AR012092A1 - ARIL AND HETEROARIL CARBOXAMIDE DERIVED COMPOUNDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, AND THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. - Google Patents

ARIL AND HETEROARIL CARBOXAMIDE DERIVED COMPOUNDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, AND THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.

Info

Publication number
AR012092A1
AR012092A1 ARP980101199A ARP980101199A AR012092A1 AR 012092 A1 AR012092 A1 AR 012092A1 AR P980101199 A ARP980101199 A AR P980101199A AR P980101199 A ARP980101199 A AR P980101199A AR 012092 A1 AR012092 A1 AR 012092A1
Authority
AR
Argentina
Prior art keywords
4alkyl
alkyl
iodo
hydrogen
6alkyl
Prior art date
Application number
ARP980101199A
Other languages
Spanish (es)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9705619.6A external-priority patent/GB9705619D0/en
Priority claimed from GBGB9726695.1A external-priority patent/GB9726695D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AR012092A1 publication Critical patent/AR012092A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos derivados de aril y heteroaril carboxamida, que comprenden compuestos de formula (I) y sus sales farmacéuticamente aceptables; en la que Qes un anillo de arilo o heteroarilo monocíclico o bicíclico, R1 es hidrogeno, alquilo C1-6 (opcionalmente sustituido con hidroxi o alcoxi C1-4), alqueniloC1-6, alquinilo C1-6, alquilo C1-6-CO, formilo, CF3CO- o alquil C1-6-SO2-, R2 es hidrogeno o hasta tres substituyentes seleccionados entre halogeno, NO2, CN,N3, CF3O-, CF3S-, CF3CO-, trifluorometildiazirinilo, alquilo C1-6, alquenilo C1-6, alquinilo C1-6, perfluoroalquilo C1-6, cicloalquilo C3-6, cicloalquilC3-6-alquilo C1-4, alquil C1-6-o, alquil C1-6-CO-, cicloalquil C3-6-alquil -C1-4-O-, cicloalquil C3-6-alquil C1-4-CO-, acetoxi, fenilo, fenoxi, benciloxi,benzoílo, fenil-alquilo C1-4, alquilm C1-6-S-, alquil C1-6-SO2-, (alquil C1-4)2NSO2-, (alquil C1-4)NHSO2-, (alquilo C1-4)NCO-, (alquilC1-4)NHCO- o CNH2;O -NR3R4 en que R3 es hidrogeno o alquilo C1-4 y R4 es hidrogeno, alquilo C1-4, Formilo, -CO2-alquilo C1-4 o CO-alquilo C1-4; o dos grupos R2 forman en comunun anillo insaturado y sin sustituir o sustituido con -OH o = O; y X es hidrogeno, halogeno, alcoxi C1-6, alquilo C1-6, amino o trifluoroacetilamino;pero cuando