AR009987A1 - Derivados de beta-tiopropionilaminoacidos, composiciones farmaceuticas que incluyen dichos derivados, procedimiento para prepararlos, uso de dichosderivados para el tratamiento de infecciones bacterianas y compuestos intermediarios de aplicacion en dicho procedimiento - Google Patents
Derivados de beta-tiopropionilaminoacidos, composiciones farmaceuticas que incluyen dichos derivados, procedimiento para prepararlos, uso de dichosderivados para el tratamiento de infecciones bacterianas y compuestos intermediarios de aplicacion en dicho procedimientoInfo
- Publication number
- AR009987A1 AR009987A1 ARP970104739A ARP970104739A AR009987A1 AR 009987 A1 AR009987 A1 AR 009987A1 AR P970104739 A ARP970104739 A AR P970104739A AR P970104739 A ARP970104739 A AR P970104739A AR 009987 A1 AR009987 A1 AR 009987A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- alkyl
- hydrogen
- aryl
- beta
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 2
- -1 SUCH DERIVATIVES Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 238000001727 in vivo Methods 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000002132 β-lactam antibiotic Substances 0.000 abstract 1
- 229940124586 β-lactam antibiotics Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Derivados de Beta-mercapto aminoácidos y solvatos o ésteres hidrolizables in vivo farmacéuticamente aceptables de formula (I) en la que R es hidrogeno,un cation formador de sales, o un grupo formador de ésteres hidroliables in vivo; R1 es deformul a (II) donde A es un arilo monocíclico o un anilloheteroarílico, y B es un arilo monocíclico, un anillo alicíclico o heterocíclico, C y D son independientemente -Zp(CR8R9)q -O -(CR8R9)q-Zp, dondep es O o 1 , y q es 0 o 3 con lacondicion de que p+q en C no sea O, R8 y R9 son independientemente hidrogeno o alquilo (C18), o juntos representan oxo, yZ es O, NR10 o S(O), donde R10 es hidrogeno alquilo (C1-6), y x es 0-2 y donde C y D están unidos en posicion orto entre síen cada un o de los anillos A y Bde la formula (b); R2 es hidrogeno, alquilo (C1-6) o aril alquilo (C1-6) R3 es hidrogeno, alquilo (C1-6) opcionalmente sustituido con hasta tres átomos dehalogeno, cicloalquilo (C3-7), aril cicloalquilo (C3-7)condensado, ciclo alquil (C3-7) alquilo (C2-6) alquenilo (C2-6), alquinilo (C2-6), arilo, aril-(CH2)m-X-(CH2)N, heterociclilo o heterociclil-(CH2)m-X-(CH2)n, donde m es O a 3, n es 1 a 3, y X es O, S(O)x, donde x es 0-2 o un enlace; R4 eshidrogeno, o un grupoacilo hidrolizable in vivo y R5 y R6 son independientemente hidrogeno y alquilo (C1-6) o juntos representan (CH2), donde r es 2 a 5 sales, solvatos, esteres.Util en el tratamiento de infecciones bacterianas en los seres humanoso animales, mediante la administracion junto con un antibiotico beta-lactama.También se porpone la síntesis de dichos derivados y demás objetos adelantados en el título.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9621692.4A GB9621692D0 (en) | 1996-10-17 | 1996-10-17 | Compounds |
| GBGB9704581.9A GB9704581D0 (en) | 1997-03-05 | 1997-03-05 | Compounds |
| GBGB9716212.7A GB9716212D0 (en) | 1997-07-31 | 1997-07-31 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009987A1 true AR009987A1 (es) | 2000-05-17 |
Family
ID=27268530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970104739A AR009987A1 (es) | 1996-10-17 | 1997-10-15 | Derivados de beta-tiopropionilaminoacidos, composiciones farmaceuticas que incluyen dichos derivados, procedimiento para prepararlos, uso de dichosderivados para el tratamiento de infecciones bacterianas y compuestos intermediarios de aplicacion en dicho procedimiento |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6156774A (es) |
| EP (1) | EP0934262A1 (es) |
| JP (1) | JP2001502345A (es) |
| AR (1) | AR009987A1 (es) |
| AU (1) | AU5050198A (es) |
| CA (1) | CA2268930A1 (es) |
| WO (1) | WO1998017639A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9811159D0 (en) * | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
| US6630510B1 (en) | 1999-10-28 | 2003-10-07 | Merck & Co., Inc. | Substituted succinic acid metallo-β-lactamase inhibitors and their use in treating bacterial infections |
| FR2844807B1 (fr) * | 2002-09-23 | 2005-11-11 | Rambach Alain | Procede de detection de microorganismes resistants a la meticilline |
| AU2003295782A1 (en) * | 2002-11-22 | 2004-06-18 | Bristol-Myers Squibb Company | Pyridinyl, pyrimidinyl and pyrazinyl amides as potassium channel openers |
| CN101267815B (zh) | 2005-09-22 | 2013-11-06 | 明治制果药业株式会社 | 金属-β-内酰胺酶抑制剂 |
| GB201317619D0 (en) | 2013-10-04 | 2013-11-20 | Uni I Oslo | Compounds |
| GB201613946D0 (en) | 2016-08-15 | 2016-09-28 | Univ Oslo | Compounds |
| WO2020117366A2 (en) * | 2018-10-11 | 2020-06-11 | Paquette Craig Michael | Renewable bio-based non-toxic aromatic-furanic monomers for use in thermosetting and thermoplastic polymers |
| CN114605375B (zh) * | 2020-12-09 | 2023-04-11 | 沈阳化工研究院有限公司 | 一种2-噻吩乙酸的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2323680A1 (fr) * | 1975-09-12 | 1977-04-08 | Nobel Hoechst Chimie | Procede de fabrication de derives n-acyles d'hydroxyarylglycines et produits nouveaux en resultant |
| WO1997030027A1 (en) * | 1996-02-13 | 1997-08-21 | Smithkline Beecham Plc | Beta-thiopropionyl-aminoacid derivatives and their use as beta-lactamase inhibitors |
-
1997
- 1997-10-10 US US09/284,098 patent/US6156774A/en not_active Expired - Fee Related
- 1997-10-10 AU AU50501/98A patent/AU5050198A/en not_active Abandoned
- 1997-10-10 CA CA002268930A patent/CA2268930A1/en not_active Abandoned
- 1997-10-10 EP EP97913147A patent/EP0934262A1/en not_active Withdrawn
- 1997-10-10 WO PCT/EP1997/005709 patent/WO1998017639A1/en not_active Application Discontinuation
- 1997-10-10 JP JP10518931A patent/JP2001502345A/ja active Pending
- 1997-10-15 AR ARP970104739A patent/AR009987A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998017639A1 (en) | 1998-04-30 |
| AU5050198A (en) | 1998-05-15 |
| JP2001502345A (ja) | 2001-02-20 |
| US6156774A (en) | 2000-12-05 |
| CA2268930A1 (en) | 1998-04-30 |
| EP0934262A1 (en) | 1999-08-11 |
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