AR010771A1 - INHIBITOR OF THE COMPLEX ADP-RIBOSILTRANSFERASA, AGENT TO CURE AN INFECTIOUS DISEASE AND USE OF THE SAME. - Google Patents
INHIBITOR OF THE COMPLEX ADP-RIBOSILTRANSFERASA, AGENT TO CURE AN INFECTIOUS DISEASE AND USE OF THE SAME.Info
- Publication number
- AR010771A1 AR010771A1 ARP970105858A AR010771A1 AR 010771 A1 AR010771 A1 AR 010771A1 AR P970105858 A ARP970105858 A AR P970105858A AR 010771 A1 AR010771 A1 AR 010771A1
- Authority
- AR
- Argentina
- Prior art keywords
- adp
- complex
- cure
- agent
- caused
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un agente inhibidor del complejo ADP-ribosiltransferasa, un agente para curar las enfermedades infecciosas causadas por el Helicobacter pylori y unagente para curar las enfermedades infecciones causadas por bacterias del tipo endotoxinas envivo, que contienen, como ingrediente activo, un derivadocarboestirílico representado por la formula (I), [en la cual R es un átomo halogeno (un átomo de fluor, cloro, bromo o yodo); la cadena lateral de laformula (II) es sustituida en las posiciones 3- o 4- en el esqueleto carboestirílico; en tanto el enlace carbono-carbono entre las posiciones 3- y4- en el esqueleto carboestirílico es un enlace simple o doble], o una sal del mismo, preferentemente ácido 2-(4-clorobenzoilamino)-3-(2-quinolo-4-nil)propionico o una sal del mismo. El derivado carboestirílico inhibe la actividad del complejo ADP-ribosiltransferasa y es capaz de mejorar los diferentessíntomas patologicos causados por la reaccion de ribosilacion del ADP de lasproteínas. El derivado carboestirílico resulta de utilidad en la cura de lasenfermedades infecciosas causadas por el Helicobacter pylori, dado que es capaz de controlar la activacion de la citotoxina vacuolante a través de lainhibicion de laactividad del complejo ADP-ribosiltransferasa. Concretamente, el derivado carboestirílico mejora diversos síndromes patologicos, por ejemplo,la ulcera causada por el Helicobacter pylori.An inhibitor agent of the ADP-ribosyltransferase complex, an agent to cure infectious diseases caused by Helicobacter pylori and an agent to cure diseases infections caused by bacteria of the endotoxin type envivo, which contain, as an active ingredient, a carbarystyrilic derivative represented by the formula ( I), [in which R is a halogen atom (a fluorine, chlorine, bromine or iodine atom); the side chain of laformula (II) is substituted at positions 3- or 4- in the carbostyril skeleton; as long as the carbon-carbon bond between positions 3- and 4- in the carbostyril skeleton is a single or double bond], or a salt thereof, preferably 2- (4-chlorobenzoylamino) -3- (2-quinolo-4 acid -nil) propionic or a salt thereof. The carbostyril derivative inhibits the activity of the ADP-ribosyltransferase complex and is able to improve the different pathological symptoms caused by the ribosilation reaction of ADP of proteins. The carbostyril derivative is useful in the cure of infectious diseases caused by Helicobacter pylori, since it is capable of controlling the activation of the vacuolating cytotoxin through the inhibition of the activity of the ADP-ribosyltransferase complex. Specifically, the carbostyril derivative improves various pathological syndromes, for example, the ulcer caused by Helicobacter pylori.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33546296 | 1996-12-16 | ||
| JP9030140A JPH10231247A (en) | 1996-12-16 | 1997-02-14 | Therapeutic agent for in vivo toxin type bacterial infection |
| JP9030139A JPH10231246A (en) | 1996-12-16 | 1997-02-14 | Adp-ribosylation inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010771A1 true AR010771A1 (en) | 2000-07-12 |
Family
ID=27286848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105858 AR010771A1 (en) | 1996-12-16 | 1997-12-12 | INHIBITOR OF THE COMPLEX ADP-RIBOSILTRANSFERASA, AGENT TO CURE AN INFECTIOUS DISEASE AND USE OF THE SAME. |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR010771A1 (en) |
| AU (1) | AU5410998A (en) |
| WO (1) | WO1998026769A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100681360B1 (en) | 2003-07-30 | 2007-02-12 | 오츠카 세이야쿠 가부시키가이샤 | Carbostyril derivatives for accelerating salivation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2872546B2 (en) * | 1992-11-26 | 1999-03-17 | 大塚製薬株式会社 | Intestinal mucosal damage protective agent |
| AU8003194A (en) * | 1993-11-05 | 1995-05-23 | Otsuka Pharmaceutical Co., Ltd. | Bismuth salt of carbostyril derivatives for the treatment of peptic ulcers |
| JP3621463B2 (en) * | 1995-04-26 | 2005-02-16 | 大塚製薬株式会社 | Carbostyryl derivative bismuth salt |
-
1997
- 1997-12-12 AU AU54109/98A patent/AU5410998A/en not_active Abandoned
- 1997-12-12 AR ARP970105858 patent/AR010771A1/en unknown
- 1997-12-12 WO PCT/JP1997/004579 patent/WO1998026769A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| AU5410998A (en) | 1998-07-15 |
| WO1998026769A1 (en) | 1998-06-25 |
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