x es hidrogeno, exclusive los compuestos en los cuales R2 es 2-alcoxi y cuando x es halogeno, exclusive los compuestos N-(7-yodo-2-metil-1, 2, 3, 4-tetrahidro-isoquinolin-5-il)-5-benzoil-2-metoxi-benzamida, N-(7-yodo-1, 2, 3, 4-tetrahidro-isoquinolin-5-il)-5-bezoil-2-metoxi-benzamida,N-(5-yodo-1, 2, 3, 4-tetrahidro-isoquinolin-7-il)-5-benzoil-2-metoxi-benzamida, N-(5-yodo-1, 2, 3, 4-tetrahidro-isoquinolin-7-il) -2-metoxi-4--trifluorometildiazirinil-benzamida,N-(5-yodo-1, 2, 3, 4-tetrahidro- isoquinolin-7-il)-2-metoxi-5-trifluorometildiazirinil-benzamida, N-(7-yodo-Compounds derived from aryl and heteroaryl carboxamide, comprising compounds of formula (I) and their pharmaceutically acceptable salts; wherein Q is a monocyclic or bicyclic aryl or heteroaryl ring, R1 is hydrogen, C1-6alkyl (optionally substituted with hydroxy or C1-4alkoxy), C1-6alkenyl, C1-6alkynyl, C1-6alkyl-CO, formyl, CF3CO- or C1-6-alkyl-SO2-, R2 is hydrogen or up to three substituents selected from halogen, NO2, CN, N3, CF3O-, CF3S-, CF3CO-, trifluoromethyldiazirinyl, C1-6 alkyl, C1-6 alkenyl , C1-6alkynyl, perfluoroC1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, C1-6alkyl-o, C1-6alkyl-CO-, C3-6cycloalkyl-C1-4alkyl -O-, C3-6-cycloalkyl-C1-4-alkyl-, acetoxy, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4-alkyl, C1-6-S-alkyl, C1-6-alkyl-SO2-, (C1-4alkyl) 2NSO2-, (C1-4alkyl) NHSO2-, (C1-4alkyl) NCO-, (C1-4alkyl) NHCO- or CNH2; O -NR3R4 where R3 is hydrogen or C1-4alkyl and R4 is hydrogen, C1-4alkyl, Formyl, -CO2-C1-4alkyl or CO-C1-4alkyl; or two R2 groups jointly form an unsaturated and unsubstituted or substituted with -OH or = O ring; and X is hydrogen, halogen, C1-6 alkoxy, C1-6 alkyl, amino or trifluoroacetylamino; but when x is hydrogen, exclusive the compounds in which R2 is 2-alkoxy and when x is halogen, exclusive the compounds N- ( 7-iodo-2-methyl-1, 2, 3, 4-tetrahydro-isoquinolin-5-yl) -5-benzoyl-2-methoxy-benzamide, N- (7-iodo-1, 2, 3, 4- tetrahydro-isoquinolin-5-yl) -5-bezoyl-2-methoxy-benzamide, N- (5-iodo-1,2,3,4-tetrahydro-isoquinolin-7-yl) -5-benzoyl-2-methoxy -benzamide, N- (5-iodo-1, 2, 3, 4-tetrahydro-isoquinolin-7-yl) -2-methoxy-4 - trifluoromethyldiazirinyl-benzamide, N- (5-iodo-1, 2, 3 , 4-tetrahydro-isoquinolin-7-yl) -2-methoxy-5-trifluoromethyldiazirinyl-benzamide, N- (7-iodo-

