AR004124A1 - PROCESS FOR THE PREPARATION OF A GROWTH HORMONE SECRETAGOGUE. - Google Patents
PROCESS FOR THE PREPARATION OF A GROWTH HORMONE SECRETAGOGUE.Info
- Publication number
- AR004124A1 AR004124A1 ARP960104931A ARP960104931A AR004124A1 AR 004124 A1 AR004124 A1 AR 004124A1 AR P960104931 A ARP960104931 A AR P960104931A AR P960104931 A ARP960104931 A AR P960104931A AR 004124 A1 AR004124 A1 AR 004124A1
- Authority
- AR
- Argentina
- Prior art keywords
- growth hormone
- preparation
- compound
- hormone secretagogue
- natural
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un proceso nuevo para la preparación del compuesto N-[1(R)-[(1,2-dihidro-1-metanosulfonil-espiro[3H-indol-3,4-piperidina]-1-ilo)carbonil]-2-(fenilmetil-oxi)etil]-2-amino-2-metil-propanamida, y sus sales, que tiene la estructura (I) y que tiene la capacidad de estimular laliberación de la hormona de crecimiento natural o endógena. Este compuesto puede usarse para tratar condiciones que requieren la estimulación de laproducción o secreción de la hormona de crecimiento como por ejemplo, en humanos con una deficiencia de la hormona de crecimiento natural o enanimales utilizados para la producción de alimentos o lana donde la estimulación de la hormona de crecimiento resultará en un animal másgrandey más productivo.A new process for the preparation of the compound N- [1 (R) - [(1,2-dihydro-1-methanesulfonyl-spiro [3H-indole-3,4-piperidine] -1-yl) carbonyl] -2- (phenylmethyl-oxy) ethyl] -2-amino-2-methyl-propanamide, and its salts, which has structure (I) and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound can be used to treat conditions that require stimulation of growth hormone production or secretion, such as in humans with a deficiency of natural growth hormone or enanimals used for the production of food or wool where stimulation of growth hormone growth hormone will result in a larger and more productive animal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US589895P | 1995-10-27 | 1995-10-27 | |
GBGB9602949.1A GB9602949D0 (en) | 1996-02-13 | 1996-02-13 | Process for the preparation of a growth hormone secretagogue |
Publications (1)
Publication Number | Publication Date |
---|---|
AR004124A1 true AR004124A1 (en) | 1998-09-30 |
Family
ID=26308687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960104931A AR004124A1 (en) | 1995-10-27 | 1996-10-25 | PROCESS FOR THE PREPARATION OF A GROWTH HORMONE SECRETAGOGUE. |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0863900A1 (en) |
JP (1) | JPH11513984A (en) |
KR (1) | KR19990067097A (en) |
AR (1) | AR004124A1 (en) |
AU (1) | AU7468596A (en) |
BR (1) | BR9610887A (en) |
CA (1) | CA2235511A1 (en) |
CZ (1) | CZ128298A3 (en) |
HR (1) | HRP960494A2 (en) |
HU (1) | HUP9902095A3 (en) |
PL (1) | PL326428A1 (en) |
SK (1) | SK51198A3 (en) |
WO (1) | WO1997015573A1 (en) |
YU (1) | YU56596A (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9601724D0 (en) * | 1996-01-29 | 1996-03-27 | Merck Sharp & Dohme | Therapeutic agents |
WO1998018815A1 (en) * | 1996-10-25 | 1998-05-07 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
US6329342B1 (en) | 1997-08-19 | 2001-12-11 | Eli Lilly And Company | Treatment of congestive heart failure with growth hormone secretagogues |
US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
US6828331B1 (en) | 1999-02-19 | 2004-12-07 | Eli Lilly And Company | Growth hormone secretagogues |
DE60140285D1 (en) | 2000-05-31 | 2009-12-10 | Pfizer Prod Inc | Use of growth hormone secretagogues to promote the mobility of the digestive tract |
US7125840B2 (en) | 2001-10-09 | 2006-10-24 | Eli Lilly And Company | Substituted dipeptides as growth hormone secretagogues |
US7396846B2 (en) | 2002-04-09 | 2008-07-08 | Eli Lilly And Company | Growth hormone secretagogues |
US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
CU23558A1 (en) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE |
EP2644618B1 (en) | 2007-02-09 | 2016-08-17 | Ocera Therapeutics, Inc. | tether intermediates for the synthesis of macrocyclic ghrelin receptor modulators |
US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
US20170121385A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL176993B1 (en) * | 1992-12-11 | 1999-08-31 | Merck & Co Inc | Spiropiperidines and their homologues stimulating growth hormone release |
-
1996
- 1996-10-23 CA CA002235511A patent/CA2235511A1/en not_active Abandoned
- 1996-10-23 CZ CZ981282A patent/CZ128298A3/en unknown
- 1996-10-23 JP JP9516736A patent/JPH11513984A/en active Pending
- 1996-10-23 BR BR9610887A patent/BR9610887A/en not_active Application Discontinuation
- 1996-10-23 SK SK511-98A patent/SK51198A3/en unknown
- 1996-10-23 HU HU9902095A patent/HUP9902095A3/en unknown
- 1996-10-23 PL PL96326428A patent/PL326428A1/en unknown
- 1996-10-23 EP EP96936868A patent/EP0863900A1/en not_active Withdrawn
- 1996-10-23 AU AU74685/96A patent/AU7468596A/en not_active Abandoned
- 1996-10-23 WO PCT/US1996/016954 patent/WO1997015573A1/en not_active Application Discontinuation
- 1996-10-23 KR KR1019980703037A patent/KR19990067097A/en not_active Application Discontinuation
- 1996-10-25 AR ARP960104931A patent/AR004124A1/en unknown
- 1996-10-25 HR HR9602949.1A patent/HRP960494A2/en not_active Application Discontinuation
- 1996-10-25 YU YU56596A patent/YU56596A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU7468596A (en) | 1997-05-15 |
CZ128298A3 (en) | 1998-07-15 |
KR19990067097A (en) | 1999-08-16 |
YU56596A (en) | 1999-09-27 |
HRP960494A2 (en) | 1998-04-30 |
JPH11513984A (en) | 1999-11-30 |
BR9610887A (en) | 1999-07-13 |
HUP9902095A2 (en) | 1999-10-28 |
EP0863900A1 (en) | 1998-09-16 |
WO1997015573A1 (en) | 1997-05-01 |
HUP9902095A3 (en) | 2001-05-28 |
CA2235511A1 (en) | 1997-05-01 |
MX9803316A (en) | 1998-09-30 |
PL326428A1 (en) | 1998-09-14 |
SK51198A3 (en) | 1998-11-04 |
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