AP9600790A0 - Process for preparation of substituted steroidal dienes and novel intermediates used in said process. - Google Patents

Process for preparation of substituted steroidal dienes and novel intermediates used in said process.

Info

Publication number
AP9600790A0
AP9600790A0 APAP/P/1996/000790A AP9600790A AP9600790A0 AP 9600790 A0 AP9600790 A0 AP 9600790A0 AP 9600790 A AP9600790 A AP 9600790A AP 9600790 A0 AP9600790 A0 AP 9600790A0
Authority
AP
ARIPO
Prior art keywords
preparation
novel intermediates
intermediates used
substituted steroidal
dienes
Prior art date
Application number
APAP/P/1996/000790A
Inventor
Neil Howard Baine
Franklin Owings
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AP9600790A0 publication Critical patent/AP9600790A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Invented is an improved process for the preparation of substituted steroidal dienes. Also invented are novel intermediates used in said process.
APAP/P/1996/000790A 1992-02-07 1993-02-05 Process for preparation of substituted steroidal dienes and novel intermediates used in said process. AP9600790A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83228092A 1992-02-07 1992-02-07

Publications (1)

Publication Number Publication Date
AP9600790A0 true AP9600790A0 (en) 1996-04-30

Family

ID=25261209

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1996/000790A AP9600790A0 (en) 1992-02-07 1993-02-05 Process for preparation of substituted steroidal dienes and novel intermediates used in said process.

Country Status (23)

Country Link
EP (1) EP0643724A4 (en)
JP (1) JPH07505140A (en)
KR (1) KR950700319A (en)
CN (1) CN1078475A (en)
AP (1) AP9600790A0 (en)
AU (1) AU666177B2 (en)
BG (1) BG98955A (en)
BR (1) BR9305837A (en)
CA (1) CA2129342A1 (en)
CZ (1) CZ188794A3 (en)
FI (1) FI943660A (en)
HU (1) HUT68303A (en)
IL (1) IL104602A (en)
MA (1) MA22788A1 (en)
MX (1) MX9300676A (en)
NO (1) NO942925L (en)
NZ (1) NZ249382A (en)
OA (1) OA10090A (en)
RU (1) RU94045824A (en)
SI (1) SI9300065A (en)
TW (1) TW327175B (en)
WO (1) WO1993016097A1 (en)
ZA (1) ZA93801B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9206413D0 (en) * 1992-03-24 1992-05-06 Smithkline Beecham Corp N-t-butyl-androst-3,5-diene-17b-carboxamide-3-carboxylic acid polymorph a
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA883034B (en) * 1987-04-29 1989-03-29 Smithkline Beckman Corp Steroid 5-alpha-reductase inhibitors
IL104601A0 (en) * 1992-02-07 1993-07-08 Smithkline Beecham Corp Process for the preparation of steroidal dienes

Also Published As

Publication number Publication date
RU94045824A (en) 1996-07-10
CA2129342A1 (en) 1993-08-19
TW327175B (en) 1998-02-21
AU666177B2 (en) 1996-02-01
NZ249382A (en) 1996-05-28
KR950700319A (en) 1995-01-16
HU9402303D0 (en) 1994-10-28
FI943660A0 (en) 1994-08-05
MA22788A1 (en) 1993-10-01
IL104602A0 (en) 1993-07-08
EP0643724A4 (en) 1995-05-10
NO942925D0 (en) 1994-08-05
OA10090A (en) 1996-12-18
NO942925L (en) 1994-08-08
MX9300676A (en) 1994-07-29
IL104602A (en) 1997-07-13
FI943660A (en) 1994-08-05
ZA93801B (en) 1993-11-05
WO1993016097A1 (en) 1993-08-19
HUT68303A (en) 1995-06-28
CN1078475A (en) 1993-11-17
SI9300065A (en) 1993-09-30
BR9305837A (en) 1997-02-18
JPH07505140A (en) 1995-06-08
EP0643724A1 (en) 1995-03-22
BG98955A (en) 1995-06-30
CZ188794A3 (en) 1994-12-15
AU3612693A (en) 1993-09-03

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