AR004124A1 - PROCESS FOR THE PREPARATION OF A GROWTH HORMONE SECRETAGOGUE. - Google Patents

PROCESS FOR THE PREPARATION OF A GROWTH HORMONE SECRETAGOGUE.

Info

Publication number
AR004124A1
AR004124A1 ARP960104931A ARP960104931A AR004124A1 AR 004124 A1 AR004124 A1 AR 004124A1 AR P960104931 A ARP960104931 A AR P960104931A AR P960104931 A ARP960104931 A AR P960104931A AR 004124 A1 AR004124 A1 AR 004124A1
Authority
AR
Argentina
Prior art keywords
growth hormone
preparation
compound
hormone secretagogue
natural
Prior art date
Application number
ARP960104931A
Other languages
Spanish (es)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602949.1A external-priority patent/GB9602949D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR004124A1 publication Critical patent/AR004124A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un proceso nuevo para la preparación del compuesto N-[1(R)-[(1,2-dihidro-1-metanosulfonil-espiro[3H-indol-3,4-piperidina]-1-ilo)carbonil]-2-(fenilmetil-oxi)etil]-2-amino-2-metil-propanamida, y sus sales, que tiene la estructura (I) y que tiene la capacidad de estimular laliberación de la hormona de crecimiento natural o endógena. Este compuesto puede usarse para tratar condiciones que requieren la estimulación de laproducción o secreción de la hormona de crecimiento como por ejemplo, en humanos con una deficiencia de la hormona de crecimiento natural o enanimales utilizados para la producción de alimentos o lana donde la estimulación de la hormona de crecimiento resultará en un animal másgrandey más productivo.A new process for the preparation of the compound N- [1 (R) - [(1,2-dihydro-1-methanesulfonyl-spiro [3H-indole-3,4-piperidine] -1-yl) carbonyl] -2- (phenylmethyl-oxy) ethyl] -2-amino-2-methyl-propanamide, and its salts, which has structure (I) and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound can be used to treat conditions that require stimulation of growth hormone production or secretion, such as in humans with a deficiency of natural growth hormone or enanimals used for the production of food or wool where stimulation of growth hormone growth hormone will result in a larger and more productive animal.

ARP960104931A 1995-10-27 1996-10-25 PROCESS FOR THE PREPARATION OF A GROWTH HORMONE SECRETAGOGUE. AR004124A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US589895P 1995-10-27 1995-10-27
GBGB9602949.1A GB9602949D0 (en) 1996-02-13 1996-02-13 Process for the preparation of a growth hormone secretagogue

Publications (1)

Publication Number Publication Date
AR004124A1 true AR004124A1 (en) 1998-09-30

Family

ID=26308687

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960104931A AR004124A1 (en) 1995-10-27 1996-10-25 PROCESS FOR THE PREPARATION OF A GROWTH HORMONE SECRETAGOGUE.

Country Status (14)

Country Link
EP (1) EP0863900A1 (en)
JP (1) JPH11513984A (en)
KR (1) KR19990067097A (en)
AR (1) AR004124A1 (en)
AU (1) AU7468596A (en)
BR (1) BR9610887A (en)
CA (1) CA2235511A1 (en)
CZ (1) CZ128298A3 (en)
HR (1) HRP960494A2 (en)
HU (1) HUP9902095A3 (en)
PL (1) PL326428A1 (en)
SK (1) SK51198A3 (en)
WO (1) WO1997015573A1 (en)
YU (1) YU56596A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601724D0 (en) * 1996-01-29 1996-03-27 Merck Sharp & Dohme Therapeutic agents
WO1998018815A1 (en) * 1996-10-25 1998-05-07 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
US6329342B1 (en) 1997-08-19 2001-12-11 Eli Lilly And Company Treatment of congestive heart failure with growth hormone secretagogues
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
US6828331B1 (en) 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
DE60140285D1 (en) 2000-05-31 2009-12-10 Pfizer Prod Inc Use of growth hormone secretagogues to promote the mobility of the digestive tract
US7125840B2 (en) 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
US7396846B2 (en) 2002-04-09 2008-07-08 Eli Lilly And Company Growth hormone secretagogues
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
CU23558A1 (en) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE
EP2644618B1 (en) 2007-02-09 2016-08-17 Ocera Therapeutics, Inc. tether intermediates for the synthesis of macrocyclic ghrelin receptor modulators
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL176993B1 (en) * 1992-12-11 1999-08-31 Merck & Co Inc Spiropiperidines and their homologues stimulating growth hormone release

Also Published As

Publication number Publication date
AU7468596A (en) 1997-05-15
CZ128298A3 (en) 1998-07-15
KR19990067097A (en) 1999-08-16
YU56596A (en) 1999-09-27
HRP960494A2 (en) 1998-04-30
JPH11513984A (en) 1999-11-30
BR9610887A (en) 1999-07-13
HUP9902095A2 (en) 1999-10-28
EP0863900A1 (en) 1998-09-16
WO1997015573A1 (en) 1997-05-01
HUP9902095A3 (en) 2001-05-28
CA2235511A1 (en) 1997-05-01
MX9803316A (en) 1998-09-30
PL326428A1 (en) 1998-09-14
SK51198A3 (en) 1998-11-04

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