AR007020A1 - TREATMENT OF ASTHMA WITH TNFR-IG - Google Patents
TREATMENT OF ASTHMA WITH TNFR-IGInfo
- Publication number
- AR007020A1 AR007020A1 ARP970101876A ARP970101876A AR007020A1 AR 007020 A1 AR007020 A1 AR 007020A1 AR P970101876 A ARP970101876 A AR P970101876A AR P970101876 A ARP970101876 A AR P970101876A AR 007020 A1 AR007020 A1 AR 007020A1
- Authority
- AR
- Argentina
- Prior art keywords
- asthma
- treatment
- tnf
- tnfr
- alpha binding
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se refiere a un método para combatir el asma con una composición que contiene una cantidad eficaz de una proteína quimérica de unión a TNF-alfaque incluye la porción soluble del receptor de TNF p55 y todos los dominios excepto elprime r dominio de la región constante de la cadena pesada de la IgG1o IgG3 humanas, y al uso de dicha proteína quimérica de unión a TNF-alfa para la preparación de un medicamento para el tratamiento del asma.Refers to a method of fighting asthma with a composition containing an effective amount of a chimeric TNF-alpha binding protein that includes the soluble portion of the TNF receptor p55 and all domains except the first domain of the constant region of the heavy chain of human IgG1 or IgG3, and the use of said TNF-alpha binding chimeric protein for the preparation of a medicament for the treatment of asthma.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1684296P | 1996-05-08 | 1996-05-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR007020A1 true AR007020A1 (en) | 1999-10-13 |
Family
ID=21779275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970101876A AR007020A1 (en) | 1996-05-08 | 1997-05-06 | TREATMENT OF ASTHMA WITH TNFR-IG |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0910413A2 (en) |
JP (1) | JP2000510113A (en) |
KR (1) | KR20000010825A (en) |
CN (1) | CN1233189A (en) |
AR (1) | AR007020A1 (en) |
AU (1) | AU725408B2 (en) |
BR (1) | BR9708928A (en) |
CA (1) | CA2253557A1 (en) |
CO (1) | CO4820397A1 (en) |
HR (1) | HRP970224A2 (en) |
MA (1) | MA24169A1 (en) |
PE (1) | PE70698A1 (en) |
TR (1) | TR199802238T2 (en) |
WO (1) | WO1997041895A2 (en) |
ZA (1) | ZA973843B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002508934A (en) * | 1997-12-29 | 2002-03-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Novel nucleic acids and polypeptides having homology to the TNF receptor |
TR200504220T2 (en) | 1998-12-17 | 2007-04-24 | Biogen Idec Ma Inc. | Active lymphotoxin-beta receptor immunoglobulin chime A method for high level expression and purification of purified protein proteins and a method for purification of active lymphotoxin-beta receptor immunoglobulin chimeric proteins. |
US20010021380A1 (en) * | 1999-04-19 | 2001-09-13 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
US20040220103A1 (en) | 1999-04-19 | 2004-11-04 | Immunex Corporation | Soluble tumor necrosis factor receptor treatment of medical disorders |
RS51041B (en) * | 2003-02-28 | 2010-10-31 | Ares Trading S.A. | Liquid formulations of tumor necrosis factor-binding protein tbp-1 |
US7335491B2 (en) * | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
SG154441A1 (en) | 2006-10-20 | 2009-08-28 | Biogen Idec Inc | Treatment of demyelinating disorders |
US8338376B2 (en) | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0417563B1 (en) * | 1989-09-12 | 2000-07-05 | F. Hoffmann-La Roche Ag | TNF-binding proteins |
WO1994006476A1 (en) * | 1992-09-15 | 1994-03-31 | Immunex Corporation | Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists |
US5684222A (en) * | 1993-01-22 | 1997-11-04 | Ontario Cancer Institute | Mutant mouse having a disrupted TNFRp55 |
CA2119089A1 (en) * | 1993-03-29 | 1994-09-30 | David Banner | Tumor necrosis factor muteins |
EP0772449A1 (en) * | 1994-07-22 | 1997-05-14 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions comprising a chimaeric tnf binding protein |
US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
IL116436A (en) * | 1995-12-18 | 2006-12-31 | Yissum Res Dev Co | Fc?Á-PE CHIMERIC PROTEIN FOR TARGETED TREATMENT OF ALLERGY RESPONSES AND |
-
1997
- 1997-05-02 AU AU27764/97A patent/AU725408B2/en not_active Ceased
- 1997-05-02 CA CA002253557A patent/CA2253557A1/en not_active Abandoned
- 1997-05-02 HR HR60/016,842A patent/HRP970224A2/en not_active Application Discontinuation
- 1997-05-02 MA MA24590A patent/MA24169A1/en unknown
- 1997-05-02 CN CN97194455A patent/CN1233189A/en active Pending
- 1997-05-02 JP JP09539522A patent/JP2000510113A/en active Pending
- 1997-05-02 BR BR9708928-1A patent/BR9708928A/en not_active Application Discontinuation
- 1997-05-02 WO PCT/EP1997/002256 patent/WO1997041895A2/en not_active Application Discontinuation
- 1997-05-02 EP EP97921849A patent/EP0910413A2/en not_active Withdrawn
- 1997-05-02 KR KR1019980708961A patent/KR20000010825A/en not_active Application Discontinuation
- 1997-05-02 TR TR1998/02238T patent/TR199802238T2/en unknown
- 1997-05-05 PE PE1997000351A patent/PE70698A1/en not_active Application Discontinuation
- 1997-05-05 ZA ZA9703843A patent/ZA973843B/en unknown
- 1997-05-06 AR ARP970101876A patent/AR007020A1/en not_active Application Discontinuation
- 1997-05-07 CO CO97024335A patent/CO4820397A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TR199802238T2 (en) | 1999-02-22 |
CO4820397A1 (en) | 1999-07-28 |
WO1997041895A2 (en) | 1997-11-13 |
CA2253557A1 (en) | 1997-11-13 |
AU2776497A (en) | 1997-11-26 |
EP0910413A2 (en) | 1999-04-28 |
HRP970224A2 (en) | 1998-04-30 |
KR20000010825A (en) | 2000-02-25 |
PE70698A1 (en) | 1998-11-18 |
ZA973843B (en) | 1997-11-10 |
WO1997041895A3 (en) | 1998-03-12 |
JP2000510113A (en) | 2000-08-08 |
BR9708928A (en) | 2000-05-09 |
MA24169A1 (en) | 1997-12-31 |
CN1233189A (en) | 1999-10-27 |
AU725408B2 (en) | 2000-10-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |