AP33A - Fluorobenzyl esters. - Google Patents
Fluorobenzyl esters. Download PDFInfo
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- AP33A AP33A APAP/P/1986/000022A AP8600022A AP33A AP 33 A AP33 A AP 33A AP 8600022 A AP8600022 A AP 8600022A AP 33 A AP33 A AP 33A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
- C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
- C07C33/483—Monocyclic
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- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
This invention
Description
FLUOROBENZYL ESTERS
This invention relates to novel fluorobenzyl esters useful as insecticides and characterised by a combination of excellent knock-down properties and lethal action to insanitary insect pests such as houseflies, cockroaches and mosquitos.
The novel fluorobenzyl esters of this invention have the general formula :
AP 0 0 0 0 3 3 where R is selected from hydrogen, alkyl of up to four carbon atoms and the trialkylsilyl group where each alkyl10 contains up to four carbon atoms, and X represents the residue of any carboxylic acid of formula X-COOH which forms an insecticidally active ester with a 3-phenoxybenzyl alcohol. More particularly X represents (a) a group of formula :
p 1
CH - C -R2 \ X' .
CH-j CH3
9 wherein (i) R and R are each selected from hydrogen, halo and alkyl of up to four carbon atoms; or (ii) R1 is hydrogen and R2 represents either a group of formula :
R3
-CH—C or a group of formula :
— CH— R4 where R3 and R4 are each selected from methyl, halo, or haloalkyl of one or two carbon atoms containing at least two fluorine atoms, and Y is chloro or bromo; or (b) X represents a group of formula :
Ar- CHR5where R5 represents an alkyl group of up to four carbon atoms and Ar represents a phenyl group optionally substituted with one or two halogen atoms.
Preferred compounds according to the invention are 10 those of formula :
(I) wherein R is hydrogen or alkyl of up to four carbon atoms,
9
R and R are each selected from halogen or alkyl of up to four carbon atoms (preferably methyl), or R^ is hydrogen and R is a group of formula :
-CH — C- R4 wherein R2 and R4 are each selected from methyl, fluoro, chloro, bromo and trifluoromethyl.
Particularly preferred compounds according to formula
I are those set out in Table I below wherein the meaning of 1 9
R and R are set out for each compound.
TABLE I
AP 0 0 0 0 3 3
Compound | R | r1 | R2 |
1 | H | ch3 | ch3 |
2 | H | H | -ch=c(ch3)2 |
3 | H | H | -ch=cci2 |
4 | H | H | -CH=CBr2 |
5 | H | H | -ch=cf2 |
6 | H | H | -CH=C(F)CF3 |
7 | H | H | -CH=C(C1)CF3 |
8 | H | H | -CH=C(Br)CF3 |
9 | H | H | -ch=c(cf3)2 |
10 | H | Cl | Cl |
11 | ch3 | H | -CH=C(C1)CF3 |
It will be appreciated that certain of the compounds 1 2 of the invention wherein R and R are not identical are capable of existing in more than one isomeric form, due to the possibility of cis and trans isomerism in the substitution pattern of the cyclopropane ring and the presence of chiral centres at and Cg of the cyclopropane ring. Thus there may be ( + )-cis , (- )-cis , (+ )-trans and (- )-trans isomers. (/here and are not identical there exists the further possibility of E and Z isomers of the group R. The scope of the invention includes each of the said isomeric forms in isolation as well as mixtures thereof, including racemic mixtures.
Especially preferred compounds according to formula I 10 include the 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl esters of the following cyclopropane acids.
2,2,3,3-tetramethylcyclopropane carboxylic acid,
2,2-dichloro-3,3-dimethylcyclopropane carboxylic acid, (+)-cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, (+)-trans-3-(2-methylprop-l-en-l-yl)-2, 2-dimethylcyclopropane carboxylic acid, (+)-cis-3-(2,2-difluorovinyl)-2,2-dimethylcyclopropane 20 carboxylic acid, ( + ) -cis-3- ( 2,2-d.ibromovinyl )-2,2-dimethylcyclopropane carboxylic acid, (+)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylic acid, (+)-cis-3-(Z-2-chloro-3,3,3-trifluoroprop-l-en-l-yl)-2,2dimethylcyclopropane carboxylic acid, (+)-cis-3-(Z-2-chloro-3,3,3-trifluoroprop-l-en-l-yl)-2,2dimethylcyclopropane carboxylic acid, (+)-cis-3-(Z-2,3,3,3-tetrafluoroprop-l-en-l-yl)-2, 2dimethylcyclopropane carboxylic acid, ( + )-trans-3-(Z-2,3,3,3-tetrafluoroprop-l-en-l-yl)-2,2dimethylcyclopropane carboxylic acid, and (+)-cis-3-(2-trifluoromethyl-3,3,3-trifluoroprop-l-en-lyl )-2,2-dimethylcyclopropane carboxylic acid.
Other compounds of the invention include
4-but-2-ynyl-2, 3,5,6-tetrafluorobenzyl (+)-cis-3-(Z-2chloro-3,3,3-trif luoroprop-l-en-l-yl )-2, 2-dimethylcyclopropane carboxylate, and the 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl esters of (+)-cis-3-(1,2-dibromo-2,2dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, and ( + )-2-( 4-chloro-phenyl )-3-methylbutyric acid.
The compounds of the invention are esters and may be prepared by conventional esterification processes, of which the following are examples.
(a) An acid of formula
X-COOH (II) where X has any of the meanings given hereinabove, may be reacted directly with a 4-alkynyl-2,3,5,6-tetrafluorobenzyl alcohol of formula :
AP 0 0 0 0 3 3
RC=e-
ch2oh (III) the reaction preferably taking place in the presence of an acid catalyst, for example, dry hydrogen chloride, or a dehydrating agent, for example, a carbodiimide such as dicyclohexylcarbodiimide.
(b) An acid halide of formula X-COHal where Hal represents a halogen atom, preferably a chlorine atom, and X has any of the meanings given hereinabove, may be reacted with the alcohol of formula III, the reaction preferably taking place in the presence or a base, for example, pyridine, trialkylamine alkali metal hydroxide or carbonate, or alkali metal alkoxide.
(c) An acid of formula II where X has any of the meanings given hereinabove, or preferably, an alkali metal salt thereof, may be reacted with halide of formula :
(IV) where Hal represents a halogen atom, preferably the bromine or cnlorine atom, or with the quaternary ammonium salts derived from such halides with tertiary amines, for example pyridine, or trialkylamines such as triethylamine.
(d) A lower alkyl ester of formula X-COOQ where Q represents a lower alkyl group containing up to six carbon atoms, preferably the methyl or ethyl group, and X has any of the meanings given hereinabove, is heated with the alcohol of formula III to effect a transesterification reaction. Preferably the process is performed in the presence of a suitable catalyst, for example, an alkali metal alkoxide, such as sodium methoxide, or an alkylated titanium derivative, such as tetramethyl titanate.
All of these conventional processes for the preparation of esters may be carried out using solvents and diluents for the various reactants where appropriate, and may be accelerated or lead to higher yields of product when performed at elevated temperatures or in the presence of appropriate catalysts, for example phase-transfer catalysts.
The preparation of individual isomers may be carried out in the same manner but commencing from the corresponding individual isomers of compounds of formula II.
These may be obtained by conventional isomer separation techniques from mixtures of isomers. Thus cis and trans isomers may be separated by fractional crystallisation of the carboxylic acids or salts thereof, whilst the various optically active species may be obtained by fractional crystallisation of salts of the acids with optically active amines, followed by regeneration of the optically pure acid. The optically pure isomeric form of the acid (or its equivalent acid chloride or ester) may then be reacted with the alcohol of formula III to produce a compound of formula
I in the form of an individually pure isomer thereof.
4-Alkynyl-2,3,5,6-tetrafluorobenzyl alcohols (III) have not been described previously. In a further aspect therefore the invention provides 4-alkynyl-2,3,5,6tetrafluorobenzyl alcohols as novel intermediates useful in the preparation of the insecticidal esters of the invention.
These compounds may be prepared from pentafluorobenzaldehyde by the following scheme.
AP 0 0 0 0 3 3
LiBr
->
N-methyl’ pyrrolidone
NaBH4/CH3OH
Key : DHP = dihydropyran; BuLi = n-butyllithium
CuBr-DMS = copper (I) bromide, complex with dimethylsulphide
Further details concerning the preparation and characterisation of 4-prop-2-ynyl-2,3,5, 6-tetrafluorobenzyl alcohol and 4-but-2-ynyl-2,3,5,6-tetrafluorobenzyl alcohols are given hereinafter in the Examples.
The compounds of formula I may be used to combat and control infestations of insect pests and also other invertebrate pests, in particular, acarine pests. The insect and acarine pests which may be combatted and controlled by the use of the invention compounds include those pests associated with agriculture (which term includes the growing of crops for food and fibre products, horticulture and animal husbandry), forestry, the storage of products of vegetable origin, such as fruit, grain and timber, and also those pests associated with the transmission of diseases of man and animals.
In order to apply the compounds to the locus of the pests they are usually formulated into compositions which include in addition to the insecticidally active ingredient or ingredients of formula I suitable inert diluent or carrier materials, and/or surface active agents. The compositions may also comprise another pesticidal material, for example another insecticide or acaricide, or a fungicide, or may also comprise a insecticide synergist, such as for example dodecyl imidazole, safroxan, or piperonyl butoxide.
The compositions may be in the form of dusting powders wherein the active ingredient is mixed with a solid diluent or carrier, for example kaolin, bentonite, kieselguhr, or talc, or they may be in the form of granules, wherein the active ingredient is absorbed in a porous granular material for example pumice.
Alternatively the compositions may be in the form of liquid preparations to be used as dips or sprays, which are generally aqueous dispersions or emulsions of the active ingredient in the presence of one or more known wetting ££ 0 0 0 0 dV agents, dispersing agents or emulsifying agents (surface active agents ).
Wetting agents, dispersing agents and emulsifying agents may be of the cationic, anionic or non-ionic type. Suitable agents of the cationic type include, for example, quaternary ammonium compounds, for example cetyltrimethyl ammonium bromide. Suitable agents of the anionic type include, for example, soaps, salts of aliphatic monoesters of sulphuric acid, for example sodium lauryl sulphate, salts of sulphonated aromatic compounds, for example sodium dodecylbenzenesulphonate, sodium, calcium or ammonium lignosulphonate, or butylnaphthalene sulphonate, and a mixture of the sodium salts of diisopropyl- and triisopropylnaphthalene sulphonates. Suitable agents of the nonionic type include, for example, the condensation products of ethylene oxide with fatty alcohols such as oleyl alcohol or cetyl alcohol, or with alkyl phenols such as octyl phenol, nonyl phenol and octyl cresol. Other non-ionic agents are the partial esters derived from long chain fatty acids and hexitol anhydrides, the condensation products of the said partial esters with ethylene oxide, and the lecithins .
The compositions may be prepared by dissolving the active ingredient in a suitable solvent, for example, a ketonic solvent such as diacetone alcohol, or an aromatic solvent such as trimethylbenzene and adding the mixture so obtained to water which may contain one or more known wetting, dispersing or emulsifying agents. Other suitable organic solvents are dimethyl formamide, ethylene dichloride, isopropyl alcohol, propylene glycol and other glycols, diacetone alcohol, toluene, kerosene, white oil, methylnaphthalene, xylenes and trichloroethylene, N-methyl2“Pyrrolidone and tetrahydro furfuryl alcohol (THFA).
The compositions to be used as sprays may also be in the form of aerosols wherein the formulation is held in a container under pressure in the presence of a propellant such as fluorotrichloromethane or dichlorodifluoromethane.
The compositions which are to be used in the form of aqueous dispersions or emulsions are generally supplied in the form of a concentrate containing a high proportion of the active ingredient or ingredients, the said concentrate to be diluted with water before use. These concentrates are often required to withstand storage for prolonged · periods and after such storage, to be capable of dilution with water to form aqueous preparations which remain homogenous for a sufficient time to enable them to be applied by conventional spray equipment. The concentrates may contain 10-85% by weight of the active ingredient or ingredients. When diluted to form aqueous preparations such preparations may contain varying amounts of the active ingredient depending upon the purpose for which they are to be used. For agricultural or horticultural purposes, an aqueous preparation containing between 0.0001% and 0.1% by weight of the active ingredient is particularly useful.
In use the compositions are applied to the pests, to the locus of the pests, to the habitat of the pests, or to growing plants liable to infestation by the pests, by any of the known means of applying pesticidal compositions, for example, by dusting or spraying.
The compositions of the invention are very toxic to wide varieties of insect and other invertebrate pests, including, for example, the following:Aphis fabae (aphids)
Megoura viceae (aphids)
Husca domestica (houseflies)
Blattella germanica (cockroaches )
Aedes aegypti (mosquitos)
Plutella xylostella (diamond back month, larvae) Tetranychus cinnabarinus (carmine spider mite)
AP 0 0 0 0 3 3
Tetranychus urticae (red spider mites)
Panonychus ulmi (citrus rust mite)
Diabrotica spp. (rootworms)
Heliothis virescens (tobacco budworms)
Chilo partellus (stem borers)
The compounds of formula I and compositions comprising them have shown themselves to be particularly useful in controlling foliar feeding pests of plants, and public health pests such as flies and mosquitos. The compounds may also be used to combat pests which inhabit the soil, for example Diabrotica spp. They may also be useful in combating insect and acarine pests which infest domestic animals, such as Lucilia sericata, and ixodid ticks such as Boophilus spp., Ixodes spp., Amblyomma spp., Rhiplcephalus spp., and Dermaceutor spp. They are expected to be effective in combating both susceptible and resistant strains of these pests in their adult, larval and intermediate stages of growth, and may be applied to the infested host animal by topical, oral or parenteral administration.
In particular, the invention compounds have useful knock-down properties which make them of value as ingredient in aerosol and like sprays designed for use against flying insect pests such as houseflies, mosquitos and the like. In such sprays they, may be used on their own or in conjunction with other insecticidal components. However, unlike other knock-down agents such as tetramethrin and allethrin many of the invention compounds combine good knock-down properties with a lethal effect at the same concentration.
In the following examples, which further illustrate the invention, the novel compounds produced were examined by infra-red and nuclear-magnetic spectroscopy, and gave spectra consistent with the indicated structures of the compounds .
EXAMPLE 1
This Example illustrates the preparation of 4-bromo-2,3,5,6-tetrafluorobenzaldehyde.
A stirred mixture of pentafluorobenzaldehyde (17.7g), anhydrous lithium bromide (8.9g) and N-methylpyrrolidone (50. cm3) was heated at 160’C under a nitrogen atmosphere for 2 hours, after which it was cooled and poured into water. The solid precipitate was collected by filtration, washed on the filter with water and dried in a dessicator over phosphorus pentoxide. After trituration with diethyl ether the residual solid was collected to yield 4-bromopentafluorobenzaldehyde (8.4g), mp. 105-108*C.
Infra red (paraffin mull): 1700 cm3
EXAMPLE 2
This Example illustrates the preparation of 4-bromo-2,3,5,6-tetrafluorobenzyl alcohol.
Sodium borohydride (l.Og) was added portionwise over a period of 30 minutes to a stirred solution of 4-bromo-2,3,5,6-tetrafluorobenzaldehyde (8.2g) in methanol (80 cm ) whilst the temperature was maintained within the range from -5 °C to +5eC, after which the mixture was stirred for 2 hours at the ambient temperature (ca 18eC). The mixture was poured into water and the precipitated white solid collected by fitration, washed with water and air dried to yield 4-bromo-2,3,5,6-tetrafluorobenzyl alchol (7.5g), mp. 60-62’C.
AP 0 0 0 0 3 3
Infra red (paraffin mull): 3400(b), 1500 (b) era-3-
EXAMPLE 3
This Example illustrates the preparation of 2-(4-bromo-2,3,5,6-tetrafluorobenzyloxy) tetrahydrofuran.
Dihydropyran (3.0g) and concentrated hydrochloric acid (0.3 cm3) were added successively to a stirred solution of 4-bromo-2,3,5,6-tetrahydrobenzyl alcohol (8.4g) in dry diethyl ether (50 cm3) and the mixture stirred for a further 15 hours after which the more volatile components were removed by evaporation under reduced pressure. The residual oil was confirmed by spectroscopic analysis as being 2-(4-bromo-2,3,5,6-tetrafluorobenzyloxy)tetrahydropyran (9.5g) of ca 95% purity.
1H NMR (CDC13) : 4.6 (m,3H),· 3.9 (m,2H); 1.6 (m,6H)
EXAMPLE 4
This Example illustrates the preparation of 2-(4prop-2-ynyl-2. 3,5,6-tetrafluorobenzyloxy)tetrahydropyran.
n-Butyllithium (2.3 cm3 of a 2.5M solution in n-hexane) was added dropwise to a solution of 2-(4-bromo2, 3,5,6-tetrafluorobenzyloxy)tetrahydropyran (1.7g) in dry tetrahydrofuran (50 cm3) maintained at a temperature of -70*C under a nitrogen atmosphere, and the resulting mixture stirred for a further 2 hours. Copper (I) bromidedimethylsulphide complex (l.lg) was added to the mixture and after stirring for a further 2 hours, propargyl chloride (0.4g) was added dropwise to the clear brownishyellow solution. The mixture was maintained at -70’C for 1 hour and then allowed to warm to the ambient temperature over a period of 4 hours. The mixture was partitioned between diethyl ether and aqueous saturated ammonium chloride solution, and the ethereal phase separated, washed with water and dried over anhydrous magnesium sulphate. Removal of the solvent by evaporation under reduced pressure yielded a residual oil (1.4g) consisting of ca.
60% of the desired product together with ca 20% 2-(2,3,5,6tetrafluorobenzyloxy) tetrahydrofuran, and ca. 20% other unidentified materials. Purification and separation was effected by means of hplc (Gilson) using a silica column eluted with a mixture of n-hexane (9 parts by volume) and diethyl ether (1 part by volume) to yield pure 2-(4prop-2-ynyl-2,3,5,6-tetrafluorobenzyloxy)tetrahydropyran (0.8g) .
