AR003140A1 - Nuevos compuestos utiles para inhibir las interacciones de las tirosinaquinasas/proteinas adaptadoras, composiciones farmaceuticas que lascontienen y metodos de aplicacion de dichos compuestos para inhibir dichas interacciones. - Google Patents

Nuevos compuestos utiles para inhibir las interacciones de las tirosinaquinasas/proteinas adaptadoras, composiciones farmaceuticas que lascontienen y metodos de aplicacion de dichos compuestos para inhibir dichas interacciones.

Info

Publication number
AR003140A1
AR003140A1 ARP960103099A AR10309996A AR003140A1 AR 003140 A1 AR003140 A1 AR 003140A1 AR P960103099 A ARP960103099 A AR P960103099A AR 10309996 A AR10309996 A AR 10309996A AR 003140 A1 AR003140 A1 AR 003140A1
Authority
AR
Argentina
Prior art keywords
compounds
inhibit
interactions
pharmaceutical compositions
methods
Prior art date
Application number
ARP960103099A
Other languages
English (en)
Original Assignee
Sugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc filed Critical Sugen Inc
Publication of AR003140A1 publication Critical patent/AR003140A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se trata de nuevos compuestos de fórmula (I), donde R1 a R12 tienen los valores indicados en la memoria descriptiva. Dichos compuestos son útiles parainhibir las interacciones proteínicas entre proteínas adaptadoras y proteínatirosinaquinasa,especialmente cuando esas interacciones comprometen unaproteinatirosinaquinasa capaz de complejar con un miembro de la familia de proteínas adaptadoras que contiene SH2 ó SH3 están asociadas con un desordenen la proliferación celular. También se proponen composiciones farmacéuticas formuladas con dichos compuestos y la aplicación de los compuestos mencionadospara inhibir las interacciones mencionadas. Específicamente, la presente invención se refiere a compuestos particulares, especialmente compuestosderivados de quinazolina, y métodos que utilizan esos compuestos.
ARP960103099A 1995-06-07 1996-06-11 Nuevos compuestos utiles para inhibir las interacciones de las tirosinaquinasas/proteinas adaptadoras, composiciones farmaceuticas que lascontienen y metodos de aplicacion de dichos compuestos para inhibir dichas interacciones. AR003140A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47613695A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
AR003140A1 true AR003140A1 (es) 1998-07-08

Family

ID=23890650

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103099A AR003140A1 (es) 1995-06-07 1996-06-11 Nuevos compuestos utiles para inhibir las interacciones de las tirosinaquinasas/proteinas adaptadoras, composiciones farmaceuticas que lascontienen y metodos de aplicacion de dichos compuestos para inhibir dichas interacciones.

Country Status (11)

