AR003573A1 - BIOTIN DERIVATIVES, PROCEDURE TO PREPARE THEM, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND PROCEDURE TO PREPARE THESE PHARMACEUTICAL COMPOSITIONS. - Google Patents
BIOTIN DERIVATIVES, PROCEDURE TO PREPARE THEM, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND PROCEDURE TO PREPARE THESE PHARMACEUTICAL COMPOSITIONS.Info
- Publication number
- AR003573A1 AR003573A1 AR60104339A AR60104339A AR003573A1 AR 003573 A1 AR003573 A1 AR 003573A1 AR 60104339 A AR60104339 A AR 60104339A AR 60104339 A AR60104339 A AR 60104339A AR 003573 A1 AR003573 A1 AR 003573A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- procedure
- prepare
- pharmaceutical compositions
- hal
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El invento se refiere a los derivados de la arilalquil-diazinona, de formula (I), en la que B representa un heterociclo aromático con 1 a 4 átomosde N,O y/o S, unido a través de un N o C, y el cual puede estar no sustituido o sustituidouna, dos o tres veces con Hal, A y/o OA, y también puede estarcondensado a un anillo de benceno o de piridina, Q está ausente o bien representa alquileno de 1 a 6 átomos de C; X es CH2, S u O; R1 y R2 representanindependientemente H o A; R3y R4 representan independientemente -OH, OR5, -S- R5, -SO-R5, -SO2-R5, Hal, metilendioxi, -NO2, -NH2,-NHR5 o -NR5R6; R5 y R6representan independientemente A, cicloalquilo de 3 a 7 átomos de C, metilencicloalquilo de 4 a 8 átomos de C oalquen ilo de 2 a 8 átomos de C; A esalquilo de 1 a 10 átomos de C eventualmente sustituido con 1 a 5 átomos de F y/o Cl, y Hal representa F, Cl, Br o I; y a sus sales aceptables desde el puntode vista fisiologico. También se refiere a unprocedimiento p ara preparar dichos compuestos, a preparaciones farmacéuticas que los contienen y al empleode los mismos para el tratamiento de procesos inflamatorios tales como las alergias, el asma y las autoinmunodeficiencias. Losnuevos compuestos pre sentanuna accion inhibidora de la fosfodiesterasa IV.The invention relates to arylalkyl diazinone derivatives of formula (I), in which B represents an aromatic heterocycle with 1 to 4 atoms of N, O and / or S, linked through an N or C, and which may be unsubstituted or substituted one, two or three times with Hal, A and / or OA, and may also be condensed to a benzene or pyridine ring, Q is absent or represents alkylene of 1 to 6 C atoms; X is CH2, S or O; R1 and R2 independently represent H or A; R3 and R4 independently represent -OH, OR5, -S-R5, -SO-R5, -SO2-R5, Hal, methylenedioxy, -NO2, -NH2, -NHR5 or -NR5R6; R5 and R6 independently represent A, cycloalkyl of 3 to 7 C atoms, methylenecycloalkyl of 4 to 8 C atoms or alkenyl yl of 2 to 8 C atoms; A is alkyl of 1 to 10 C atoms optionally substituted with 1 to 5 F and / or Cl atoms, and Hal represents F, Cl, Br or I; and its physiologically acceptable salts. It also refers to a procedure for preparing said compounds, to pharmaceutical preparations containing them and to the use of the same for the treatment of inflammatory processes such as allergies, asthma and autoimmunodeficiencies. The new compounds have a phosphodiesterase IV inhibitory action.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19534016A DE19534016A1 (en) | 1995-09-14 | 1995-09-14 | Biotin derivatives |
| DE19533975A DE19533975A1 (en) | 1995-09-14 | 1995-09-14 | Arylalkyl diazinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003573A1 true AR003573A1 (en) | 2000-04-12 |
Family
ID=45724360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR60104339A AR003573A1 (en) | 1995-09-14 | 1996-09-13 | BIOTIN DERIVATIVES, PROCEDURE TO PREPARE THEM, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND PROCEDURE TO PREPARE THESE PHARMACEUTICAL COMPOSITIONS. |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR003573A1 (en) |
-
1996
