AP2013007335A0 - Topical ophthalmological pharmaceutical composition containing regorafenib - Google Patents

Topical ophthalmological pharmaceutical composition containing regorafenib

Info

Publication number: AP2013007335A0
Authority: AP; ARIPO
Prior art keywords: pharmaceutical composition; composition containing; ophthalmological pharmaceutical; topical ophthalmological; containing regorafenib
Prior art date: 2011-06-28

Application number

AP2013007335A

Other languages

English (en)

Inventor

Julia Freundlieb

Michael Bottger

Claudia Hirth-Dietrich

Original Assignee

Bayer Healthcare Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-06-28

Filing date

2012-06-26

Publication date

2013-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46456546&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2013007335(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-06-26 Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc

2013-12-31 Publication of AP2013007335A0 publication Critical patent/AP2013007335A0/xx

Links

239000002138 L01XE21 - Regorafenib Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
FNHKPVJBJVTLMP-UHFFFAOYSA-N regorafenib Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 FNHKPVJBJVTLMP-UHFFFAOYSA-N 0.000 title 1
229960004836 regorafenib Drugs 0.000 title 1
230000000699 topical effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts

AP2013007335A 2011-06-28 2012-06-26 Topical ophthalmological pharmaceutical composition containing regorafenib AP2013007335A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP11171719		2011-06-28
EP12155281		2012-02-14
PCT/EP2012/062365 WO2013000917A1 (en)	2011-06-28	2012-06-26	Topical ophthalmological pharmaceutical composition containing regorafenib

Publications (1)

Publication Number	Publication Date
AP2013007335A0 true AP2013007335A0 (en)	2013-12-31

Family

ID=46456546

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2013007335A AP2013007335A0 (en)	2011-06-28	2012-06-26	Topical ophthalmological pharmaceutical composition containing regorafenib

Country Status (25)

Country	Link
US (1)	US20140296301A1 (xx)
EP (1)	EP2726059A1 (xx)
JP (1)	JP5998213B2 (xx)
KR (1)	KR20140048218A (xx)
CN (1)	CN103889399A (xx)
AP (1)	AP2013007335A0 (xx)
AR (1)	AR086800A1 (xx)
AU (1)	AU2012277905A1 (xx)
BR (1)	BR112013033831A2 (xx)
CA (1)	CA2840329A1 (xx)
CL (1)	CL2013003700A1 (xx)
CO (1)	CO6920289A2 (xx)
CR (1)	CR20130693A (xx)
CU (1)	CU24163B1 (xx)
DO (1)	DOP2013000314A (xx)
EA (1)	EA201400064A1 (xx)
EC (1)	ECSP13013106A (xx)
GT (1)	GT201300322A (xx)
HK (1)	HK1197176A1 (xx)
MX (1)	MX2013015287A (xx)
PE (1)	PE20141031A1 (xx)
TN (1)	TN2013000533A1 (xx)
UY (1)	UY34166A (xx)
WO (1)	WO2013000917A1 (xx)
ZA (1)	ZA201400646B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG155996A1 (en)	2004-09-29	2009-10-29	Bayer Schering Pharma Ag	Thermodynamically stable form of bay 43-9006 tosylate
AR081060A1 (es)	2010-04-15	2012-06-06	Bayer Schering Pharma Ag	Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
UY35183A (es) *	2012-12-21	2014-07-31	Bayer Healthcare Llc	Composición farmacéutica oftalmológica tópica que contiene regorafenib
WO2015011659A1 (en) *	2013-07-24	2015-01-29	Dr. Reddys Laboratories Limited	Crystalline polymorphic forms of regorafenib and processes for the preparation of polymorph i of regorafenib
CN103923000A (zh) *	2014-01-29	2014-07-16	苏州晶云药物科技有限公司	几种新晶型及其制备方法
CN104546776B (zh) *	2015-02-10	2017-08-22	杭州朱养心药业有限公司	瑞戈非尼片剂药物组合物和制法
WO2016200688A1 (en) *	2015-06-06	2016-12-15	Cloudbreak Therapeutics, Llc	Compositions and methods for treating pterygium
WO2017210130A1 (en)	2016-06-02	2017-12-07	Cloudbreak Therapeutics, Llc	Compositions and methods of using nintedanib for improving glaucoma surgery success

