AR002251A1 - DERIVATIVES OF SULFONAMIDES, PROCEDURE FOR THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS AND USE OF THE COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR DISEASES ASSOCIATED WITH ENDOTHELINE. - Google Patents

DERIVATIVES OF SULFONAMIDES, PROCEDURE FOR THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS AND USE OF THE COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR DISEASES ASSOCIATED WITH ENDOTHELINE.

Info

Publication number
AR002251A1
AR002251A1 ARP950100297A AR10029795A AR002251A1 AR 002251 A1 AR002251 A1 AR 002251A1 AR P950100297 A ARP950100297 A AR P950100297A AR 10029795 A AR10029795 A AR 10029795A AR 002251 A1 AR002251 A1 AR 002251A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
phenyl
alkoxy
alkyl
lower alkoxy
Prior art date
Application number
ARP950100297A
Other languages
Spanish (es)
Original Assignee
Speedel Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Pharma Ag filed Critical Speedel Pharma Ag
Publication of AR002251A1 publication Critical patent/AR002251A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Los compuestos de fórmula (I) en donde R1 es heterocíclilo;R2 eshidrógeno, alquilo inferior, alcoxilo inferior, alquiltio inferior, alcoxiloinferior-alquilo inferior, alquilsulfonilo inferior-alcoxilo inferior, fenilo, alquilo inferior- fenilo,alcoxilo inferior-fenilo, alquileno inferior-dioxifenilo, fenilo alquilo inferior, alquilo inferior-fenilo,alquilo inferior, alcoxilo inferior fenilo-alquilo inferior, alquileno inferior dioxifeniloalquilo inferior, heterociclilo o heterocicl o-alquilo inferior; R3 es alquilo inferior alcoxilo inferior, formilo, haloalquilo inferior, hidroxilo-alquiloinferior amino-alquilo inferior o un radical -CH2O-A-alquilo inferior,-(CH2)m-O -(CD G)nCH,-(CH2)m-O-(CD G)n OR9,-(CH2)m-O-(CD G)n NH2 ó -(CH2)m-O-(CD G)n-B-R9;R4 y R8 son hidrógeno,alcoxilo inferior o halógeno;R9 significa heterociclilo; fenilo o fenilo sustituido con alquilo inferior, alcoxilo inferior y/ohalógeno, ó alquilo inferior;D y G significan hidrógeno o alquiloinferior ; A significa un grupo 1,2 dihidroxi-etileno cetalizado; B significa -OC(O)O,O(C(O)NH, -NH(C(O)NH- e -NHC(O)O-, n es 2, 3 ó 4; y m es 0 ó 1, son sustancias que inhiben los receptores de la endotelia. Pueden utilizarse, por lo tanto,parael trata miento de enfermedades que están asociadas a las actividades de la endotelina, en particular, las enfermedades circulatorias como la hipertensión,isquemia, espasmos vasculares y angina pectoris.The compounds of formula (I) wherein R1 is heterocyclyl; R2 is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkoxy-lower alkyl, lower alkylsulfonyl-lower alkoxy, phenyl, lower alkyl-phenyl, lower alkoxy-phenyl, lower alkylene -dioxyphenyl, phenyl lower alkyl, lower alkyl-phenyl, lower alkyl, lower alkoxy phenyl-lower alkyl, lower alkylene dioxyphenyl lower alkyl, heterocyclyl or heterocyclic o-lower alkyl; R3 is lower alkyl lower alkoxy, formyl, halo lower alkyl, hydroxyl-lower alkyl amino-lower alkyl or a radical -CH2O-A-lower alkyl, - (CH2) mO - (CD G) nCH, - (CH2) mO- (CD G) n OR9, - (CH2) mO- (CD G) n NH2 or - (CH2) mO- (CD G) nB-R9, R4 and R8 are hydrogen, lower alkoxy or halogen, R9 signifies heterocyclyl; phenyl or phenyl substituted with lower alkyl, lower alkoxy and / or halogen, or lower alkyl, D and G signify hydrogen or lower alkyl; A signifies a 1,2-dihydroxy-ethylene ketalized group; B means -OC (O) O, O (C (O) NH, -NH (C (O) NH- and -NHC (O) O-, n is 2, 3 or 4; and m is 0 or 1, they are Substances that inhibit endothelial receptors They can therefore be used for the treatment of diseases that are associated with endothelin activities, in particular circulatory diseases such as hypertension, ischemia, vascular spasms and angina pectoris.

ARP950100297A 1994-11-25 1995-11-23 DERIVATIVES OF SULFONAMIDES, PROCEDURE FOR THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS AND USE OF THE COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR DISEASES ASSOCIATED WITH ENDOTHELINE. AR002251A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH355994 1994-11-25

Publications (1)

Publication Number Publication Date
AR002251A1 true AR002251A1 (en) 1998-03-11

Family

ID=4258608

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP950100297A AR002251A1 (en) 1994-11-25 1995-11-23 DERIVATIVES OF SULFONAMIDES, PROCEDURE FOR THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS AND USE OF THE COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR DISEASES ASSOCIATED WITH ENDOTHELINE.
ARP970105148A AR010549A2 (en) 1994-11-25 1997-11-04 DERIVATIVES OF SULFONAMIDES USEFUL AS SYNTHESIS INTERMEDIARIES.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP970105148A AR010549A2 (en) 1994-11-25 1997-11-04 DERIVATIVES OF SULFONAMIDES USEFUL AS SYNTHESIS INTERMEDIARIES.

Country Status (9)

Country Link
AR (2) AR002251A1 (en)
BR (1) BR9505528A (en)
CO (1) CO4650181A1 (en)
PE (1) PE52496A1 (en)
PL (1) PL185692B1 (en)
TR (1) TR199501486A2 (en)
UY (1) UY24100A1 (en)
WO (1) WO1996016963A1 (en)
ZA (1) ZA959808B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI284642B (en) * 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides
EP1345920B1 (en) 2000-12-18 2006-04-12 Actelion Pharmaceuticals Ltd. Novel sulfamides and their use as endothelin receptor antagonists
CN1930135B (en) 2004-03-05 2011-12-28 弗·哈夫曼-拉罗切有限公司 Diaminopyrimidines as P2X3 and P2X2/3 antagonists
AR062501A1 (en) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd THERAPEUTIC COMPOSITIONS
MX2010001837A (en) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Iron with actively cooled soleplate and method for cooling the soleplate.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2086544C1 (en) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity

Also Published As

Publication number Publication date
WO1996016963A1 (en) 1996-06-06
AR010549A2 (en) 2000-06-28
ZA959808B (en) 1996-05-27
TR199501486A2 (en) 1996-07-21
PL185692B1 (en) 2003-07-31
UY24100A1 (en) 2000-12-29
BR9505528A (en) 1997-11-04
PE52496A1 (en) 1996-12-12
PL311487A1 (en) 1996-05-27
CO4650181A1 (en) 1998-09-03

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