AR010205A1 - Un compuesto farmaceutico - Google Patents

Un compuesto farmaceutico

Info

Publication number
AR010205A1
AR010205A1 ARP960105722A ARP960105722A AR010205A1 AR 010205 A1 AR010205 A1 AR 010205A1 AR P960105722 A ARP960105722 A AR P960105722A AR P960105722 A ARP960105722 A AR P960105722A AR 010205 A1 AR010205 A1 AR 010205A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydrogen
alkoxy
optionally substituted
pharmaceutical compound
Prior art date
Application number
ARP960105722A
Other languages
English (en)
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of AR010205A1 publication Critical patent/AR010205A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, ***e
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Un compuesto farmacéutico de la formula (I), en donde R1 y R2 son cada uno hidrogeno, C1-4-alquilo, C1-4-alcoxi, HO-C1-4-alquilo, C1-4-alcoxi-C1-4-alquilo, C1-4-alquiltio, halo o PhCRR, en donde Ph es fenilo opcionalmente substituido y R yR son cada uno hidrogeno o C1-4-alquilo, o R1 y R2 juntocon el átomo de carbono al cual están unidos forman un grupo C3-6-cicloalquilo; R3, R4 y R5 son cada uno hidrogeno, halo, nitro, C1-4-alquilo, C1-4-alcoxi,C1-4-alquiltio, C1-4-alquil-CO-,C1-4-a lquil-S(O)m-, en donde m es 0, 1 o 2, R RN-SO2-, -COOR, -CONRR, -NRR, -N(OR)COOR, -COR, -NHSO2R, en dondeR y R son cada uno hidrogeno o C1-4-alquilo; R6 y R7 son cada uno hidrogeno o C1-4-alquilo, y n es 1 a 6; X es oxígeno o azufre; W esformula (I I) en dondep es 4 a 7 y q y r son cada uno 1 a 3; Y es >CO o -CH(OH)-; y Z es fenilo opcionalmente substituido o heteroarilo opcionalmente substituido; y salesy ésteres del mismo.
ARP960105722A 1995-12-19 1996-12-17 Un compuesto farmaceutico AR010205A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9525963A GB2308362A (en) 1995-12-19 1995-12-19 Pharmaceutical indole derivatives

Publications (1)

Publication Number Publication Date
AR010205A1 true AR010205A1 (es) 2000-06-07

Family

ID=10785702

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960105722A AR010205A1 (es) 1995-12-19 1996-12-17 Un compuesto farmaceutico

Country Status (27)

