AR012723A1 - Derivados triptolidos utiles en el tratamiento de enfermedades autoinmunes y usos en la fabricacion de medicamentos - Google Patents

Derivados triptolidos utiles en el tratamiento de enfermedades autoinmunes y usos en la fabricacion de medicamentos

Info

Publication number
AR012723A1
AR012723A1 ARP980102327A ARP980102327A AR012723A1 AR 012723 A1 AR012723 A1 AR 012723A1 AR P980102327 A ARP980102327 A AR P980102327A AR P980102327 A ARP980102327 A AR P980102327A AR 012723 A1 AR012723 A1 AR 012723A1
Authority
AR
Argentina
Prior art keywords
medicines
manufacture
treatment
triptolid
autoimmune diseases
Prior art date
Application number
ARP980102327A
Other languages
English (en)
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of AR012723A1 publication Critical patent/AR012723A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Derivados triptolidos de formulas (I),donde X es I, Br, Cl, F o -CN; R1 y R2 son cada uno independientemente H o -OR5; R3 es H, -C(=O) (CH2)nCO2H o unaminoácido adecuado; R4 es H o -OH; R5 es H, -C(=O)(CH2)nCO2H o un aminoácido adecuado, y n es el numero entero 2, 3, 4, 5 o 6, y sus estereoisomeros,enantiomeros y sales farmacéuticamente aceptables, con la condicion de que R1 y R2 sean H cuando R3 sea distinto de H. Dichos derivados se usan en lafabricacion de medicamentos para tratamientode un paciente que sufre una enfermedad autoinmune, consistente en administrar a dicho paciente unacantidad efectiva de los derivados triptolidos definidos más arriba.
ARP980102327A 1997-05-23 1998-05-20 Derivados triptolidos utiles en el tratamiento de enfermedades autoinmunes y usos en la fabricacion de medicamentos AR012723A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86248897A 1997-05-23 1997-05-23

Publications (1)

Publication Number Publication Date
AR012723A1 true AR012723A1 (es) 2000-11-08

Family

ID=25338616

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980102327A AR012723A1 (es) 1997-05-23 1998-05-20 Derivados triptolidos utiles en el tratamiento de enfermedades autoinmunes y usos en la fabricacion de medicamentos

Country Status (21)

Country Link
EP (1) EP0983275B1 (es)
JP (1) JP2001525851A (es)
KR (1) KR20010012822A (es)
CN (1) CN1257507A (es)
AR (1) AR012723A1 (es)
AT (1) ATE222910T1 (es)
AU (1) AU741917B2 (es)
BR (1) BR9809678A (es)
CA (1) CA2287977A1 (es)
DE (1) DE69807466T2 (es)
DK (1) DK0983275T3 (es)
ES (1) ES2178207T3 (es)
HK (1) HK1026096A1 (es)
HU (1) HUP0003398A3 (es)
IL (1) IL133088A0 (es)
NO (1) NO995723L (es)
NZ (1) NZ500762A (es)
PT (1) PT983275E (es)
TW (1) TW434235B (es)
WO (1) WO1998052951A1 (es)
ZA (1) ZA984174B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329148B1 (en) 1999-02-16 2001-12-11 The Board Of Trustees Of The Leland Stanford University Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
CA2448795A1 (en) * 2001-03-15 2002-09-26 Pharmagenesis, Inc. Amino acid derivatives of triptolide compounds as immune modulators and anticancer agent
US7847109B2 (en) 2002-05-31 2010-12-07 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
CN100398544C (zh) * 2002-09-18 2008-07-02 成都达远药物有限公司 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
CN1726025A (zh) * 2002-12-17 2006-01-25 泛华医药公司 作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物
CN1223595C (zh) 2002-12-27 2005-10-19 中国科学院上海药物研究所 雷公藤内酯醇衍生物及其应用
US6943259B2 (en) * 2003-02-25 2005-09-13 Pharmagenesis, Inc. Halogenated triptolide derivatives as immunomodulators and anticancer agents
WO2005062913A2 (en) 2003-12-24 2005-07-14 Pharmagenesis, Inc. Triplide 5,6-derivatives as immunomodulators and anticancer agents
CN1917893A (zh) 2004-02-09 2007-02-21 美国泛华医药公司 从雷公藤多苷中分离雷公藤内酯醇化合物的方法
ATE554758T1 (de) 2004-03-02 2012-05-15 Pharmagenesis Inc Triptolid-lacton-ring-derivate als immunmodulatoren und mittel gegen krebs
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
WO2006044496A2 (en) 2004-10-13 2006-04-27 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
US8268882B2 (en) * 2009-02-05 2012-09-18 Pharmagenesis, Inc. Triptolide C-ring derivatives as anticancer agents and immune modulators
WO2017070878A1 (zh) 2015-10-29 2017-05-04 徐荣臻 C14-位羟基酯化的雷公藤甲素氨基酸衍生物、及其制备方法和应用
CN114716503B (zh) * 2022-03-23 2024-03-12 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一种雷公藤氯内酯醇的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005108A (en) * 1973-04-03 1977-01-25 Research Corporation Novel anti-leukemic diterpenoid triepoxides
US5430054A (en) * 1989-12-22 1995-07-04 Jiangsu Family Planning Institute Preparation methods of diterpene lactone compounds and application of the same to antifertility
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods

Also Published As

Publication number Publication date
JP2001525851A (ja) 2001-12-11
HUP0003398A2 (en) 2001-03-28
DK0983275T3 (da) 2002-12-23
DE69807466D1 (de) 2002-10-02
CA2287977A1 (en) 1998-11-26
ZA984174B (en) 1998-11-23
TW434235B (en) 2001-05-16
PT983275E (pt) 2003-01-31
BR9809678A (pt) 2000-07-11
HUP0003398A3 (en) 2001-09-28
NO995723L (no) 2000-01-21
CN1257507A (zh) 2000-06-21
IL133088A0 (en) 2001-03-19
KR20010012822A (ko) 2001-02-26
HK1026096A1 (en) 2000-12-01
NZ500762A (en) 2001-08-31
AU7260798A (en) 1998-12-11
WO1998052951A1 (en) 1998-11-26
DE69807466T2 (de) 2003-04-24
ES2178207T3 (es) 2002-12-16
NO995723D0 (no) 1999-11-22
ATE222910T1 (de) 2002-09-15
AU741917B2 (en) 2001-12-13
EP0983275A1 (en) 2000-03-08
EP0983275B1 (en) 2002-08-28

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