ARP980101199A 1997-03-18 1998-03-17 ARIL AND HETEROARIL CARBOXAMIDE DERIVED COMPOUNDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, AND THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. AR012092A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9705619.6A GB9705619D0 (en) 1997-03-18 1997-03-18 Novel compounds
GBGB9726695.1A GB9726695D0 (en) 1997-12-17 1997-12-17 Novel compounds

Publications (1)

Publication Number Publication Date
AR012092A1 true AR012092A1 (en) 2000-09-27

Family

ID=26311215

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980101199A AR012092A1 (en) 1997-03-18 1998-03-17 ARIL AND HETEROARIL CARBOXAMIDE DERIVED COMPOUNDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, AND THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.

Country Status (16)

Country Link
EP (1) EP0968190A1 (en)
JP (1) JP3690423B2 (en)
KR (1) KR100568654B1 (en)
CN (1) CN1183116C (en)
AR (1) AR012092A1 (en)
AU (1) AU737955B2 (en)
BR (1) BR9809047A (en)
CA (1) CA2284218A1 (en)
CO (1) CO4950553A1 (en)
IL (1) IL131756A0 (en)
NO (1) NO314081B1 (en)
NZ (1) NZ337424A (en)
PL (1) PL192116B1 (en)
TR (1) TR199902283T2 (en)
TW (1) TW555694B (en)
WO (1) WO1998041508A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9726695D0 (en) 1997-12-17 1998-02-18 Smithkline Beecham Plc Novel compounds
EP1025087A1 (en) * 1997-10-24 2000-08-09 Smithkline Beecham Plc Substituted isoquinoline derivatives and their use as anticonvulsants
GB9817424D0 (en) * 1998-08-11 1998-10-07 Smithkline Beecham Plc Novel compounds
JP2004517029A (en) * 1998-12-03 2004-06-10 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Topiramate and related derivatives for the treatment of schizophrenia
CA2373510A1 (en) * 1999-05-12 2000-11-23 Ortho-Mcneil Pharmaceutical, Inc. Pyrazole carboxamides useful for the treatment of obesity and other disorders
FR2795724B1 (en) * 1999-07-02 2002-12-13 Sanofi Synthelabo NOVEL BENZENE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9915589D0 (en) 1999-07-02 1999-09-01 Smithkline Beecham Plc Novel compounds
ES2316777T3 (en) * 2002-02-15 2009-04-16 Glaxo Group Limited VINYLLOID RECEIVERS MODULATORS.
GB0210762D0 (en) * 2002-05-10 2002-06-19 Glaxo Group Ltd Compounds
AU2003249534A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc 6,6-fused heteroaryl derivatives as matrix metalloproteinase inhibitors
GB0226724D0 (en) * 2002-11-15 2002-12-24 Merck Sharp & Dohme Therapeutic agents
KR20060027338A (en) 2003-06-12 2006-03-27 아스텔라스세이야쿠 가부시키가이샤 Benzamide derivative or salt thereof
BRPI0415167A (en) * 2003-10-07 2006-11-28 Renovis Inc amine compound as ion channel ligands and uses thereof
GB2413129A (en) * 2003-10-07 2005-10-19 Renovis Inc Aromatic amide compounds as ion channel ligands and uses thereof
JP2007518816A (en) * 2004-01-23 2007-07-12 アムジエン・インコーポレーテツド Vanilloid receptor ligands and their use in the treatment of inflammatory and neuropathic pain
JP2008513426A (en) * 2004-09-20 2008-05-01 バイオリポックス エービー Pyrazole compounds useful for the treatment of inflammation
SE0403117D0 (en) * 2004-12-21 2004-12-21 Astrazeneca Ab New compounds 1
JP2009545579A (en) 2006-08-01 2009-12-24 グラクソ グループ リミテッド Pyrazolo [3,4-B] pyridine compounds and their use as PDE4 inhibitors
CN106608901B (en) * 2015-10-22 2020-10-16 彭莉 Dihydroxydimethyltetrahydroisoquinoline-3-formyl-Lys (Lys-Ala), and synthesis, activity and application thereof
CN111138359A (en) * 2020-01-19 2020-05-12 浙江农林大学暨阳学院 Method for preparing 3-carbonyl-4-azido-N-benzenesulfonyl-1, 2,3, 4-tetrahydroisoquinoline compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022900A (en) * 1970-09-09 1977-05-10 Marion Laboratories, Inc. Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents
BR9709906A (en) * 1996-06-17 1999-08-10 Smithkline Beecham Plc Substituted benzamide derivatives and their use as anticonvulsants

Also Published As

Publication number Publication date
CN1255124A (en) 2000-05-31
NO314081B1 (en) 2003-01-27
JP2001515504A (en) 2001-09-18
TW555694B (en) 2003-10-01
EP0968190A1 (en) 2000-01-05
NZ337424A (en) 2001-08-31
CN1183116C (en) 2005-01-05
WO1998041508A1 (en) 1998-09-24
PL335676A1 (en) 2000-05-08
KR20000076342A (en) 2000-12-26
CA2284218A1 (en) 1998-09-24
KR100568654B1 (en) 2006-04-07
BR9809047A (en) 2000-08-01
TR199902283T2 (en) 1999-12-21
JP3690423B2 (en) 2005-08-31
IL131756A0 (en) 2001-03-19
CO4950553A1 (en) 2000-09-01
NO994510D0 (en) 1999-09-17
PL192116B1 (en) 2006-08-31
AU6412898A (en) 1998-10-12
NO994510L (en) 1999-09-17
AU737955B2 (en) 2001-09-06