1H NMR (CDCl-jJ^ : 4.6 (m,3H); 3.9 (m,2H); 3.6 (d,2H);
2.0 (t,lH); 1.6 (m,6H)
Infra red (liquid film): 3300, 2700 cm”^
EXAMPLE 5
This Example illustrates the preparation of 4-prop2-ynyl-2,3,5,6-tetrafluorobenzyl alcohol.
A mixture of 2-(4-prop-2-ynyl-2,3, 5,6-tetrafluorobenzyloxy) tetrahydropyran (0.8g), dilute hydrochloric acid
3 (2N, 5 cnr) and methanol (30 cnr) was stirred together at the ambient temperature for 2 hours, after which the more volatile portion was removed by evaporation under reduced pressure. The residue was extracted with diethyl ether, the extracts combined, washed with water, and dried over anhydrous magnesium sulphate. Removal of the solvent by evaporation under reduced presure yielded an oil which crystallised on standing to give 4-prop-2-ynyl-2,3,5,625 tetrafluorobenzyl alcohol (0.5g), mp. 51-52’C, after recrystallisation from petroleum ether (boiling range 60-80’C).
APO 0 0 0 3 3 1H NMR (CDC13) : 4.8 (s,2H); 3.6 (m,2H);, 2.3 (broad
S,1H); 1.0 (t,lH)
Infra red (paraffin mull): 3400 cm^.
EXAMPLE 6
This Example illustrates the preparation of 4-prop5 2-ynyl-2, 3,5,6-tetrafluorobenzyl (+)-cis-3-(Z-2-chloro3,3, 3-trifluoroprop-l-en-l-yl)-2,2-dimethylcyclopropane carboxylate (Product I).
A mixture of ( +)-cis-3-(Z-2-chloro-3,3,3-trifluoroprop-l-en-l-yl )-2,2-dimethylcyclopropane carboxylic acid (0.12g), 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl alcohol (0.12g), dicyclohexylcarbodiimide (0.134g), dichloromethane (10 cm ) and a trace of N,N-dimethylaminopyridine was stirred at the ambient temperature for 1 hour. After removal of the solid component by filtration the filtrate was concentrated by evaporation of the solvent and the residual oil subjected to purification by flash chromatography using dichloromethane as eluant to yield pure 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl (+)-cis-3(Z-2-chloro-3,3,3-trifluoroprop-l-en-l-yl )-2,2-dimethyl20 cyclopropane carboxylate (150 mg).
J-H NMR (CDC13) ; 6.9 (d,lH); 5.2 (s,2H); 3.6 (m,2H);
2.0 (m,3H); 1.35 (s,6H)
Infra red (liquid film): 3300, 1730, 1650 cm^.
EXAMPLE 7
By the use of a procedure similar to that illustrated in Example 6 the following compounds of formula I may also be prepared from the appropriate carboxylic acids.
(i) 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl (+) cis/trans
-3-(2-methylprop-l-en-l-yl)-2,2-dimethylcyclopropane carboxylate (cis:trans ratio 3:7) - Product II.
ΧΗ NMR (CDC13)^ : [5.3(d), 5.2(s), 4.2 (d)-3H)];
3.6 (m,2H); 2.0 (t,lH); 1.7 (s,6H)? 1.2 (dd,6H)
Infra red (liquid film): 3300, 1730 cm“^.
(ii) 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl (+)-cis-3(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate - Product III.
1H NMR (CDC13)^ : 6.2 (d,2H); 5.2 (d,2H); 3.6 (m,2H);_2.0 (m,3H); 1.2 (s,6H)
Infra red (liquid film): 3300, 1730, 1650 cm“^.
(iii) 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl (+)-trans3-(Z-2-chloro-3,3,3-trifluoroprop-l-en-l-yl)-2,220 dimethylcyclopropane carboxylate - Product IV.
1H NMR (CDCl·^^ : 6.1 (d,lH); 5.25 (s,2H); 3.6 (q,2H); 2.4 (m,lH); 2.0 (t,lH);
1.7 (d,lH); 1.3 (d,6H)
Infra red (liquid film): 3300, 1730, 1650 cm^.
AP 0 0 0 0 3 3 (iv) 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl 2,2,3,3tetramethylcyclopropane carboxylate - Product V.
1H NMR (CDC13) t :'5.1(s,2H); 3.6 (m,2H); 2.0 (t,lH) Ό 1.2 (d,13H).
(v) 4-prop-2-ynyl)-2,3,5,6-tetrafluorobenzyl (+)-cis-3(Z-2-chloro-3,3,3-trifluoroprop-l-en-l-yl)-2,2dimethylcyclopropane carboxylate - Product VI.
1H NMR -,CDC13) : 6.9 (d,lH),· 5.25 (s,2H); 3.2 m,2H); 2.0 (m,3H),· 1.3 (s,6H).
(vi) 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl (+)-cis-3-(2 bromo-3,3,3-trifluoroprop-l-en-l-yl)-2,2-dimethylcyclopropane carboxylate - Product VII.
1H NMR (CDCl-j)^ : 6.9 (d,lH); 5.08 (s,2H); 3.5 (m,2H); 1.93 (m,3H); 1.16 (s,6H).
Infra red (liquid film) : 3300, 1730 cm-X (vii) 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl (+)-3-(1,2dibromo-2,2-dichloroethyl 7-2,2-dimethylcyclopropane carboxylate - Product VIII.
1H NMR (CDC13) : 5.4 (m,lH); 5.2 (s,2H); 3.6 (m,2H); 2.0 (m,3H); 1.3 (d,6H).
(viii) 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl (+)-2-(4chlorophenyl)-3-methylbutyrate - Product IX.
XH NMR (CDC13)^ : 5.17 (m,2H); 3.6 (m,2H); 3.1 (d,lH); 2.3 (m,lH); 2.07 (t,lH); 1.04 (d,3H); 0.75 (d,3H).