Country Link
US (4) US5780496A (es)
EP (1) EP0831809A4 (es)
JP (1) JPH11506770A (es)
KR (1) KR19990022369A (es)
CN (1) CN1192680A (es)
AR (1) AR003140A1 (es)
BR (1) BR9609353A (es)
CA (1) CA2224103A1 (es)
IL (1) IL122427A0 (es)
MX (1) MX9709442A (es)
WO (1) WO1996040115A1 (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04278450A (ja) 1991-03-04 1992-10-05 Adam Heller バイオセンサー及び分析物を分析する方法
US5593852A (en) * 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
US6376529B1 (en) 1995-06-07 2002-04-23 Peng Cho Tang Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof
US5786488A (en) * 1996-11-13 1998-07-28 Sugen, Inc. Synthetic methods for the preparation of indolyquinones
AU7625498A (en) 1996-12-03 1998-06-29 Sugen, Inc. Adaptor protein FRS2 and relate products and methods
US6051597A (en) * 1997-06-13 2000-04-18 Merck & Co., Inc. Indolylquinones as antidiabetic agents
WO1999043636A2 (en) 1998-02-27 1999-09-02 The United States Of America As Represented By Thesecretary Of The Department Of Health And Human Services Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs
US6077849A (en) * 1998-04-02 2000-06-20 Merck & Co., Inc. Antidiabetic agents
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US20080076997A1 (en) * 1998-04-30 2008-03-27 Abbott Diabetes Care, Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) * 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US6307090B1 (en) 1999-01-22 2001-10-23 The United States Of America As Represented By The Department Of Health And Human Services Acylated oligopeptide derivatives having cell signal inhibiting activity
JP4604161B2 (ja) * 1999-03-23 2010-12-22 アメリカ合衆国 フェニルアラニン誘導体
US7226991B1 (en) * 1999-03-23 2007-06-05 United States Of America, Represented By The Secretary, Department Of Health And Human Services Phenylalanine derivatives
US7871981B2 (en) * 1999-10-22 2011-01-18 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell motility, angiogenesis, and metastasis
ATE362767T1 (de) 1999-10-22 2007-06-15 Us Gov Health & Human Serv Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren
US6165728A (en) * 1999-11-19 2000-12-26 Isis Pharmaceuticals Inc. Antisense modulation of NCK-2 expression
US7425537B2 (en) * 2000-08-22 2008-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SH2 domain binding inhibitors
US6977241B2 (en) * 2000-08-22 2005-12-20 The United States Of America As Represented By The Department Of Health & Human Services SH2 domain binding inhibitors
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US7151162B2 (en) * 2001-12-06 2006-12-19 The University Of Children's Hospital Of Both Cantons Of Basel Nuclear protein
US7057052B2 (en) * 2002-09-26 2006-06-06 Duke University Heterocyclic quinones as pharmaceutical agents
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
US20040138104A1 (en) * 2003-01-14 2004-07-15 The Government Of The United States Of America Represented By The Secretary, Peptides
US20050119163A1 (en) 2003-09-18 2005-06-02 The Government Of The United States Of America, As Represented By The Secretary, SH2 domain binding inhibitors
US8600920B2 (en) * 2003-11-28 2013-12-03 World Assets Consulting Ag, Llc Affinity propagation in adaptive network-based systems
PE20060373A1 (es) 2004-06-24 2006-04-29 Smithkline Beecham Corp Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2
BRPI0515811A (pt) * 2004-12-06 2008-08-05 Aventis Pharma Sa indóis substituìdos, processo para preparação, bem como utilização dos mesmos, medicamento e composição farmacêutica
FR2878849B1 (fr) * 2004-12-06 2008-09-12 Aventis Pharma Sa Indoles substitues, compositions les contenant, procede de fabrication et utilisation
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
JP2012520257A (ja) 2009-03-10 2012-09-06 グラクソ グループ リミテッド Ｉｋｋ２阻害剤としてのインドール誘導体
TWI481401B (zh) * 2010-01-27 2015-04-21 Takeda Pharmaceutical 藥劑
US9912758B2 (en) 2014-12-16 2018-03-06 Yahoo Holdings, Inc. Continuing an application session on a different device
EP3860998B1 (en) 2018-10-05 2023-12-27 Annapurna Bio Inc. Compounds and compositions for treating conditions associated with apj receptor activity
KR102267662B1 (ko) * 2019-11-19 2021-06-22 한국화학연구원 벤즈아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917820A (en) * 1969-05-29 1975-11-04 Canadian Patents Dev Antibiotic cochliodinol and production by chaetomium, cochliodes and chaetomium globsum
JPH0236591B2 (ja) * 1979-08-27 1990-08-17 Kyoto Pharma Ind Kinonjudotai
JPS6191167A (ja) * 1984-10-08 1986-05-09 Kyoto Yakuhin Kogyo Kk キノン誘導体
JPS6360966A (ja) * 1986-08-29 1988-03-17 Kyoto Yakuhin Kogyo Kk キノン誘導体
SE8903455D0 (sv) * 1989-10-19 1989-10-19 Joakim Nelson Dynamiska digitala foerbindelsenaet (dfn)
US5469431A (en) * 1993-07-12 1995-11-21 Philips Electronics North America Corp. Method of and apparatus for channel mapping with relative service identification
DE4329010A1 (de) * 1993-08-28 1995-03-02 Sel Alcatel Ag Funksystem
US6205143B1 (en) * 1996-03-14 2001-03-20 Telefonaktiebolaget L M Ericsson System supporting variable bandwidth asynchronous transfer mode network access for wireline and wireless communications
US5841777A (en) * 1996-08-30 1998-11-24 Hewlett-Packard Company System and method for accommodating ABR and CBR traffic on a shared communications channel
US6363058B1 (en) * 1997-09-24 2002-03-26 Telefonaktiebolaget L M Ericsson (Publ) Multi-service handling by a single mobile station
FI980293A (fi) * 1998-02-09 1999-08-10 Nokia Networks Oy Multimedia- ja monipalvelupuhelut matkaviestinverkossa
WO2000033589A1 (en) * 1998-11-30 2000-06-08 Nokia Networks Oy Air interface capacity scheduling method

Also Published As

Publication number Publication date
JPH11506770A (ja) 1999-06-15
MX9709442A (es) 1998-02-28
US20020016353A1 (en) 2002-02-07
EP0831809A4 (en) 2001-11-28
AU697120B2 (en) 1998-09-24
US6239161B1 (en) 2001-05-29
US6090838A (en) 2000-07-18
CN1192680A (zh) 1998-09-09
IL122427A0 (en) 1998-06-15
US5780496A (en) 1998-07-14
EP0831809A1 (en) 1998-04-01
AU5979996A (en) 1996-12-30
BR9609353A (pt) 1999-05-11
WO1996040115A1 (en) 1996-12-19
CA2224103A1 (en) 1996-12-19
KR19990022369A (ko) 1999-03-25

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