Similar Documents

Publication Publication Date Title
AR012092A1 (en) ARIL AND HETEROARIL CARBOXAMIDE DERIVED COMPOUNDS, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, AND THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.
AR053232A1 (en) CONDENSED PIRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR EMPLOYMENT IN THE MANUFACTURE OF ANTI-INFLAMMATORY THERAPEUTIC AGENTS AND FOR THE TREATMENT OF DISEASES RELATED TO THE IMMUNOLOGICAL SYSTEM.
AR002746A1 (en) PIRIMIDINE-DERIVED COMPOUNDS CONDENSED WITH A HETERO-CYCLIC RING AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH COMPOUNDS.
AR018175A1 (en) COMPOUNDS OF INDOL-3-GLIOXYLAMIDES REPLACED, USEFUL AS ANTITUMURAL MEDICINES, PHARMACEUTICAL COMPOSITIONS FORMULATED WITH SUCH DERIVATIVES, USE OF SUCH DERIVATIVES FOR THE PREPARATION OF ANTITUMORAL MEDICINES AND PREPARED MEDICINES.
ATE29255T1 (en) SUCCINIMID DERIVATIVES AND THEIR PREPARATION.
CY1111093T1 (en) 2,4, DIF (OTHER-) ARYLAMINE (-OXY) -5-SUBSTITUTED PYRIMIDINES AS A NEEDLE
ES2623982T3 (en) HETEROCYCLIC COMPOUNDS OF CHEMIOKIN RECEPTOR UNION WITH POTENTIATED EFFECTIVENESS
BR9911182A (en) Compound, use of the same, process for the treatment of a mammal, including man, of conditions susceptible of improvement by an atypical beta-adrenoreceptor agonist, pharmaceutical composition, and, process for the preparation of a compound.
AR053987A1 (en) DERIVATIVES OF MALONAMIDE. PROCESS OF OBTAINING AND PHARMACEUTICAL COMPOSITIONS.
AR006360A1 (en) DERIVATIVES OF 1,2,3,4-TETRAHIDRONAFTALENO SUBSTITUTED, USE OF THE SAME FOR THE PREPARATION OF MEDICINES AND PROCEDURE FOR THE PREPARATION.
SE7704256L (en) NEW SUBSTITUTED FLUORACYLRESORCIN FOR MEDICINES, COSMETICS AND PESTICIDES AND PROCEDURES FOR THE MANUFACTURE
EA200200119A1 (en) β-CARBOLINE DRUGS
SE0101579D0 (en) New compounds
DE3853577D1 (en) Benzylidene-malononitrile derivatives for inhibiting proliferative processes in mammalian cells.
DK71780A (en) PROCEDURE FOR THE PREPARATION OF DIPHENYL HYDANTOIN DERIVATIVES
AR004970A1 (en) SALTS OF QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE SUCH SALTS AND PROCEDURES FOR PREPARING SUCH SALTS.
MX9204342A (en) INDOLES.
ATE56006T1 (en) SUCCINIMIDE DERIVATIVES, PREPARATION AND USE.
CO5160261A1 (en) SUBSTITUTED BIFENYL DERIVATIVES THAT ARE NK-1 ANTAGONISTS, THEIR SYNTHESIS PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU643290B2 (en) Derivatives of 2-aminoalkyl-5-arylalkyl-1,3-dioxanes, their preparation and their therapeutic application
HRP20010630B1 (en) 4-heterocyclysulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidine derivatives, their preparation and use as endothelin receptor antagonists
AR027454A1 (en) DERIVATIVES OF BETA-ALANINA, USEFUL AS RECEIVER ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE USE OF THEM FOR THE PREPARATION OF MEDICINES
AR029375A1 (en) CARBOXAMIDE DERIVATIVES, A PROCEDURE FOR THEIR PREPARATION, A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEMSELVES AND THE USE OF SUCH DERIVATIVE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
YU16196A (en) Use of new benyoquinoline-3- ona and theirs pharmaceutical acceptable salts for the manufakture of medicamene
AR029091A1 (en) USE OF COMPOUNDS OF 1-AMINO-5-PHENYLPENTANE-3-OL AND / OR 1-AMINO-6-PHENYLHEXAN-3-OL FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH ANTAGONIST EFFECT OF N-METHYL-D-ASPARTATE- (NMDA)

Legal Events

Date Code Title Description
FB Suspension of granting procedure