Infra red (liquid film) : 3300, 1730 cm-1
EXAMPLE 8
This Example illustrates the preparation of the 4prop-2-ynyl-2,3,5,6-tetrafluorobenzyl esters of (+)-cis and ( + )-trans-3-(Z-2,3,3,3-tetrafluoroprop-1-efi-T-yl)-2, 2dimethylcyclopropane carboxylic acids.
Dicyclohexylcarbodiimide (0.4g) was added to a stirred mixture of 3-(Z-2,3,3,3-tetrafluoroprop-l-en-l-yl)-2, 2dimethylcyclopropane carboxylic acid (0.45g, 88% w/w (+)cis isomer, 12% w/w (+)-trans isomer), 4-prop-2-ynyl2,3,5,6-tetrafluorobenzyl alcohol (0.42g), 410 dimethylaminopyridine (O.Olg) and dichloromethane (10.0cm2) and the mixture stirred for 1 hour. After removal of the solid component by filtration the filtrate wae concentrated by evaporation of the solvent. The residual oil was subjected to purification by h.p.l.c. (Gilson), using a silica gel column eluted with a 1j1 by volume mixture of petroleum ether (boiling range 40-60*C and dichloromethane to yield 4-prop-2-ynyl-2,3,5,6-tetrafluorobenzyl (+)-cis(Z-2,3,3,3-tetrafluoroprop-l-en-l-yl)-2,2-dimethylcyclopropane carboxylate (A, Product X, 400 mg) and 4-prop-220 ynyl-2,3,5,6-tetrafluorobenzyl (+)-trans-3-(Z-2,3,3,3tetrafluoroprop-l-en-l-yl)-2,2-dimethylcyclopropane carboxylate (B, Product XI, 91 mg).
1H NMR (CDCl-j)^ : (A)- 6.2 (d,05H); 5.9 (d,0.5H); 5.2 (s,2H); 3.63 (m,2H); 2.07 (m,3H); 1.27 (s,6H).
(B)- 5.7 (d,0.5H); 5.1 (d,0.5H); 5.3 (s,2H); 3.6 (m,2H); 2.4 (m,lH);
2.05 (t,lH); 1.6 (d,lH); 1.25 (d,6H).
AP 0 0 0 0 3 3
EXAMPLE 9
By the use of procedures similar to those described in Examples 4 and 5 above 2-(4-but-2-ynyl-2,3,5,6-tetrafluorobenzyloxy)tetrahydropyran (C) was obtained from 2-(4bromo-2, 3,5, 6-tetrafluorobenzyloxy)tetrahydropyran and but5 2-ynyl bromide and converted to 4-but-2-ynyl)-2,3,5,6tetrafluorobenzyl alcohol (D).
NMR (CDC13) Ϊ : (D) — 4.8 (d,2H); 3.6 (s,2H): 2.5 (bs,lH); 1.8 (t,3H).
Infra red (liquid film) : 3400 cm^
EXAMPLE 10
By the use of a procedure similar to that illustrated in Example 6 the alcohol (D) was converted to 4-but-2-ynyl
2,3,5,6-tetrafluorobenzyl (+)-cis-3-(Z-2-chloro-3,3,3tetrafluoroprop-l-en-l-yl)-2,2-dimethylcyclopropane carboxylate (Product XII).
1H NMR (CDC13)
6.9 (d,lH); 5.25 (s,2H); 3.6 (bs,2H); 2.1 (m,2H); 1.8 (t,3H); 1.3 (s,6H).
Infra red (liquid film)
1730, 1650 cm1
EXAMPLE 11 .20
This Example illustrates the preparation of 3-bromo-ltrimethylsilylpropyne.
A solution of triphenylphosphine (2.7g) in dry diethyl ether (30 cn?) was added dropwise to a stirred mixture of l-trimethylsilylpropyn-3-ol (1.19g) and 1,2-dibromotetra21 chloroethane (3.38g) and sodium dried diethyl ether (30cm^) over a period of 8 minutes whilst the temperature was maintained at within the range -3 to +3*C. After stirring for a further 10 minutes the solid was removed by filtration and the filtrate concentrated by evaporation of the solvent under reduced pressure. The residual oil was purified by distillation to yield 3-bromo-l-trimethylsilylpropyne (0.9g) as a colourless oil (bp. 68’C/ 20 mm Hg).
1H NMR (CDC13)^· : 0.2 (s,9H)? 3.9 (s,2H).
Infra red (liquid film) : 2200 cm-1
EXAMPLE 12
By the use of procedures similar to those described in Examples 4 and 5 above 2-(4-trimethylsilylprop-2-ynyl2,3,5,6-tetrafluorobenzyloxy)tetrahydropyran (E) was . obtained from 3-bromo-l-trimethylsilylpropyne and 2-(415 bromo-2,3,5,6-tetrafluorobenzyloxy)tetrahydropyran, and converted to 4-trimethylsilylprop-2-ynyl-2,3,5,6-tetrafluorobenzyl alcohol (F).
1H NMR (CDC13) ¢5 : (F)- 4.8 (d,2H); 3.6 (s,2H); 0.1 (s,9H).
Infra red (liquid film) : 3400, 2200 cm^
EXAMPLE 13
By the use of a procedure similar to that illustrated in Example 6 the alcohol (F) was converted to 4trimethylsilylprop-2-ynyl-2,3,5,6-tetrafluorobenzyl ( + )cis-3-(2,2-dichloroviny1)-2,2-dlmethylcyclopropane carboxylate (Product XIII).
APO 0 0 0 3 3 ΧΗ NMR (CDC13) : 6.3 (d,lH); 5.25 (d,2H); 3.6 (bs,2H);
2.0 (m,2H); 1.3 (s,6H); 0.1 (s,9H).
Infra red (liquid film) : 2200, 1730, 1650 cm-1
EXAMPLE 14
This Example illustrates the insecticidal properties of the Products of this invention.
The activity of the Product was determined using a variety of insect pests. The Product was used in the form of liquid preparations containing 500, 100 or 10 parts per million (ppm) by weight of the Product. The preparations were made by dissolving the Product in a mixture of solvents consisting of 4 parts by volume of acetone and 1 part by volume of diacetone alcohol. The solutions were then diluted with water containing 0.01% by weight of a wetting agent sold under the trade name LISSAPOL NX until the liquid preparations contained the required concentration of the Product. Lissapol is a Registered Trade Mark.
The test procedure adopted with regard to each pest was basically the same and comprised supporting a number of the pests on a medium which was usually a host plant or a foodstuff on which the pests feed, and treating either or both the pests and tixe medium with the preparations. The mortality of the pests was then assessed c.t periods usually vsrying from one to three days after the treatment.
Details are given in Table II.
The results of the tests are given in Table III for each of the Products at the rate in parts per million given in the second column as a grading of mortality designated as A, B, C or N wherein A indicates 100% mortality of at an application rate of lOppm, B indicates 100% mortality at
100 ppm, C indicates 100% mortality at 500 ppm and N represents less then 100% mortality at 500 ppm.
In Table III the pest organism used is designated by a letter code and the pest species, the support medium or food, and the type and duration of test is given in Table II.
APO 0 0 0 3 3
TABLE II
2 | |
O | |
M | tn |
£4 | >1 |
It) | |
2 | Ό |
o | |
Q |
6m
O EH cn w ω cu £·
E·
Q O O E-ι 6m Qi \ Ο Σ CU P CU M □ Q cn ω Σ cn ω
V-M υ
ω cu cn
E-1 cn
Cxi
E-
cn | r-* |
06 | IM |
63 | M |
E- | IM |
E- | |
63 | Φ |
J | rM |
xi | |
63 | It) |
Q | E- |
O | |
U |
tn
CM vO tn tn tn <n
rM | «—1 | rM | ||||
mJ | mJ | mJ | It) | It) | It) | It) |
O | U | o | 3 | 3 | 3 | 3 |
It) | It) | e) | Ό | Ό | T3 | Ό |
mJ | mJ | MJ | •rM | •rM | rM | Ή |
G | d | c | tn | tn | tn | to |
0 | 0 | 0 | Φ | Φ | Φ | Φ |
U | u | u | 06 | 06 | 06 | oi |
mJ
O it)
MJ
C u
C it)
Φ
X) c
Φ
Mm
6m
Φ
(MM | CU | lM | — | ||||||
It) | It) | <mm | Φ | mJ | rM | ||||
Φ | u | n) | CUO | 0 | 0 | ||||
rM | Φ | It) Φ | CU | 0 | |||||
Ό | rM | CU Φ | 2 | ||||||
MM | Φ | Φ | VMM | tn | 0 | Mm | |||
It) | VMM | O' | Φ | It) | c | Mm | M | c | It) |
Φ | It) | n) | O | Φ | 0 | φ Φ | mJ | 0 | σ» |
r-M | Φ | X) | rd | MJ | MJ N | tn | mJ | 3 | |
r—1 | X3 | f-H | MJ | rM -rM | It) | mJ | «9 | ||
It) | •M | 0 | •rM It) | r*4 | 0 | ||||
U | o | u | 6m E | CU | U |
□
Ό it)
Φ it) o
•M mJ
Mm in □
jz υ
X d
It)
Mm mJ
Φ
E·
1m
Φ
Ό
M cu tn
Ό
Φ
Mm tn
tn | it) | It) | MJ | ||||||||||
tn | Mm | r—*v | c | MJ | o | rM | |||||||
G | Φ | Mm | Φ | —* | it) | •rM | tn | 3 | |||||
Φ | CU | Φ | u | E | Φ | Φ | c | X | Ό | ||||
O' | CU | in | Mm | tn | Mm | mJ | It) | It) | CU | It) | rtj | ||
Φ | 3 | 0 | 3 | 0 | -rM | 0 | rM | > | E | E | u | ||
It) | rM | JZ | rM | XI | Mm | ? - | It) | Mm | Mm | S | •rM | 1 | |
U | rM | •rM | T3 | Xi | It) | Φ | c | mJ | |||||
•rM | It) | Mm | Φ | E | > | □ | rM | σ> | tn | tn | |||
tn | mJ | It) | MJ | Φ | X> | It) | rC | Φ | Φ | ||||
Mm | It) | Φ | Mm | mJ | tn | 0 | E | . It) | o | E | •M | ||
Φ | > | rM | It) | tn | •rM | 0 | <M | Mm | rM | It) | 0 | rM | |
CU | tn | Mm | CU | x: | CJ | mJ | 0 | rM | 0 | Ό | (MM | ||
Ό | It) | c | Φ | mJ | u | 0 | 5 | Φ | Mm | Φ | |||
tn | •rM | CU | Φ | 0 | N | 0 | It) | Mm | mJ | mJ | X | It) | tn |
3 | It) | Φ | r-M | •rM | •*M | J3 | XI | 0 | mJ | U | U | 3 | |
N | cu | rM | Mm | •H | i0 | rM | 0 | It) | 0 | II) | 0 | tn | 0 |
> | It) | •rM | 0 | X | E | Φ | mJ | •rM | 1m | rM | υ | 3 | X |
Σ | 2 | u | 2 | Q | CQ | Σ |
ecu
Σ
J 'z cu u
CQ
Q
«)
Ό •H tn
Φ
Mm
Ό
C <0
Ό
Φ mJ
R)
Φ
Mm mJ
Φ
Mm
Φ
S
Ή
Ό
Φ
E
Ό
C «3 to
MJ tn
Φ
CU
X mJ «3
JZ mJ <0
Φ mJ (0
U rM
Ό
C •M mJ to
Φ mJ mJ u
<0 mJ
C o
u indicates that the medium was treated before infestation with the pests.
TABLE III
PRODUCT | TU | MP | NL | MD | BG | HV | CP | DB |
I | A | A | B | A | A | B | A | A |
II | B | A | C | B | B | B | A | A |
III | A | B | N | A | A | A | A | B |
IV | A | A | N | A | A | A | A | A |
V | C | A | B | B | B | B | A | A |
X | - | B | C | B | B | B | A | A |
XI | B | B | C | A | B | B | A | A |
XII | fl | A | B | B | B | A | A | A |
XIII | B | C | N | C | C | C | C | A |
APO 0 0 0 3 3
In the test against Musca domestica the knock-down effect was observed. Products I, III, IV and XI gave the most rapid knock-down.
Claims (8)
1. λ f Tu<_'f obenzy 1 ester character 1 sed in that it conforms to the formula:
inhere R is selected -from halogen, -alkyl of up to 4 cartoon atoms and tr ialky Isi ly I where each alkyl group contains up to 4 carbon atoms, and X represents <a> a group of formu la
CH
C
CH, \ / /C \ , CH, wherein <i> R and R are each selected from hydrogen, halo and alkyl of up to four carbon atoms; or <ii> R is hydrogen and R * represents either a group of formula:
— CH __ C ’«Oj or a group of formula.:
-Ί
RJ _CH _ c _ r4
I I
Y Y
3 4 where R and R are each selected from methyl, halo or haloalkyl of up one or two carbon atoms containing at least two fluorine atoms, and V is chlorine or bromo; or <b) X represents a group of formula:
Ar_ CHR5 — where R represents an alkyl group of up to four carbon atoms and fir represents a pheny I group optionally substituted with one or two halogen atoms.
AP 0 0 0 0 3 3
2. fin ester according to claim 1 of formula:
R __ C-^CH.
CH2 — 0 -C - CH
II
CH.
-/ /c\
CH.
where R is hydrogen or alkyl of up to four carbon atoms, 1 2 and R and R are each selected from halogen or alkyl of up to four carbon atoms, or R I is hydrogen and R is a group of formula:
bad original
R3
I 4 _ CH - C - R
3 4 wherein R end R are each selected -from methyl, -fluoro, chloro, bromo and trif luoromethyI.
3. The ester according to claim 2 wherein R is hydrogen,
R is hydrogen and R L is dich lorovinyI or
2-ch loro-3,3,3-trif luoroprop-l-en-1-y I.
4. fin insecticidal composition comprising an insecticidal ly effective amount o-f the ester of claim 1 in association with an insecticidally inert diluent or carrier material.
5. fl method o-f combating insect pests at a locus which comprises treating the locus with an insecticidal ly e-f-fective amount o-f the composition o-f claim 4.
6. The method o-f claim 5 wherein the insect pests are
-flying insect pests, and the composition comprises an amount o-f the compound o-f claim 1 sufficient to cause rapid knock-down of the pests.
7. R process for preparing the ester of comprises reacting an acid of formula esterifyable derivative thereof, with formu la:
claim 1 which
X-COOH, or an an alcohol of
BAD ORIGINAL &
R__C== C —CH
CH20H wherein X and R are as defined in claim 1
8. Rn alcohol of formula:
AP 0 0 0 0 3 3 wherein R is hydrogen or alkyl of up to four cartoon atoms.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858505819A GB8505819D0 (en) | 1985-03-06 | 1985-03-06 | Fluorobenzyl esters |
Publications (2)
Publication Number | Publication Date |
---|---|
AP8600022A0 AP8600022A0 (en) | 1986-02-01 |
AP33A true AP33A (en) | 1988-12-22 |
Family
ID=10575551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
APAP/P/1986/000022A AP33A (en) | 1985-03-06 | 1986-02-19 | Fluorobenzyl esters. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0196156B1 (en) |
JP (1) | JPS61207361A (en) |
KR (1) | KR860007194A (en) |
CN (1) | CN86101408A (en) |
AP (1) | AP33A (en) |
AT (1) | ATE50243T1 (en) |
AU (1) | AU588284B2 (en) |
BR (1) | BR8600949A (en) |
DE (1) | DE3668885D1 (en) |
ES (1) | ES8704442A1 (en) |
GB (2) | GB8505819D0 (en) |
HU (1) | HU199065B (en) |
MY (1) | MY101806A (en) |
NZ (1) | NZ215183A (en) |
OA (1) | OA08264A (en) |
ZA (1) | ZA861209B (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8629806D0 (en) * | 1986-12-12 | 1987-01-21 | Ici Plc | Fluorobenzyl esters |
FR2610624B1 (en) * | 1987-02-06 | 1989-06-09 | Roussel Uclaf | NOVEL ESTERS OF PYRETHRIC ACID-LIKE CYCLOPROPANECARBOXYLIC ACIDS, THEIR PREPARATION PROCESS AND THEIR APPLICATION TO PEST CONTROL |
DE3705224A1 (en) * | 1987-02-19 | 1988-09-01 | Bayer Ag | (+) 1R-TRANS-2,2-DIMETHYL-3- (2,2-DICHLORVINYL) -CYCLOPROPANCARBONIC ACID-2,3,5,6-TETRAFLUOROBE CYLESTER |
GB2208509B (en) * | 1987-08-06 | 1990-11-21 | Ici Plc | Insecticidal cyclopropane carboxylic acid esters and intermediates therefor |
US5045566A (en) * | 1987-11-17 | 1991-09-03 | Ici Americas Inc. | Novel imidate insecticides |
US4994488A (en) * | 1988-10-31 | 1991-02-19 | Ici Americas Inc. | Novel imidate insecticides |
FR2672592B1 (en) * | 1991-02-07 | 1994-05-20 | Roussel Uclaf | NOVEL ESTERS OF ACID 3- (3,3,3-TRIFLUORO 2-CHLORO PROPENYL) 2,2-DIMETHYL CYCLOPROPANECARBONECARBOXYLIQUE, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS PESTICIDES. |
GB2257702A (en) * | 1991-07-17 | 1993-01-20 | Ici Plc | Insecticidal and acaricidal compounds |
JP2004143151A (en) * | 2002-10-02 | 2004-05-20 | Dainippon Jochugiku Co Ltd | Fly repellant incense |
JP5082424B2 (en) * | 2005-12-22 | 2012-11-28 | 住友化学株式会社 | 4-alkoxymethyl-2,3,5,6-tetrafluorotoluene, process for producing the same and use thereof |
US20110124923A1 (en) * | 2005-12-22 | 2011-05-26 | Sumitomo Chemical Company, Limited | Tetrafluorotoluene compound, method for producing same and use thereof |
TWI370812B (en) * | 2006-01-23 | 2012-08-21 | Sumitomo Chemical Co | Ester compound and its use |
MX2008014232A (en) | 2006-05-11 | 2008-11-14 | Sumitomo Chemical Co | Ester compound and its use in pest control. |
JP4855325B2 (en) * | 2007-04-18 | 2012-01-18 | 大日本除蟲菊株式会社 | A room temperature volatile insecticide or a room temperature volatile insecticide containing a benzyl alcohol ester derivative as an active ingredient. |
JP2009143810A (en) * | 2007-12-11 | 2009-07-02 | Sumitomo Chemical Co Ltd | Cyclopropane carboxylate and use of the same |
JP5251116B2 (en) | 2007-12-21 | 2013-07-31 | 住友化学株式会社 | Cyclopropanecarboxylic acid ester and use thereof |
CN102030649B (en) * | 2010-11-15 | 2013-12-25 | 中山凯中有限公司 | Propargyl fluoride pyrethroid compound and application thereof |
JP7220954B2 (en) * | 2019-06-07 | 2023-02-13 | 大日本除蟲菊株式会社 | Ester compound and its use |
CN111533644B (en) * | 2020-03-25 | 2022-12-09 | 浙江工业大学 | Synthetic method of key intermediate 4-propargyl-2, 3,5, 6-tetrafluorobenzyl alcohol of fluorobenzyl insecticides |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3795696A (en) * | 1970-06-13 | 1974-03-05 | Sumitomo Chemical Co | Alkynylbenzyl cyclopropane-carboxylates |
EP0016513A2 (en) * | 1979-02-14 | 1980-10-01 | Imperial Chemical Industries Plc | Esters of halogenated substituted cyclopropanoic acids, their preparation and use as insecticides |
EP0031199A1 (en) * | 1979-12-21 | 1981-07-01 | Imperial Chemical Industries Plc | Substituted benzyl esters of cyclopropane carboxylic acids and their preparation, compositions containing them and methods of combating insect pests therewith, and substituted benzyl alcohols |
EP0054360A2 (en) * | 1980-12-17 | 1982-06-23 | Imperial Chemical Industries Plc | Fluorobenzyl cyclopropane carboxylates, their preparation, compositions comprising them and their use as insecticides |
EP0060617A1 (en) * | 1981-03-18 | 1982-09-22 | Imperial Chemical Industries Plc | Fluorobenzyl cyclopropane carboxylates, their preparation, compositions and use as insecticides |
-
1985
- 1985-03-06 GB GB858505819A patent/GB8505819D0/en active Pending
-
1986
- 1986-02-11 DE DE8686300921T patent/DE3668885D1/en not_active Expired - Fee Related
- 1986-02-11 EP EP86300921A patent/EP0196156B1/en not_active Expired - Lifetime
- 1986-02-11 GB GB08603274A patent/GB2171994B/en not_active Expired
- 1986-02-11 AT AT86300921T patent/ATE50243T1/en not_active IP Right Cessation
- 1986-02-17 NZ NZ215183A patent/NZ215183A/en unknown
- 1986-02-18 ZA ZA861209A patent/ZA861209B/en unknown
- 1986-02-19 AP APAP/P/1986/000022A patent/AP33A/en active
- 1986-02-25 AU AU54050/86A patent/AU588284B2/en not_active Ceased
- 1986-03-05 OA OA58803A patent/OA08264A/en unknown
- 1986-03-05 BR BR8600949A patent/BR8600949A/en unknown
- 1986-03-05 HU HU86903A patent/HU199065B/en not_active IP Right Cessation
- 1986-03-06 ES ES552733A patent/ES8704442A1/en not_active Expired
- 1986-03-06 KR KR1019860001572A patent/KR860007194A/en not_active Application Discontinuation
- 1986-03-06 CN CN198686101408A patent/CN86101408A/en active Pending
- 1986-03-06 JP JP61047491A patent/JPS61207361A/en active Pending
-
1987
- 1987-08-07 MY MYPI87001240A patent/MY101806A/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3795696A (en) * | 1970-06-13 | 1974-03-05 | Sumitomo Chemical Co | Alkynylbenzyl cyclopropane-carboxylates |
EP0016513A2 (en) * | 1979-02-14 | 1980-10-01 | Imperial Chemical Industries Plc | Esters of halogenated substituted cyclopropanoic acids, their preparation and use as insecticides |
EP0031199A1 (en) * | 1979-12-21 | 1981-07-01 | Imperial Chemical Industries Plc | Substituted benzyl esters of cyclopropane carboxylic acids and their preparation, compositions containing them and methods of combating insect pests therewith, and substituted benzyl alcohols |
EP0054360A2 (en) * | 1980-12-17 | 1982-06-23 | Imperial Chemical Industries Plc | Fluorobenzyl cyclopropane carboxylates, their preparation, compositions comprising them and their use as insecticides |
EP0060617A1 (en) * | 1981-03-18 | 1982-09-22 | Imperial Chemical Industries Plc | Fluorobenzyl cyclopropane carboxylates, their preparation, compositions and use as insecticides |
Also Published As
Publication number | Publication date |
---|---|
BR8600949A (en) | 1986-11-11 |
AU588284B2 (en) | 1989-09-14 |
MY101806A (en) | 1992-01-31 |
GB2171994B (en) | 1988-12-14 |
ES552733A0 (en) | 1987-04-01 |
EP0196156A1 (en) | 1986-10-01 |
GB2171994A (en) | 1986-09-10 |
EP0196156B1 (en) | 1990-02-07 |
AP8600022A0 (en) | 1986-02-01 |
OA08264A (en) | 1987-10-30 |
ATE50243T1 (en) | 1990-02-15 |
HU199065B (en) | 1990-01-29 |
NZ215183A (en) | 1989-10-27 |
KR860007194A (en) | 1986-10-08 |
JPS61207361A (en) | 1986-09-13 |
GB8505819D0 (en) | 1985-04-11 |
HUT42292A (en) | 1987-07-28 |
GB8603274D0 (en) | 1986-03-19 |
CN86101408A (en) | 1986-09-17 |
DE3668885D1 (en) | 1990-03-15 |
ES8704442A1 (en) | 1987-04-01 |
AU5405086A (en) | 1986-09-11 |
ZA861209B (en) | 1986-11-26 |
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