo, indolilo, naftilo, benzodioxanilo o quinililo, cada uno optativamente sustituido con entreuno a tres grupos seleccionados entreF, Cl, Br, I, -OH, -OR3, alquilo C1-6, alcoxi C1-6-CF3-CN, -S-alquilo C1-6 o NH2; o su sal farmacéuticamente aceptable,composiciones farmacéuticas que utilizan estos compuestos para la inhibicion de la absorcion de serotonina y el tratamiento de trstornos en el SNC,particularmente la depresion y suuso para la manufactura de un medicamento.Serotonergic agents represented by the general formula (1) wherein: R1 is selected from H, OH, OR2, or halogen (F, Cl, Br, I); R3 is C1-6 lower alkyl; (CH2) nAr; n is an integer selected from 0, 1 or 2; X is CH or CH2; R2 is H or together is O; Ar is selected from phenyl, benzyl, pyridinyl, pyrimidinyl, pyrazinyl, furyl, thienyl, pyrrolyl, indolyl, naphthyl, benzodioxanyl or quinylyl, each optionally substituted with three groups selected from F, Cl, Br, I, -OH, - OR3, C1-6 alkyl, C1-6-CF3-CN alkoxy, -S-C1-6 alkyl or NH2; or its pharmaceutically acceptable salt, pharmaceutical compositions that use these compounds for inhibition of serotonin absorption and treatment of CNS disorders, particularly depression and use for the manufacture of a medicament.

ARP990101974A 1998-04-29 1999-04-28 SEROTONERGIC AGENTS, PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AR015035A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6904198A 1998-04-29 1998-04-29

Publications (1)

Publication Number Publication Date
AR015035A1 true AR015035A1 (en) 2001-04-11

Family

ID=22086346

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101974A AR015035A1 (en) 1998-04-29 1999-04-28 SEROTONERGIC AGENTS, PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT

Country Status (7)

Country Link
EP (1) EP1076658A1 (en)
JP (1) JP2002513018A (en)
CN (1) CN1307576A (en)
AR (1) AR015035A1 (en)
AU (1) AU3765899A (en)
CA (1) CA2330577A1 (en)
WO (1) WO1999055697A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002048105A2 (en) * 2000-11-16 2002-06-20 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
CN1492863A (en) * 2000-12-22 2004-04-28 Heterocyclylalkylindole or azaindole compounds as 5-hydroxytryptamine-6 ligands
AR072297A1 (en) 2008-06-27 2010-08-18 Novartis Ag DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE.
UY36390A (en) 2014-11-05 2016-06-01 Flexus Biosciences Inc MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP2017538678A (en) 2014-11-05 2017-12-28 フレクサス・バイオサイエンシーズ・インコーポレイテッドＦｌｅｘｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． Immunomodulator

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271352B (en) * 1993-04-08 1997-05-27 Boehringer Ingelheim Italia INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM
DE19615232A1 (en) * 1996-04-18 1997-10-23 Merck Patent Gmbh New carbamoyl derivatives and their use as 5-HT ¶1¶¶A¶ antagonists
US5846982A (en) * 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake

Also Published As

Publication number Publication date
AU3765899A (en) 1999-11-16
JP2002513018A (en) 2002-05-08
EP1076658A1 (en) 2001-02-21
WO1999055697A1 (en) 1999-11-04
CA2330577A1 (en) 1999-11-04
CN1307576A (en) 2001-08-08

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