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2732222B1 (fr) *	1995-03-28	1997-04-25	Oreal	Utilisation d'un antagoniste de cgrp pour le traitement des prurits et des dysesthesies oculaires et palpebraux
SI1511516T1 (sl) *	2002-05-28	2009-06-30	Nycomed Gmbh	Topično uporaben farmacevtski pripravek
UA84156C2 (ru) *	2003-07-23	2008-09-25	Байер Фармасьютикалс Корпорейшн	Фторозамещённая омега-карбоксиарилдифенилмочевина для лечения и профилактики болезней и состояний
CN101175475B (zh)	2005-05-10	2010-04-14	爱尔康公司	包含活性成分、泊洛沙姆或美洛沙泊表面活性剂和二醇的混悬制剂、其用于生产治疗眼科病症的药物的用途
NZ563984A (en)	2005-06-08	2011-11-25	Targegen Inc	Methods and compositions for the treatment of ocular disorders
MX2008006379A (es)	2005-11-29	2009-03-03	Smithkline Beecham Corp	Metodo de tratamiento.
EP1962828A1 (en) *	2005-12-15	2008-09-03	Bayer HealthCare AG	Diaryl urea for treating inflammatory skin, eye and/or ear diseases
US20070149593A1 (en)	2005-12-23	2007-06-28	Alcon, Inc.	PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
WO2008027341A2 (en)	2006-08-30	2008-03-06	Merck & Co., Inc.	Topical ophthalmic formulations
AR062927A1 (es)	2006-10-11	2008-12-17	Bayer Healthcare Ag	4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
RU2470635C2 (ru) *	2007-05-11	2012-12-27	Сантен Фармасьютикал Ко., Лтд.	Профилактическое или терапевтическое средство, применяемое при заболеваниях заднего отдела глаза
DE102007055341A1 (de) *	2007-11-19	2009-05-20	Bayer Animal Health Gmbh	Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
CA2760687A1 (en)	2009-05-01	2010-11-04	Ophthotech Corporation	Methods for treating or preventing ophthalmological diseases
WO2011009016A1 (en)	2009-07-16	2011-01-20	Glaxo Wellcome Manufacturing Pte Ltd	Treatment method

2012
- 2012-06-26 WO PCT/EP2012/062365 patent/WO2013000917A1/en active Application Filing
- 2012-06-26 CU CU20130168A patent/CU24163B1/es active IP Right Grant
- 2012-06-26 EA EA201400064A patent/EA201400064A1/ru unknown
- 2012-06-26 KR KR1020147002095A patent/KR20140048218A/ko not_active Application Discontinuation
- 2012-06-26 MX MX2013015287A patent/MX2013015287A/es not_active Application Discontinuation
- 2012-06-26 BR BR112013033831A patent/BR112013033831A2/pt not_active IP Right Cessation
- 2012-06-26 PE PE2013002872A patent/PE20141031A1/es not_active Application Discontinuation
- 2012-06-26 US US14/128,356 patent/US20140296301A1/en not_active Abandoned
- 2012-06-26 AP AP2013007335A patent/AP2013007335A0/xx unknown
- 2012-06-26 EP EP12731396.3A patent/EP2726059A1/en not_active Withdrawn
- 2012-06-26 CN CN201280042504.9A patent/CN103889399A/zh active Pending
- 2012-06-26 JP JP2014517661A patent/JP5998213B2/ja not_active Expired - Fee Related
- 2012-06-26 CA CA2840329A patent/CA2840329A1/en not_active Abandoned
- 2012-06-26 AU AU2012277905A patent/AU2012277905A1/en not_active Abandoned
- 2012-06-27 UY UY0001034166A patent/UY34166A/es not_active Application Discontinuation
- 2012-06-28 AR ARP120102339A patent/AR086800A1/es active Pending
2013
- 2013-12-20 CR CR20130693A patent/CR20130693A/es unknown
- 2013-12-23 GT GT201300322A patent/GT201300322A/es unknown
- 2013-12-23 CL CL2013003700A patent/CL2013003700A1/es unknown
- 2013-12-24 EC EC2013013106A patent/ECSP13013106A/es unknown
- 2013-12-26 CO CO13300167A patent/CO6920289A2/es not_active Application Discontinuation
- 2013-12-26 DO DO2013000314A patent/DOP2013000314A/es unknown
- 2013-12-27 TN TNP2013000533A patent/TN2013000533A1/fr unknown
2014
- 2014-01-27 ZA ZA2014/00646A patent/ZA201400646B/en unknown
- 2014-10-22 HK HK14110517A patent/HK1197176A1/xx unknown

Also Published As

Publication number	Publication date
KR20140048218A (ko)	2014-04-23
CR20130693A (es)	2016-05-02
UY34166A (es)	2013-01-31
ZA201400646B (en)	2015-11-25
HK1197176A1 (en)	2015-01-09
GT201300322A (es)	2014-11-13
EA201400064A1 (ru)	2014-05-30
CL2013003700A1 (es)	2014-07-18
CN103889399A (zh)	2014-06-25
WO2013000917A1 (en)	2013-01-03
NZ619229A (en)	2016-04-29
DOP2013000314A (es)	2014-04-15
TN2013000533A1 (en)	2015-03-30
MX2013015287A (es)	2014-03-31
EP2726059A1 (en)	2014-05-07
CU20130168A7 (es)	2014-04-24
AU2012277905A8 (en)	2014-01-30
AR086800A1 (es)	2014-01-22
CU24163B1 (es)	2016-03-31
ECSP13013106A (es)	2014-01-31
CA2840329A1 (en)	2013-01-03
US20140296301A1 (en)	2014-10-02
AU2012277905A1 (en)	2014-01-16
BR112013033831A2 (pt)	2017-02-14
PE20141031A1 (es)	2014-08-21
CO6920289A2 (es)	2014-04-10
JP5998213B2 (ja)	2016-09-28
JP2014518233A (ja)	2014-07-28

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