AR009293A1 - QUATERNARY AMMONIUM COMPOSITE C3-C7 CYCLLOALKYL SUBSTITUTED, COMPOSITIONS CONTAINING THEM, USE OF THE SAME FOR THE MANUFACTURE OF MEDICINAL PRODUCTS, PROCEDURE FOR THE PREPARATION - Google Patents

Abstract

Un compuesto de amonio cuaternario C3-C7 cicloalquil sustituido, segun formula (I), en la que R es fenilo, cicloalquilo C3-C7 o heteroarilo, estandocada uno de ellos opcionalmente condensado con benceno o con cicloalquilo C3-C7 y opcionalmentes ustituidos, incluyendo la parte condensada con benceno o concicloalquilo C3-C7, con 1 a 3 sustituyentes seleccionados cada uno, independientemente, entre alquilo C1-C4, fluoroalquilo (C1-C4), alcoxi C1-C4,fluoroalcoxi(C1-C4), alcanoíloC2 -C4, halo, alcoxicarbonilo C1-C4, cicloalquilo C3-C7, -S(O)p(alquilo C1-C4), ciano, -NR7R8, -S(O)pNR7R8, -NR7(alcanoílo C1-C4) y -CONR7R8, o R es 2,3-dihidrobenzo[b]furanilo o cromanilo; R1 y R2 se seleccionan cada uno,independienteme nte, entre H y alquilo C1-C6 o,cuando se toman conjuntamente, son alquileno C2-C6; R3 y R4 se seleccionan cada uno, independientemente, entre H y alquilo C1-C6, cuando se tomanconjuntamente, son alquileno C1-C4 no ramificado; R5es fenilo, nafti lo, bencilo, tienilo, benzo[b]tienilo o indolilo, estando cada uno opcionalmentesustituido con 1 a 3 sustituyentes seleccionados cada uno, independientemente entre alquilo C1-C4, fluoroalquilo(C1-C4), alcoxi C1-C4, halo yciano, o R5 es1,3-b enzodioxolan-4 o 5-ilo o 1,4-benzodioxan-5 o 6-ilo; R6 es cicloalquilo C3-C7 opcionalmente sustituido con 1 a 3 sustituyentes seleccionados cada uno,independientemente, entre alquilo C1-C4, alcoxi C1-C4, halo, ciano, fluoroalquilo (C1 -C4) y fluoroalcoxi(C1-C4); R7 y R8 se seleccionan cada uno,independientemente, entre H y alquilo C1-C4 o, cuando se toman conjuntamente, son alquileno C4-C6; T es carbonilo; Y es alquileno C2-C4 no ramificado; Za esun anionfarmacéuticamente acept able; m es 0 o 1; n es 1 o 2; p es 0, 1 o 2; y heteroarilo, usado en la definicion de R, significa tienilo o un grupoA substituted C3-C7 cycloalkyl quaternary ammonium compound, according to formula (I), in which R is phenyl, C3-C7 cycloalkyl or heteroaryl, each being optionally fused with benzene or with C3-C7 cycloalkyl and optionally substituted, including the condensed part with benzene or C3-C7 cycloalkyl, with 1 to 3 substituents each independently selected from C1-C4 alkyl, fluoro (C1-C4) alkyl, C1-C4 alkoxy, fluoro (C1-C4) alkoxy, C2-C4 alkanoyl , halo, C1-C4 alkoxycarbonyl, C3-C7 cycloalkyl, -S (O) p (C1-C4 alkyl), cyano, -NR7R8, -S (O) pNR7R8, -NR7 (C1-C4 alkanoyl) and -CONR7R8, or R is 2,3-dihydrobenzo [b] furanyl or chromanyl; R1 and R2 are each independently selected from H and C1-C6 alkyl or, when taken together, are C2-C6 alkylene; R3 and R4 are each independently selected from H and C1-C6 alkyl, when taken together, are unbranched C1-C4 alkylene; R5 is phenyl, naphthyl, benzyl, thienyl, benzo [b] thienyl, or indolyl, each optionally being substituted with 1 to 3 substituents each independently selected from C1-C4 alkyl, (C1-C4) fluoroalkyl, C1-C4 alkoxy, halo ycian, or R5 is 1,3-b-enzyme-dioxolan-4 or 5-yl or 1,4-benzodioxan-5 or 6-yl; R6 is C3-C7 cycloalkyl optionally substituted with 1 to 3 substituents each independently selected from C1-C4 alkyl, C1-C4 alkoxy, halo, cyano, fluoroalkyl (C1-C4) and fluoroalkoxy (C1-C4); R7 and R8 are each independently selected from H and C1-C4 alkyl or, when taken together, are C4-C6 alkylene; T is carbonyl; Y is unbranched C2-C4 alkylene; Za is an anionpharmaceutically acceptable; m is 0 or 1; n is 1 or 2; p is 0, 1 or 2; and heteroaryl, used in the definition of R, means thienyl or a group