- 1996-09-13 AR AR60104339A patent/AR003573A1/en not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0108395B8 (en) | pyrrolopyrimidinone derivatives, preparation and use processes | |
| HUP0301249A2 (en) | Benzamide compounds as apo b secretion inhibitors pharmaceutical compositions containing them and their use | |
| HUP0400828A2 (en) | Fused heterocyclic aminopyrimidines, their use and pharmaceutical compositions containing them | |
| EA200200708A1 (en) | Derivatives of benzene and their use as modulators of JNK | |
| UA26427A (en) | DERIVATIVES OF XAHTICH IN THE FORM OF A MIXTURE OF ISOMERS OR INDIVIDUAL ISOMERS WHICH HAVE THE PROPERTY OF AN ADHESIC PROTECTOR | |
| AR020727A1 (en) | USE OF 3-AMINO-4-ARIL-MALEIMIDAS DERIVATIVE COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR CONDITIONS ASSOCIATED WITH A NEED FOR INHIBITION OF LAGSK-3, SUCH COMPOUNDS, PROCEDURE FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM | |
| HUP0402313A2 (en) | Phenyl-piperazine derivatives as serotonin reuptake inhibitors, pharmaceutical compositions containing them and use thereof | |
| HUP0302980A2 (en) | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moeties as inhibitors of protein junkinases and pharmaceutical compositions containing them | |
| HUP0004595A2 (en) | Acyclic metalloprotease inhibitors | |
| HUP0302487A2 (en) | New mandelic acid derivatives and their use as throbin inhibitors, process for their preparation and pharmaceutical compositions containing them | |
| DK1263730T3 (en) | Amine derivatives for the treatment of apoptosis | |
| AR020165A1 (en) | DERIVATIVES OF REPLACED PYRIMIDINS, ITS PREPARATION PROCEDURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE USE OF THEM FOR THE PREPARATION OF MEDICINES | |
| ES2195933T3 (en) | NEW DERIVATIVES OF FLAVONAS, XANTONAS AND CUMARINAS. | |
| AR013079A1 (en) | SUBSTITUTED DERIVATIVES OF TETRAHIDROFURANO-3-ONAS, TETRAHIDROPIRANO-3- ONAS AND TETRAHIDROTIOFEN-3-ONAS, A PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION OF A MEDICINAL PRODUCT USEFUL AS INTERMEDIATE PROTEIN INHIBITORS | |
| AR021068A1 (en) | BENZOILPIRIDAZINAS AND PROCEDURES TO PREPARE THEM; PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCEDURE TO PREPARE THEM, AND USE OF DICHASBENZOILPIRIDAZINAS | |
| NO973213L (en) | New 2- (1H) -quinoline compounds, processes for the preparation thereof, and pharmaceutical compositions comprising these | |
| AR019256A1 (en) | USE OF TETRACICLE DERIVATIVES [6-6-2-0 (2.27) .0 (9.14)] HEXADECA-2 (7), 3, 5, 9 (14), 10,12-HEXAENE, FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS CONACTION PHOSPHOLIPASE INHIBITORY, DERIVATIVE REFERRALS AND PHARMACEUTICAL PREPARATION CONTAINING AT LEAST ONE OF SUCH DERIVATIVES | |
| ES2183492T3 (en) | NEW NITRON DERIVATIVES, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| ES2192263T3 (en) | DERIVATIVES OF BENZO (C) QUINOLIZINA, ITS PREPARATION AND EMPLOYMENT AS INHIBITORS OF 5-ALFA-REDUCTASAS. | |
| AR003573A1 (en) | BIOTIN DERIVATIVES, PROCEDURE TO PREPARE THEM, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND PROCEDURE TO PREPARE THESE PHARMACEUTICAL COMPOSITIONS. | |
| PT97766A (en) | DEPREPARATION OF ISOCROMAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| AR034692A1 (en) | INHIBITORS OF THE INTEGRIN ALFAVBETA3, A PROCEDURE FOR THEIR PREPARATION, THE MEDICATIONS BASED ON THESE COMPOUNDS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT TO COMBAT DISEASE BASED ON THE EXISTING BASIS | |
| AR005549A1 (en) | DERIVATIVES OF 1-PIRAZOL-3-ILETIL-4-INDOL-3-ILPIPERIDINA, A PROCEDURE FOR PREPARING THEM, MEDICINES AND PHARMACEUTICAL PREPARATIONS THAT CONTAIN THEM, A PROCEDURE FOR PREPARING THE PHARMACEUTICAL PREPARATIONS AND USE OF THE SAME MEDICINAL PREPARATIONS FOR THE PREPARATIONS | |
| ES2172294T3 (en) | NEW DERIVATIVES OF 1-INDANOL, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| ES2172023T3 (en) | NEW SUBSTITUTED TETRAHYDRA-PYRIDINIC DERIVATIVES, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |