AR002507A1 - Proceso mejorado para sintetizar intermediarios de carbapenem - Google Patents

Proceso mejorado para sintetizar intermediarios de carbapenem

Info

Publication number
AR002507A1
AR002507A1 ARP960103190A AR10319096A AR002507A1 AR 002507 A1 AR002507 A1 AR 002507A1 AR P960103190 A ARP960103190 A AR P960103190A AR 10319096 A AR10319096 A AR 10319096A AR 002507 A1 AR002507 A1 AR 002507A1
Authority
AR
Argentina
Prior art keywords
formula
compound
improved process
carbapenem
intermediaries
Prior art date
Application number
ARP960103190A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602921.0A external-priority patent/GB9602921D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR002507A1 publication Critical patent/AR002507A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un proceso mejorado para sintetizar intermediarios de carbapenem de fórmula (1), en donde R representa H o metilo y P representa trietilsililo otrimetilsililo, donde comprende: a) opcionalmente, ciclar un compuesto de fórmula (2) para dar un compuesto de fórmula (3); b) tratar un compuesto defórmula (3) ó (4) con P-Cl, en donde P es como se definió anteriormente, en presencia de una base y un solvente substancialmente no reactivo, paraproducir (1) ó (2) y, c) opcionalmente, ciclar el compuesto de fórmula (1) para dar el compuesto de fórmula (2).
ARP960103190A 1995-06-28 1996-06-18 Proceso mejorado para sintetizar intermediarios de carbapenem AR002507A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58595P 1995-06-28 1995-06-28
GBGB9602921.0A GB9602921D0 (en) 1996-02-13 1996-02-13 Improved process for synthesizing carbapenem intermediates

Publications (1)

Publication Number Publication Date
AR002507A1 true AR002507A1 (es) 1998-03-25

Family

ID=26308678

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103190A AR002507A1 (es) 1995-06-28 1996-06-18 Proceso mejorado para sintetizar intermediarios de carbapenem

Country Status (13)

Country Link
EP (1) EP0836607A1 (es)
JP (1) JPH11513979A (es)
KR (1) KR19990028406A (es)
CN (1) CN1193322A (es)
AR (1) AR002507A1 (es)
AU (1) AU696543B2 (es)
BR (1) BR9609338A (es)
CA (1) CA2224439A1 (es)
CZ (1) CZ419097A3 (es)
EA (1) EA199800096A1 (es)
HU (1) HUP9903016A3 (es)
SK (1) SK176597A3 (es)
WO (1) WO1997001564A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2326648E (pt) 2008-07-30 2012-10-31 Ranbaxy Lab Ltd Processo de preparação de compostos de carbapenem
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
JP2675625B2 (ja) * 1989-01-12 1997-11-12 鐘淵化学工業株式会社 エノールシリルエーテル化合物の製造方法
NZ234411A (en) * 1989-07-18 1991-05-28 Merck & Co Inc Preparation of 2-diazo-3-silyloxy-3-butenoate esters
DE3934100A1 (de) * 1989-10-12 1991-04-18 Bayer Ag Verfahren zur herstellung von 0-silylierten hydroxylverbindungen und ihre verwendung zur herstellung von estergruppen aufweisenden isocyanaten

Also Published As

Publication number Publication date
JPH11513979A (ja) 1999-11-30
CA2224439A1 (en) 1997-01-16
KR19990028406A (ko) 1999-04-15
MX9800041A (es) 1998-08-30
AU696543B2 (en) 1998-09-10
HUP9903016A2 (hu) 2000-03-28
BR9609338A (pt) 1999-05-11
CZ419097A3 (cs) 1998-07-15
CN1193322A (zh) 1998-09-16
SK176597A3 (en) 1998-07-08
AU6392196A (en) 1997-01-30
HUP9903016A3 (en) 2000-04-28
EP0836607A1 (en) 1998-04-22
WO1997001564A1 (en) 1997-01-16
EA199800096A1 (ru) 1998-08-27

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