Country Link
US (1) US5773448A (es)
EP (1) EP0780388B1 (es)
JP (1) JPH09202784A (es)
KR (1) KR970042503A (es)
CN (1) CN1157822A (es)
AR (1) AR010205A1 (es)
AT (1) ATE204273T1 (es)
AU (1) AU720711B2 (es)
BR (1) BR9606066A (es)
CA (1) CA2193039C (es)
CZ (1) CZ372296A3 (es)
DE (1) DE69614491T2 (es)
DK (1) DK0780388T3 (es)
ES (1) ES2159693T3 (es)
GB (1) GB2308362A (es)
HU (1) HUP9603498A3 (es)
IL (1) IL119844A (es)
MX (1) MX9606531A (es)
NO (1) NO307512B1 (es)
NZ (1) NZ299959A (es)
PE (1) PE26198A1 (es)
PL (1) PL317526A1 (es)
PT (1) PT780388E (es)
SG (1) SG47206A1 (es)
TR (1) TR199601018A1 (es)
YU (1) YU67096A (es)
ZA (1) ZA9610589B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9810886D0 (en) * 1998-05-13 1998-07-22 Lilly Industries Ltd Pharmaceutical compounds
GB2362826A (en) * 2000-06-02 2001-12-05 Lilly Co Eli A pharmaceutical composition comprising a serotonin transport inhibitor and a serotonin recptor antagonist
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
CN106928122A (zh) * 2017-03-07 2017-07-07 贵州大学 3‑烷氧基季碳氧化吲哚及其制备方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411890A (en) * 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4035369A (en) * 1975-10-08 1977-07-12 Janssen Pharmaceutica N.V. 1-Benzazolylalkyl-4-substituted-piperidines
US4432978A (en) * 1979-07-30 1984-02-21 Pfizer Inc. Hexahydro-trans-pyridoindole
US4254127A (en) * 1980-04-03 1981-03-03 Janssen Pharmaceutica, N.V. 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives
FR2523964B1 (fr) * 1982-03-23 1985-09-27 Sanofi Sa Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation
IL69132A (en) * 1982-07-14 1986-02-28 Roussel Uclaf Benzo-and naphtho-thiopyranopyrimidinones,their preparation and pharmaceutical compositions containing them
US4658038A (en) * 1982-10-07 1987-04-14 Research Foundation For Mental Hygiene, Inc. N-acylated 5-hydroxytryptophan amide derivatives
US4608374A (en) * 1983-11-07 1986-08-26 Hoechst-Roussel Pharmaceuticals Inc. 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents
GB8332704D0 (en) * 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals
DE3563964D1 (en) * 1984-10-16 1988-09-01 Synthelabo Piperidine derivatives, their preparation and their therapeutical application
US4789676A (en) * 1986-03-05 1988-12-06 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives, usefull as anxiolytic agents
FR2634207B1 (fr) * 1988-07-12 1990-09-07 Synthelabo Derives de ((piperidinyl-4)methyl) benzazepines, leur preparation et leur application en therapeutique
EP0351283A1 (fr) * 1988-07-12 1990-01-17 Synthelabo Dérivés de [(pipéridinyl-4) méthyl]-2 dihydro-2,3 1H-isoindole et tétrahydro-2,3,4,5 1H-benzazépines, leur préparation et leur application en thérapeutique
FR2635524B1 (fr) * 1988-08-19 1992-04-24 Adir Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
TW203049B (es) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
FR2661177A1 (fr) * 1990-04-23 1991-10-25 Rhone Poulenc Sante Derives du naphtosultame antagonistes de la serotonine, leur preparation et les medicaments les contenant.
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
FR2679561A1 (fr) * 1991-07-26 1993-01-29 Schneider Marc Nouveaux derives de l'(indolyl-1) alkylamine substituee par une chaine presentant des groupements carbonyles conjugues a un noyau aromatique.
SE9103752D0 (sv) 1991-12-18 1991-12-18 Astra Ab New compounds
TW218875B (es) * 1992-03-09 1994-01-11 Takeda Pharm Industry Co Ltd
TW226019B (es) * 1992-03-23 1994-07-01 Sankyo Co
EP0572235A3 (en) * 1992-05-28 1994-06-01 Tanabe Seiyaku Co Beta-carboline derivatives with anticholecystoquinine activity
CA2147503A1 (en) * 1992-11-06 1994-05-26 Judith M. Pisano Substituted dipeptide analogs promote release of growth hormone
SK282166B6 (sk) * 1992-12-11 2001-11-06 Merck & Co., Inc. Spiropiperidínové deriváty, spôsob ich výroby a farmaceutický prostriedok s ich obsahom
US5578593A (en) * 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
NZ277486A (en) * 1993-12-23 1997-03-24 Novo Nordisk As Synthetic peptides with growth hormone releasing properties
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US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues

Also Published As

Publication number Publication date
IL119844A0 (en) 1997-03-18
GB9525963D0 (en) 1996-02-21
CA2193039A1 (en) 1997-06-20
US5773448A (en) 1998-06-30
DE69614491D1 (de) 2001-09-20
HU9603498D0 (en) 1997-02-28
SG47206A1 (en) 1998-03-20
HUP9603498A3 (en) 2001-04-28
KR970042503A (ko) 1997-07-24
CA2193039C (en) 2006-04-04
YU67096A (sh) 1999-03-04
ATE204273T1 (de) 2001-09-15
BR9606066A (pt) 1998-09-01
IL119844A (en) 2000-12-06
NO965448D0 (no) 1996-12-18
NZ299959A (en) 1998-09-24
GB2308362A (en) 1997-06-25
CZ372296A3 (en) 1997-08-13
PE26198A1 (es) 1998-05-27
PT780388E (pt) 2001-12-28
JPH09202784A (ja) 1997-08-05
EP0780388A1 (en) 1997-06-25
NO307512B1 (no) 2000-04-17
ES2159693T3 (es) 2001-10-16
MX9606531A (es) 1997-06-28
AU7546096A (en) 1997-06-26
DE69614491T2 (de) 2002-04-18
AU720711B2 (en) 2000-06-08
ZA9610589B (en) 1998-01-16
NO965448L (no) 1997-06-20
PL317526A1 (en) 1997-06-23
CN1157822A (zh) 1997-08-27
HUP9603498A2 (hu) 1998-09-28
TR199601018A1 (tr) 1997-07-21
EP0780388B1 (en) 2001-08-16
DK0780388T3 (da) 2001-10-08

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal